Amino acid dipepetide frequency for Corynebacterium argentoratense DSM 44202

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.433AlaAla: 16.433 ± 0.222	1.125AlaCys: 1.125 ± 0.046	7.167AlaAsp: 7.167 ± 0.116	7.605AlaGlu: 7.605 ± 0.145	3.565AlaPhe: 3.565 ± 0.088	9.937AlaGly: 9.937 ± 0.144	2.679AlaHis: 2.679 ± 0.072	5.569AlaIle: 5.569 ± 0.1	3.728AlaLys: 3.728 ± 0.096	11.732AlaLeu: 11.732 ± 0.167	2.781AlaMet: 2.781 ± 0.081	2.677AlaAsn: 2.677 ± 0.073	5.211AlaPro: 5.211 ± 0.109	4.903AlaGln: 4.903 ± 0.113	7.141AlaArg: 7.141 ± 0.122	6.441AlaSer: 6.441 ± 0.109	7.003AlaThr: 7.003 ± 0.105	9.805AlaVal: 9.805 ± 0.159	1.484AlaTrp: 1.484 ± 0.052	2.413AlaTyr: 2.413 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	1.132CysAla: 1.132 ± 0.05	0.101CysCys: 0.101 ± 0.012	0.602CysAsp: 0.602 ± 0.034	0.552CysGlu: 0.552 ± 0.028	0.305CysPhe: 0.305 ± 0.021	0.912CysGly: 0.912 ± 0.038	0.196CysHis: 0.196 ± 0.016	0.399CysIle: 0.399 ± 0.026	0.166CysLys: 0.166 ± 0.018	0.65CysLeu: 0.65 ± 0.03	0.174CysMet: 0.174 ± 0.016	0.234CysAsn: 0.234 ± 0.022	0.525CysPro: 0.525 ± 0.029	0.227CysGln: 0.227 ± 0.018	0.413CysArg: 0.413 ± 0.027	0.633CysSer: 0.633 ± 0.034	0.509CysThr: 0.509 ± 0.029	0.82CysVal: 0.82 ± 0.04	0.104CysTrp: 0.104 ± 0.015	0.179CysTyr: 0.179 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	8.125AspAla: 8.125 ± 0.134	0.562AspCys: 0.562 ± 0.032	3.905AspAsp: 3.905 ± 0.093	3.711AspGlu: 3.711 ± 0.089	1.946AspPhe: 1.946 ± 0.058	5.152AspGly: 5.152 ± 0.105	1.26AspHis: 1.26 ± 0.048	3.163AspIle: 3.163 ± 0.078	2.113AspLys: 2.113 ± 0.07	5.329AspLeu: 5.329 ± 0.089	1.324AspMet: 1.324 ± 0.05	2.022AspAsn: 2.022 ± 0.071	3.771AspPro: 3.771 ± 0.084	1.727AspGln: 1.727 ± 0.055	3.29AspArg: 3.29 ± 0.079	3.514AspSer: 3.514 ± 0.078	3.371AspThr: 3.371 ± 0.084	5.801AspVal: 5.801 ± 0.099	0.706AspTrp: 0.706 ± 0.036	1.568AspTyr: 1.568 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	6.801GluAla: 6.801 ± 0.124	0.457GluCys: 0.457 ± 0.026	3.438GluAsp: 3.438 ± 0.085	4.048GluGlu: 4.048 ± 0.099	2.067GluPhe: 2.067 ± 0.06	4.623GluGly: 4.623 ± 0.098	1.797GluHis: 1.797 ± 0.06	2.941GluIle: 2.941 ± 0.072	2.102GluLys: 2.102 ± 0.076	6.624GluLeu: 6.624 ± 0.12	1.213GluMet: 1.213 ± 0.046	1.401GluAsn: 1.401 ± 0.058	2.669GluPro: 2.669 ± 0.088	3.219GluGln: 3.219 ± 0.087	3.92GluArg: 3.92 ± 0.087	2.773GluSer: 2.773 ± 0.071	2.65GluThr: 2.65 ± 0.071	4.853GluVal: 4.853 ± 0.089	0.656GluTrp: 0.656 ± 0.032	1.353GluTyr: 1.353 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.769PheAla: 3.769 ± 0.075	0.308PheCys: 0.308 ± 0.025	2.498PheAsp: 2.498 ± 0.071	1.813PheGlu: 1.813 ± 0.057	1.364PhePhe: 1.364 ± 0.055	3.363PheGly: 3.363 ± 0.078	0.641PheHis: 0.641 ± 0.036	1.641PheIle: 1.641 ± 0.057	0.893PheLys: 0.893 ± 0.039	2.652PheLeu: 2.652 ± 0.075	0.658PheMet: 0.658 ± 0.036	1.139PheAsn: 1.139 ± 0.049	1.377PhePro: 1.377 ± 0.052	0.762PheGln: 0.762 ± 0.036	1.55PheArg: 1.55 ± 0.044	2.12PheSer: 2.12 ± 0.063	1.901PheThr: 1.901 ± 0.053	2.677PheVal: 2.677 ± 0.068	0.401PheTrp: 0.401 ± 0.029	0.827PheTyr: 0.827 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	9.049GlyAla: 9.049 ± 0.129	0.834GlyCys: 0.834 ± 0.04	4.716GlyAsp: 4.716 ± 0.096	4.717GlyGlu: 4.717 ± 0.096	3.207GlyPhe: 3.207 ± 0.071	7.021GlyGly: 7.021 ± 0.136	1.948GlyHis: 1.948 ± 0.057	4.512GlyIle: 4.512 ± 0.092	2.992GlyLys: 2.992 ± 0.075	8.107GlyLeu: 8.107 ± 0.126	2.21GlyMet: 2.21 ± 0.058	2.246GlyAsn: 2.246 ± 0.059	3.35GlyPro: 3.35 ± 0.071	2.824GlyGln: 2.824 ± 0.074	5.061GlyArg: 5.061 ± 0.09	5.13GlySer: 5.13 ± 0.115	4.999GlyThr: 4.999 ± 0.1	7.905GlyVal: 7.905 ± 0.114	1.305GlyTrp: 1.305 ± 0.042	2.185GlyTyr: 2.185 ± 0.07	0.0GlyXaa: 0.0 ± 0.0
His	2.412HisAla: 2.412 ± 0.067	0.252HisCys: 0.252 ± 0.022	1.348HisAsp: 1.348 ± 0.054	1.157HisGlu: 1.157 ± 0.038	0.696HisPhe: 0.696 ± 0.034	1.959HisGly: 1.959 ± 0.058	0.617HisHis: 0.617 ± 0.039	1.107HisIle: 1.107 ± 0.052	0.545HisLys: 0.545 ± 0.031	1.808HisLeu: 1.808 ± 0.059	0.509HisMet: 0.509 ± 0.029	0.759HisAsn: 0.759 ± 0.038	1.628HisPro: 1.628 ± 0.057	0.721HisGln: 0.721 ± 0.038	1.349HisArg: 1.349 ± 0.054	1.328HisSer: 1.328 ± 0.047	1.472HisThr: 1.472 ± 0.062	1.654HisVal: 1.654 ± 0.052	0.273HisTrp: 0.273 ± 0.022	0.564HisTyr: 0.564 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	6.388IleAla: 6.388 ± 0.121	0.431IleCys: 0.431 ± 0.027	4.117IleAsp: 4.117 ± 0.073	3.149IleGlu: 3.149 ± 0.072	1.421IlePhe: 1.421 ± 0.06	4.406IleGly: 4.406 ± 0.098	0.995IleHis: 0.995 ± 0.044	2.649IleIle: 2.649 ± 0.077	1.527IleLys: 1.527 ± 0.06	3.824IleLeu: 3.824 ± 0.089	0.92IleMet: 0.92 ± 0.04	1.75IleAsn: 1.75 ± 0.059	2.478IlePro: 2.478 ± 0.069	1.223IleGln: 1.223 ± 0.043	2.586IleArg: 2.586 ± 0.065	2.821IleSer: 2.821 ± 0.069	3.184IleThr: 3.184 ± 0.074	4.528IleVal: 4.528 ± 0.085	0.365IleTrp: 0.365 ± 0.027	0.932IleTyr: 0.932 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.867LysAla: 3.867 ± 0.112	0.128LysCys: 0.128 ± 0.015	2.039LysAsp: 2.039 ± 0.071	1.933LysGlu: 1.933 ± 0.061	0.855LysPhe: 0.855 ± 0.036	2.43LysGly: 2.43 ± 0.074	0.738LysHis: 0.738 ± 0.035	1.507LysIle: 1.507 ± 0.055	1.706LysLys: 1.706 ± 0.078	2.979LysLeu: 2.979 ± 0.075	0.767LysMet: 0.767 ± 0.038	1.066LysAsn: 1.066 ± 0.048	1.817LysPro: 1.817 ± 0.077	1.427LysGln: 1.427 ± 0.053	1.989LysArg: 1.989 ± 0.064	1.585LysSer: 1.585 ± 0.066	1.911LysThr: 1.911 ± 0.07	2.712LysVal: 2.712 ± 0.077	0.32LysTrp: 0.32 ± 0.022	0.62LysTyr: 0.62 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	11.628LeuAla: 11.628 ± 0.16	0.865LeuCys: 0.865 ± 0.038	6.249LeuAsp: 6.249 ± 0.109	5.074LeuGlu: 5.074 ± 0.112	2.808LeuPhe: 2.808 ± 0.074	8.285LeuGly: 8.285 ± 0.119	1.868LeuHis: 1.868 ± 0.066	4.615LeuIle: 4.615 ± 0.087	3.159LeuLys: 3.159 ± 0.082	8.745LeuLeu: 8.745 ± 0.146	2.011LeuMet: 2.011 ± 0.057	2.573LeuAsn: 2.573 ± 0.08	5.026LeuPro: 5.026 ± 0.098	2.685LeuGln: 2.685 ± 0.066	6.065LeuArg: 6.065 ± 0.106	6.294LeuSer: 6.294 ± 0.12	5.243LeuThr: 5.243 ± 0.095	7.456LeuVal: 7.456 ± 0.128	1.114LeuTrp: 1.114 ± 0.043	1.757LeuTyr: 1.757 ± 0.05	0.002LeuXaa: 0.002 ± 0.002
Met	2.533MetAla: 2.533 ± 0.067	0.207MetCys: 0.207 ± 0.018	1.188MetAsp: 1.188 ± 0.047	1.107MetGlu: 1.107 ± 0.045	0.751MetPhe: 0.751 ± 0.037	1.832MetGly: 1.832 ± 0.061	0.535MetHis: 0.535 ± 0.031	1.124MetIle: 1.124 ± 0.044	0.792MetLys: 0.792 ± 0.037	2.377MetLeu: 2.377 ± 0.072	0.555MetMet: 0.555 ± 0.032	0.744MetAsn: 0.744 ± 0.038	1.246MetPro: 1.246 ± 0.045	0.661MetGln: 0.661 ± 0.032	1.414MetArg: 1.414 ± 0.051	1.732MetSer: 1.732 ± 0.055	1.452MetThr: 1.452 ± 0.042	1.838MetVal: 1.838 ± 0.058	0.252MetTrp: 0.252 ± 0.021	0.409MetTyr: 0.409 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.022AsnAla: 3.022 ± 0.07	0.23AsnCys: 0.23 ± 0.018	1.653AsnAsp: 1.653 ± 0.062	1.421AsnGlu: 1.421 ± 0.056	0.897AsnPhe: 0.897 ± 0.041	2.191AsnGly: 2.191 ± 0.066	0.58AsnHis: 0.58 ± 0.034	1.419AsnIle: 1.419 ± 0.053	1.067AsnLys: 1.067 ± 0.046	2.533AsnLeu: 2.533 ± 0.074	0.666AsnMet: 0.666 ± 0.032	1.175AsnAsn: 1.175 ± 0.054	2.19AsnPro: 2.19 ± 0.069	1.018AsnGln: 1.018 ± 0.044	1.484AsnArg: 1.484 ± 0.052	1.664AsnSer: 1.664 ± 0.06	1.852AsnThr: 1.852 ± 0.07	2.176AsnVal: 2.176 ± 0.064	0.361AsnTrp: 0.361 ± 0.023	0.776AsnTyr: 0.776 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	5.8ProAla: 5.8 ± 0.123	0.332ProCys: 0.332 ± 0.024	3.241ProAsp: 3.241 ± 0.088	4.056ProGlu: 4.056 ± 0.102	1.533ProPhe: 1.533 ± 0.05	4.565ProGly: 4.565 ± 0.095	1.195ProHis: 1.195 ± 0.052	2.208ProIle: 2.208 ± 0.05	1.697ProLys: 1.697 ± 0.07	4.248ProLeu: 4.248 ± 0.082	1.157ProMet: 1.157 ± 0.038	1.56ProAsn: 1.56 ± 0.059	1.896ProPro: 1.896 ± 0.074	2.035ProGln: 2.035 ± 0.063	2.747ProArg: 2.747 ± 0.077	3.033ProSer: 3.033 ± 0.083	3.317ProThr: 3.317 ± 0.076	4.376ProVal: 4.376 ± 0.074	0.759ProTrp: 0.759 ± 0.041	1.106ProTyr: 1.106 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	4.437GlnAla: 4.437 ± 0.112	0.259GlnCys: 0.259 ± 0.021	1.578GlnAsp: 1.578 ± 0.051	1.798GlnGlu: 1.798 ± 0.05	0.985GlnPhe: 0.985 ± 0.055	2.622GlnGly: 2.622 ± 0.078	0.855GlnHis: 0.855 ± 0.039	1.641GlnIle: 1.641 ± 0.05	0.975GlnLys: 0.975 ± 0.042	4.073GlnLeu: 4.073 ± 0.093	0.822GlnMet: 0.822 ± 0.034	0.704GlnAsn: 0.704 ± 0.035	2.118GlnPro: 2.118 ± 0.071	2.072GlnGln: 2.072 ± 0.072	2.762GlnArg: 2.762 ± 0.072	1.702GlnSer: 1.702 ± 0.05	1.444GlnThr: 1.444 ± 0.055	2.621GlnVal: 2.621 ± 0.061	0.749GlnTrp: 0.749 ± 0.038	0.635GlnTyr: 0.635 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	6.557ArgAla: 6.557 ± 0.136	0.494ArgCys: 0.494 ± 0.027	3.536ArgAsp: 3.536 ± 0.085	3.86ArgGlu: 3.86 ± 0.078	2.009ArgPhe: 2.009 ± 0.063	4.779ArgGly: 4.779 ± 0.088	1.318ArgHis: 1.318 ± 0.047	3.154ArgIle: 3.154 ± 0.068	1.903ArgLys: 1.903 ± 0.063	5.424ArgLeu: 5.424 ± 0.115	1.596ArgMet: 1.596 ± 0.051	1.735ArgAsn: 1.735 ± 0.058	2.849ArgPro: 2.849 ± 0.079	2.107ArgGln: 2.107 ± 0.062	4.736ArgArg: 4.736 ± 0.115	3.512ArgSer: 3.512 ± 0.081	3.544ArgThr: 3.544 ± 0.08	4.941ArgVal: 4.941 ± 0.11	0.9ArgTrp: 0.9 ± 0.043	1.545ArgTyr: 1.545 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	6.471SerAla: 6.471 ± 0.111	0.444SerCys: 0.444 ± 0.029	3.501SerAsp: 3.501 ± 0.08	3.34SerGlu: 3.34 ± 0.08	2.009SerPhe: 2.009 ± 0.065	5.543SerGly: 5.543 ± 0.106	1.164SerHis: 1.164 ± 0.048	2.796SerIle: 2.796 ± 0.075	1.838SerLys: 1.838 ± 0.063	5.157SerLeu: 5.157 ± 0.091	1.497SerMet: 1.497 ± 0.049	1.687SerAsn: 1.687 ± 0.057	2.921SerPro: 2.921 ± 0.073	1.865SerGln: 1.865 ± 0.051	3.539SerArg: 3.539 ± 0.075	4.023SerSer: 4.023 ± 0.107	4.046SerThr: 4.046 ± 0.094	4.766SerVal: 4.766 ± 0.089	0.827SerTrp: 0.827 ± 0.035	1.319SerTyr: 1.319 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	6.4ThrAla: 6.4 ± 0.119	0.539ThrCys: 0.539 ± 0.035	3.153ThrAsp: 3.153 ± 0.077	2.916ThrGlu: 2.916 ± 0.069	1.918ThrPhe: 1.918 ± 0.054	4.969ThrGly: 4.969 ± 0.102	1.387ThrHis: 1.387 ± 0.053	3.275ThrIle: 3.275 ± 0.074	1.757ThrLys: 1.757 ± 0.067	5.646ThrLeu: 5.646 ± 0.1	1.293ThrMet: 1.293 ± 0.04	1.651ThrAsn: 1.651 ± 0.057	4.003ThrPro: 4.003 ± 0.085	1.973ThrGln: 1.973 ± 0.058	3.126ThrArg: 3.126 ± 0.071	3.38ThrSer: 3.38 ± 0.082	3.998ThrThr: 3.998 ± 0.089	5.172ThrVal: 5.172 ± 0.1	0.834ThrTrp: 0.834 ± 0.039	1.377ThrTyr: 1.377 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	10.764ValAla: 10.764 ± 0.172	0.89ValCys: 0.89 ± 0.036	6.32ValAsp: 6.32 ± 0.109	5.359ValGlu: 5.359 ± 0.111	2.758ValPhe: 2.758 ± 0.078	6.707ValGly: 6.707 ± 0.123	1.712ValHis: 1.712 ± 0.054	4.338ValIle: 4.338 ± 0.101	2.367ValLys: 2.367 ± 0.076	8.175ValLeu: 8.175 ± 0.144	1.832ValMet: 1.832 ± 0.061	2.185ValAsn: 2.185 ± 0.062	4.031ValPro: 4.031 ± 0.094	2.161ValGln: 2.161 ± 0.064	5.017ValArg: 5.017 ± 0.095	4.935ValSer: 4.935 ± 0.086	4.842ValThr: 4.842 ± 0.102	8.495ValVal: 8.495 ± 0.154	0.998ValTrp: 0.998 ± 0.045	1.596ValTyr: 1.596 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	1.384TrpAla: 1.384 ± 0.053	0.171TrpCys: 0.171 ± 0.018	0.673TrpAsp: 0.673 ± 0.032	0.723TrpGlu: 0.723 ± 0.035	0.511TrpPhe: 0.511 ± 0.03	0.946TrpGly: 0.946 ± 0.039	0.259TrpHis: 0.259 ± 0.02	0.671TrpIle: 0.671 ± 0.033	0.438TrpLys: 0.438 ± 0.027	1.435TrpLeu: 1.435 ± 0.061	0.378TrpMet: 0.378 ± 0.025	0.401TrpAsn: 0.401 ± 0.029	0.545TrpPro: 0.545 ± 0.036	0.507TrpGln: 0.507 ± 0.028	0.875TrpArg: 0.875 ± 0.039	0.812TrpSer: 0.812 ± 0.034	0.641TrpThr: 0.641 ± 0.03	1.135TrpVal: 1.135 ± 0.047	0.32TrpTrp: 0.32 ± 0.024	0.252TrpTyr: 0.252 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.428TyrAla: 2.428 ± 0.075	0.204TyrCys: 0.204 ± 0.018	1.442TyrAsp: 1.442 ± 0.048	1.263TyrGlu: 1.263 ± 0.045	0.753TyrPhe: 0.753 ± 0.036	2.075TyrGly: 2.075 ± 0.055	0.416TyrHis: 0.416 ± 0.027	0.965TyrIle: 0.965 ± 0.038	0.63TyrLys: 0.63 ± 0.032	2.002TyrLeu: 2.002 ± 0.061	0.386TyrMet: 0.386 ± 0.024	0.665TyrAsn: 0.665 ± 0.031	1.208TyrPro: 1.208 ± 0.045	0.733TyrGln: 0.733 ± 0.036	1.437TyrArg: 1.437 ± 0.059	1.319TyrSer: 1.319 ± 0.043	1.386TyrThr: 1.386 ± 0.052	1.75TyrVal: 1.75 ± 0.051	0.35TyrTrp: 0.35 ± 0.025	0.525TyrTyr: 0.525 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.002	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1870 proteins (603294 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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