Amino acid dipepetide frequency for Rhizobium etli (strain CFN 42 / ATCC 51251)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.422AlaAla: 16.422 ± 0.15	1.018AlaCys: 1.018 ± 0.024	6.67AlaAsp: 6.67 ± 0.07	7.514AlaGlu: 7.514 ± 0.078	4.518AlaPhe: 4.518 ± 0.048	10.219AlaGly: 10.219 ± 0.089	2.095AlaHis: 2.095 ± 0.035	6.969AlaIle: 6.969 ± 0.063	4.386AlaLys: 4.386 ± 0.056	12.253AlaLeu: 12.253 ± 0.104	3.416AlaMet: 3.416 ± 0.045	3.099AlaAsn: 3.099 ± 0.047	4.733AlaPro: 4.733 ± 0.061	3.291AlaGln: 3.291 ± 0.049	7.682AlaArg: 7.682 ± 0.077	6.595AlaSer: 6.595 ± 0.067	5.606AlaThr: 5.606 ± 0.059	8.519AlaVal: 8.519 ± 0.073	1.362AlaTrp: 1.362 ± 0.032	2.606AlaTyr: 2.606 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	0.892CysAla: 0.892 ± 0.023	0.123CysCys: 0.123 ± 0.008	0.505CysAsp: 0.505 ± 0.017	0.443CysGlu: 0.443 ± 0.017	0.359CysPhe: 0.359 ± 0.014	0.893CysGly: 0.893 ± 0.021	0.267CysHis: 0.267 ± 0.013	0.425CysIle: 0.425 ± 0.015	0.211CysLys: 0.211 ± 0.011	0.834CysLeu: 0.834 ± 0.021	0.167CysMet: 0.167 ± 0.01	0.219CysAsn: 0.219 ± 0.011	0.407CysPro: 0.407 ± 0.013	0.238CysGln: 0.238 ± 0.011	0.686CysArg: 0.686 ± 0.022	0.505CysSer: 0.505 ± 0.015	0.391CysThr: 0.391 ± 0.014	0.583CysVal: 0.583 ± 0.018	0.116CysTrp: 0.116 ± 0.008	0.214CysTyr: 0.214 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	6.341AspAla: 6.341 ± 0.073	0.5AspCys: 0.5 ± 0.016	3.144AspAsp: 3.144 ± 0.052	3.509AspGlu: 3.509 ± 0.049	2.374AspPhe: 2.374 ± 0.04	5.047AspGly: 5.047 ± 0.058	1.303AspHis: 1.303 ± 0.026	3.423AspIle: 3.423 ± 0.047	1.908AspLys: 1.908 ± 0.035	5.7AspLeu: 5.7 ± 0.058	1.344AspMet: 1.344 ± 0.027	1.513AspAsn: 1.513 ± 0.034	3.228AspPro: 3.228 ± 0.045	1.735AspGln: 1.735 ± 0.035	4.248AspArg: 4.248 ± 0.047	2.18AspSer: 2.18 ± 0.032	2.389AspThr: 2.389 ± 0.042	4.062AspVal: 4.062 ± 0.05	0.931AspTrp: 0.931 ± 0.022	1.578AspTyr: 1.578 ± 0.029	0.0AspXaa: 0.0 ± 0.0
Glu	7.351GluAla: 7.351 ± 0.068	0.374GluCys: 0.374 ± 0.015	2.755GluAsp: 2.755 ± 0.042	3.517GluGlu: 3.517 ± 0.054	1.945GluPhe: 1.945 ± 0.031	4.145GluGly: 4.145 ± 0.051	1.19GluHis: 1.19 ± 0.027	3.971GluIle: 3.971 ± 0.047	2.804GluLys: 2.804 ± 0.042	5.464GluLeu: 5.464 ± 0.06	1.568GluMet: 1.568 ± 0.029	1.932GluAsn: 1.932 ± 0.035	2.58GluPro: 2.58 ± 0.046	2.097GluGln: 2.097 ± 0.038	4.808GluArg: 4.808 ± 0.064	2.488GluSer: 2.488 ± 0.046	3.601GluThr: 3.601 ± 0.049	3.698GluVal: 3.698 ± 0.053	0.692GluTrp: 0.692 ± 0.02	1.059GluTyr: 1.059 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	4.648PheAla: 4.648 ± 0.056	0.428PheCys: 0.428 ± 0.017	2.75PheAsp: 2.75 ± 0.039	2.208PheGlu: 2.208 ± 0.038	1.633PhePhe: 1.633 ± 0.03	3.648PheGly: 3.648 ± 0.05	0.821PheHis: 0.821 ± 0.021	1.941PheIle: 1.941 ± 0.036	1.156PheLys: 1.156 ± 0.026	3.63PheLeu: 3.63 ± 0.048	0.843PheMet: 0.843 ± 0.021	1.174PheAsn: 1.174 ± 0.027	1.698PhePro: 1.698 ± 0.033	1.098PheGln: 1.098 ± 0.024	2.47PheArg: 2.47 ± 0.035	2.599PheSer: 2.599 ± 0.043	1.97PheThr: 1.97 ± 0.031	2.96PheVal: 2.96 ± 0.042	0.582PheTrp: 0.582 ± 0.02	1.051PheTyr: 1.051 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	8.329GlyAla: 8.329 ± 0.079	0.84GlyCys: 0.84 ± 0.02	4.301GlyAsp: 4.301 ± 0.053	4.848GlyGlu: 4.848 ± 0.051	3.65GlyPhe: 3.65 ± 0.046	6.746GlyGly: 6.746 ± 0.087	1.865GlyHis: 1.865 ± 0.034	5.031GlyIle: 5.031 ± 0.058	3.608GlyLys: 3.608 ± 0.047	8.495GlyLeu: 8.495 ± 0.077	2.249GlyMet: 2.249 ± 0.035	2.451GlyAsn: 2.451 ± 0.045	3.117GlyPro: 3.117 ± 0.043	2.654GlyGln: 2.654 ± 0.037	5.964GlyArg: 5.964 ± 0.061	4.806GlySer: 4.806 ± 0.057	4.393GlyThr: 4.393 ± 0.06	5.525GlyVal: 5.525 ± 0.053	1.269GlyTrp: 1.269 ± 0.031	2.302GlyTyr: 2.302 ± 0.035	0.0GlyXaa: 0.0 ± 0.0
His	2.214HisAla: 2.214 ± 0.04	0.233HisCys: 0.233 ± 0.011	1.253HisAsp: 1.253 ± 0.029	1.107HisGlu: 1.107 ± 0.026	0.941HisPhe: 0.941 ± 0.022	1.909HisGly: 1.909 ± 0.035	0.593HisHis: 0.593 ± 0.022	1.084HisIle: 1.084 ± 0.025	0.515HisLys: 0.515 ± 0.018	2.12HisLeu: 2.12 ± 0.038	0.526HisMet: 0.526 ± 0.013	0.509HisAsn: 0.509 ± 0.017	1.297HisPro: 1.297 ± 0.031	0.611HisGln: 0.611 ± 0.018	1.538HisArg: 1.538 ± 0.035	1.031HisSer: 1.031 ± 0.021	0.785HisThr: 0.785 ± 0.02	1.515HisVal: 1.515 ± 0.031	0.306HisTrp: 0.306 ± 0.013	0.574HisTyr: 0.574 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.809IleAla: 7.809 ± 0.068	0.568IleCys: 0.568 ± 0.017	3.866IleAsp: 3.866 ± 0.052	3.821IleGlu: 3.821 ± 0.052	2.118IlePhe: 2.118 ± 0.038	5.332IleGly: 5.332 ± 0.06	1.009IleHis: 1.009 ± 0.026	2.793IleIle: 2.793 ± 0.04	1.664IleLys: 1.664 ± 0.035	4.935IleLeu: 4.935 ± 0.059	1.144IleMet: 1.144 ± 0.025	1.572IleAsn: 1.572 ± 0.032	2.519IlePro: 2.519 ± 0.039	1.299IleGln: 1.299 ± 0.028	3.653IleArg: 3.653 ± 0.045	3.715IleSer: 3.715 ± 0.048	2.826IleThr: 2.826 ± 0.04	4.665IleVal: 4.665 ± 0.058	0.69IleTrp: 0.69 ± 0.019	1.305IleTyr: 1.305 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.726LysAla: 4.726 ± 0.064	0.175LysCys: 0.175 ± 0.01	1.94LysAsp: 1.94 ± 0.036	1.873LysGlu: 1.873 ± 0.039	1.057LysPhe: 1.057 ± 0.023	2.794LysGly: 2.794 ± 0.044	0.662LysHis: 0.662 ± 0.019	2.152LysIle: 2.152 ± 0.041	1.525LysLys: 1.525 ± 0.039	3.641LysLeu: 3.641 ± 0.051	0.933LysMet: 0.933 ± 0.026	1.076LysAsn: 1.076 ± 0.025	2.23LysPro: 2.23 ± 0.04	1.194LysGln: 1.194 ± 0.03	2.524LysArg: 2.524 ± 0.04	2.314LysSer: 2.314 ± 0.042	2.255LysThr: 2.255 ± 0.041	2.618LysVal: 2.618 ± 0.037	0.399LysTrp: 0.399 ± 0.013	0.731LysTyr: 0.731 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	12.539LeuAla: 12.539 ± 0.093	0.915LeuCys: 0.915 ± 0.022	5.813LeuAsp: 5.813 ± 0.06	5.277LeuGlu: 5.277 ± 0.062	3.786LeuPhe: 3.786 ± 0.06	7.675LeuGly: 7.675 ± 0.066	1.891LeuHis: 1.891 ± 0.035	5.272LeuIle: 5.272 ± 0.063	4.072LeuLys: 4.072 ± 0.05	9.343LeuLeu: 9.343 ± 0.102	2.365LeuMet: 2.365 ± 0.038	2.78LeuAsn: 2.78 ± 0.043	5.367LeuPro: 5.367 ± 0.059	2.991LeuGln: 2.991 ± 0.044	6.373LeuArg: 6.373 ± 0.066	6.986LeuSer: 6.986 ± 0.064	5.618LeuThr: 5.618 ± 0.06	7.088LeuVal: 7.088 ± 0.07	1.076LeuTrp: 1.076 ± 0.024	2.133LeuTyr: 2.133 ± 0.035	0.0LeuXaa: 0.0 ± 0.0
Met	3.022MetAla: 3.022 ± 0.042	0.151MetCys: 0.151 ± 0.009	1.129MetAsp: 1.129 ± 0.027	1.233MetGlu: 1.233 ± 0.026	0.726MetPhe: 0.726 ± 0.018	1.664MetGly: 1.664 ± 0.035	0.432MetHis: 0.432 ± 0.015	1.527MetIle: 1.527 ± 0.03	1.17MetLys: 1.17 ± 0.025	2.596MetLeu: 2.596 ± 0.037	0.697MetMet: 0.697 ± 0.022	0.879MetAsn: 0.879 ± 0.024	1.503MetPro: 1.503 ± 0.027	0.864MetGln: 0.864 ± 0.02	1.831MetArg: 1.831 ± 0.033	1.769MetSer: 1.769 ± 0.034	1.864MetThr: 1.864 ± 0.032	1.704MetVal: 1.704 ± 0.032	0.185MetTrp: 0.185 ± 0.01	0.318MetTyr: 0.318 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.275AsnAla: 3.275 ± 0.048	0.241AsnCys: 0.241 ± 0.011	1.601AsnAsp: 1.601 ± 0.034	1.445AsnGlu: 1.445 ± 0.029	1.179AsnPhe: 1.179 ± 0.027	2.686AsnGly: 2.686 ± 0.041	0.605AsnHis: 0.605 ± 0.017	1.631AsnIle: 1.631 ± 0.034	0.828AsnLys: 0.828 ± 0.023	2.837AsnLeu: 2.837 ± 0.041	0.675AsnMet: 0.675 ± 0.019	0.843AsnAsn: 0.843 ± 0.03	1.842AsnPro: 1.842 ± 0.034	0.864AsnGln: 0.864 ± 0.021	1.976AsnArg: 1.976 ± 0.033	1.557AsnSer: 1.557 ± 0.027	1.334AsnThr: 1.334 ± 0.03	2.039AsnVal: 2.039 ± 0.04	0.465AsnTrp: 0.465 ± 0.018	0.73AsnTyr: 0.73 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	5.778ProAla: 5.778 ± 0.071	0.326ProCys: 0.326 ± 0.015	3.362ProAsp: 3.362 ± 0.049	3.548ProGlu: 3.548 ± 0.041	1.976ProPhe: 1.976 ± 0.034	3.986ProGly: 3.986 ± 0.049	1.067ProHis: 1.067 ± 0.027	2.401ProIle: 2.401 ± 0.033	1.791ProLys: 1.791 ± 0.034	4.667ProLeu: 4.667 ± 0.059	1.124ProMet: 1.124 ± 0.023	1.345ProAsn: 1.345 ± 0.029	2.248ProPro: 2.248 ± 0.04	1.611ProGln: 1.611 ± 0.031	2.697ProArg: 2.697 ± 0.039	2.827ProSer: 2.827 ± 0.044	2.293ProThr: 2.293 ± 0.039	4.036ProVal: 4.036 ± 0.05	0.636ProTrp: 0.636 ± 0.022	1.204ProTyr: 1.204 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.874GlnAla: 3.874 ± 0.049	0.203GlnCys: 0.203 ± 0.01	1.35GlnAsp: 1.35 ± 0.026	1.562GlnGlu: 1.562 ± 0.03	1.098GlnPhe: 1.098 ± 0.025	2.162GlnGly: 2.162 ± 0.039	0.628GlnHis: 0.628 ± 0.017	1.85GlnIle: 1.85 ± 0.034	1.202GlnLys: 1.202 ± 0.027	2.897GlnLeu: 2.897 ± 0.047	0.947GlnMet: 0.947 ± 0.023	0.906GlnAsn: 0.906 ± 0.024	1.776GlnPro: 1.776 ± 0.034	1.373GlnGln: 1.373 ± 0.035	2.345GlnArg: 2.345 ± 0.038	1.955GlnSer: 1.955 ± 0.033	1.781GlnThr: 1.781 ± 0.034	2.056GlnVal: 2.056 ± 0.037	0.393GlnTrp: 0.393 ± 0.015	0.652GlnTyr: 0.652 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	6.968ArgAla: 6.968 ± 0.069	0.518ArgCys: 0.518 ± 0.019	3.888ArgAsp: 3.888 ± 0.051	4.04ArgGlu: 4.04 ± 0.056	2.87ArgPhe: 2.87 ± 0.039	4.521ArgGly: 4.521 ± 0.053	1.823ArgHis: 1.823 ± 0.031	4.142ArgIle: 4.142 ± 0.047	2.628ArgLys: 2.628 ± 0.043	7.664ArgLeu: 7.664 ± 0.083	1.916ArgMet: 1.916 ± 0.033	2.104ArgAsn: 2.104 ± 0.035	3.372ArgPro: 3.372 ± 0.049	2.783ArgGln: 2.783 ± 0.036	5.712ArgArg: 5.712 ± 0.076	3.983ArgSer: 3.983 ± 0.05	3.2ArgThr: 3.2 ± 0.042	4.156ArgVal: 4.156 ± 0.058	0.969ArgTrp: 0.969 ± 0.024	1.752ArgTyr: 1.752 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.525SerAla: 6.525 ± 0.067	0.449SerCys: 0.449 ± 0.017	3.251SerAsp: 3.251 ± 0.048	3.122SerGlu: 3.122 ± 0.044	2.559SerPhe: 2.559 ± 0.04	5.982SerGly: 5.982 ± 0.058	1.252SerHis: 1.252 ± 0.026	3.312SerIle: 3.312 ± 0.05	1.904SerLys: 1.904 ± 0.034	5.858SerLeu: 5.858 ± 0.067	1.466SerMet: 1.466 ± 0.029	1.656SerAsn: 1.656 ± 0.033	2.869SerPro: 2.869 ± 0.042	1.74SerGln: 1.74 ± 0.03	3.953SerArg: 3.953 ± 0.047	3.549SerSer: 3.549 ± 0.05	2.888SerThr: 2.888 ± 0.034	4.271SerVal: 4.271 ± 0.051	0.831SerTrp: 0.831 ± 0.023	1.438SerTyr: 1.438 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.16ThrAla: 6.16 ± 0.065	0.414ThrCys: 0.414 ± 0.018	2.74ThrAsp: 2.74 ± 0.047	2.764ThrGlu: 2.764 ± 0.041	2.066ThrPhe: 2.066 ± 0.037	4.838ThrGly: 4.838 ± 0.065	0.993ThrHis: 0.993 ± 0.022	3.245ThrIle: 3.245 ± 0.041	1.619ThrLys: 1.619 ± 0.029	5.461ThrLeu: 5.461 ± 0.065	1.279ThrMet: 1.279 ± 0.024	1.392ThrAsn: 1.392 ± 0.027	2.863ThrPro: 2.863 ± 0.039	1.317ThrGln: 1.317 ± 0.029	3.041ThrArg: 3.041 ± 0.04	3.076ThrSer: 3.076 ± 0.046	2.777ThrThr: 2.777 ± 0.044	4.342ThrVal: 4.342 ± 0.048	0.632ThrTrp: 0.632 ± 0.021	1.242ThrTyr: 1.242 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	8.436ValAla: 8.436 ± 0.068	0.61ValCys: 0.61 ± 0.019	4.039ValAsp: 4.039 ± 0.05	4.374ValGlu: 4.374 ± 0.052	2.87ValPhe: 2.87 ± 0.038	5.239ValGly: 5.239 ± 0.056	1.345ValHis: 1.345 ± 0.032	4.325ValIle: 4.325 ± 0.055	2.546ValLys: 2.546 ± 0.036	7.03ValLeu: 7.03 ± 0.07	1.805ValMet: 1.805 ± 0.032	2.062ValAsn: 2.062 ± 0.036	3.461ValPro: 3.461 ± 0.049	1.934ValGln: 1.934 ± 0.033	4.58ValArg: 4.58 ± 0.054	4.773ValSer: 4.773 ± 0.058	4.431ValThr: 4.431 ± 0.045	5.617ValVal: 5.617 ± 0.079	0.819ValTrp: 0.819 ± 0.022	1.531ValTyr: 1.531 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.194TrpAla: 1.194 ± 0.028	0.131TrpCys: 0.131 ± 0.008	0.606TrpAsp: 0.606 ± 0.02	0.567TrpGlu: 0.567 ± 0.017	0.555TrpPhe: 0.555 ± 0.018	0.814TrpGly: 0.814 ± 0.022	0.318TrpHis: 0.318 ± 0.014	0.718TrpIle: 0.718 ± 0.025	0.553TrpLys: 0.553 ± 0.019	1.564TrpLeu: 1.564 ± 0.036	0.347TrpMet: 0.347 ± 0.013	0.49TrpAsn: 0.49 ± 0.018	0.668TrpPro: 0.668 ± 0.02	0.554TrpGln: 0.554 ± 0.017	1.071TrpArg: 1.071 ± 0.027	0.831TrpSer: 0.831 ± 0.023	0.736TrpThr: 0.736 ± 0.022	0.715TrpVal: 0.715 ± 0.021	0.234TrpTrp: 0.234 ± 0.01	0.293TrpTyr: 0.293 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.472TyrAla: 2.472 ± 0.036	0.262TyrCys: 0.262 ± 0.013	1.494TyrAsp: 1.494 ± 0.027	1.265TyrGlu: 1.265 ± 0.027	1.028TyrPhe: 1.028 ± 0.026	2.145TyrGly: 2.145 ± 0.033	0.503TyrHis: 0.503 ± 0.018	1.089TyrIle: 1.089 ± 0.025	0.727TyrLys: 0.727 ± 0.023	2.37TyrLeu: 2.37 ± 0.04	0.449TyrMet: 0.449 ± 0.016	0.65TyrAsn: 0.65 ± 0.018	1.145TyrPro: 1.145 ± 0.025	0.763TyrGln: 0.763 ± 0.022	1.861TyrArg: 1.861 ± 0.032	1.336TyrSer: 1.336 ± 0.027	1.124TyrThr: 1.124 ± 0.03	1.66TyrVal: 1.66 ± 0.033	0.371TyrTrp: 0.371 ± 0.016	0.655TyrTyr: 0.655 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5921 proteins (1851644 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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