Amino acid dipepetide frequency for Streptococcus pasteurianus (strain ATCC 43144 / JCM 5346 / CDC 1723-81)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.937AlaAla: 5.937 ± 0.141	0.471AlaCys: 0.471 ± 0.028	4.588AlaAsp: 4.588 ± 0.1	5.192AlaGlu: 5.192 ± 0.111	3.465AlaPhe: 3.465 ± 0.079	5.498AlaGly: 5.498 ± 0.11	1.265AlaHis: 1.265 ± 0.049	6.531AlaIle: 6.531 ± 0.112	5.387AlaLys: 5.387 ± 0.109	7.39AlaLeu: 7.39 ± 0.133	1.945AlaMet: 1.945 ± 0.063	3.356AlaAsn: 3.356 ± 0.084	1.973AlaPro: 1.973 ± 0.069	3.068AlaGln: 3.068 ± 0.088	2.783AlaArg: 2.783 ± 0.084	4.445AlaSer: 4.445 ± 0.103	4.377AlaThr: 4.377 ± 0.089	5.517AlaVal: 5.517 ± 0.095	0.631AlaTrp: 0.631 ± 0.037	2.806AlaTyr: 2.806 ± 0.067	0.0AlaXaa: 0.0 ± 0.0
Cys	0.357CysAla: 0.357 ± 0.023	0.049CysCys: 0.049 ± 0.009	0.35CysAsp: 0.35 ± 0.027	0.295CysGlu: 0.295 ± 0.023	0.29CysPhe: 0.29 ± 0.024	0.517CysGly: 0.517 ± 0.031	0.202CysHis: 0.202 ± 0.022	0.344CysIle: 0.344 ± 0.025	0.26CysLys: 0.26 ± 0.024	0.678CysLeu: 0.678 ± 0.038	0.144CysMet: 0.144 ± 0.017	0.223CysAsn: 0.223 ± 0.019	0.249CysPro: 0.249 ± 0.022	0.322CysGln: 0.322 ± 0.025	0.218CysArg: 0.218 ± 0.019	0.353CysSer: 0.353 ± 0.027	0.255CysThr: 0.255 ± 0.022	0.334CysVal: 0.334 ± 0.025	0.049CysTrp: 0.049 ± 0.009	0.195CysTyr: 0.195 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.758AspAla: 3.758 ± 0.089	0.38AspCys: 0.38 ± 0.031	3.735AspAsp: 3.735 ± 0.092	4.463AspGlu: 4.463 ± 0.08	3.449AspPhe: 3.449 ± 0.091	3.795AspGly: 3.795 ± 0.098	0.824AspHis: 0.824 ± 0.039	4.828AspIle: 4.828 ± 0.095	4.264AspLys: 4.264 ± 0.082	5.735AspLeu: 5.735 ± 0.105	1.731AspMet: 1.731 ± 0.054	2.975AspAsn: 2.975 ± 0.068	1.386AspPro: 1.386 ± 0.052	1.585AspGln: 1.585 ± 0.046	1.85AspArg: 1.85 ± 0.062	3.421AspSer: 3.421 ± 0.091	3.251AspThr: 3.251 ± 0.082	4.377AspVal: 4.377 ± 0.089	0.606AspTrp: 0.606 ± 0.037	3.129AspTyr: 3.129 ± 0.08	0.0AspXaa: 0.0 ± 0.0
Glu	5.31GluAla: 5.31 ± 0.111	0.295GluCys: 0.295 ± 0.025	3.565GluAsp: 3.565 ± 0.08	5.593GluGlu: 5.593 ± 0.141	2.704GluPhe: 2.704 ± 0.07	3.349GluGly: 3.349 ± 0.081	1.383GluHis: 1.383 ± 0.052	5.261GluIle: 5.261 ± 0.108	5.867GluLys: 5.867 ± 0.111	7.091GluLeu: 7.091 ± 0.121	1.817GluMet: 1.817 ± 0.056	4.257GluAsn: 4.257 ± 0.09	1.53GluPro: 1.53 ± 0.052	2.62GluGln: 2.62 ± 0.079	3.11GluArg: 3.11 ± 0.092	3.221GluSer: 3.221 ± 0.077	3.862GluThr: 3.862 ± 0.087	4.663GluVal: 4.663 ± 0.107	0.566GluTrp: 0.566 ± 0.029	2.033GluTyr: 2.033 ± 0.066	0.0GluXaa: 0.0 ± 0.0
Phe	3.547PheAla: 3.547 ± 0.083	0.304PheCys: 0.304 ± 0.023	3.242PheAsp: 3.242 ± 0.073	3.054PheGlu: 3.054 ± 0.082	2.119PhePhe: 2.119 ± 0.073	3.338PheGly: 3.338 ± 0.081	0.752PheHis: 0.752 ± 0.037	3.229PheIle: 3.229 ± 0.092	2.551PheLys: 2.551 ± 0.067	4.498PheLeu: 4.498 ± 0.1	1.154PheMet: 1.154 ± 0.047	2.161PheAsn: 2.161 ± 0.063	1.569PhePro: 1.569 ± 0.069	1.448PheGln: 1.448 ± 0.053	1.444PheArg: 1.444 ± 0.054	3.37PheSer: 3.37 ± 0.081	2.655PheThr: 2.655 ± 0.073	3.314PheVal: 3.314 ± 0.074	0.497PheTrp: 0.497 ± 0.032	1.797PheTyr: 1.797 ± 0.061	0.0PheXaa: 0.0 ± 0.0
Gly	4.69GlyAla: 4.69 ± 0.114	0.439GlyCys: 0.439 ± 0.028	3.627GlyAsp: 3.627 ± 0.089	3.609GlyGlu: 3.609 ± 0.082	3.312GlyPhe: 3.312 ± 0.079	4.294GlyGly: 4.294 ± 0.115	1.302GlyHis: 1.302 ± 0.048	5.647GlyIle: 5.647 ± 0.103	4.588GlyLys: 4.588 ± 0.083	6.336GlyLeu: 6.336 ± 0.116	1.843GlyMet: 1.843 ± 0.058	2.896GlyAsn: 2.896 ± 0.076	1.298GlyPro: 1.298 ± 0.047	2.549GlyGln: 2.549 ± 0.071	2.553GlyArg: 2.553 ± 0.081	3.642GlySer: 3.642 ± 0.088	3.778GlyThr: 3.778 ± 0.092	5.111GlyVal: 5.111 ± 0.099	0.624GlyTrp: 0.624 ± 0.036	2.743GlyTyr: 2.743 ± 0.069	0.0GlyXaa: 0.0 ± 0.0
His	1.177HisAla: 1.177 ± 0.048	0.132HisCys: 0.132 ± 0.015	1.059HisAsp: 1.059 ± 0.045	1.068HisGlu: 1.068 ± 0.044	1.182HisPhe: 1.182 ± 0.043	1.172HisGly: 1.172 ± 0.046	0.532HisHis: 0.532 ± 0.029	1.358HisIle: 1.358 ± 0.048	0.984HisLys: 0.984 ± 0.047	2.036HisLeu: 2.036 ± 0.068	0.441HisMet: 0.441 ± 0.027	0.778HisAsn: 0.778 ± 0.038	0.871HisPro: 0.871 ± 0.04	0.84HisGln: 0.84 ± 0.04	0.789HisArg: 0.789 ± 0.042	0.991HisSer: 0.991 ± 0.039	0.938HisThr: 0.938 ± 0.043	1.226HisVal: 1.226 ± 0.052	0.153HisTrp: 0.153 ± 0.017	1.028HisTyr: 1.028 ± 0.045	0.0HisXaa: 0.0 ± 0.0
Ile	6.464IleAla: 6.464 ± 0.134	0.611IleCys: 0.611 ± 0.034	4.619IleAsp: 4.619 ± 0.097	4.881IleGlu: 4.881 ± 0.095	3.581IlePhe: 3.581 ± 0.086	5.143IleGly: 5.143 ± 0.108	1.216IleHis: 1.216 ± 0.05	5.758IleIle: 5.758 ± 0.122	4.531IleLys: 4.531 ± 0.109	7.655IleLeu: 7.655 ± 0.161	1.799IleMet: 1.799 ± 0.063	3.421IleAsn: 3.421 ± 0.083	2.846IlePro: 2.846 ± 0.084	2.386IleGln: 2.386 ± 0.059	2.723IleArg: 2.723 ± 0.079	5.382IleSer: 5.382 ± 0.1	4.407IleThr: 4.407 ± 0.091	5.275IleVal: 5.275 ± 0.11	0.59IleTrp: 0.59 ± 0.033	2.667IleTyr: 2.667 ± 0.075	0.0IleXaa: 0.0 ± 0.0
Lys	5.427LysAla: 5.427 ± 0.111	0.225LysCys: 0.225 ± 0.02	3.895LysAsp: 3.895 ± 0.084	5.786LysGlu: 5.786 ± 0.109	2.168LysPhe: 2.168 ± 0.057	3.632LysGly: 3.632 ± 0.083	1.239LysHis: 1.239 ± 0.039	4.993LysIle: 4.993 ± 0.09	5.129LysLys: 5.129 ± 0.113	5.854LysLeu: 5.854 ± 0.103	2.021LysMet: 2.021 ± 0.056	3.63LysAsn: 3.63 ± 0.093	1.963LysPro: 1.963 ± 0.059	2.653LysGln: 2.653 ± 0.065	3.177LysArg: 3.177 ± 0.072	3.795LysSer: 3.795 ± 0.084	4.052LysThr: 4.052 ± 0.091	4.621LysVal: 4.621 ± 0.097	0.568LysTrp: 0.568 ± 0.037	2.339LysTyr: 2.339 ± 0.067	0.0LysXaa: 0.0 ± 0.0
Leu	8.884LeuAla: 8.884 ± 0.149	0.522LeuCys: 0.522 ± 0.03	5.789LeuAsp: 5.789 ± 0.123	6.573LeuGlu: 6.573 ± 0.128	4.287LeuPhe: 4.287 ± 0.097	6.505LeuGly: 6.505 ± 0.127	1.583LeuHis: 1.583 ± 0.057	6.794LeuIle: 6.794 ± 0.13	6.397LeuLys: 6.397 ± 0.108	9.567LeuLeu: 9.567 ± 0.172	2.46LeuMet: 2.46 ± 0.076	4.294LeuAsn: 4.294 ± 0.084	3.776LeuPro: 3.776 ± 0.088	3.338LeuGln: 3.338 ± 0.086	3.424LeuArg: 3.424 ± 0.089	7.184LeuSer: 7.184 ± 0.131	6.49LeuThr: 6.49 ± 0.118	7.051LeuVal: 7.051 ± 0.123	0.691LeuTrp: 0.691 ± 0.041	3.099LeuTyr: 3.099 ± 0.072	0.0LeuXaa: 0.0 ± 0.0
Met	2.056MetAla: 2.056 ± 0.063	0.134MetCys: 0.134 ± 0.016	1.246MetAsp: 1.246 ± 0.047	1.402MetGlu: 1.402 ± 0.051	0.908MetPhe: 0.908 ± 0.037	1.62MetGly: 1.62 ± 0.063	0.401MetHis: 0.401 ± 0.026	2.112MetIle: 2.112 ± 0.062	1.905MetLys: 1.905 ± 0.056	2.412MetLeu: 2.412 ± 0.07	0.764MetMet: 0.764 ± 0.043	1.205MetAsn: 1.205 ± 0.045	0.861MetPro: 0.861 ± 0.04	0.926MetGln: 0.926 ± 0.044	0.982MetArg: 0.982 ± 0.039	1.797MetSer: 1.797 ± 0.053	2.244MetThr: 2.244 ± 0.065	1.711MetVal: 1.711 ± 0.054	0.193MetTrp: 0.193 ± 0.017	0.64MetTyr: 0.64 ± 0.033	0.0MetXaa: 0.0 ± 0.0
Asn	3.193AsnAla: 3.193 ± 0.089	0.29AsnCys: 0.29 ± 0.022	2.625AsnAsp: 2.625 ± 0.062	2.664AsnGlu: 2.664 ± 0.067	2.08AsnPhe: 2.08 ± 0.064	3.511AsnGly: 3.511 ± 0.081	1.19AsnHis: 1.19 ± 0.048	3.519AsnIle: 3.519 ± 0.08	2.737AsnLys: 2.737 ± 0.069	4.885AsnLeu: 4.885 ± 0.088	1.233AsnMet: 1.233 ± 0.045	2.096AsnAsn: 2.096 ± 0.072	2.296AsnPro: 2.296 ± 0.064	2.237AsnGln: 2.237 ± 0.067	2.054AsnArg: 2.054 ± 0.061	2.579AsnSer: 2.579 ± 0.078	2.312AsnThr: 2.312 ± 0.061	3.096AsnVal: 3.096 ± 0.068	0.508AsnTrp: 0.508 ± 0.035	2.087AsnTyr: 2.087 ± 0.062	0.0AsnXaa: 0.0 ± 0.0
Pro	2.205ProAla: 2.205 ± 0.07	0.165ProCys: 0.165 ± 0.019	2.179ProAsp: 2.179 ± 0.072	2.709ProGlu: 2.709 ± 0.068	1.578ProPhe: 1.578 ± 0.053	1.606ProGly: 1.606 ± 0.058	0.627ProHis: 0.627 ± 0.031	2.411ProIle: 2.411 ± 0.07	2.084ProLys: 2.084 ± 0.067	2.859ProLeu: 2.859 ± 0.075	0.745ProMet: 0.745 ± 0.036	1.646ProAsn: 1.646 ± 0.06	0.501ProPro: 0.501 ± 0.032	1.186ProGln: 1.186 ± 0.047	0.98ProArg: 0.98 ± 0.044	1.889ProSer: 1.889 ± 0.061	1.957ProThr: 1.957 ± 0.06	2.463ProVal: 2.463 ± 0.066	0.285ProTrp: 0.285 ± 0.026	1.307ProTyr: 1.307 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	3.351GlnAla: 3.351 ± 0.084	0.139GlnCys: 0.139 ± 0.016	1.84GlnAsp: 1.84 ± 0.06	3.064GlnGlu: 3.064 ± 0.075	1.625GlnPhe: 1.625 ± 0.053	2.072GlnGly: 2.072 ± 0.062	0.643GlnHis: 0.643 ± 0.029	2.752GlnIle: 2.752 ± 0.072	3.003GlnLys: 3.003 ± 0.077	3.837GlnLeu: 3.837 ± 0.096	0.919GlnMet: 0.919 ± 0.04	1.806GlnAsn: 1.806 ± 0.055	1.049GlnPro: 1.049 ± 0.041	1.379GlnGln: 1.379 ± 0.052	1.265GlnArg: 1.265 ± 0.055	2.065GlnSer: 2.065 ± 0.055	2.314GlnThr: 2.314 ± 0.061	2.759GlnVal: 2.759 ± 0.07	0.276GlnTrp: 0.276 ± 0.024	1.277GlnTyr: 1.277 ± 0.045	0.0GlnXaa: 0.0 ± 0.0
Arg	2.491ArgAla: 2.491 ± 0.079	0.193ArgCys: 0.193 ± 0.022	2.307ArgAsp: 2.307 ± 0.062	2.871ArgGlu: 2.871 ± 0.087	1.933ArgPhe: 1.933 ± 0.062	2.195ArgGly: 2.195 ± 0.065	0.861ArgHis: 0.861 ± 0.038	2.846ArgIle: 2.846 ± 0.06	2.836ArgLys: 2.836 ± 0.082	3.96ArgLeu: 3.96 ± 0.104	1.077ArgMet: 1.077 ± 0.04	1.678ArgAsn: 1.678 ± 0.055	1.168ArgPro: 1.168 ± 0.044	1.766ArgGln: 1.766 ± 0.061	1.862ArgArg: 1.862 ± 0.07	1.864ArgSer: 1.864 ± 0.056	1.875ArgThr: 1.875 ± 0.064	2.653ArgVal: 2.653 ± 0.074	0.272ArgTrp: 0.272 ± 0.022	1.481ArgTyr: 1.481 ± 0.051	0.0ArgXaa: 0.0 ± 0.0
Ser	4.118SerAla: 4.118 ± 0.095	0.346SerCys: 0.346 ± 0.026	4.038SerAsp: 4.038 ± 0.099	3.899SerGlu: 3.899 ± 0.099	3.024SerPhe: 3.024 ± 0.089	4.668SerGly: 4.668 ± 0.11	1.302SerHis: 1.302 ± 0.049	4.34SerIle: 4.34 ± 0.096	3.946SerLys: 3.946 ± 0.081	6.171SerLeu: 6.171 ± 0.112	1.388SerMet: 1.388 ± 0.054	2.762SerAsn: 2.762 ± 0.076	1.694SerPro: 1.694 ± 0.061	2.755SerGln: 2.755 ± 0.079	2.405SerArg: 2.405 ± 0.067	4.505SerSer: 4.505 ± 0.18	3.446SerThr: 3.446 ± 0.087	4.192SerVal: 4.192 ± 0.099	0.557SerTrp: 0.557 ± 0.03	2.481SerTyr: 2.481 ± 0.074	0.0SerXaa: 0.0 ± 0.0
Thr	4.447ThrAla: 4.447 ± 0.098	0.32ThrCys: 0.32 ± 0.025	3.41ThrAsp: 3.41 ± 0.084	3.59ThrGlu: 3.59 ± 0.085	2.889ThrPhe: 2.889 ± 0.071	4.222ThrGly: 4.222 ± 0.09	1.096ThrHis: 1.096 ± 0.041	4.73ThrIle: 4.73 ± 0.091	3.519ThrLys: 3.519 ± 0.093	5.916ThrLeu: 5.916 ± 0.119	1.3ThrMet: 1.3 ± 0.046	2.621ThrAsn: 2.621 ± 0.072	2.37ThrPro: 2.37 ± 0.073	1.861ThrGln: 1.861 ± 0.056	1.949ThrArg: 1.949 ± 0.06	3.888ThrSer: 3.888 ± 0.085	3.609ThrThr: 3.609 ± 0.105	4.503ThrVal: 4.503 ± 0.099	0.49ThrTrp: 0.49 ± 0.027	2.405ThrTyr: 2.405 ± 0.066	0.0ThrXaa: 0.0 ± 0.0
Val	6.086ValAla: 6.086 ± 0.107	0.369ValCys: 0.369 ± 0.026	4.349ValAsp: 4.349 ± 0.092	4.61ValGlu: 4.61 ± 0.124	3.068ValPhe: 3.068 ± 0.078	4.593ValGly: 4.593 ± 0.103	1.209ValHis: 1.209 ± 0.047	5.478ValIle: 5.478 ± 0.1	4.588ValLys: 4.588 ± 0.084	6.747ValLeu: 6.747 ± 0.127	1.715ValMet: 1.715 ± 0.059	3.18ValAsn: 3.18 ± 0.089	2.432ValPro: 2.432 ± 0.068	1.977ValGln: 1.977 ± 0.061	2.623ValArg: 2.623 ± 0.082	4.807ValSer: 4.807 ± 0.09	4.869ValThr: 4.869 ± 0.107	5.304ValVal: 5.304 ± 0.115	0.557ValTrp: 0.557 ± 0.037	2.5ValTyr: 2.5 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.517TrpAla: 0.517 ± 0.033	0.058TrpCys: 0.058 ± 0.01	0.45TrpAsp: 0.45 ± 0.028	0.532TrpGlu: 0.532 ± 0.032	0.436TrpPhe: 0.436 ± 0.03	0.589TrpGly: 0.589 ± 0.03	0.214TrpHis: 0.214 ± 0.021	0.545TrpIle: 0.545 ± 0.027	0.508TrpLys: 0.508 ± 0.032	1.0TrpLeu: 1.0 ± 0.052	0.221TrpMet: 0.221 ± 0.021	0.48TrpAsn: 0.48 ± 0.028	0.135TrpPro: 0.135 ± 0.016	0.441TrpGln: 0.441 ± 0.029	0.362TrpArg: 0.362 ± 0.027	0.613TrpSer: 0.613 ± 0.04	0.441TrpThr: 0.441 ± 0.032	0.55TrpVal: 0.55 ± 0.03	0.112TrpTrp: 0.112 ± 0.016	0.362TrpTyr: 0.362 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.609TyrAla: 2.609 ± 0.068	0.242TyrCys: 0.242 ± 0.021	2.63TyrAsp: 2.63 ± 0.077	2.24TyrGlu: 2.24 ± 0.064	1.947TyrPhe: 1.947 ± 0.065	2.564TyrGly: 2.564 ± 0.072	0.917TyrHis: 0.917 ± 0.04	2.479TyrIle: 2.479 ± 0.08	2.084TyrLys: 2.084 ± 0.068	4.082TyrLeu: 4.082 ± 0.091	0.799TyrMet: 0.799 ± 0.039	1.725TyrAsn: 1.725 ± 0.062	1.413TyrPro: 1.413 ± 0.057	2.098TyrGln: 2.098 ± 0.066	1.636TyrArg: 1.636 ± 0.056	2.224TyrSer: 2.224 ± 0.065	2.007TyrThr: 2.007 ± 0.065	2.34TyrVal: 2.34 ± 0.063	0.341TyrTrp: 0.341 ± 0.025	1.643TyrTyr: 1.643 ± 0.071	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1864 proteins (569143 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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