Amino acid dipepetide frequency for Citrus vein enation virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.903AlaAla: 4.903 ± 0.658
0.919AlaCys: 0.919 ± 0.31
3.065AlaAsp: 3.065 ± 0.622
4.597AlaGlu: 4.597 ± 0.666
2.452AlaPhe: 2.452 ± 0.531
4.903AlaGly: 4.903 ± 0.414
1.839AlaHis: 1.839 ± 0.677
3.065AlaIle: 3.065 ± 0.604
2.452AlaLys: 2.452 ± 0.471
6.742AlaLeu: 6.742 ± 1.509
1.839AlaMet: 1.839 ± 0.569
1.839AlaAsn: 1.839 ± 0.653
5.21AlaPro: 5.21 ± 1.226
3.984AlaGln: 3.984 ± 0.6
7.049AlaArg: 7.049 ± 1.022
5.823AlaSer: 5.823 ± 0.421
1.226AlaThr: 1.226 ± 0.435
6.129AlaVal: 6.129 ± 0.682
0.919AlaTrp: 0.919 ± 0.302
3.678AlaTyr: 3.678 ± 0.648
0.0AlaXaa: 0.0 ± 0.0
Cys
1.839CysAla: 1.839 ± 0.987
0.306CysCys: 0.306 ± 0.191
0.919CysAsp: 0.919 ± 0.41
1.839CysGlu: 1.839 ± 0.514
0.613CysPhe: 0.613 ± 0.476
1.226CysGly: 1.226 ± 0.33
0.613CysHis: 0.613 ± 0.218
0.0CysIle: 0.0 ± 0.0
0.306CysLys: 0.306 ± 0.191
4.903CysLeu: 4.903 ± 1.294
0.0CysMet: 0.0 ± 0.0
0.613CysAsn: 0.613 ± 0.476
0.613CysPro: 0.613 ± 0.396
0.613CysGln: 0.613 ± 0.379
1.532CysArg: 1.532 ± 0.356
2.145CysSer: 2.145 ± 0.829
0.0CysThr: 0.0 ± 0.0
1.226CysVal: 1.226 ± 0.33
0.919CysTrp: 0.919 ± 0.726
1.226CysTyr: 1.226 ± 0.33
0.0CysXaa: 0.0 ± 0.0
Asp
3.371AspAla: 3.371 ± 0.514
1.532AspCys: 1.532 ± 0.592
4.597AspAsp: 4.597 ± 2.342
3.984AspGlu: 3.984 ± 0.459
1.226AspPhe: 1.226 ± 0.758
5.21AspGly: 5.21 ± 0.898
0.613AspHis: 0.613 ± 0.218
0.613AspIle: 0.613 ± 0.502
1.839AspLys: 1.839 ± 0.647
5.823AspLeu: 5.823 ± 0.899
0.306AspMet: 0.306 ± 0.191
1.226AspAsn: 1.226 ± 0.828
1.226AspPro: 1.226 ± 0.235
1.532AspGln: 1.532 ± 0.802
1.226AspArg: 1.226 ± 1.346
3.984AspSer: 3.984 ± 0.597
2.758AspThr: 2.758 ± 0.285
2.452AspVal: 2.452 ± 0.508
1.226AspTrp: 1.226 ± 0.456
0.306AspTyr: 0.306 ± 0.372
0.0AspXaa: 0.0 ± 0.0
Glu
3.984GluAla: 3.984 ± 0.699
2.145GluCys: 2.145 ± 0.434
5.823GluAsp: 5.823 ± 0.129
4.291GluGlu: 4.291 ± 1.12
3.678GluPhe: 3.678 ± 0.683
4.903GluGly: 4.903 ± 0.745
0.613GluHis: 0.613 ± 0.379
1.226GluIle: 1.226 ± 0.33
3.371GluLys: 3.371 ± 0.939
3.984GluLeu: 3.984 ± 0.805
0.919GluMet: 0.919 ± 0.444
3.371GluAsn: 3.371 ± 0.404
3.065GluPro: 3.065 ± 0.525
1.226GluGln: 1.226 ± 0.553
4.903GluArg: 4.903 ± 0.984
2.758GluSer: 2.758 ± 0.906
1.839GluThr: 1.839 ± 0.647
1.839GluVal: 1.839 ± 0.478
0.613GluTrp: 0.613 ± 0.383
1.839GluTyr: 1.839 ± 1.284
0.0GluXaa: 0.0 ± 0.0
Phe
2.452PheAla: 2.452 ± 0.666
1.226PheCys: 1.226 ± 0.612
2.758PheAsp: 2.758 ± 0.746
1.839PheGlu: 1.839 ± 0.318
0.613PhePhe: 0.613 ± 0.476
1.226PheGly: 1.226 ± 0.531
1.532PheHis: 1.532 ± 0.491
0.0PheIle: 0.0 ± 0.0
2.145PheLys: 2.145 ± 0.564
2.452PheLeu: 2.452 ± 0.759
0.613PheMet: 0.613 ± 0.218
0.613PheAsn: 0.613 ± 0.379
0.919PhePro: 0.919 ± 0.239
1.226PheGln: 1.226 ± 0.494
2.758PheArg: 2.758 ± 1.13
4.291PheSer: 4.291 ± 0.255
3.065PheThr: 3.065 ± 0.468
1.839PheVal: 1.839 ± 0.318
1.226PheTrp: 1.226 ± 0.235
0.919PheTyr: 0.919 ± 0.574
0.0PheXaa: 0.0 ± 0.0
Gly
2.452GlyAla: 2.452 ± 0.315
0.919GlyCys: 0.919 ± 0.31
4.903GlyAsp: 4.903 ± 1.127
2.145GlyGlu: 2.145 ± 0.843
3.984GlyPhe: 3.984 ± 0.86
7.355GlyGly: 7.355 ± 1.84
1.226GlyHis: 1.226 ± 0.326
3.371GlyIle: 3.371 ± 0.694
5.21GlyLys: 5.21 ± 1.005
7.355GlyLeu: 7.355 ± 0.375
1.839GlyMet: 1.839 ± 0.411
2.758GlyAsn: 2.758 ± 0.69
2.452GlyPro: 2.452 ± 1.136
4.291GlyGln: 4.291 ± 0.731
4.291GlyArg: 4.291 ± 0.362
7.662GlySer: 7.662 ± 1.009
3.678GlyThr: 3.678 ± 0.828
4.597GlyVal: 4.597 ± 0.666
3.371GlyTrp: 3.371 ± 0.272
2.452GlyTyr: 2.452 ± 1.085
0.0GlyXaa: 0.0 ± 0.0
His
1.839HisAla: 1.839 ± 0.318
0.613HisCys: 0.613 ± 0.744
0.306HisAsp: 0.306 ± 0.372
0.613HisGlu: 0.613 ± 0.379
0.0HisPhe: 0.0 ± 0.0
0.0HisGly: 0.0 ± 0.0
0.0HisHis: 0.0 ± 0.0
1.226HisIle: 1.226 ± 0.33
0.613HisLys: 0.613 ± 0.383
1.839HisLeu: 1.839 ± 0.74
1.532HisMet: 1.532 ± 0.491
0.306HisAsn: 0.306 ± 0.372
0.613HisPro: 0.613 ± 0.502
0.613HisGln: 0.613 ± 0.383
1.532HisArg: 1.532 ± 0.491
1.839HisSer: 1.839 ± 0.987
0.919HisThr: 0.919 ± 0.726
1.839HisVal: 1.839 ± 0.621
0.306HisTrp: 0.306 ± 0.191
1.226HisTyr: 1.226 ± 0.435
0.0HisXaa: 0.0 ± 0.0
Ile
2.145IleAla: 2.145 ± 0.424
2.145IleCys: 2.145 ± 0.173
1.532IleAsp: 1.532 ± 0.496
1.532IleGlu: 1.532 ± 0.585
1.839IlePhe: 1.839 ± 0.604
4.597IleGly: 4.597 ± 0.174
1.226IleHis: 1.226 ± 0.33
1.532IleIle: 1.532 ± 0.386
0.919IleLys: 0.919 ± 0.302
7.355IleLeu: 7.355 ± 1.691
1.532IleMet: 1.532 ± 0.664
1.226IleAsn: 1.226 ± 0.449
3.065IlePro: 3.065 ± 1.214
3.678IleGln: 3.678 ± 0.845
1.532IleArg: 1.532 ± 0.491
2.452IleSer: 2.452 ± 0.531
1.226IleThr: 1.226 ± 0.828
2.758IleVal: 2.758 ± 1.244
0.613IleTrp: 0.613 ± 0.218
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
5.21LysAla: 5.21 ± 0.757
1.226LysCys: 1.226 ± 0.375
0.919LysAsp: 0.919 ± 0.302
4.597LysGlu: 4.597 ± 0.772
0.919LysPhe: 0.919 ± 0.239
3.984LysGly: 3.984 ± 0.753
0.613LysHis: 0.613 ± 0.218
2.758LysIle: 2.758 ± 0.533
1.839LysLys: 1.839 ± 0.737
3.065LysLeu: 3.065 ± 0.67
0.919LysMet: 0.919 ± 0.398
1.226LysAsn: 1.226 ± 0.435
2.758LysPro: 2.758 ± 0.573
1.839LysGln: 1.839 ± 0.538
3.678LysArg: 3.678 ± 0.686
2.758LysSer: 2.758 ± 0.676
2.452LysThr: 2.452 ± 0.492
2.758LysVal: 2.758 ± 0.907
1.226LysTrp: 1.226 ± 0.326
0.919LysTyr: 0.919 ± 0.239
0.306LysXaa: 0.306 ± 0.336
Leu
9.194LeuAla: 9.194 ± 1.81
2.758LeuCys: 2.758 ± 0.26
3.065LeuAsp: 3.065 ± 0.364
7.355LeuGlu: 7.355 ± 1.22
3.065LeuPhe: 3.065 ± 0.884
11.339LeuGly: 11.339 ± 0.708
1.839LeuHis: 1.839 ± 0.677
4.597LeuIle: 4.597 ± 1.167
3.371LeuLys: 3.371 ± 0.676
14.404LeuLeu: 14.404 ± 2.485
2.758LeuMet: 2.758 ± 0.734
1.839LeuAsn: 1.839 ± 0.538
9.807LeuPro: 9.807 ± 1.799
1.839LeuGln: 1.839 ± 0.411
7.662LeuArg: 7.662 ± 0.609
7.355LeuSer: 7.355 ± 1.359
7.968LeuThr: 7.968 ± 0.752
5.21LeuVal: 5.21 ± 0.906
1.226LeuTrp: 1.226 ± 0.649
3.065LeuTyr: 3.065 ± 0.713
0.0LeuXaa: 0.0 ± 0.0
Met
2.758MetAla: 2.758 ± 0.472
0.0MetCys: 0.0 ± 0.0
0.306MetAsp: 0.306 ± 0.372
0.306MetGlu: 0.306 ± 0.277
0.613MetPhe: 0.613 ± 0.218
2.452MetGly: 2.452 ± 0.201
0.613MetHis: 0.613 ± 0.218
2.145MetIle: 2.145 ± 0.696
1.532MetLys: 1.532 ± 0.664
2.145MetLeu: 2.145 ± 0.696
2.758MetMet: 2.758 ± 0.907
0.306MetAsn: 0.306 ± 0.191
0.613MetPro: 0.613 ± 0.379
0.0MetGln: 0.0 ± 0.0
2.145MetArg: 2.145 ± 0.916
1.532MetSer: 1.532 ± 0.664
2.145MetThr: 2.145 ± 0.874
2.145MetVal: 2.145 ± 0.366
0.306MetTrp: 0.306 ± 0.191
1.226MetTyr: 1.226 ± 0.491
0.0MetXaa: 0.0 ± 0.0
Asn
2.758AsnAla: 2.758 ± 0.539
0.306AsnCys: 0.306 ± 0.277
1.839AsnAsp: 1.839 ± 1.33
1.532AsnGlu: 1.532 ± 0.702
0.919AsnPhe: 0.919 ± 0.31
2.758AsnGly: 2.758 ± 0.494
0.0AsnHis: 0.0 ± 0.0
1.532AsnIle: 1.532 ± 0.271
0.306AsnLys: 0.306 ± 0.277
2.452AsnLeu: 2.452 ± 0.569
0.919AsnMet: 0.919 ± 0.434
2.145AsnAsn: 2.145 ± 0.366
2.145AsnPro: 2.145 ± 0.293
1.839AsnGln: 1.839 ± 0.559
4.903AsnArg: 4.903 ± 1.412
1.839AsnSer: 1.839 ± 0.385
2.145AsnThr: 2.145 ± 0.544
0.919AsnVal: 0.919 ± 0.31
1.532AsnTrp: 1.532 ± 0.271
1.226AsnTyr: 1.226 ± 0.326
0.0AsnXaa: 0.0 ± 0.0
Pro
3.371ProAla: 3.371 ± 0.996
0.919ProCys: 0.919 ± 1.115
2.452ProAsp: 2.452 ± 0.678
3.678ProGlu: 3.678 ± 1.611
0.613ProPhe: 0.613 ± 0.383
2.758ProGly: 2.758 ± 0.502
1.226ProHis: 1.226 ± 0.758
5.21ProIle: 5.21 ± 1.11
3.371ProLys: 3.371 ± 0.898
4.597ProLeu: 4.597 ± 1.595
0.613ProMet: 0.613 ± 0.218
2.452ProAsn: 2.452 ± 0.46
4.903ProPro: 4.903 ± 1.769
2.145ProGln: 2.145 ± 0.842
3.371ProArg: 3.371 ± 0.615
7.049ProSer: 7.049 ± 2.284
4.597ProThr: 4.597 ± 0.174
3.065ProVal: 3.065 ± 1.088
1.226ProTrp: 1.226 ± 0.326
2.145ProTyr: 2.145 ± 1.235
0.0ProXaa: 0.0 ± 0.0
Gln
3.984GlnAla: 3.984 ± 1.205
0.0GlnCys: 0.0 ± 0.0
0.919GlnAsp: 0.919 ± 0.239
1.839GlnGlu: 1.839 ± 0.943
0.613GlnPhe: 0.613 ± 0.476
2.145GlnGly: 2.145 ± 0.766
0.613GlnHis: 0.613 ± 0.218
1.839GlnIle: 1.839 ± 0.385
1.226GlnLys: 1.226 ± 0.235
3.371GlnLeu: 3.371 ± 0.22
0.613GlnMet: 0.613 ± 0.218
2.452GlnAsn: 2.452 ± 0.87
3.371GlnPro: 3.371 ± 0.729
0.919GlnGln: 0.919 ± 0.239
2.145GlnArg: 2.145 ± 0.846
2.145GlnSer: 2.145 ± 0.173
2.758GlnThr: 2.758 ± 0.494
3.371GlnVal: 3.371 ± 0.935
1.532GlnTrp: 1.532 ± 0.344
0.919GlnTyr: 0.919 ± 0.302
0.0GlnXaa: 0.0 ± 0.0
Arg
6.129ArgAla: 6.129 ± 1.436
1.226ArgCys: 1.226 ± 0.553
3.678ArgAsp: 3.678 ± 0.371
3.065ArgGlu: 3.065 ± 0.254
2.758ArgPhe: 2.758 ± 0.475
2.452ArgGly: 2.452 ± 0.661
1.226ArgHis: 1.226 ± 0.456
4.291ArgIle: 4.291 ± 1.089
0.919ArgLys: 0.919 ± 0.46
7.355ArgLeu: 7.355 ± 1.284
2.758ArgMet: 2.758 ± 0.922
4.597ArgAsn: 4.597 ± 0.952
4.597ArgPro: 4.597 ± 1.388
2.452ArgGln: 2.452 ± 0.641
11.339ArgArg: 11.339 ± 4.435
5.21ArgSer: 5.21 ± 0.617
2.145ArgThr: 2.145 ± 0.999
5.516ArgVal: 5.516 ± 1.288
0.919ArgTrp: 0.919 ± 0.41
1.532ArgTyr: 1.532 ± 0.442
0.0ArgXaa: 0.0 ± 0.0
Ser
3.065SerAla: 3.065 ± 0.618
2.145SerCys: 2.145 ± 0.512
3.371SerAsp: 3.371 ± 0.974
3.678SerGlu: 3.678 ± 0.814
3.678SerPhe: 3.678 ± 0.627
6.742SerGly: 6.742 ± 1.205
0.306SerHis: 0.306 ± 0.191
3.984SerIle: 3.984 ± 0.885
3.984SerLys: 3.984 ± 1.094
11.952SerLeu: 11.952 ± 1.276
1.226SerMet: 1.226 ± 0.375
1.532SerAsn: 1.532 ± 0.543
5.21SerPro: 5.21 ± 0.64
2.145SerGln: 2.145 ± 0.544
3.065SerArg: 3.065 ± 0.895
6.436SerSer: 6.436 ± 1.44
7.049SerThr: 7.049 ± 2.122
5.823SerVal: 5.823 ± 1.036
2.145SerTrp: 2.145 ± 0.434
2.758SerTyr: 2.758 ± 0.567
0.0SerXaa: 0.0 ± 0.0
Thr
5.21ThrAla: 5.21 ± 1.226
0.919ThrCys: 0.919 ± 0.472
2.452ThrAsp: 2.452 ± 0.925
2.145ThrGlu: 2.145 ± 0.478
2.145ThrPhe: 2.145 ± 0.576
3.371ThrGly: 3.371 ± 0.615
0.919ThrHis: 0.919 ± 0.726
0.613ThrIle: 0.613 ± 0.323
3.984ThrLys: 3.984 ± 0.988
6.436ThrLeu: 6.436 ± 0.884
1.532ThrMet: 1.532 ± 0.442
1.226ThrAsn: 1.226 ± 0.326
3.984ThrPro: 3.984 ± 0.621
1.532ThrGln: 1.532 ± 0.409
3.371ThrArg: 3.371 ± 0.828
6.742ThrSer: 6.742 ± 0.515
3.678ThrThr: 3.678 ± 1.185
3.678ThrVal: 3.678 ± 0.686
0.0ThrTrp: 0.0 ± 0.0
0.0ThrTyr: 0.0 ± 0.0
0.0ThrXaa: 0.0 ± 0.0
Val
5.21ValAla: 5.21 ± 1.178
0.919ValCys: 0.919 ± 0.239
1.226ValAsp: 1.226 ± 0.326
3.371ValGlu: 3.371 ± 0.524
1.532ValPhe: 1.532 ± 0.617
4.903ValGly: 4.903 ± 1.014
0.919ValHis: 0.919 ± 0.769
2.452ValIle: 2.452 ± 0.569
4.903ValLys: 4.903 ± 1.428
6.436ValLeu: 6.436 ± 1.451
0.613ValMet: 0.613 ± 0.476
2.758ValAsn: 2.758 ± 1.138
4.597ValPro: 4.597 ± 1.991
2.452ValGln: 2.452 ± 0.438
4.597ValArg: 4.597 ± 1.157
4.597ValSer: 4.597 ± 1.504
3.065ValThr: 3.065 ± 0.757
5.516ValVal: 5.516 ± 1.164
0.613ValTrp: 0.613 ± 0.379
2.758ValTyr: 2.758 ± 0.676
0.0ValXaa: 0.0 ± 0.0
Trp
1.532TrpAla: 1.532 ± 0.442
0.613TrpCys: 0.613 ± 0.383
0.0TrpAsp: 0.0 ± 0.0
1.532TrpGlu: 1.532 ± 0.356
0.306TrpPhe: 0.306 ± 0.372
1.226TrpGly: 1.226 ± 0.711
0.306TrpHis: 0.306 ± 0.372
0.306TrpIle: 0.306 ± 0.336
2.145TrpLys: 2.145 ± 0.366
4.291TrpLeu: 4.291 ± 0.579
1.532TrpMet: 1.532 ± 0.482
0.0TrpAsn: 0.0 ± 0.0
0.613TrpPro: 0.613 ± 0.379
0.613TrpGln: 0.613 ± 0.218
1.839TrpArg: 1.839 ± 0.576
1.839TrpSer: 1.839 ± 0.521
0.919TrpThr: 0.919 ± 0.302
0.306TrpVal: 0.306 ± 0.372
0.0TrpTrp: 0.0 ± 0.0
0.306TrpTyr: 0.306 ± 0.372
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.226TyrAla: 1.226 ± 0.235
0.613TyrCys: 0.613 ± 0.218
0.919TyrAsp: 0.919 ± 0.726
2.452TyrGlu: 2.452 ± 0.492
2.145TyrPhe: 2.145 ± 0.612
2.758TyrGly: 2.758 ± 0.487
1.532TyrHis: 1.532 ± 0.802
2.145TyrIle: 2.145 ± 0.766
1.839TyrLys: 1.839 ± 0.647
2.758TyrLeu: 2.758 ± 0.472
0.919TyrMet: 0.919 ± 0.472
1.532TyrAsn: 1.532 ± 0.702
0.0TyrPro: 0.0 ± 0.0
1.839TyrGln: 1.839 ± 0.559
1.226TyrArg: 1.226 ± 0.435
1.839TyrSer: 1.839 ± 0.478
0.306TyrThr: 0.306 ± 0.336
2.145TyrVal: 2.145 ± 0.982
0.306TyrTrp: 0.306 ± 0.372
0.613TyrTyr: 0.613 ± 0.218
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.306XaaVal: 0.306 ± 0.336
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (3264 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski