Amino acid dipepetide frequency for Candidatus Nitrosopelagicus brevis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.829AlaAla: 4.829 ± 0.186
0.626AlaCys: 0.626 ± 0.052
3.083AlaAsp: 3.083 ± 0.103
4.148AlaGlu: 4.148 ± 0.154
2.454AlaPhe: 2.454 ± 0.095
4.336AlaGly: 4.336 ± 0.14
0.954AlaHis: 0.954 ± 0.051
5.386AlaIle: 5.386 ± 0.134
5.924AlaLys: 5.924 ± 0.173
5.131AlaLeu: 5.131 ± 0.114
1.649AlaMet: 1.649 ± 0.074
2.507AlaAsn: 2.507 ± 0.083
2.038AlaPro: 2.038 ± 0.096
1.993AlaGln: 1.993 ± 0.101
2.16AlaArg: 2.16 ± 0.065
3.944AlaSer: 3.944 ± 0.116
3.345AlaThr: 3.345 ± 0.105
3.849AlaVal: 3.849 ± 0.111
0.506AlaTrp: 0.506 ± 0.036
1.696AlaTyr: 1.696 ± 0.073
0.0AlaXaa: 0.0 ± 0.0
Cys
0.565CysAla: 0.565 ± 0.039
0.106CysCys: 0.106 ± 0.017
0.631CysAsp: 0.631 ± 0.045
0.684CysGlu: 0.684 ± 0.04
0.432CysPhe: 0.432 ± 0.036
0.97CysGly: 0.97 ± 0.047
0.247CysHis: 0.247 ± 0.028
0.641CysIle: 0.641 ± 0.042
0.872CysLys: 0.872 ± 0.045
0.626CysLeu: 0.626 ± 0.04
0.273CysMet: 0.273 ± 0.026
0.514CysAsn: 0.514 ± 0.044
0.512CysPro: 0.512 ± 0.039
0.326CysGln: 0.326 ± 0.028
0.376CysArg: 0.376 ± 0.03
0.734CysSer: 0.734 ± 0.053
0.62CysThr: 0.62 ± 0.041
0.655CysVal: 0.655 ± 0.038
0.074CysTrp: 0.074 ± 0.014
0.366CysTyr: 0.366 ± 0.034
0.0CysXaa: 0.0 ± 0.0
Asp
3.923AspAla: 3.923 ± 0.1
0.596AspCys: 0.596 ± 0.041
3.66AspAsp: 3.66 ± 0.118
4.856AspGlu: 4.856 ± 0.117
2.749AspPhe: 2.749 ± 0.084
4.005AspGly: 4.005 ± 0.134
0.938AspHis: 0.938 ± 0.057
4.768AspIle: 4.768 ± 0.12
4.278AspLys: 4.278 ± 0.115
4.734AspLeu: 4.734 ± 0.129
1.617AspMet: 1.617 ± 0.065
2.492AspAsn: 2.492 ± 0.079
2.179AspPro: 2.179 ± 0.075
1.41AspGln: 1.41 ± 0.057
1.908AspArg: 1.908 ± 0.062
4.35AspSer: 4.35 ± 0.109
2.746AspThr: 2.746 ± 0.09
4.617AspVal: 4.617 ± 0.121
0.61AspTrp: 0.61 ± 0.041
2.168AspTyr: 2.168 ± 0.074
0.0AspXaa: 0.0 ± 0.0
Glu
3.589GluAla: 3.589 ± 0.141
0.673GluCys: 0.673 ± 0.045
3.637GluAsp: 3.637 ± 0.086
5.394GluGlu: 5.394 ± 0.135
3.57GluPhe: 3.57 ± 0.105
3.409GluGly: 3.409 ± 0.094
1.376GluHis: 1.376 ± 0.064
7.88GluIle: 7.88 ± 0.15
8.397GluLys: 8.397 ± 0.169
6.701GluLeu: 6.701 ± 0.14
2.123GluMet: 2.123 ± 0.077
4.813GluAsn: 4.813 ± 0.118
2.171GluPro: 2.171 ± 0.138
2.322GluGln: 2.322 ± 0.096
2.409GluArg: 2.409 ± 0.084
4.784GluSer: 4.784 ± 0.117
3.642GluThr: 3.642 ± 0.109
3.872GluVal: 3.872 ± 0.116
0.652GluTrp: 0.652 ± 0.04
2.155GluTyr: 2.155 ± 0.079
0.0GluXaa: 0.0 ± 0.0
Phe
2.929PheAla: 2.929 ± 0.115
0.533PheCys: 0.533 ± 0.045
3.223PheAsp: 3.223 ± 0.095
3.57PheGlu: 3.57 ± 0.107
1.903PhePhe: 1.903 ± 0.087
3.462PheGly: 3.462 ± 0.1
0.737PheHis: 0.737 ± 0.048
2.749PheIle: 2.749 ± 0.095
2.56PheLys: 2.56 ± 0.082
3.923PheLeu: 3.923 ± 0.129
0.965PheMet: 0.965 ± 0.056
1.943PheAsn: 1.943 ± 0.077
1.675PhePro: 1.675 ± 0.08
1.291PheGln: 1.291 ± 0.061
1.442PheArg: 1.442 ± 0.058
3.952PheSer: 3.952 ± 0.127
2.38PheThr: 2.38 ± 0.086
3.321PheVal: 3.321 ± 0.101
0.408PheTrp: 0.408 ± 0.034
1.476PheTyr: 1.476 ± 0.071
0.0PheXaa: 0.0 ± 0.0
Gly
4.254GlyAla: 4.254 ± 0.146
0.724GlyCys: 0.724 ± 0.047
3.454GlyAsp: 3.454 ± 0.109
3.761GlyGlu: 3.761 ± 0.115
3.159GlyPhe: 3.159 ± 0.099
4.766GlyGly: 4.766 ± 0.148
1.28GlyHis: 1.28 ± 0.056
6.531GlyIle: 6.531 ± 0.143
5.86GlyLys: 5.86 ± 0.139
5.524GlyLeu: 5.524 ± 0.146
2.126GlyMet: 2.126 ± 0.067
2.775GlyAsn: 2.775 ± 0.093
1.951GlyPro: 1.951 ± 0.093
1.85GlyGln: 1.85 ± 0.075
2.364GlyArg: 2.364 ± 0.088
3.965GlySer: 3.965 ± 0.1
3.925GlyThr: 3.925 ± 0.127
4.522GlyVal: 4.522 ± 0.122
0.673GlyTrp: 0.673 ± 0.038
2.195GlyTyr: 2.195 ± 0.079
0.0GlyXaa: 0.0 ± 0.0
His
1.068HisAla: 1.068 ± 0.056
0.217HisCys: 0.217 ± 0.023
1.116HisAsp: 1.116 ± 0.07
1.238HisGlu: 1.238 ± 0.062
0.795HisPhe: 0.795 ± 0.045
1.251HisGly: 1.251 ± 0.061
0.451HisHis: 0.451 ± 0.037
1.275HisIle: 1.275 ± 0.054
1.079HisLys: 1.079 ± 0.057
1.513HisLeu: 1.513 ± 0.065
0.469HisMet: 0.469 ± 0.035
0.79HisAsn: 0.79 ± 0.043
0.946HisPro: 0.946 ± 0.055
0.493HisGln: 0.493 ± 0.033
0.689HisArg: 0.689 ± 0.042
1.227HisSer: 1.227 ± 0.061
0.92HisThr: 0.92 ± 0.043
1.267HisVal: 1.267 ± 0.06
0.186HisTrp: 0.186 ± 0.021
0.607HisTyr: 0.607 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
5.595IleAla: 5.595 ± 0.12
0.864IleCys: 0.864 ± 0.05
5.306IleAsp: 5.306 ± 0.123
6.417IleGlu: 6.417 ± 0.132
3.554IlePhe: 3.554 ± 0.115
6.157IleGly: 6.157 ± 0.143
1.471IleHis: 1.471 ± 0.058
7.602IleIle: 7.602 ± 0.179
6.698IleLys: 6.698 ± 0.152
7.615IleLeu: 7.615 ± 0.191
1.922IleMet: 1.922 ± 0.071
3.957IleAsn: 3.957 ± 0.113
4.106IlePro: 4.106 ± 0.111
2.672IleGln: 2.672 ± 0.083
3.032IleArg: 3.032 ± 0.094
7.114IleSer: 7.114 ± 0.15
4.943IleThr: 4.943 ± 0.139
5.733IleVal: 5.733 ± 0.131
0.565IleTrp: 0.565 ± 0.039
2.03IleTyr: 2.03 ± 0.073
0.0IleXaa: 0.0 ± 0.0
Lys
4.132LysAla: 4.132 ± 0.145
0.883LysCys: 0.883 ± 0.052
4.54LysAsp: 4.54 ± 0.115
6.592LysGlu: 6.592 ± 0.173
4.172LysPhe: 4.172 ± 0.12
4.238LysGly: 4.238 ± 0.136
1.307LysHis: 1.307 ± 0.061
9.656LysIle: 9.656 ± 0.174
9.69LysLys: 9.69 ± 0.267
7.085LysLeu: 7.085 ± 0.159
2.722LysMet: 2.722 ± 0.096
5.964LysAsn: 5.964 ± 0.138
2.857LysPro: 2.857 ± 0.093
2.958LysGln: 2.958 ± 0.09
3.038LysArg: 3.038 ± 0.105
5.802LysSer: 5.802 ± 0.128
5.01LysThr: 5.01 ± 0.101
4.623LysVal: 4.623 ± 0.122
0.676LysTrp: 0.676 ± 0.041
2.539LysTyr: 2.539 ± 0.104
0.0LysXaa: 0.0 ± 0.0
Leu
5.678LeuAla: 5.678 ± 0.126
0.769LeuCys: 0.769 ± 0.044
5.436LeuAsp: 5.436 ± 0.112
6.929LeuGlu: 6.929 ± 0.138
3.379LeuPhe: 3.379 ± 0.118
5.852LeuGly: 5.852 ± 0.136
1.521LeuHis: 1.521 ± 0.065
6.459LeuIle: 6.459 ± 0.15
7.347LeuLys: 7.347 ± 0.136
6.648LeuLeu: 6.648 ± 0.145
2.046LeuMet: 2.046 ± 0.073
3.878LeuAsn: 3.878 ± 0.118
3.22LeuPro: 3.22 ± 0.101
2.685LeuGln: 2.685 ± 0.08
3.297LeuArg: 3.297 ± 0.087
6.375LeuSer: 6.375 ± 0.142
4.591LeuThr: 4.591 ± 0.1
5.518LeuVal: 5.518 ± 0.126
0.639LeuTrp: 0.639 ± 0.04
2.128LeuTyr: 2.128 ± 0.086
0.0LeuXaa: 0.0 ± 0.0
Met
1.842MetAla: 1.842 ± 0.07
0.204MetCys: 0.204 ± 0.023
1.402MetAsp: 1.402 ± 0.065
1.755MetGlu: 1.755 ± 0.07
0.906MetPhe: 0.906 ± 0.053
1.903MetGly: 1.903 ± 0.08
0.448MetHis: 0.448 ± 0.039
2.348MetIle: 2.348 ± 0.074
2.513MetLys: 2.513 ± 0.081
2.253MetLeu: 2.253 ± 0.077
0.808MetMet: 0.808 ± 0.048
1.495MetAsn: 1.495 ± 0.055
1.116MetPro: 1.116 ± 0.055
0.835MetGln: 0.835 ± 0.04
0.906MetArg: 0.906 ± 0.046
2.022MetSer: 2.022 ± 0.075
1.553MetThr: 1.553 ± 0.063
1.651MetVal: 1.651 ± 0.069
0.241MetTrp: 0.241 ± 0.026
0.71MetTyr: 0.71 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
3.0AsnAla: 3.0 ± 0.101
0.583AsnCys: 0.583 ± 0.04
2.926AsnAsp: 2.926 ± 0.079
3.851AsnGlu: 3.851 ± 0.097
2.595AsnPhe: 2.595 ± 0.104
2.852AsnGly: 2.852 ± 0.083
0.806AsnHis: 0.806 ± 0.046
3.894AsnIle: 3.894 ± 0.109
3.607AsnLys: 3.607 ± 0.1
4.71AsnLeu: 4.71 ± 0.143
1.431AsnMet: 1.431 ± 0.056
2.621AsnAsn: 2.621 ± 0.095
2.428AsnPro: 2.428 ± 0.078
1.747AsnGln: 1.747 ± 0.07
1.683AsnArg: 1.683 ± 0.077
4.172AsnSer: 4.172 ± 0.145
2.354AsnThr: 2.354 ± 0.08
3.382AsnVal: 3.382 ± 0.095
0.512AsnTrp: 0.512 ± 0.038
1.773AsnTyr: 1.773 ± 0.082
0.0AsnXaa: 0.0 ± 0.0
Pro
2.049ProAla: 2.049 ± 0.084
0.276ProCys: 0.276 ± 0.025
2.545ProAsp: 2.545 ± 0.075
3.496ProGlu: 3.496 ± 0.129
1.598ProPhe: 1.598 ± 0.069
2.319ProGly: 2.319 ± 0.104
0.745ProHis: 0.745 ± 0.046
2.937ProIle: 2.937 ± 0.097
3.244ProLys: 3.244 ± 0.11
2.913ProLeu: 2.913 ± 0.105
0.909ProMet: 0.909 ± 0.046
1.908ProAsn: 1.908 ± 0.075
1.222ProPro: 1.222 ± 0.066
1.068ProGln: 1.068 ± 0.056
1.222ProArg: 1.222 ± 0.057
2.481ProSer: 2.481 ± 0.091
2.009ProThr: 2.009 ± 0.082
2.391ProVal: 2.391 ± 0.088
0.384ProTrp: 0.384 ± 0.033
1.187ProTyr: 1.187 ± 0.053
0.0ProXaa: 0.0 ± 0.0
Gln
1.702GlnAla: 1.702 ± 0.079
0.297GlnCys: 0.297 ± 0.028
1.524GlnAsp: 1.524 ± 0.059
2.086GlnGlu: 2.086 ± 0.071
1.346GlnPhe: 1.346 ± 0.063
1.686GlnGly: 1.686 ± 0.079
0.49GlnHis: 0.49 ± 0.032
3.043GlnIle: 3.043 ± 0.093
3.493GlnLys: 3.493 ± 0.093
2.425GlnLeu: 2.425 ± 0.084
0.925GlnMet: 0.925 ± 0.051
1.993GlnAsn: 1.993 ± 0.082
0.806GlnPro: 0.806 ± 0.049
1.036GlnGln: 1.036 ± 0.072
1.097GlnArg: 1.097 ± 0.061
1.877GlnSer: 1.877 ± 0.075
1.755GlnThr: 1.755 ± 0.067
2.025GlnVal: 2.025 ± 0.076
0.257GlnTrp: 0.257 ± 0.023
0.838GlnTyr: 0.838 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
1.922ArgAla: 1.922 ± 0.086
0.376ArgCys: 0.376 ± 0.03
2.12ArgAsp: 2.12 ± 0.075
2.521ArgGlu: 2.521 ± 0.075
1.498ArgPhe: 1.498 ± 0.069
2.147ArgGly: 2.147 ± 0.09
0.61ArgHis: 0.61 ± 0.039
3.194ArgIle: 3.194 ± 0.093
3.504ArgLys: 3.504 ± 0.103
3.162ArgLeu: 3.162 ± 0.093
0.975ArgMet: 0.975 ± 0.05
1.779ArgAsn: 1.779 ± 0.062
1.193ArgPro: 1.193 ± 0.053
1.105ArgGln: 1.105 ± 0.054
1.474ArgArg: 1.474 ± 0.073
2.012ArgSer: 2.012 ± 0.068
1.837ArgThr: 1.837 ± 0.071
2.205ArgVal: 2.205 ± 0.088
0.323ArgTrp: 0.323 ± 0.031
1.15ArgTyr: 1.15 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
3.997SerAla: 3.997 ± 0.116
0.708SerCys: 0.708 ± 0.048
4.273SerAsp: 4.273 ± 0.125
5.256SerGlu: 5.256 ± 0.146
3.21SerPhe: 3.21 ± 0.1
5.124SerGly: 5.124 ± 0.111
1.317SerHis: 1.317 ± 0.063
6.004SerIle: 6.004 ± 0.141
6.719SerLys: 6.719 ± 0.147
6.216SerLeu: 6.216 ± 0.144
1.879SerMet: 1.879 ± 0.076
3.512SerAsn: 3.512 ± 0.109
2.245SerPro: 2.245 ± 0.072
2.38SerGln: 2.38 ± 0.083
2.396SerArg: 2.396 ± 0.091
4.957SerSer: 4.957 ± 0.133
3.751SerThr: 3.751 ± 0.12
4.222SerVal: 4.222 ± 0.113
0.647SerTrp: 0.647 ± 0.045
2.11SerTyr: 2.11 ± 0.085
0.0SerXaa: 0.0 ± 0.0
Thr
3.165ThrAla: 3.165 ± 0.094
0.549ThrCys: 0.549 ± 0.036
3.096ThrAsp: 3.096 ± 0.099
3.777ThrGlu: 3.777 ± 0.109
2.319ThrPhe: 2.319 ± 0.091
4.053ThrGly: 4.053 ± 0.105
1.005ThrHis: 1.005 ± 0.056
4.845ThrIle: 4.845 ± 0.115
4.79ThrLys: 4.79 ± 0.122
4.503ThrLeu: 4.503 ± 0.111
1.299ThrMet: 1.299 ± 0.06
2.717ThrAsn: 2.717 ± 0.08
2.364ThrPro: 2.364 ± 0.082
1.606ThrGln: 1.606 ± 0.065
1.845ThrArg: 1.845 ± 0.062
3.941ThrSer: 3.941 ± 0.118
2.947ThrThr: 2.947 ± 0.091
3.549ThrVal: 3.549 ± 0.106
0.451ThrTrp: 0.451 ± 0.043
1.474ThrTyr: 1.474 ± 0.069
0.0ThrXaa: 0.0 ± 0.0
Val
3.944ValAla: 3.944 ± 0.127
0.777ValCys: 0.777 ± 0.043
3.886ValAsp: 3.886 ± 0.108
4.506ValGlu: 4.506 ± 0.11
2.924ValPhe: 2.924 ± 0.086
4.464ValGly: 4.464 ± 0.119
1.113ValHis: 1.113 ± 0.05
5.638ValIle: 5.638 ± 0.121
5.089ValLys: 5.089 ± 0.121
5.41ValLeu: 5.41 ± 0.122
1.715ValMet: 1.715 ± 0.063
3.239ValAsn: 3.239 ± 0.095
2.388ValPro: 2.388 ± 0.086
1.702ValGln: 1.702 ± 0.063
2.232ValArg: 2.232 ± 0.081
4.503ValSer: 4.503 ± 0.103
4.005ValThr: 4.005 ± 0.098
4.479ValVal: 4.479 ± 0.125
0.554ValTrp: 0.554 ± 0.045
1.956ValTyr: 1.956 ± 0.072
0.0ValXaa: 0.0 ± 0.0
Trp
0.562TrpAla: 0.562 ± 0.041
0.082TrpCys: 0.082 ± 0.016
0.477TrpAsp: 0.477 ± 0.037
0.522TrpGlu: 0.522 ± 0.036
0.429TrpPhe: 0.429 ± 0.032
0.573TrpGly: 0.573 ± 0.043
0.18TrpHis: 0.18 ± 0.024
0.761TrpIle: 0.761 ± 0.045
0.785TrpLys: 0.785 ± 0.045
0.689TrpLeu: 0.689 ± 0.05
0.305TrpMet: 0.305 ± 0.029
0.58TrpAsn: 0.58 ± 0.044
0.284TrpPro: 0.284 ± 0.027
0.265TrpGln: 0.265 ± 0.027
0.329TrpArg: 0.329 ± 0.034
0.522TrpSer: 0.522 ± 0.04
0.459TrpThr: 0.459 ± 0.041
0.594TrpVal: 0.594 ± 0.044
0.172TrpTrp: 0.172 ± 0.025
0.294TrpTyr: 0.294 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.816TyrAla: 1.816 ± 0.081
0.382TyrCys: 0.382 ± 0.032
2.269TyrAsp: 2.269 ± 0.082
2.211TyrGlu: 2.211 ± 0.08
1.447TyrPhe: 1.447 ± 0.062
2.094TyrGly: 2.094 ± 0.072
0.602TyrHis: 0.602 ± 0.04
1.744TyrIle: 1.744 ± 0.069
2.036TyrLys: 2.036 ± 0.075
2.616TyrLeu: 2.616 ± 0.076
0.753TyrMet: 0.753 ± 0.046
1.45TyrAsn: 1.45 ± 0.059
1.203TyrPro: 1.203 ± 0.057
0.957TyrGln: 0.957 ± 0.048
1.206TyrArg: 1.206 ± 0.055
2.187TyrSer: 2.187 ± 0.074
1.503TyrThr: 1.503 ± 0.064
2.046TyrVal: 2.046 ± 0.076
0.334TyrTrp: 0.334 ± 0.034
1.1TyrTyr: 1.1 ± 0.063
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1444 proteins (377279 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski