Amino acid dipepetide frequency for Rhodococcus aetherivorans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.76AlaAla: 21.76 ± 0.195	0.945AlaCys: 0.945 ± 0.024	8.444AlaAsp: 8.444 ± 0.076	8.473AlaGlu: 8.473 ± 0.083	3.54AlaPhe: 3.54 ± 0.048	12.926AlaGly: 12.926 ± 0.105	2.814AlaHis: 2.814 ± 0.041	4.176AlaIle: 4.176 ± 0.05	2.428AlaLys: 2.428 ± 0.051	14.146AlaLeu: 14.146 ± 0.114	2.618AlaMet: 2.618 ± 0.039	1.995AlaAsn: 1.995 ± 0.038	6.825AlaPro: 6.825 ± 0.083	3.671AlaGln: 3.671 ± 0.049	10.009AlaArg: 10.009 ± 0.084	5.436AlaSer: 5.436 ± 0.058	7.543AlaThr: 7.543 ± 0.061	13.067AlaVal: 13.067 ± 0.111	1.658AlaTrp: 1.658 ± 0.028	2.318AlaTyr: 2.318 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	1.024CysAla: 1.024 ± 0.028	0.091CysCys: 0.091 ± 0.007	0.445CysAsp: 0.445 ± 0.015	0.394CysGlu: 0.394 ± 0.015	0.224CysPhe: 0.224 ± 0.011	0.929CysGly: 0.929 ± 0.024	0.198CysHis: 0.198 ± 0.01	0.243CysIle: 0.243 ± 0.012	0.099CysLys: 0.099 ± 0.007	0.649CysLeu: 0.649 ± 0.019	0.118CysMet: 0.118 ± 0.008	0.142CysAsn: 0.142 ± 0.009	0.47CysPro: 0.47 ± 0.017	0.145CysGln: 0.145 ± 0.009	0.611CysArg: 0.611 ± 0.018	0.433CysSer: 0.433 ± 0.016	0.513CysThr: 0.513 ± 0.016	0.594CysVal: 0.594 ± 0.021	0.116CysTrp: 0.116 ± 0.007	0.144CysTyr: 0.144 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	8.121AspAla: 8.121 ± 0.076	0.386AspCys: 0.386 ± 0.015	4.028AspAsp: 4.028 ± 0.052	4.338AspGlu: 4.338 ± 0.057	1.63AspPhe: 1.63 ± 0.035	6.193AspGly: 6.193 ± 0.064	1.393AspHis: 1.393 ± 0.031	2.097AspIle: 2.097 ± 0.036	1.017AspLys: 1.017 ± 0.028	6.718AspLeu: 6.718 ± 0.073	0.867AspMet: 0.867 ± 0.024	0.93AspAsn: 0.93 ± 0.026	4.863AspPro: 4.863 ± 0.049	1.277AspGln: 1.277 ± 0.027	5.446AspArg: 5.446 ± 0.055	2.469AspSer: 2.469 ± 0.039	3.405AspThr: 3.405 ± 0.047	5.552AspVal: 5.552 ± 0.06	0.887AspTrp: 0.887 ± 0.025	1.251AspTyr: 1.251 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	6.546GluAla: 6.546 ± 0.08	0.372GluCys: 0.372 ± 0.015	2.698GluAsp: 2.698 ± 0.044	2.873GluGlu: 2.873 ± 0.055	1.876GluPhe: 1.876 ± 0.033	3.659GluGly: 3.659 ± 0.053	1.79GluHis: 1.79 ± 0.032	2.759GluIle: 2.759 ± 0.04	1.321GluLys: 1.321 ± 0.035	6.85GluLeu: 6.85 ± 0.075	1.03GluMet: 1.03 ± 0.029	1.217GluAsn: 1.217 ± 0.026	3.34GluPro: 3.34 ± 0.049	2.402GluGln: 2.402 ± 0.042	5.365GluArg: 5.365 ± 0.066	2.792GluSer: 2.792 ± 0.042	2.932GluThr: 2.932 ± 0.043	4.682GluVal: 4.682 ± 0.056	0.821GluTrp: 0.821 ± 0.021	1.191GluTyr: 1.191 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.155PheAla: 4.155 ± 0.048	0.287PheCys: 0.287 ± 0.013	2.49PheAsp: 2.49 ± 0.046	1.7PheGlu: 1.7 ± 0.032	0.94PhePhe: 0.94 ± 0.03	3.444PheGly: 3.444 ± 0.043	0.658PheHis: 0.658 ± 0.023	0.646PheIle: 0.646 ± 0.019	0.384PheLys: 0.384 ± 0.015	2.655PheLeu: 2.655 ± 0.048	0.419PheMet: 0.419 ± 0.016	0.521PheAsn: 0.521 ± 0.017	1.386PhePro: 1.386 ± 0.027	0.583PheGln: 0.583 ± 0.019	1.855PheArg: 1.855 ± 0.031	1.433PheSer: 1.433 ± 0.032	1.96PheThr: 1.96 ± 0.036	2.916PheVal: 2.916 ± 0.049	0.384PheTrp: 0.384 ± 0.016	0.665PheTyr: 0.665 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	10.945GlyAla: 10.945 ± 0.096	0.774GlyCys: 0.774 ± 0.022	5.097GlyAsp: 5.097 ± 0.055	4.702GlyGlu: 4.702 ± 0.053	3.126GlyPhe: 3.126 ± 0.042	8.044GlyGly: 8.044 ± 0.097	2.129GlyHis: 2.129 ± 0.034	4.124GlyIle: 4.124 ± 0.053	1.978GlyLys: 1.978 ± 0.034	8.976GlyLeu: 8.976 ± 0.083	2.047GlyMet: 2.047 ± 0.033	1.764GlyAsn: 1.764 ± 0.033	4.835GlyPro: 4.835 ± 0.056	2.332GlyGln: 2.332 ± 0.043	7.476GlyArg: 7.476 ± 0.066	5.102GlySer: 5.102 ± 0.055	6.152GlyThr: 6.152 ± 0.066	7.736GlyVal: 7.736 ± 0.056	1.636GlyTrp: 1.636 ± 0.033	2.287GlyTyr: 2.287 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.635HisAla: 2.635 ± 0.037	0.204HisCys: 0.204 ± 0.01	1.39HisAsp: 1.39 ± 0.026	1.229HisGlu: 1.229 ± 0.03	0.658HisPhe: 0.658 ± 0.019	2.269HisGly: 2.269 ± 0.036	0.701HisHis: 0.701 ± 0.021	0.726HisIle: 0.726 ± 0.022	0.316HisLys: 0.316 ± 0.014	2.41HisLeu: 2.41 ± 0.04	0.365HisMet: 0.365 ± 0.016	0.392HisAsn: 0.392 ± 0.014	1.729HisPro: 1.729 ± 0.034	0.522HisGln: 0.522 ± 0.017	2.148HisArg: 2.148 ± 0.032	1.063HisSer: 1.063 ± 0.027	1.296HisThr: 1.296 ± 0.026	1.8HisVal: 1.8 ± 0.034	0.317HisTrp: 0.317 ± 0.012	0.466HisTyr: 0.466 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.596IleAla: 5.596 ± 0.058	0.316IleCys: 0.316 ± 0.013	3.004IleAsp: 3.004 ± 0.051	2.415IleGlu: 2.415 ± 0.038	0.885IlePhe: 0.885 ± 0.024	3.964IleGly: 3.964 ± 0.051	0.72IleHis: 0.72 ± 0.021	1.026IleIle: 1.026 ± 0.028	0.633IleLys: 0.633 ± 0.02	3.051IleLeu: 3.051 ± 0.048	0.539IleMet: 0.539 ± 0.019	0.743IleAsn: 0.743 ± 0.02	2.114IlePro: 2.114 ± 0.032	0.687IleGln: 0.687 ± 0.022	2.575IleArg: 2.575 ± 0.039	1.776IleSer: 1.776 ± 0.035	2.374IleThr: 2.374 ± 0.041	3.808IleVal: 3.808 ± 0.054	0.373IleTrp: 0.373 ± 0.015	0.644IleTyr: 0.644 ± 0.018	0.0IleXaa: 0.0 ± 0.0
Lys	2.29LysAla: 2.29 ± 0.042	0.096LysCys: 0.096 ± 0.007	0.956LysAsp: 0.956 ± 0.028	0.85LysGlu: 0.85 ± 0.024	0.527LysPhe: 0.527 ± 0.018	1.366LysGly: 1.366 ± 0.031	0.4LysHis: 0.4 ± 0.017	0.925LysIle: 0.925 ± 0.028	0.573LysLys: 0.573 ± 0.021	1.739LysLeu: 1.739 ± 0.033	0.372LysMet: 0.372 ± 0.015	0.431LysAsn: 0.431 ± 0.017	1.041LysPro: 1.041 ± 0.028	0.554LysGln: 0.554 ± 0.017	1.227LysArg: 1.227 ± 0.034	0.934LysSer: 0.934 ± 0.026	1.111LysThr: 1.111 ± 0.029	1.665LysVal: 1.665 ± 0.035	0.251LysTrp: 0.251 ± 0.012	0.43LysTyr: 0.43 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	14.803LeuAla: 14.803 ± 0.103	0.773LeuCys: 0.773 ± 0.02	7.342LeuAsp: 7.342 ± 0.079	5.309LeuGlu: 5.309 ± 0.057	2.809LeuPhe: 2.809 ± 0.044	9.72LeuGly: 9.72 ± 0.088	2.22LeuHis: 2.22 ± 0.036	3.419LeuIle: 3.419 ± 0.051	1.359LeuLys: 1.359 ± 0.034	10.285LeuLeu: 10.285 ± 0.115	1.544LeuMet: 1.544 ± 0.029	1.585LeuAsn: 1.585 ± 0.031	5.993LeuPro: 5.993 ± 0.065	2.31LeuGln: 2.31 ± 0.04	8.281LeuArg: 8.281 ± 0.066	5.215LeuSer: 5.215 ± 0.057	6.509LeuThr: 6.509 ± 0.058	9.502LeuVal: 9.502 ± 0.091	1.209LeuTrp: 1.209 ± 0.027	1.714LeuTyr: 1.714 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	2.179MetAla: 2.179 ± 0.039	0.167MetCys: 0.167 ± 0.01	0.806MetAsp: 0.806 ± 0.019	0.659MetGlu: 0.659 ± 0.019	0.585MetPhe: 0.585 ± 0.018	1.316MetGly: 1.316 ± 0.027	0.393MetHis: 0.393 ± 0.015	0.817MetIle: 0.817 ± 0.023	0.385MetLys: 0.385 ± 0.016	1.916MetLeu: 1.916 ± 0.033	0.34MetMet: 0.34 ± 0.013	0.454MetAsn: 0.454 ± 0.015	1.055MetPro: 1.055 ± 0.023	0.511MetGln: 0.511 ± 0.016	1.467MetArg: 1.467 ± 0.026	1.476MetSer: 1.476 ± 0.028	1.77MetThr: 1.77 ± 0.029	1.441MetVal: 1.441 ± 0.035	0.245MetTrp: 0.245 ± 0.011	0.327MetTyr: 0.327 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.181AsnAla: 2.181 ± 0.04	0.14AsnCys: 0.14 ± 0.009	0.872AsnAsp: 0.872 ± 0.024	0.86AsnGlu: 0.86 ± 0.022	0.552AsnPhe: 0.552 ± 0.019	1.64AsnGly: 1.64 ± 0.03	0.398AsnHis: 0.398 ± 0.015	0.806AsnIle: 0.806 ± 0.023	0.351AsnLys: 0.351 ± 0.015	1.87AsnLeu: 1.87 ± 0.031	0.341AsnMet: 0.341 ± 0.014	0.415AsnAsn: 0.415 ± 0.015	1.459AsnPro: 1.459 ± 0.029	0.457AsnGln: 0.457 ± 0.017	1.336AsnArg: 1.336 ± 0.026	0.926AsnSer: 0.926 ± 0.022	1.095AsnThr: 1.095 ± 0.026	1.509AsnVal: 1.509 ± 0.032	0.297AsnTrp: 0.297 ± 0.015	0.466AsnTyr: 0.466 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	8.163ProAla: 8.163 ± 0.094	0.29ProCys: 0.29 ± 0.013	4.589ProAsp: 4.589 ± 0.053	4.139ProGlu: 4.139 ± 0.05	1.553ProPhe: 1.553 ± 0.03	6.069ProGly: 6.069 ± 0.066	1.31ProHis: 1.31 ± 0.027	1.965ProIle: 1.965 ± 0.035	1.046ProLys: 1.046 ± 0.027	5.081ProLeu: 5.081 ± 0.056	1.045ProMet: 1.045 ± 0.024	1.006ProAsn: 1.006 ± 0.022	3.151ProPro: 3.151 ± 0.06	1.581ProGln: 1.581 ± 0.034	3.804ProArg: 3.804 ± 0.051	2.853ProSer: 2.853 ± 0.035	3.426ProThr: 3.426 ± 0.046	5.578ProVal: 5.578 ± 0.056	0.832ProTrp: 0.832 ± 0.022	1.103ProTyr: 1.103 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.177GlnAla: 3.177 ± 0.042	0.178GlnCys: 0.178 ± 0.011	1.136GlnAsp: 1.136 ± 0.025	1.175GlnGlu: 1.175 ± 0.027	0.812GlnPhe: 0.812 ± 0.023	1.814GlnGly: 1.814 ± 0.039	0.613GlnHis: 0.613 ± 0.019	1.285GlnIle: 1.285 ± 0.026	0.487GlnLys: 0.487 ± 0.019	3.047GlnLeu: 3.047 ± 0.046	0.544GlnMet: 0.544 ± 0.017	0.503GlnAsn: 0.503 ± 0.016	1.456GlnPro: 1.456 ± 0.031	1.095GlnGln: 1.095 ± 0.03	2.425GlnArg: 2.425 ± 0.037	1.19GlnSer: 1.19 ± 0.028	1.3GlnThr: 1.3 ± 0.027	2.454GlnVal: 2.454 ± 0.04	0.521GlnTrp: 0.521 ± 0.016	0.582GlnTyr: 0.582 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	9.411ArgAla: 9.411 ± 0.085	0.623ArgCys: 0.623 ± 0.019	4.548ArgAsp: 4.548 ± 0.05	4.482ArgGlu: 4.482 ± 0.054	2.558ArgPhe: 2.558 ± 0.047	5.701ArgGly: 5.701 ± 0.06	1.924ArgHis: 1.924 ± 0.033	3.883ArgIle: 3.883 ± 0.053	1.511ArgLys: 1.511 ± 0.037	8.088ArgLeu: 8.088 ± 0.083	1.927ArgMet: 1.927 ± 0.034	1.545ArgAsn: 1.545 ± 0.032	4.567ArgPro: 4.567 ± 0.051	2.027ArgGln: 2.027 ± 0.038	7.646ArgArg: 7.646 ± 0.09	4.132ArgSer: 4.132 ± 0.055	5.27ArgThr: 5.27 ± 0.057	6.201ArgVal: 6.201 ± 0.066	1.474ArgTrp: 1.474 ± 0.03	1.96ArgTyr: 1.96 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	6.419SerAla: 6.419 ± 0.068	0.381SerCys: 0.381 ± 0.015	2.832SerAsp: 2.832 ± 0.038	2.471SerGlu: 2.471 ± 0.041	1.593SerPhe: 1.593 ± 0.03	5.359SerGly: 5.359 ± 0.051	0.91SerHis: 0.91 ± 0.02	1.877SerIle: 1.877 ± 0.032	0.885SerLys: 0.885 ± 0.024	4.62SerLeu: 4.62 ± 0.057	1.163SerMet: 1.163 ± 0.027	0.883SerAsn: 0.883 ± 0.023	2.851SerPro: 2.851 ± 0.037	1.144SerGln: 1.144 ± 0.023	3.603SerArg: 3.603 ± 0.039	2.615SerSer: 2.615 ± 0.043	3.153SerThr: 3.153 ± 0.046	4.488SerVal: 4.488 ± 0.044	0.838SerTrp: 0.838 ± 0.021	1.058SerTyr: 1.058 ± 0.026	0.001SerXaa: 0.001 ± 0.001
Thr	8.537ThrAla: 8.537 ± 0.082	0.41ThrCys: 0.41 ± 0.016	3.868ThrAsp: 3.868 ± 0.054	3.515ThrGlu: 3.515 ± 0.047	1.751ThrPhe: 1.751 ± 0.033	6.334ThrGly: 6.334 ± 0.062	1.222ThrHis: 1.222 ± 0.026	2.092ThrIle: 2.092 ± 0.035	1.005ThrLys: 1.005 ± 0.028	5.846ThrLeu: 5.846 ± 0.048	1.051ThrMet: 1.051 ± 0.027	1.024ThrAsn: 1.024 ± 0.024	3.906ThrPro: 3.906 ± 0.049	1.271ThrGln: 1.271 ± 0.026	4.081ThrArg: 4.081 ± 0.05	3.008ThrSer: 3.008 ± 0.048	4.102ThrThr: 4.102 ± 0.059	6.791ThrVal: 6.791 ± 0.074	0.854ThrTrp: 0.854 ± 0.021	1.249ThrTyr: 1.249 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	12.847ValAla: 12.847 ± 0.104	0.779ValCys: 0.779 ± 0.022	6.241ValAsp: 6.241 ± 0.063	5.158ValGlu: 5.158 ± 0.057	2.668ValPhe: 2.668 ± 0.042	7.436ValGly: 7.436 ± 0.072	2.082ValHis: 2.082 ± 0.039	3.135ValIle: 3.135 ± 0.048	1.374ValLys: 1.374 ± 0.028	10.112ValLeu: 10.112 ± 0.081	1.393ValMet: 1.393 ± 0.029	1.659ValAsn: 1.659 ± 0.03	5.633ValPro: 5.633 ± 0.068	2.176ValGln: 2.176 ± 0.034	6.957ValArg: 6.957 ± 0.067	4.362ValSer: 4.362 ± 0.056	5.919ValThr: 5.919 ± 0.069	9.563ValVal: 9.563 ± 0.09	1.086ValTrp: 1.086 ± 0.028	1.54ValTyr: 1.54 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.582TrpAla: 1.582 ± 0.031	0.156TrpCys: 0.156 ± 0.009	0.761TrpAsp: 0.761 ± 0.021	0.685TrpGlu: 0.685 ± 0.02	0.533TrpPhe: 0.533 ± 0.019	1.064TrpGly: 1.064 ± 0.027	0.335TrpHis: 0.335 ± 0.011	0.666TrpIle: 0.666 ± 0.019	0.294TrpLys: 0.294 ± 0.012	1.615TrpLeu: 1.615 ± 0.035	0.311TrpMet: 0.311 ± 0.014	0.381TrpAsn: 0.381 ± 0.014	0.717TrpPro: 0.717 ± 0.022	0.533TrpGln: 0.533 ± 0.017	1.245TrpArg: 1.245 ± 0.028	0.897TrpSer: 0.897 ± 0.024	0.929TrpThr: 0.929 ± 0.022	1.124TrpVal: 1.124 ± 0.023	0.324TrpTrp: 0.324 ± 0.015	0.336TrpTyr: 0.336 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.418TyrAla: 2.418 ± 0.039	0.211TyrCys: 0.211 ± 0.01	1.319TyrAsp: 1.319 ± 0.033	1.092TyrGlu: 1.092 ± 0.028	0.665TyrPhe: 0.665 ± 0.02	2.017TyrGly: 2.017 ± 0.031	0.426TyrHis: 0.426 ± 0.016	0.575TyrIle: 0.575 ± 0.018	0.292TyrLys: 0.292 ± 0.013	2.23TyrLeu: 2.23 ± 0.033	0.272TyrMet: 0.272 ± 0.014	0.381TyrAsn: 0.381 ± 0.014	1.195TyrPro: 1.195 ± 0.028	0.514TyrGln: 0.514 ± 0.018	1.92TyrArg: 1.92 ± 0.035	1.032TyrSer: 1.032 ± 0.023	1.158TyrThr: 1.158 ± 0.029	1.652TyrVal: 1.652 ± 0.035	0.363TyrTrp: 0.363 ± 0.018	0.441TyrTyr: 0.441 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5509 proteins (1815698 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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