Amino acid dipepetide frequency for Gordonia phage BENtherdunthat

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.769AlaAla: 13.769 ± 0.969
0.918AlaCys: 0.918 ± 0.272
6.942AlaAsp: 6.942 ± 0.651
8.721AlaGlu: 8.721 ± 0.807
2.697AlaPhe: 2.697 ± 0.889
9.466AlaGly: 9.466 ± 0.861
2.008AlaHis: 2.008 ± 0.415
5.737AlaIle: 5.737 ± 0.717
3.328AlaLys: 3.328 ± 0.532
10.557AlaLeu: 10.557 ± 0.759
2.983AlaMet: 2.983 ± 0.555
2.926AlaAsn: 2.926 ± 0.432
5.737AlaPro: 5.737 ± 0.737
4.532AlaGln: 4.532 ± 0.586
7.86AlaArg: 7.86 ± 0.749
6.426AlaSer: 6.426 ± 0.675
6.426AlaThr: 6.426 ± 0.755
8.09AlaVal: 8.09 ± 1.221
1.721AlaTrp: 1.721 ± 0.32
2.524AlaTyr: 2.524 ± 0.314
0.0AlaXaa: 0.0 ± 0.0
Cys
1.147CysAla: 1.147 ± 0.268
0.287CysCys: 0.287 ± 0.117
1.09CysAsp: 1.09 ± 0.247
0.631CysGlu: 0.631 ± 0.196
0.402CysPhe: 0.402 ± 0.147
1.147CysGly: 1.147 ± 0.307
0.516CysHis: 0.516 ± 0.213
0.344CysIle: 0.344 ± 0.127
0.516CysLys: 0.516 ± 0.183
0.803CysLeu: 0.803 ± 0.195
0.115CysMet: 0.115 ± 0.079
0.459CysAsn: 0.459 ± 0.167
0.631CysPro: 0.631 ± 0.243
0.344CysGln: 0.344 ± 0.157
0.746CysArg: 0.746 ± 0.248
1.033CysSer: 1.033 ± 0.273
0.459CysThr: 0.459 ± 0.195
0.746CysVal: 0.746 ± 0.199
0.631CysTrp: 0.631 ± 0.176
0.229CysTyr: 0.229 ± 0.112
0.0CysXaa: 0.0 ± 0.0
Asp
6.999AspAla: 6.999 ± 0.58
0.688AspCys: 0.688 ± 0.212
3.787AspAsp: 3.787 ± 0.598
4.475AspGlu: 4.475 ± 0.599
1.606AspPhe: 1.606 ± 0.284
5.565AspGly: 5.565 ± 0.714
1.549AspHis: 1.549 ± 0.3
3.098AspIle: 3.098 ± 0.437
2.065AspLys: 2.065 ± 0.377
4.647AspLeu: 4.647 ± 0.584
1.262AspMet: 1.262 ± 0.263
1.606AspAsn: 1.606 ± 0.309
4.705AspPro: 4.705 ± 0.437
1.836AspGln: 1.836 ± 0.331
4.303AspArg: 4.303 ± 0.58
3.959AspSer: 3.959 ± 0.467
2.983AspThr: 2.983 ± 0.401
5.737AspVal: 5.737 ± 0.465
1.033AspTrp: 1.033 ± 0.213
1.606AspTyr: 1.606 ± 0.324
0.0AspXaa: 0.0 ± 0.0
Glu
7.86GluAla: 7.86 ± 0.826
1.09GluCys: 1.09 ± 0.289
3.098GluAsp: 3.098 ± 0.405
2.754GluGlu: 2.754 ± 0.533
2.065GluPhe: 2.065 ± 0.361
3.844GluGly: 3.844 ± 0.471
1.779GluHis: 1.779 ± 0.313
2.524GluIle: 2.524 ± 0.421
2.41GluLys: 2.41 ± 0.395
5.852GluLeu: 5.852 ± 0.778
1.32GluMet: 1.32 ± 0.264
0.803GluAsn: 0.803 ± 0.205
2.983GluPro: 2.983 ± 0.717
2.869GluGln: 2.869 ± 0.384
4.934GluArg: 4.934 ± 0.677
3.27GluSer: 3.27 ± 0.533
3.614GluThr: 3.614 ± 0.437
4.819GluVal: 4.819 ± 0.557
2.065GluTrp: 2.065 ± 0.448
1.09GluTyr: 1.09 ± 0.26
0.0GluXaa: 0.0 ± 0.0
Phe
3.155PheAla: 3.155 ± 0.366
0.287PheCys: 0.287 ± 0.128
1.549PheAsp: 1.549 ± 0.32
1.147PheGlu: 1.147 ± 0.208
0.574PhePhe: 0.574 ± 0.136
3.098PheGly: 3.098 ± 0.457
0.516PheHis: 0.516 ± 0.153
0.803PheIle: 0.803 ± 0.193
1.033PheLys: 1.033 ± 0.257
1.434PheLeu: 1.434 ± 0.289
0.861PheMet: 0.861 ± 0.337
0.861PheAsn: 0.861 ± 0.234
1.205PhePro: 1.205 ± 0.264
0.975PheGln: 0.975 ± 0.2
1.893PheArg: 1.893 ± 0.372
1.549PheSer: 1.549 ± 0.343
1.664PheThr: 1.664 ± 0.286
1.893PheVal: 1.893 ± 0.292
0.459PheTrp: 0.459 ± 0.182
0.975PheTyr: 0.975 ± 0.286
0.0PheXaa: 0.0 ± 0.0
Gly
7.516GlyAla: 7.516 ± 1.213
0.803GlyCys: 0.803 ± 0.231
5.393GlyAsp: 5.393 ± 0.651
3.614GlyGlu: 3.614 ± 0.454
3.098GlyPhe: 3.098 ± 0.573
9.696GlyGly: 9.696 ± 2.433
1.836GlyHis: 1.836 ± 0.351
4.016GlyIle: 4.016 ± 0.595
3.385GlyLys: 3.385 ± 0.417
6.368GlyLeu: 6.368 ± 0.52
1.951GlyMet: 1.951 ± 0.353
2.238GlyAsn: 2.238 ± 0.406
4.073GlyPro: 4.073 ± 0.401
2.582GlyGln: 2.582 ± 0.416
6.139GlyArg: 6.139 ± 0.454
4.762GlySer: 4.762 ± 0.706
5.336GlyThr: 5.336 ± 0.522
6.942GlyVal: 6.942 ± 0.78
2.065GlyTrp: 2.065 ± 0.339
2.352GlyTyr: 2.352 ± 0.261
0.0GlyXaa: 0.0 ± 0.0
His
1.893HisAla: 1.893 ± 0.315
0.287HisCys: 0.287 ± 0.126
1.262HisAsp: 1.262 ± 0.252
1.147HisGlu: 1.147 ± 0.284
0.402HisPhe: 0.402 ± 0.171
1.893HisGly: 1.893 ± 0.298
0.631HisHis: 0.631 ± 0.215
1.549HisIle: 1.549 ± 0.311
0.516HisLys: 0.516 ± 0.193
1.779HisLeu: 1.779 ± 0.368
0.631HisMet: 0.631 ± 0.195
0.459HisAsn: 0.459 ± 0.173
1.549HisPro: 1.549 ± 0.373
0.688HisGln: 0.688 ± 0.198
1.664HisArg: 1.664 ± 0.309
1.147HisSer: 1.147 ± 0.274
1.721HisThr: 1.721 ± 0.306
2.065HisVal: 2.065 ± 0.323
0.746HisTrp: 0.746 ± 0.251
0.803HisTyr: 0.803 ± 0.264
0.0HisXaa: 0.0 ± 0.0
Ile
5.737IleAla: 5.737 ± 0.606
0.516IleCys: 0.516 ± 0.154
3.614IleAsp: 3.614 ± 0.443
2.639IleGlu: 2.639 ± 0.451
0.918IlePhe: 0.918 ± 0.287
4.934IleGly: 4.934 ± 0.492
0.746IleHis: 0.746 ± 0.202
1.779IleIle: 1.779 ± 0.33
1.779IleLys: 1.779 ± 0.607
3.557IleLeu: 3.557 ± 0.388
0.746IleMet: 0.746 ± 0.237
1.434IleAsn: 1.434 ± 0.294
2.697IlePro: 2.697 ± 0.356
1.836IleGln: 1.836 ± 0.248
3.672IleArg: 3.672 ± 0.372
1.779IleSer: 1.779 ± 0.282
3.328IleThr: 3.328 ± 0.468
3.385IleVal: 3.385 ± 0.451
0.631IleTrp: 0.631 ± 0.219
0.688IleTyr: 0.688 ± 0.207
0.0IleXaa: 0.0 ± 0.0
Lys
4.131LysAla: 4.131 ± 0.555
0.402LysCys: 0.402 ± 0.159
2.41LysAsp: 2.41 ± 0.529
1.951LysGlu: 1.951 ± 0.282
1.147LysPhe: 1.147 ± 0.199
2.582LysGly: 2.582 ± 0.543
0.975LysHis: 0.975 ± 0.211
1.262LysIle: 1.262 ± 0.251
2.41LysLys: 2.41 ± 0.523
3.041LysLeu: 3.041 ± 0.315
0.402LysMet: 0.402 ± 0.127
1.262LysAsn: 1.262 ± 0.27
1.951LysPro: 1.951 ± 0.29
1.205LysGln: 1.205 ± 0.272
2.582LysArg: 2.582 ± 0.456
1.664LysSer: 1.664 ± 0.375
2.811LysThr: 2.811 ± 0.432
2.295LysVal: 2.295 ± 0.397
0.631LysTrp: 0.631 ± 0.164
0.803LysTyr: 0.803 ± 0.202
0.0LysXaa: 0.0 ± 0.0
Leu
9.811LeuAla: 9.811 ± 0.857
0.746LeuCys: 0.746 ± 0.206
4.991LeuAsp: 4.991 ± 0.702
3.672LeuGlu: 3.672 ± 0.654
1.549LeuPhe: 1.549 ± 0.256
6.368LeuGly: 6.368 ± 0.574
1.664LeuHis: 1.664 ± 0.325
2.926LeuIle: 2.926 ± 0.421
2.295LeuLys: 2.295 ± 0.36
5.622LeuLeu: 5.622 ± 0.612
1.033LeuMet: 1.033 ± 0.232
1.836LeuAsn: 1.836 ± 0.255
5.049LeuPro: 5.049 ± 0.543
2.467LeuGln: 2.467 ± 0.343
6.139LeuArg: 6.139 ± 0.517
4.303LeuSer: 4.303 ± 0.487
5.622LeuThr: 5.622 ± 0.552
5.68LeuVal: 5.68 ± 0.678
1.721LeuTrp: 1.721 ± 0.368
1.549LeuTyr: 1.549 ± 0.319
0.0LeuXaa: 0.0 ± 0.0
Met
2.926MetAla: 2.926 ± 0.526
0.402MetCys: 0.402 ± 0.16
0.918MetAsp: 0.918 ± 0.224
0.631MetGlu: 0.631 ± 0.211
0.229MetPhe: 0.229 ± 0.164
1.492MetGly: 1.492 ± 0.335
0.344MetHis: 0.344 ± 0.162
0.975MetIle: 0.975 ± 0.269
0.861MetLys: 0.861 ± 0.22
1.09MetLeu: 1.09 ± 0.253
0.402MetMet: 0.402 ± 0.141
0.746MetAsn: 0.746 ± 0.202
1.606MetPro: 1.606 ± 0.295
0.402MetGln: 0.402 ± 0.153
2.008MetArg: 2.008 ± 0.466
2.41MetSer: 2.41 ± 0.311
2.065MetThr: 2.065 ± 0.334
1.721MetVal: 1.721 ± 0.291
0.402MetTrp: 0.402 ± 0.177
0.344MetTyr: 0.344 ± 0.158
0.0MetXaa: 0.0 ± 0.0
Asn
3.672AsnAla: 3.672 ± 0.6
0.459AsnCys: 0.459 ± 0.178
1.664AsnAsp: 1.664 ± 0.336
1.262AsnGlu: 1.262 ± 0.247
0.459AsnPhe: 0.459 ± 0.163
3.041AsnGly: 3.041 ± 0.52
0.574AsnHis: 0.574 ± 0.18
1.09AsnIle: 1.09 ± 0.316
0.402AsnLys: 0.402 ± 0.139
2.123AsnLeu: 2.123 ± 0.353
0.402AsnMet: 0.402 ± 0.129
0.688AsnAsn: 0.688 ± 0.244
2.18AsnPro: 2.18 ± 0.283
0.975AsnGln: 0.975 ± 0.231
2.639AsnArg: 2.639 ± 0.447
1.262AsnSer: 1.262 ± 0.251
2.18AsnThr: 2.18 ± 0.305
1.779AsnVal: 1.779 ± 0.331
0.402AsnTrp: 0.402 ± 0.133
0.459AsnTyr: 0.459 ± 0.131
0.0AsnXaa: 0.0 ± 0.0
Pro
6.368ProAla: 6.368 ± 0.642
1.205ProCys: 1.205 ± 0.29
4.131ProAsp: 4.131 ± 0.533
5.622ProGlu: 5.622 ± 0.866
1.147ProPhe: 1.147 ± 0.274
4.418ProGly: 4.418 ± 0.458
1.09ProHis: 1.09 ± 0.202
2.983ProIle: 2.983 ± 0.404
2.811ProLys: 2.811 ± 0.332
3.442ProLeu: 3.442 ± 0.483
1.033ProMet: 1.033 ± 0.251
1.377ProAsn: 1.377 ± 0.232
2.983ProPro: 2.983 ± 0.517
1.492ProGln: 1.492 ± 0.286
3.328ProArg: 3.328 ± 0.43
3.213ProSer: 3.213 ± 0.397
3.844ProThr: 3.844 ± 0.385
4.532ProVal: 4.532 ± 0.519
0.688ProTrp: 0.688 ± 0.186
1.32ProTyr: 1.32 ± 0.329
0.0ProXaa: 0.0 ± 0.0
Gln
3.787GlnAla: 3.787 ± 0.514
0.459GlnCys: 0.459 ± 0.144
1.377GlnAsp: 1.377 ± 0.31
2.065GlnGlu: 2.065 ± 0.298
1.033GlnPhe: 1.033 ± 0.181
2.18GlnGly: 2.18 ± 0.361
0.803GlnHis: 0.803 ± 0.24
2.008GlnIle: 2.008 ± 0.32
1.09GlnLys: 1.09 ± 0.232
2.41GlnLeu: 2.41 ± 0.323
0.975GlnMet: 0.975 ± 0.203
1.205GlnAsn: 1.205 ± 0.239
1.836GlnPro: 1.836 ± 0.236
1.836GlnGln: 1.836 ± 0.379
3.155GlnArg: 3.155 ± 0.441
1.721GlnSer: 1.721 ± 0.272
2.065GlnThr: 2.065 ± 0.437
2.582GlnVal: 2.582 ± 0.392
1.205GlnTrp: 1.205 ± 0.253
0.746GlnTyr: 0.746 ± 0.184
0.0GlnXaa: 0.0 ± 0.0
Arg
7.114ArgAla: 7.114 ± 0.56
1.32ArgCys: 1.32 ± 0.357
4.877ArgAsp: 4.877 ± 0.441
5.221ArgGlu: 5.221 ± 0.558
1.893ArgPhe: 1.893 ± 0.287
4.59ArgGly: 4.59 ± 0.452
2.524ArgHis: 2.524 ± 0.505
4.475ArgIle: 4.475 ± 0.562
3.041ArgLys: 3.041 ± 0.465
5.393ArgLeu: 5.393 ± 0.454
2.123ArgMet: 2.123 ± 0.309
1.951ArgAsn: 1.951 ± 0.294
3.787ArgPro: 3.787 ± 0.552
2.639ArgGln: 2.639 ± 0.351
6.999ArgArg: 6.999 ± 1.126
4.188ArgSer: 4.188 ± 0.512
4.36ArgThr: 4.36 ± 0.413
4.934ArgVal: 4.934 ± 0.565
1.836ArgTrp: 1.836 ± 0.299
1.951ArgTyr: 1.951 ± 0.421
0.0ArgXaa: 0.0 ± 0.0
Ser
6.426SerAla: 6.426 ± 0.587
0.516SerCys: 0.516 ± 0.204
3.672SerAsp: 3.672 ± 0.428
4.59SerGlu: 4.59 ± 0.557
1.434SerPhe: 1.434 ± 0.26
6.713SerGly: 6.713 ± 0.772
1.377SerHis: 1.377 ± 0.331
1.836SerIle: 1.836 ± 0.261
1.32SerLys: 1.32 ± 0.267
3.614SerLeu: 3.614 ± 0.447
1.951SerMet: 1.951 ± 0.405
1.779SerAsn: 1.779 ± 0.41
2.869SerPro: 2.869 ± 0.373
1.32SerGln: 1.32 ± 0.229
3.959SerArg: 3.959 ± 0.606
4.131SerSer: 4.131 ± 0.675
3.959SerThr: 3.959 ± 0.569
4.819SerVal: 4.819 ± 0.667
0.918SerTrp: 0.918 ± 0.238
0.918SerTyr: 0.918 ± 0.229
0.0SerXaa: 0.0 ± 0.0
Thr
7.745ThrAla: 7.745 ± 0.906
0.516ThrCys: 0.516 ± 0.163
4.188ThrAsp: 4.188 ± 0.515
3.614ThrGlu: 3.614 ± 0.47
1.836ThrPhe: 1.836 ± 0.329
4.877ThrGly: 4.877 ± 0.572
1.721ThrHis: 1.721 ± 0.335
3.901ThrIle: 3.901 ± 0.433
1.836ThrLys: 1.836 ± 0.275
5.049ThrLeu: 5.049 ± 0.529
0.975ThrMet: 0.975 ± 0.251
1.893ThrAsn: 1.893 ± 0.283
3.959ThrPro: 3.959 ± 0.414
2.352ThrGln: 2.352 ± 0.399
4.303ThrArg: 4.303 ± 0.434
3.844ThrSer: 3.844 ± 0.566
3.787ThrThr: 3.787 ± 0.606
5.508ThrVal: 5.508 ± 0.562
1.434ThrTrp: 1.434 ± 0.294
1.262ThrTyr: 1.262 ± 0.285
0.0ThrXaa: 0.0 ± 0.0
Val
9.352ValAla: 9.352 ± 0.754
0.918ValCys: 0.918 ± 0.235
4.991ValAsp: 4.991 ± 0.569
5.049ValGlu: 5.049 ± 0.467
1.893ValPhe: 1.893 ± 0.284
5.049ValGly: 5.049 ± 0.641
1.377ValHis: 1.377 ± 0.321
3.041ValIle: 3.041 ± 0.488
3.041ValLys: 3.041 ± 0.477
4.877ValLeu: 4.877 ± 0.584
1.893ValMet: 1.893 ± 0.3
2.467ValAsn: 2.467 ± 0.414
4.647ValPro: 4.647 ± 0.522
2.41ValGln: 2.41 ± 0.334
5.221ValArg: 5.221 ± 0.665
5.106ValSer: 5.106 ± 0.601
4.705ValThr: 4.705 ± 0.621
6.54ValVal: 6.54 ± 0.669
2.18ValTrp: 2.18 ± 0.384
1.492ValTyr: 1.492 ± 0.354
0.0ValXaa: 0.0 ± 0.0
Trp
1.836TrpAla: 1.836 ± 0.339
0.287TrpCys: 0.287 ± 0.111
1.492TrpAsp: 1.492 ± 0.278
0.861TrpGlu: 0.861 ± 0.196
0.688TrpPhe: 0.688 ± 0.176
1.262TrpGly: 1.262 ± 0.254
0.287TrpHis: 0.287 ± 0.122
1.262TrpIle: 1.262 ± 0.286
0.975TrpLys: 0.975 ± 0.237
2.123TrpLeu: 2.123 ± 0.341
0.516TrpMet: 0.516 ± 0.147
1.147TrpAsn: 1.147 ± 0.287
1.377TrpPro: 1.377 ± 0.288
1.033TrpGln: 1.033 ± 0.212
1.779TrpArg: 1.779 ± 0.324
1.033TrpSer: 1.033 ± 0.248
1.664TrpThr: 1.664 ± 0.294
1.033TrpVal: 1.033 ± 0.231
0.516TrpTrp: 0.516 ± 0.198
0.516TrpTyr: 0.516 ± 0.15
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.123TyrAla: 2.123 ± 0.409
0.172TyrCys: 0.172 ± 0.089
2.065TyrAsp: 2.065 ± 0.349
1.377TyrGlu: 1.377 ± 0.32
0.861TyrPhe: 0.861 ± 0.206
1.951TyrGly: 1.951 ± 0.352
0.516TyrHis: 0.516 ± 0.157
0.803TyrIle: 0.803 ± 0.193
0.803TyrLys: 0.803 ± 0.277
1.32TyrLeu: 1.32 ± 0.332
0.344TyrMet: 0.344 ± 0.119
0.574TyrAsn: 0.574 ± 0.167
1.205TyrPro: 1.205 ± 0.286
0.746TyrGln: 0.746 ± 0.252
1.893TyrArg: 1.893 ± 0.298
1.32TyrSer: 1.32 ± 0.314
2.008TyrThr: 2.008 ± 0.35
1.147TyrVal: 1.147 ± 0.208
0.402TyrTrp: 0.402 ± 0.155
0.746TyrTyr: 0.746 ± 0.191
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 102 proteins (17431 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski