Amino acid dipepetide frequency for Infectious bronchitis virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.124AlaAla: 5.124 ± 0.948
2.391AlaCys: 2.391 ± 0.649
3.53AlaAsp: 3.53 ± 1.008
2.05AlaGlu: 2.05 ± 0.527
3.188AlaPhe: 3.188 ± 1.637
3.872AlaGly: 3.872 ± 1.053
0.911AlaHis: 0.911 ± 0.323
4.896AlaIle: 4.896 ± 1.449
4.896AlaLys: 4.896 ± 1.205
5.58AlaLeu: 5.58 ± 1.795
1.594AlaMet: 1.594 ± 0.279
3.758AlaAsn: 3.758 ± 0.67
2.733AlaPro: 2.733 ± 0.847
2.277AlaGln: 2.277 ± 0.437
2.619AlaArg: 2.619 ± 0.798
3.872AlaSer: 3.872 ± 0.897
4.555AlaThr: 4.555 ± 1.144
4.555AlaVal: 4.555 ± 1.254
1.025AlaTrp: 1.025 ± 0.208
3.302AlaTyr: 3.302 ± 0.735
0.0AlaXaa: 0.0 ± 0.0
Cys
1.594CysAla: 1.594 ± 0.477
1.48CysCys: 1.48 ± 0.655
1.822CysAsp: 1.822 ± 0.351
1.936CysGlu: 1.936 ± 0.603
1.48CysPhe: 1.48 ± 0.393
2.961CysGly: 2.961 ± 0.755
0.455CysHis: 0.455 ± 0.232
1.366CysIle: 1.366 ± 0.431
2.164CysLys: 2.164 ± 0.404
2.05CysLeu: 2.05 ± 0.561
0.228CysMet: 0.228 ± 0.116
2.05CysAsn: 2.05 ± 0.589
0.797CysPro: 0.797 ± 0.507
0.797CysGln: 0.797 ± 0.277
1.366CysArg: 1.366 ± 0.431
1.594CysSer: 1.594 ± 0.488
1.594CysThr: 1.594 ± 0.777
3.188CysVal: 3.188 ± 0.523
0.569CysTrp: 0.569 ± 0.29
2.733CysTyr: 2.733 ± 0.773
0.0CysXaa: 0.0 ± 0.0
Asp
4.327AspAla: 4.327 ± 0.849
1.48AspCys: 1.48 ± 0.599
3.302AspAsp: 3.302 ± 1.392
3.188AspGlu: 3.188 ± 1.11
3.644AspPhe: 3.644 ± 0.904
4.441AspGly: 4.441 ± 1.497
0.683AspHis: 0.683 ± 0.756
3.074AspIle: 3.074 ± 0.905
2.961AspLys: 2.961 ± 0.698
4.669AspLeu: 4.669 ± 0.754
0.569AspMet: 0.569 ± 0.478
2.619AspAsn: 2.619 ± 0.798
2.05AspPro: 2.05 ± 0.617
1.936AspGln: 1.936 ± 1.067
1.936AspArg: 1.936 ± 0.574
4.099AspSer: 4.099 ± 0.562
2.391AspThr: 2.391 ± 0.449
4.669AspVal: 4.669 ± 1.046
0.455AspTrp: 0.455 ± 0.232
2.847AspTyr: 2.847 ± 1.04
0.0AspXaa: 0.0 ± 0.0
Glu
2.391GluAla: 2.391 ± 0.975
1.253GluCys: 1.253 ± 0.553
3.074GluAsp: 3.074 ± 0.591
3.416GluGlu: 3.416 ± 1.13
2.619GluPhe: 2.619 ± 1.113
2.619GluGly: 2.619 ± 0.697
0.911GluHis: 0.911 ± 0.45
2.164GluIle: 2.164 ± 0.587
3.188GluLys: 3.188 ± 0.98
3.985GluLeu: 3.985 ± 0.402
0.569GluMet: 0.569 ± 0.515
2.277GluAsn: 2.277 ± 0.722
2.277GluPro: 2.277 ± 0.511
2.05GluGln: 2.05 ± 0.589
1.366GluArg: 1.366 ± 0.507
2.505GluSer: 2.505 ± 0.961
2.505GluThr: 2.505 ± 0.621
3.758GluVal: 3.758 ± 1.241
0.228GluTrp: 0.228 ± 0.116
2.505GluTyr: 2.505 ± 0.663
0.0GluXaa: 0.0 ± 0.0
Phe
2.391PheAla: 2.391 ± 0.873
2.391PheCys: 2.391 ± 0.666
3.872PheAsp: 3.872 ± 0.774
3.416PheGlu: 3.416 ± 0.982
1.822PhePhe: 1.822 ± 0.729
2.505PheGly: 2.505 ± 0.797
0.342PheHis: 0.342 ± 0.143
3.53PheIle: 3.53 ± 0.863
3.644PheLys: 3.644 ± 1.242
3.985PheLeu: 3.985 ± 1.338
0.911PheMet: 0.911 ± 0.279
4.213PheAsn: 4.213 ± 1.121
0.228PhePro: 0.228 ± 0.71
1.822PheGln: 1.822 ± 0.773
1.366PheArg: 1.366 ± 1.095
3.985PheSer: 3.985 ± 0.93
3.758PheThr: 3.758 ± 0.937
7.402PheVal: 7.402 ± 1.271
1.594PheTrp: 1.594 ± 0.728
2.619PheTyr: 2.619 ± 0.395
0.0PheXaa: 0.0 ± 0.0
Gly
3.188GlyAla: 3.188 ± 0.451
1.936GlyCys: 1.936 ± 0.876
4.327GlyAsp: 4.327 ± 0.832
2.277GlyGlu: 2.277 ± 0.467
3.985GlyPhe: 3.985 ± 0.666
4.669GlyGly: 4.669 ± 1.362
1.708GlyHis: 1.708 ± 0.672
2.961GlyIle: 2.961 ± 0.928
3.644GlyLys: 3.644 ± 0.776
4.099GlyLeu: 4.099 ± 0.968
1.366GlyMet: 1.366 ± 0.388
3.644GlyAsn: 3.644 ± 0.597
2.277GlyPro: 2.277 ± 1.458
0.797GlyGln: 0.797 ± 1.058
2.277GlyArg: 2.277 ± 3.883
5.352GlySer: 5.352 ± 1.241
3.416GlyThr: 3.416 ± 0.812
6.946GlyVal: 6.946 ± 1.529
0.911GlyTrp: 0.911 ± 0.599
1.936GlyTyr: 1.936 ± 0.648
0.0GlyXaa: 0.0 ± 0.0
His
1.594HisAla: 1.594 ± 0.611
1.025HisCys: 1.025 ± 0.34
0.569HisAsp: 0.569 ± 0.29
1.253HisGlu: 1.253 ± 0.448
1.253HisPhe: 1.253 ± 0.448
1.366HisGly: 1.366 ± 0.766
0.342HisHis: 0.342 ± 0.174
0.797HisIle: 0.797 ± 0.366
1.139HisLys: 1.139 ± 0.58
1.48HisLeu: 1.48 ± 0.354
0.569HisMet: 0.569 ± 0.159
1.594HisAsn: 1.594 ± 0.554
0.797HisPro: 0.797 ± 0.238
0.342HisGln: 0.342 ± 0.174
0.228HisArg: 0.228 ± 0.278
0.683HisSer: 0.683 ± 0.378
1.139HisThr: 1.139 ± 0.511
1.366HisVal: 1.366 ± 0.503
0.228HisTrp: 0.228 ± 0.116
0.228HisTyr: 0.228 ± 0.116
0.0HisXaa: 0.0 ± 0.0
Ile
3.985IleAla: 3.985 ± 0.565
0.569IleCys: 0.569 ± 0.264
2.619IleAsp: 2.619 ± 0.516
1.936IleGlu: 1.936 ± 0.964
2.847IlePhe: 2.847 ± 0.391
2.619IleGly: 2.619 ± 1.13
0.569IleHis: 0.569 ± 0.307
2.619IleIle: 2.619 ± 1.18
2.05IleLys: 2.05 ± 0.545
6.377IleLeu: 6.377 ± 1.257
1.025IleMet: 1.025 ± 0.34
2.505IleAsn: 2.505 ± 0.491
3.074IlePro: 3.074 ± 0.515
2.847IleGln: 2.847 ± 1.666
1.708IleArg: 1.708 ± 0.492
3.416IleSer: 3.416 ± 0.867
4.213IleThr: 4.213 ± 2.201
4.783IleVal: 4.783 ± 0.755
0.455IleTrp: 0.455 ± 0.232
2.961IleTyr: 2.961 ± 0.864
0.0IleXaa: 0.0 ± 0.0
Lys
5.352LysAla: 5.352 ± 1.199
2.05LysCys: 2.05 ± 0.725
3.416LysAsp: 3.416 ± 0.777
2.733LysGlu: 2.733 ± 0.547
3.985LysPhe: 3.985 ± 0.868
3.302LysGly: 3.302 ± 1.11
1.48LysHis: 1.48 ± 0.431
2.391LysIle: 2.391 ± 0.489
2.733LysLys: 2.733 ± 1.185
5.01LysLeu: 5.01 ± 1.701
1.139LysMet: 1.139 ± 0.38
2.961LysAsn: 2.961 ± 0.934
3.188LysPro: 3.188 ± 0.644
2.505LysGln: 2.505 ± 0.666
2.164LysArg: 2.164 ± 0.765
4.213LysSer: 4.213 ± 0.792
2.847LysThr: 2.847 ± 0.51
4.896LysVal: 4.896 ± 1.257
1.025LysTrp: 1.025 ± 0.662
3.074LysTyr: 3.074 ± 0.949
0.0LysXaa: 0.0 ± 0.0
Leu
7.174LeuAla: 7.174 ± 1.213
2.733LeuCys: 2.733 ± 0.776
3.985LeuAsp: 3.985 ± 1.899
3.302LeuGlu: 3.302 ± 1.482
4.896LeuPhe: 4.896 ± 0.918
4.213LeuGly: 4.213 ± 0.707
1.936LeuHis: 1.936 ± 0.395
4.327LeuIle: 4.327 ± 0.859
5.693LeuLys: 5.693 ± 1.664
7.743LeuLeu: 7.743 ± 3.197
1.48LeuMet: 1.48 ± 0.354
3.985LeuAsn: 3.985 ± 2.187
3.302LeuPro: 3.302 ± 1.005
3.872LeuGln: 3.872 ± 1.571
2.619LeuArg: 2.619 ± 0.928
6.263LeuSer: 6.263 ± 0.767
5.124LeuThr: 5.124 ± 2.871
7.402LeuVal: 7.402 ± 1.479
1.025LeuTrp: 1.025 ± 0.832
4.555LeuTyr: 4.555 ± 1.299
0.0LeuXaa: 0.0 ± 0.0
Met
1.48MetAla: 1.48 ± 0.57
0.342MetCys: 0.342 ± 0.174
0.797MetAsp: 0.797 ± 0.238
0.569MetGlu: 0.569 ± 0.159
1.253MetPhe: 1.253 ± 0.637
0.797MetGly: 0.797 ± 0.406
0.911MetHis: 0.911 ± 0.464
0.342MetIle: 0.342 ± 0.505
0.342MetLys: 0.342 ± 0.767
1.936MetLeu: 1.936 ± 0.357
0.569MetMet: 0.569 ± 0.664
0.797MetAsn: 0.797 ± 1.014
1.025MetPro: 1.025 ± 0.293
0.683MetGln: 0.683 ± 0.286
0.797MetArg: 0.797 ± 0.238
1.48MetSer: 1.48 ± 0.475
0.911MetThr: 0.911 ± 0.279
1.253MetVal: 1.253 ± 0.6
0.0MetTrp: 0.0 ± 0.0
1.48MetTyr: 1.48 ± 0.431
0.0MetXaa: 0.0 ± 0.0
Asn
4.099AsnAla: 4.099 ± 0.732
2.391AsnCys: 2.391 ± 0.64
2.05AsnAsp: 2.05 ± 0.691
1.936AsnGlu: 1.936 ± 1.154
3.644AsnPhe: 3.644 ± 1.712
4.555AsnGly: 4.555 ± 1.26
0.569AsnHis: 0.569 ± 0.159
3.758AsnIle: 3.758 ± 1.023
3.53AsnLys: 3.53 ± 1.747
6.149AsnLeu: 6.149 ± 1.033
1.025AsnMet: 1.025 ± 0.49
3.53AsnAsn: 3.53 ± 1.843
1.936AsnPro: 1.936 ± 0.72
1.708AsnGln: 1.708 ± 0.341
1.253AsnArg: 1.253 ± 0.457
3.644AsnSer: 3.644 ± 0.703
2.619AsnThr: 2.619 ± 0.624
4.441AsnVal: 4.441 ± 1.387
1.139AsnTrp: 1.139 ± 0.492
2.391AsnTyr: 2.391 ± 0.594
0.0AsnXaa: 0.0 ± 0.0
Pro
2.164ProAla: 2.164 ± 1.517
0.569ProCys: 0.569 ± 0.434
2.505ProAsp: 2.505 ± 1.598
2.164ProGlu: 2.164 ± 0.968
1.708ProPhe: 1.708 ± 0.575
2.505ProGly: 2.505 ± 0.934
0.683ProHis: 0.683 ± 0.348
2.619ProIle: 2.619 ± 0.651
3.53ProLys: 3.53 ± 2.245
3.188ProLeu: 3.188 ± 0.76
0.342ProMet: 0.342 ± 0.259
2.619ProAsn: 2.619 ± 0.503
2.277ProPro: 2.277 ± 1.054
1.708ProGln: 1.708 ± 0.4
1.708ProArg: 1.708 ± 0.791
1.936ProSer: 1.936 ± 0.606
2.164ProThr: 2.164 ± 0.817
2.619ProVal: 2.619 ± 0.563
0.569ProTrp: 0.569 ± 0.159
1.253ProTyr: 1.253 ± 0.448
0.0ProXaa: 0.0 ± 0.0
Gln
2.05GlnAla: 2.05 ± 1.743
1.025GlnCys: 1.025 ± 0.333
1.936GlnAsp: 1.936 ± 0.983
1.708GlnGlu: 1.708 ± 0.476
1.708GlnPhe: 1.708 ± 0.513
1.936GlnGly: 1.936 ± 0.597
1.025GlnHis: 1.025 ± 0.54
1.822GlnIle: 1.822 ± 0.386
2.505GlnLys: 2.505 ± 0.537
3.416GlnLeu: 3.416 ± 1.575
0.455GlnMet: 0.455 ± 0.232
1.253GlnAsn: 1.253 ± 0.35
0.797GlnPro: 0.797 ± 0.288
2.277GlnGln: 2.277 ± 1.44
1.48GlnArg: 1.48 ± 0.848
3.188GlnSer: 3.188 ± 2.074
2.847GlnThr: 2.847 ± 0.696
2.391GlnVal: 2.391 ± 0.472
0.911GlnTrp: 0.911 ± 0.393
1.822GlnTyr: 1.822 ± 0.839
0.0GlnXaa: 0.0 ± 0.0
Arg
3.302ArgAla: 3.302 ± 1.239
1.025ArgCys: 1.025 ± 0.438
2.277ArgAsp: 2.277 ± 0.688
1.708ArgGlu: 1.708 ± 0.82
1.594ArgPhe: 1.594 ± 0.485
2.505ArgGly: 2.505 ± 0.575
0.797ArgHis: 0.797 ± 0.238
2.277ArgIle: 2.277 ± 0.385
1.936ArgLys: 1.936 ± 0.88
2.391ArgLeu: 2.391 ± 1.405
0.455ArgMet: 0.455 ± 0.328
3.188ArgAsn: 3.188 ± 0.592
1.253ArgPro: 1.253 ± 1.156
1.48ArgGln: 1.48 ± 1.558
2.05ArgArg: 2.05 ± 1.237
1.936ArgSer: 1.936 ± 1.357
1.48ArgThr: 1.48 ± 0.692
3.074ArgVal: 3.074 ± 1.952
0.114ArgTrp: 0.114 ± 0.31
1.594ArgTyr: 1.594 ± 0.434
0.0ArgXaa: 0.0 ± 0.0
Ser
4.327SerAla: 4.327 ± 0.841
1.822SerCys: 1.822 ± 0.749
2.847SerAsp: 2.847 ± 0.659
2.277SerGlu: 2.277 ± 0.463
5.352SerPhe: 5.352 ± 1.112
5.01SerGly: 5.01 ± 1.493
0.911SerHis: 0.911 ± 0.323
3.872SerIle: 3.872 ± 1.22
3.985SerLys: 3.985 ± 0.99
5.807SerLeu: 5.807 ± 1.374
0.683SerMet: 0.683 ± 0.584
3.074SerAsn: 3.074 ± 0.741
2.05SerPro: 2.05 ± 0.607
2.847SerGln: 2.847 ± 0.673
2.961SerArg: 2.961 ± 2.566
5.693SerSer: 5.693 ± 2.677
3.758SerThr: 3.758 ± 1.082
6.946SerVal: 6.946 ± 2.092
0.683SerTrp: 0.683 ± 0.576
3.188SerTyr: 3.188 ± 1.107
0.0SerXaa: 0.0 ± 0.0
Thr
4.327ThrAla: 4.327 ± 1.699
1.594ThrCys: 1.594 ± 0.811
2.505ThrAsp: 2.505 ± 0.467
2.961ThrGlu: 2.961 ± 0.756
2.505ThrPhe: 2.505 ± 0.663
3.644ThrGly: 3.644 ± 1.963
0.569ThrHis: 0.569 ± 0.159
2.733ThrIle: 2.733 ± 0.534
2.619ThrLys: 2.619 ± 0.601
4.669ThrLeu: 4.669 ± 1.199
1.708ThrMet: 1.708 ± 0.577
3.074ThrAsn: 3.074 ± 0.89
3.644ThrPro: 3.644 ± 0.545
2.847ThrGln: 2.847 ± 1.381
2.733ThrArg: 2.733 ± 0.651
5.124ThrSer: 5.124 ± 0.979
4.099ThrThr: 4.099 ± 0.751
6.035ThrVal: 6.035 ± 1.578
0.683ThrTrp: 0.683 ± 0.656
1.594ThrTyr: 1.594 ± 0.492
0.0ThrXaa: 0.0 ± 0.0
Val
4.783ValAla: 4.783 ± 1.606
3.416ValCys: 3.416 ± 1.39
6.263ValAsp: 6.263 ± 1.751
4.669ValGlu: 4.669 ± 1.825
4.896ValPhe: 4.896 ± 0.875
4.555ValGly: 4.555 ± 0.625
1.594ValHis: 1.594 ± 0.811
5.238ValIle: 5.238 ± 0.822
5.807ValLys: 5.807 ± 1.73
7.971ValLeu: 7.971 ± 2.134
1.594ValMet: 1.594 ± 0.454
5.238ValAsn: 5.238 ± 1.276
2.961ValPro: 2.961 ± 0.636
2.619ValGln: 2.619 ± 0.994
2.391ValArg: 2.391 ± 0.83
5.921ValSer: 5.921 ± 1.21
5.807ValThr: 5.807 ± 1.312
10.59ValVal: 10.59 ± 2.983
0.911ValTrp: 0.911 ± 0.2
3.53ValTyr: 3.53 ± 1.473
0.0ValXaa: 0.0 ± 0.0
Trp
0.228TrpAla: 0.228 ± 0.116
0.569TrpCys: 0.569 ± 0.457
0.797TrpAsp: 0.797 ± 0.288
0.569TrpGlu: 0.569 ± 0.336
1.139TrpPhe: 1.139 ± 0.231
0.569TrpGly: 0.569 ± 0.53
0.569TrpHis: 0.569 ± 0.401
0.455TrpIle: 0.455 ± 0.267
0.683TrpLys: 0.683 ± 0.348
1.936TrpLeu: 1.936 ± 1.132
0.228TrpMet: 0.228 ± 0.116
0.911TrpAsn: 0.911 ± 0.577
0.455TrpPro: 0.455 ± 0.328
0.0TrpGln: 0.0 ± 0.0
0.683TrpArg: 0.683 ± 0.476
0.911TrpSer: 0.911 ± 0.305
0.228TrpThr: 0.228 ± 0.116
1.139TrpVal: 1.139 ± 0.231
0.455TrpTrp: 0.455 ± 0.328
0.911TrpTyr: 0.911 ± 0.719
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.847TyrAla: 2.847 ± 0.817
2.164TyrCys: 2.164 ± 0.41
2.961TyrAsp: 2.961 ± 1.303
1.594TyrGlu: 1.594 ± 0.811
2.277TyrPhe: 2.277 ± 0.414
3.074TyrGly: 3.074 ± 0.775
1.025TyrHis: 1.025 ± 0.34
1.936TyrIle: 1.936 ± 0.986
3.416TyrLys: 3.416 ± 1.034
3.188TyrLeu: 3.188 ± 0.857
1.139TyrMet: 1.139 ± 0.393
3.074TyrAsn: 3.074 ± 1.003
1.708TyrPro: 1.708 ± 0.344
1.139TyrGln: 1.139 ± 0.418
2.733TyrArg: 2.733 ± 0.679
2.277TyrSer: 2.277 ± 0.449
4.213TyrThr: 4.213 ± 1.477
3.302TyrVal: 3.302 ± 0.696
0.455TyrTrp: 0.455 ± 0.392
2.847TyrTyr: 2.847 ± 0.804
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (8783 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski