Amino acid dipepetide frequency for Kurthia sibirica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.499AlaAla: 6.499 ± 0.11
0.606AlaCys: 0.606 ± 0.026
3.919AlaAsp: 3.919 ± 0.072
4.636AlaGlu: 4.636 ± 0.094
3.306AlaPhe: 3.306 ± 0.062
5.328AlaGly: 5.328 ± 0.09
1.434AlaHis: 1.434 ± 0.036
7.249AlaIle: 7.249 ± 0.091
5.18AlaLys: 5.18 ± 0.078
7.83AlaLeu: 7.83 ± 0.103
2.367AlaMet: 2.367 ± 0.055
3.205AlaAsn: 3.205 ± 0.066
2.21AlaPro: 2.21 ± 0.054
3.241AlaGln: 3.241 ± 0.066
2.643AlaArg: 2.643 ± 0.061
4.53AlaSer: 4.53 ± 0.079
4.908AlaThr: 4.908 ± 0.083
5.677AlaVal: 5.677 ± 0.083
0.551AlaTrp: 0.551 ± 0.023
2.532AlaTyr: 2.532 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.429CysAla: 0.429 ± 0.02
0.096CysCys: 0.096 ± 0.012
0.383CysAsp: 0.383 ± 0.021
0.41CysGlu: 0.41 ± 0.023
0.275CysPhe: 0.275 ± 0.018
0.603CysGly: 0.603 ± 0.029
0.197CysHis: 0.197 ± 0.013
0.494CysIle: 0.494 ± 0.023
0.309CysLys: 0.309 ± 0.016
0.614CysLeu: 0.614 ± 0.026
0.178CysMet: 0.178 ± 0.012
0.27CysAsn: 0.27 ± 0.016
0.315CysPro: 0.315 ± 0.017
0.242CysGln: 0.242 ± 0.018
0.255CysArg: 0.255 ± 0.017
0.446CysSer: 0.446 ± 0.02
0.405CysThr: 0.405 ± 0.021
0.399CysVal: 0.399 ± 0.02
0.061CysTrp: 0.061 ± 0.007
0.245CysTyr: 0.245 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.076AspAla: 4.076 ± 0.081
0.367AspCys: 0.367 ± 0.018
3.04AspAsp: 3.04 ± 0.062
4.512AspGlu: 4.512 ± 0.081
2.806AspPhe: 2.806 ± 0.054
3.464AspGly: 3.464 ± 0.068
1.256AspHis: 1.256 ± 0.033
4.075AspIle: 4.075 ± 0.062
3.091AspLys: 3.091 ± 0.063
5.04AspLeu: 5.04 ± 0.066
1.44AspMet: 1.44 ± 0.036
1.802AspAsn: 1.802 ± 0.053
1.466AspPro: 1.466 ± 0.037
1.978AspGln: 1.978 ± 0.049
2.003AspArg: 2.003 ± 0.046
2.727AspSer: 2.727 ± 0.056
2.79AspThr: 2.79 ± 0.058
3.9AspVal: 3.9 ± 0.073
0.547AspTrp: 0.547 ± 0.023
2.26AspTyr: 2.26 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
5.291GluAla: 5.291 ± 0.086
0.302GluCys: 0.302 ± 0.016
3.443GluAsp: 3.443 ± 0.07
5.587GluGlu: 5.587 ± 0.099
2.441GluPhe: 2.441 ± 0.059
3.658GluGly: 3.658 ± 0.064
1.399GluHis: 1.399 ± 0.036
5.068GluIle: 5.068 ± 0.088
5.881GluLys: 5.881 ± 0.095
7.035GluLeu: 7.035 ± 0.09
1.95GluMet: 1.95 ± 0.05
3.342GluAsn: 3.342 ± 0.063
1.794GluPro: 1.794 ± 0.053
3.614GluGln: 3.614 ± 0.069
2.993GluArg: 2.993 ± 0.067
2.962GluSer: 2.962 ± 0.061
3.23GluThr: 3.23 ± 0.065
4.73GluVal: 4.73 ± 0.075
0.636GluTrp: 0.636 ± 0.027
1.839GluTyr: 1.839 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
3.245PheAla: 3.245 ± 0.065
0.327PheCys: 0.327 ± 0.019
2.713PheAsp: 2.713 ± 0.056
2.991PheGlu: 2.991 ± 0.059
2.31PhePhe: 2.31 ± 0.061
3.123PheGly: 3.123 ± 0.063
0.839PheHis: 0.839 ± 0.027
4.005PheIle: 4.005 ± 0.082
2.746PheLys: 2.746 ± 0.055
4.026PheLeu: 4.026 ± 0.085
1.264PheMet: 1.264 ± 0.037
2.029PheAsn: 2.029 ± 0.047
1.377PhePro: 1.377 ± 0.041
1.393PheGln: 1.393 ± 0.035
1.263PheArg: 1.263 ± 0.039
3.063PheSer: 3.063 ± 0.061
2.872PheThr: 2.872 ± 0.056
3.07PheVal: 3.07 ± 0.058
0.389PheTrp: 0.389 ± 0.02
1.639PheTyr: 1.639 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
4.899GlyAla: 4.899 ± 0.08
0.469GlyCys: 0.469 ± 0.025
3.288GlyAsp: 3.288 ± 0.065
3.835GlyGlu: 3.835 ± 0.065
3.099GlyPhe: 3.099 ± 0.068
4.454GlyGly: 4.454 ± 0.088
1.372GlyHis: 1.372 ± 0.04
5.436GlyIle: 5.436 ± 0.089
4.504GlyLys: 4.504 ± 0.076
5.827GlyLeu: 5.827 ± 0.093
1.893GlyMet: 1.893 ± 0.052
2.402GlyAsn: 2.402 ± 0.065
1.435GlyPro: 1.435 ± 0.046
2.424GlyGln: 2.424 ± 0.053
2.48GlyArg: 2.48 ± 0.057
3.63GlySer: 3.63 ± 0.068
3.876GlyThr: 3.876 ± 0.077
4.712GlyVal: 4.712 ± 0.099
0.654GlyTrp: 0.654 ± 0.022
2.593GlyTyr: 2.593 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
1.6HisAla: 1.6 ± 0.045
0.177HisCys: 0.177 ± 0.014
1.111HisAsp: 1.111 ± 0.035
1.258HisGlu: 1.258 ± 0.034
1.101HisPhe: 1.101 ± 0.035
1.272HisGly: 1.272 ± 0.039
0.646HisHis: 0.646 ± 0.029
1.669HisIle: 1.669 ± 0.045
1.074HisLys: 1.074 ± 0.031
1.965HisLeu: 1.965 ± 0.045
0.555HisMet: 0.555 ± 0.024
0.818HisAsn: 0.818 ± 0.028
0.937HisPro: 0.937 ± 0.033
0.797HisGln: 0.797 ± 0.03
0.847HisArg: 0.847 ± 0.031
1.167HisSer: 1.167 ± 0.037
1.161HisThr: 1.161 ± 0.036
1.362HisVal: 1.362 ± 0.034
0.159HisTrp: 0.159 ± 0.014
0.938HisTyr: 0.938 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
7.438IleAla: 7.438 ± 0.096
0.644IleCys: 0.644 ± 0.025
4.811IleAsp: 4.811 ± 0.079
5.825IleGlu: 5.825 ± 0.087
3.345IlePhe: 3.345 ± 0.069
5.844IleGly: 5.844 ± 0.093
1.765IleHis: 1.765 ± 0.038
7.003IleIle: 7.003 ± 0.108
4.605IleLys: 4.605 ± 0.073
6.967IleLeu: 6.967 ± 0.115
2.059IleMet: 2.059 ± 0.053
3.377IleAsn: 3.377 ± 0.053
3.273IlePro: 3.273 ± 0.065
2.937IleGln: 2.937 ± 0.048
3.012IleArg: 3.012 ± 0.055
4.937IleSer: 4.937 ± 0.065
4.818IleThr: 4.818 ± 0.075
6.376IleVal: 6.376 ± 0.089
0.618IleTrp: 0.618 ± 0.029
2.415IleTyr: 2.415 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
4.714LysAla: 4.714 ± 0.077
0.294LysCys: 0.294 ± 0.02
3.771LysAsp: 3.771 ± 0.068
5.724LysGlu: 5.724 ± 0.094
2.042LysPhe: 2.042 ± 0.05
3.929LysGly: 3.929 ± 0.077
1.194LysHis: 1.194 ± 0.032
5.454LysIle: 5.454 ± 0.083
6.648LysLys: 6.648 ± 0.109
6.17LysLeu: 6.17 ± 0.097
2.484LysMet: 2.484 ± 0.054
3.994LysAsn: 3.994 ± 0.071
2.221LysPro: 2.221 ± 0.047
2.912LysGln: 2.912 ± 0.067
2.931LysArg: 2.931 ± 0.058
3.798LysSer: 3.798 ± 0.062
4.208LysThr: 4.208 ± 0.077
4.309LysVal: 4.309 ± 0.083
0.729LysTrp: 0.729 ± 0.033
2.357LysTyr: 2.357 ± 0.057
0.0LysXaa: 0.0 ± 0.0
Leu
8.044LeuAla: 8.044 ± 0.103
0.64LeuCys: 0.64 ± 0.027
4.616LeuAsp: 4.616 ± 0.076
5.916LeuGlu: 5.916 ± 0.083
4.761LeuPhe: 4.761 ± 0.083
5.654LeuGly: 5.654 ± 0.096
2.032LeuHis: 2.032 ± 0.051
7.132LeuIle: 7.132 ± 0.127
6.356LeuLys: 6.356 ± 0.081
10.286LeuLeu: 10.286 ± 0.162
2.495LeuMet: 2.495 ± 0.058
4.37LeuAsn: 4.37 ± 0.07
3.839LeuPro: 3.839 ± 0.076
4.417LeuGln: 4.417 ± 0.084
3.401LeuArg: 3.401 ± 0.068
6.344LeuSer: 6.344 ± 0.098
6.079LeuThr: 6.079 ± 0.087
6.283LeuVal: 6.283 ± 0.089
0.728LeuTrp: 0.728 ± 0.031
3.085LeuTyr: 3.085 ± 0.052
0.0LeuXaa: 0.0 ± 0.0
Met
2.264MetAla: 2.264 ± 0.043
0.12MetCys: 0.12 ± 0.011
1.522MetAsp: 1.522 ± 0.044
1.573MetGlu: 1.573 ± 0.039
0.969MetPhe: 0.969 ± 0.032
1.617MetGly: 1.617 ± 0.048
0.51MetHis: 0.51 ± 0.021
2.265MetIle: 2.265 ± 0.049
2.531MetLys: 2.531 ± 0.043
2.66MetLeu: 2.66 ± 0.059
0.96MetMet: 0.96 ± 0.035
1.616MetAsn: 1.616 ± 0.041
1.049MetPro: 1.049 ± 0.033
1.097MetGln: 1.097 ± 0.037
1.154MetArg: 1.154 ± 0.033
1.808MetSer: 1.808 ± 0.043
2.4MetThr: 2.4 ± 0.046
1.566MetVal: 1.566 ± 0.038
0.187MetTrp: 0.187 ± 0.015
0.842MetTyr: 0.842 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.271AsnAla: 3.271 ± 0.065
0.344AsnCys: 0.344 ± 0.021
2.543AsnAsp: 2.543 ± 0.057
3.156AsnGlu: 3.156 ± 0.06
1.802AsnPhe: 1.802 ± 0.043
3.08AsnGly: 3.08 ± 0.065
0.986AsnHis: 0.986 ± 0.033
3.576AsnIle: 3.576 ± 0.067
3.298AsnLys: 3.298 ± 0.07
3.914AsnLeu: 3.914 ± 0.07
1.299AsnMet: 1.299 ± 0.038
2.313AsnAsn: 2.313 ± 0.059
1.837AsnPro: 1.837 ± 0.046
1.662AsnGln: 1.662 ± 0.049
1.97AsnArg: 1.97 ± 0.044
2.497AsnSer: 2.497 ± 0.063
2.609AsnThr: 2.609 ± 0.066
2.614AsnVal: 2.614 ± 0.055
0.47AsnTrp: 0.47 ± 0.024
1.901AsnTyr: 1.901 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
2.333ProAla: 2.333 ± 0.053
0.16ProCys: 0.16 ± 0.014
1.562ProAsp: 1.562 ± 0.043
2.215ProGlu: 2.215 ± 0.05
1.777ProPhe: 1.777 ± 0.046
1.834ProGly: 1.834 ± 0.055
0.758ProHis: 0.758 ± 0.029
2.813ProIle: 2.813 ± 0.05
2.183ProLys: 2.183 ± 0.054
3.344ProLeu: 3.344 ± 0.061
0.841ProMet: 0.841 ± 0.032
1.614ProAsn: 1.614 ± 0.05
0.822ProPro: 0.822 ± 0.03
1.367ProGln: 1.367 ± 0.036
0.972ProArg: 0.972 ± 0.035
2.072ProSer: 2.072 ± 0.049
2.413ProThr: 2.413 ± 0.061
2.491ProVal: 2.491 ± 0.053
0.284ProTrp: 0.284 ± 0.018
1.31ProTyr: 1.31 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
3.221GlnAla: 3.221 ± 0.074
0.215GlnCys: 0.215 ± 0.014
1.702GlnAsp: 1.702 ± 0.045
2.52GlnGlu: 2.52 ± 0.046
1.839GlnPhe: 1.839 ± 0.042
2.036GlnGly: 2.036 ± 0.046
0.902GlnHis: 0.902 ± 0.032
2.898GlnIle: 2.898 ± 0.056
2.865GlnLys: 2.865 ± 0.066
4.902GlnLeu: 4.902 ± 0.082
1.257GlnMet: 1.257 ± 0.037
1.682GlnAsn: 1.682 ± 0.044
1.268GlnPro: 1.268 ± 0.038
3.177GlnGln: 3.177 ± 0.102
1.719GlnArg: 1.719 ± 0.042
2.417GlnSer: 2.417 ± 0.052
2.114GlnThr: 2.114 ± 0.05
2.386GlnVal: 2.386 ± 0.059
0.447GlnTrp: 0.447 ± 0.024
1.503GlnTyr: 1.503 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
2.568ArgAla: 2.568 ± 0.051
0.21ArgCys: 0.21 ± 0.016
1.974ArgAsp: 1.974 ± 0.05
2.481ArgGlu: 2.481 ± 0.057
1.842ArgPhe: 1.842 ± 0.044
2.119ArgGly: 2.119 ± 0.053
0.82ArgHis: 0.82 ± 0.033
3.0ArgIle: 3.0 ± 0.057
2.811ArgLys: 2.811 ± 0.058
3.614ArgLeu: 3.614 ± 0.058
1.2ArgMet: 1.2 ± 0.037
1.666ArgAsn: 1.666 ± 0.044
1.249ArgPro: 1.249 ± 0.038
1.848ArgGln: 1.848 ± 0.04
1.635ArgArg: 1.635 ± 0.051
2.096ArgSer: 2.096 ± 0.053
2.004ArgThr: 2.004 ± 0.048
2.424ArgVal: 2.424 ± 0.053
0.363ArgTrp: 0.363 ± 0.02
1.457ArgTyr: 1.457 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
4.271SerAla: 4.271 ± 0.078
0.405SerCys: 0.405 ± 0.021
2.867SerAsp: 2.867 ± 0.058
3.428SerGlu: 3.428 ± 0.067
3.162SerPhe: 3.162 ± 0.064
3.984SerGly: 3.984 ± 0.072
1.174SerHis: 1.174 ± 0.038
5.168SerIle: 5.168 ± 0.084
4.185SerLys: 4.185 ± 0.076
5.695SerLeu: 5.695 ± 0.08
1.718SerMet: 1.718 ± 0.037
2.742SerAsn: 2.742 ± 0.06
1.953SerPro: 1.953 ± 0.046
2.068SerGln: 2.068 ± 0.051
1.997SerArg: 1.997 ± 0.051
3.976SerSer: 3.976 ± 0.074
3.834SerThr: 3.834 ± 0.073
3.931SerVal: 3.931 ± 0.068
0.539SerTrp: 0.539 ± 0.022
2.3SerTyr: 2.3 ± 0.057
0.0SerXaa: 0.0 ± 0.0
Thr
5.019ThrAla: 5.019 ± 0.098
0.341ThrCys: 0.341 ± 0.022
2.959ThrAsp: 2.959 ± 0.063
3.565ThrGlu: 3.565 ± 0.065
2.638ThrPhe: 2.638 ± 0.056
3.973ThrGly: 3.973 ± 0.066
1.115ThrHis: 1.115 ± 0.037
5.726ThrIle: 5.726 ± 0.089
4.113ThrLys: 4.113 ± 0.079
5.662ThrLeu: 5.662 ± 0.08
1.686ThrMet: 1.686 ± 0.041
2.816ThrAsn: 2.816 ± 0.069
2.402ThrPro: 2.402 ± 0.059
1.874ThrGln: 1.874 ± 0.045
1.841ThrArg: 1.841 ± 0.047
3.777ThrSer: 3.777 ± 0.061
4.305ThrThr: 4.305 ± 0.089
4.639ThrVal: 4.639 ± 0.076
0.532ThrTrp: 0.532 ± 0.024
2.061ThrTyr: 2.061 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
5.588ValAla: 5.588 ± 0.08
0.528ValCys: 0.528 ± 0.026
3.813ValAsp: 3.813 ± 0.072
4.821ValGlu: 4.821 ± 0.074
2.911ValPhe: 2.911 ± 0.064
4.546ValGly: 4.546 ± 0.086
1.303ValHis: 1.303 ± 0.038
5.661ValIle: 5.661 ± 0.088
4.606ValLys: 4.606 ± 0.08
6.605ValLeu: 6.605 ± 0.094
1.864ValMet: 1.864 ± 0.048
3.025ValAsn: 3.025 ± 0.056
2.259ValPro: 2.259 ± 0.049
2.386ValGln: 2.386 ± 0.049
2.407ValArg: 2.407 ± 0.051
4.234ValSer: 4.234 ± 0.079
4.348ValThr: 4.348 ± 0.073
5.112ValVal: 5.112 ± 0.073
0.516ValTrp: 0.516 ± 0.023
2.131ValTyr: 2.131 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
0.54TrpAla: 0.54 ± 0.024
0.069TrpCys: 0.069 ± 0.008
0.393TrpAsp: 0.393 ± 0.021
0.385TrpGlu: 0.385 ± 0.019
0.428TrpPhe: 0.428 ± 0.02
0.543TrpGly: 0.543 ± 0.024
0.247TrpHis: 0.247 ± 0.018
0.729TrpIle: 0.729 ± 0.03
0.51TrpLys: 0.51 ± 0.024
1.065TrpLeu: 1.065 ± 0.035
0.28TrpMet: 0.28 ± 0.017
0.413TrpAsn: 0.413 ± 0.022
0.222TrpPro: 0.222 ± 0.016
0.551TrpGln: 0.551 ± 0.026
0.378TrpArg: 0.378 ± 0.021
0.615TrpSer: 0.615 ± 0.027
0.534TrpThr: 0.534 ± 0.026
0.531TrpVal: 0.531 ± 0.022
0.097TrpTrp: 0.097 ± 0.01
0.32TrpTyr: 0.32 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.54TyrAla: 2.54 ± 0.055
0.313TyrCys: 0.313 ± 0.017
2.21TyrAsp: 2.21 ± 0.059
2.359TyrGlu: 2.359 ± 0.062
1.826TyrPhe: 1.826 ± 0.042
2.22TyrGly: 2.22 ± 0.047
0.667TyrHis: 0.667 ± 0.025
2.647TyrIle: 2.647 ± 0.052
2.39TyrLys: 2.39 ± 0.065
3.258TyrLeu: 3.258 ± 0.06
0.918TyrMet: 0.918 ± 0.031
1.647TyrAsn: 1.647 ± 0.054
1.239TyrPro: 1.239 ± 0.034
1.084TyrGln: 1.084 ± 0.037
1.479TyrArg: 1.479 ± 0.046
2.3TyrSer: 2.3 ± 0.052
2.137TyrThr: 2.137 ± 0.067
2.153TyrVal: 2.153 ± 0.047
0.341TyrTrp: 0.341 ± 0.021
1.52TyrTyr: 1.52 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3241 proteins (959671 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski