Amino acid dipepetide frequency for Lentisphaera araneosa HTCC2155

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.951AlaAla: 4.951 ± 0.076	0.941AlaCys: 0.941 ± 0.025	3.968AlaAsp: 3.968 ± 0.053	4.82AlaGlu: 4.82 ± 0.067	3.01AlaPhe: 3.01 ± 0.046	4.631AlaGly: 4.631 ± 0.07	1.541AlaHis: 1.541 ± 0.026	4.585AlaIle: 4.585 ± 0.061	5.559AlaLys: 5.559 ± 0.065	7.257AlaLeu: 7.257 ± 0.078	1.961AlaMet: 1.961 ± 0.037	2.995AlaAsn: 2.995 ± 0.046	2.605AlaPro: 2.605 ± 0.046	2.881AlaGln: 2.881 ± 0.044	2.856AlaArg: 2.856 ± 0.045	4.571AlaSer: 4.571 ± 0.051	2.942AlaThr: 2.942 ± 0.043	3.991AlaVal: 3.991 ± 0.055	1.005AlaTrp: 1.005 ± 0.023	2.581AlaTyr: 2.581 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.837CysAla: 0.837 ± 0.023	0.142CysCys: 0.142 ± 0.009	0.779CysAsp: 0.779 ± 0.023	0.73CysGlu: 0.73 ± 0.02	0.576CysPhe: 0.576 ± 0.019	0.882CysGly: 0.882 ± 0.025	0.443CysHis: 0.443 ± 0.015	0.647CysIle: 0.647 ± 0.021	0.667CysLys: 0.667 ± 0.021	1.241CysLeu: 1.241 ± 0.028	0.241CysMet: 0.241 ± 0.012	0.419CysAsn: 0.419 ± 0.016	0.583CysPro: 0.583 ± 0.02	0.438CysGln: 0.438 ± 0.016	0.529CysArg: 0.529 ± 0.019	0.863CysSer: 0.863 ± 0.023	0.597CysThr: 0.597 ± 0.018	0.624CysVal: 0.624 ± 0.021	0.135CysTrp: 0.135 ± 0.01	0.404CysTyr: 0.404 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.532AspAla: 3.532 ± 0.053	0.625AspCys: 0.625 ± 0.022	3.361AspAsp: 3.361 ± 0.067	4.129AspGlu: 4.129 ± 0.059	3.289AspPhe: 3.289 ± 0.044	3.935AspGly: 3.935 ± 0.076	1.406AspHis: 1.406 ± 0.034	3.818AspIle: 3.818 ± 0.058	4.572AspLys: 4.572 ± 0.064	6.394AspLeu: 6.394 ± 0.066	1.372AspMet: 1.372 ± 0.03	2.67AspAsn: 2.67 ± 0.046	2.475AspPro: 2.475 ± 0.04	2.521AspGln: 2.521 ± 0.037	2.394AspArg: 2.394 ± 0.041	3.541AspSer: 3.541 ± 0.043	2.305AspThr: 2.305 ± 0.041	2.927AspVal: 2.927 ± 0.05	0.942AspTrp: 0.942 ± 0.025	2.405AspTyr: 2.405 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	4.886GluAla: 4.886 ± 0.07	0.571GluCys: 0.571 ± 0.019	3.582GluAsp: 3.582 ± 0.052	4.825GluGlu: 4.825 ± 0.078	2.954GluPhe: 2.954 ± 0.045	3.969GluGly: 3.969 ± 0.05	1.319GluHis: 1.319 ± 0.032	4.711GluIle: 4.711 ± 0.058	5.866GluLys: 5.866 ± 0.061	7.461GluLeu: 7.461 ± 0.07	1.697GluMet: 1.697 ± 0.03	3.541GluAsn: 3.541 ± 0.045	1.713GluPro: 1.713 ± 0.035	2.67GluGln: 2.67 ± 0.038	2.839GluArg: 2.839 ± 0.043	4.028GluSer: 4.028 ± 0.053	2.95GluThr: 2.95 ± 0.047	4.105GluVal: 4.105 ± 0.055	0.843GluTrp: 0.843 ± 0.02	2.071GluTyr: 2.071 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.071PheAla: 3.071 ± 0.05	0.685PheCys: 0.685 ± 0.019	3.053PheAsp: 3.053 ± 0.045	2.682PheGlu: 2.682 ± 0.04	2.387PhePhe: 2.387 ± 0.042	2.746PheGly: 2.746 ± 0.044	1.02PheHis: 1.02 ± 0.024	3.393PheIle: 3.393 ± 0.044	3.171PheLys: 3.171 ± 0.05	4.368PheLeu: 4.368 ± 0.059	1.186PheMet: 1.186 ± 0.026	2.294PheAsn: 2.294 ± 0.042	1.65PhePro: 1.65 ± 0.028	1.369PheGln: 1.369 ± 0.026	1.776PheArg: 1.776 ± 0.034	3.584PheSer: 3.584 ± 0.046	2.786PheThr: 2.786 ± 0.039	2.403PheVal: 2.403 ± 0.039	0.572PheTrp: 0.572 ± 0.019	1.78PheTyr: 1.78 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	4.131GlyAla: 4.131 ± 0.059	0.679GlyCys: 0.679 ± 0.02	3.707GlyAsp: 3.707 ± 0.076	4.08GlyGlu: 4.08 ± 0.043	3.085GlyPhe: 3.085 ± 0.043	4.515GlyGly: 4.515 ± 0.076	1.588GlyHis: 1.588 ± 0.029	4.218GlyIle: 4.218 ± 0.051	5.279GlyLys: 5.279 ± 0.066	5.909GlyLeu: 5.909 ± 0.067	1.7GlyMet: 1.7 ± 0.031	2.617GlyAsn: 2.617 ± 0.055	1.916GlyPro: 1.916 ± 0.042	2.391GlyGln: 2.391 ± 0.045	2.992GlyArg: 2.992 ± 0.044	4.186GlySer: 4.186 ± 0.058	3.22GlyThr: 3.22 ± 0.049	3.908GlyVal: 3.908 ± 0.053	0.904GlyTrp: 0.904 ± 0.023	2.321GlyTyr: 2.321 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	1.42HisAla: 1.42 ± 0.03	0.349HisCys: 0.349 ± 0.017	1.278HisAsp: 1.278 ± 0.033	1.354HisGlu: 1.354 ± 0.026	1.192HisPhe: 1.192 ± 0.029	1.707HisGly: 1.707 ± 0.035	0.69HisHis: 0.69 ± 0.024	1.372HisIle: 1.372 ± 0.029	1.599HisLys: 1.599 ± 0.034	2.346HisLeu: 2.346 ± 0.043	0.506HisMet: 0.506 ± 0.017	1.045HisAsn: 1.045 ± 0.026	1.236HisPro: 1.236 ± 0.029	0.948HisGln: 0.948 ± 0.022	1.026HisArg: 1.026 ± 0.025	1.635HisSer: 1.635 ± 0.032	1.045HisThr: 1.045 ± 0.027	1.123HisVal: 1.123 ± 0.028	0.368HisTrp: 0.368 ± 0.016	0.984HisTyr: 0.984 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	4.943IleAla: 4.943 ± 0.055	0.981IleCys: 0.981 ± 0.028	4.303IleAsp: 4.303 ± 0.061	4.391IleGlu: 4.391 ± 0.043	2.92IlePhe: 2.92 ± 0.047	3.721IleGly: 3.721 ± 0.048	1.522IleHis: 1.522 ± 0.033	4.755IleIle: 4.755 ± 0.061	5.207IleLys: 5.207 ± 0.059	6.02IleLeu: 6.02 ± 0.068	1.438IleMet: 1.438 ± 0.031	3.461IleAsn: 3.461 ± 0.052	2.86IlePro: 2.86 ± 0.044	2.322IleGln: 2.322 ± 0.034	2.747IleArg: 2.747 ± 0.039	5.09IleSer: 5.09 ± 0.053	3.338IleThr: 3.338 ± 0.061	3.334IleVal: 3.334 ± 0.044	0.651IleTrp: 0.651 ± 0.02	2.46IleTyr: 2.46 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	5.931LysAla: 5.931 ± 0.075	0.582LysCys: 0.582 ± 0.018	4.655LysAsp: 4.655 ± 0.049	5.712LysGlu: 5.712 ± 0.067	2.881LysPhe: 2.881 ± 0.046	4.627LysGly: 4.627 ± 0.058	1.698LysHis: 1.698 ± 0.032	5.381LysIle: 5.381 ± 0.062	7.092LysLys: 7.092 ± 0.093	7.284LysLeu: 7.284 ± 0.074	2.14LysMet: 2.14 ± 0.035	4.661LysAsn: 4.661 ± 0.054	2.904LysPro: 2.904 ± 0.051	2.912LysGln: 2.912 ± 0.042	3.272LysArg: 3.272 ± 0.05	5.274LysSer: 5.274 ± 0.056	4.156LysThr: 4.156 ± 0.054	4.622LysVal: 4.622 ± 0.059	0.998LysTrp: 0.998 ± 0.025	2.586LysTyr: 2.586 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	7.484LeuAla: 7.484 ± 0.072	1.289LeuCys: 1.289 ± 0.026	5.745LeuAsp: 5.745 ± 0.06	6.45LeuGlu: 6.45 ± 0.071	4.154LeuPhe: 4.154 ± 0.064	5.687LeuGly: 5.687 ± 0.056	1.969LeuHis: 1.969 ± 0.035	6.824LeuIle: 6.824 ± 0.072	8.548LeuLys: 8.548 ± 0.089	8.995LeuLeu: 8.995 ± 0.094	2.468LeuMet: 2.468 ± 0.036	5.294LeuAsn: 5.294 ± 0.064	4.094LeuPro: 4.094 ± 0.052	3.321LeuGln: 3.321 ± 0.045	4.123LeuArg: 4.123 ± 0.055	7.689LeuSer: 7.689 ± 0.069	4.684LeuThr: 4.684 ± 0.058	5.039LeuVal: 5.039 ± 0.059	1.074LeuTrp: 1.074 ± 0.028	3.204LeuTyr: 3.204 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.918MetAla: 1.918 ± 0.038	0.222MetCys: 0.222 ± 0.011	1.45MetAsp: 1.45 ± 0.028	1.325MetGlu: 1.325 ± 0.028	0.751MetPhe: 0.751 ± 0.019	1.676MetGly: 1.676 ± 0.03	0.454MetHis: 0.454 ± 0.016	1.688MetIle: 1.688 ± 0.032	2.34MetLys: 2.34 ± 0.037	2.005MetLeu: 2.005 ± 0.036	0.629MetMet: 0.629 ± 0.021	1.425MetAsn: 1.425 ± 0.03	1.159MetPro: 1.159 ± 0.026	0.86MetGln: 0.86 ± 0.024	1.184MetArg: 1.184 ± 0.027	1.869MetSer: 1.869 ± 0.032	1.459MetThr: 1.459 ± 0.028	1.224MetVal: 1.224 ± 0.028	0.238MetTrp: 0.238 ± 0.012	0.721MetTyr: 0.721 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.04AsnAla: 3.04 ± 0.041	0.587AsnCys: 0.587 ± 0.019	2.914AsnAsp: 2.914 ± 0.052	3.04AsnGlu: 3.04 ± 0.047	2.47AsnPhe: 2.47 ± 0.041	3.319AsnGly: 3.319 ± 0.051	1.2AsnHis: 1.2 ± 0.029	3.452AsnIle: 3.452 ± 0.049	4.005AsnLys: 4.005 ± 0.049	4.593AsnLeu: 4.593 ± 0.058	1.071AsnMet: 1.071 ± 0.023	2.627AsnAsn: 2.627 ± 0.055	2.401AsnPro: 2.401 ± 0.037	1.919AsnGln: 1.919 ± 0.036	1.953AsnArg: 1.953 ± 0.035	3.343AsnSer: 3.343 ± 0.049	2.659AsnThr: 2.659 ± 0.036	2.155AsnVal: 2.155 ± 0.042	0.73AsnTrp: 0.73 ± 0.021	1.955AsnTyr: 1.955 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	2.679ProAla: 2.679 ± 0.038	0.324ProCys: 0.324 ± 0.016	2.31ProAsp: 2.31 ± 0.037	3.408ProGlu: 3.408 ± 0.046	1.814ProPhe: 1.814 ± 0.034	2.535ProGly: 2.535 ± 0.05	1.099ProHis: 1.099 ± 0.03	2.22ProIle: 2.22 ± 0.035	3.031ProLys: 3.031 ± 0.046	3.366ProLeu: 3.366 ± 0.044	0.921ProMet: 0.921 ± 0.025	2.145ProAsn: 2.145 ± 0.036	1.327ProPro: 1.327 ± 0.042	1.736ProGln: 1.736 ± 0.035	1.425ProArg: 1.425 ± 0.031	2.732ProSer: 2.732 ± 0.041	1.861ProThr: 1.861 ± 0.036	2.368ProVal: 2.368 ± 0.034	0.596ProTrp: 0.596 ± 0.02	1.44ProTyr: 1.44 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.102GlnAla: 3.102 ± 0.041	0.351GlnCys: 0.351 ± 0.015	1.957GlnAsp: 1.957 ± 0.035	2.827GlnGlu: 2.827 ± 0.041	1.593GlnPhe: 1.593 ± 0.031	2.457GlnGly: 2.457 ± 0.039	0.842GlnHis: 0.842 ± 0.025	2.52GlnIle: 2.52 ± 0.038	3.187GlnLys: 3.187 ± 0.049	3.748GlnLeu: 3.748 ± 0.045	0.945GlnMet: 0.945 ± 0.021	1.909GlnAsn: 1.909 ± 0.034	1.032GlnPro: 1.032 ± 0.028	1.571GlnGln: 1.571 ± 0.032	1.631GlnArg: 1.631 ± 0.031	2.646GlnSer: 2.646 ± 0.041	1.741GlnThr: 1.741 ± 0.035	2.518GlnVal: 2.518 ± 0.041	0.591GlnTrp: 0.591 ± 0.019	1.313GlnTyr: 1.313 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	2.733ArgAla: 2.733 ± 0.042	0.48ArgCys: 0.48 ± 0.018	2.376ArgAsp: 2.376 ± 0.037	2.937ArgGlu: 2.937 ± 0.044	2.076ArgPhe: 2.076 ± 0.037	2.657ArgGly: 2.657 ± 0.039	1.031ArgHis: 1.031 ± 0.026	2.642ArgIle: 2.642 ± 0.039	3.304ArgLys: 3.304 ± 0.047	4.103ArgLeu: 4.103 ± 0.059	1.118ArgMet: 1.118 ± 0.026	2.072ArgAsn: 2.072 ± 0.034	1.658ArgPro: 1.658 ± 0.032	1.742ArgGln: 1.742 ± 0.034	2.058ArgArg: 2.058 ± 0.04	2.768ArgSer: 2.768 ± 0.04	1.978ArgThr: 1.978 ± 0.033	2.532ArgVal: 2.532 ± 0.043	0.555ArgTrp: 0.555 ± 0.021	1.701ArgTyr: 1.701 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	4.552SerAla: 4.552 ± 0.042	0.965SerCys: 0.965 ± 0.025	3.813SerAsp: 3.813 ± 0.046	4.364SerGlu: 4.364 ± 0.052	3.645SerPhe: 3.645 ± 0.051	4.423SerGly: 4.423 ± 0.049	1.689SerHis: 1.689 ± 0.029	4.414SerIle: 4.414 ± 0.048	4.95SerLys: 4.95 ± 0.057	7.616SerLeu: 7.616 ± 0.088	1.693SerMet: 1.693 ± 0.031	3.08SerAsn: 3.08 ± 0.039	2.932SerPro: 2.932 ± 0.042	2.88SerGln: 2.88 ± 0.043	2.921SerArg: 2.921 ± 0.047	5.319SerSer: 5.319 ± 0.065	3.317SerThr: 3.317 ± 0.047	3.653SerVal: 3.653 ± 0.047	1.026SerTrp: 1.026 ± 0.027	2.485SerTyr: 2.485 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	3.338ThrAla: 3.338 ± 0.047	0.56ThrCys: 0.56 ± 0.019	2.637ThrAsp: 2.637 ± 0.044	2.928ThrGlu: 2.928 ± 0.043	2.221ThrPhe: 2.221 ± 0.038	3.508ThrGly: 3.508 ± 0.06	1.156ThrHis: 1.156 ± 0.028	3.256ThrIle: 3.256 ± 0.06	3.172ThrLys: 3.172 ± 0.045	5.206ThrLeu: 5.206 ± 0.068	1.049ThrMet: 1.049 ± 0.023	1.979ThrAsn: 1.979 ± 0.043	2.524ThrPro: 2.524 ± 0.039	1.878ThrGln: 1.878 ± 0.034	2.002ThrArg: 2.002 ± 0.039	3.24ThrSer: 3.24 ± 0.041	2.186ThrThr: 2.186 ± 0.039	2.835ThrVal: 2.835 ± 0.056	0.747ThrTrp: 0.747 ± 0.02	1.898ThrTyr: 1.898 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	3.796ValAla: 3.796 ± 0.053	0.837ValCys: 0.837 ± 0.022	3.535ValAsp: 3.535 ± 0.052	3.629ValGlu: 3.629 ± 0.056	2.58ValPhe: 2.58 ± 0.036	3.108ValGly: 3.108 ± 0.051	1.241ValHis: 1.241 ± 0.029	3.855ValIle: 3.855 ± 0.049	4.221ValLys: 4.221 ± 0.054	5.3ValLeu: 5.3 ± 0.057	1.287ValMet: 1.287 ± 0.027	2.785ValAsn: 2.785 ± 0.041	2.186ValPro: 2.186 ± 0.041	1.886ValGln: 1.886 ± 0.035	2.42ValArg: 2.42 ± 0.037	3.883ValSer: 3.883 ± 0.049	2.636ValThr: 2.636 ± 0.051	3.145ValVal: 3.145 ± 0.05	0.629ValTrp: 0.629 ± 0.018	1.97ValTyr: 1.97 ± 0.033	0.0ValXaa: 0.0 ± 0.0
Trp	0.868TrpAla: 0.868 ± 0.023	0.148TrpCys: 0.148 ± 0.01	0.899TrpAsp: 0.899 ± 0.024	0.801TrpGlu: 0.801 ± 0.021	0.511TrpPhe: 0.511 ± 0.017	0.948TrpGly: 0.948 ± 0.028	0.415TrpHis: 0.415 ± 0.015	0.675TrpIle: 0.675 ± 0.02	0.995TrpLys: 0.995 ± 0.027	1.225TrpLeu: 1.225 ± 0.031	0.358TrpMet: 0.358 ± 0.014	0.716TrpAsn: 0.716 ± 0.022	0.539TrpPro: 0.539 ± 0.018	0.696TrpGln: 0.696 ± 0.021	0.659TrpArg: 0.659 ± 0.02	0.875TrpSer: 0.875 ± 0.022	0.679TrpThr: 0.679 ± 0.021	0.691TrpVal: 0.691 ± 0.02	0.188TrpTrp: 0.188 ± 0.011	0.435TrpTyr: 0.435 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.438TyrAla: 2.438 ± 0.043	0.458TyrCys: 0.458 ± 0.015	2.29TyrAsp: 2.29 ± 0.038	2.17TyrGlu: 2.17 ± 0.037	1.864TyrPhe: 1.864 ± 0.036	2.297TyrGly: 2.297 ± 0.041	0.9TyrHis: 0.9 ± 0.026	2.036TyrIle: 2.036 ± 0.036	2.604TyrLys: 2.604 ± 0.042	3.698TyrLeu: 3.698 ± 0.053	0.817TyrMet: 0.817 ± 0.022	1.696TyrAsn: 1.696 ± 0.035	1.544TyrPro: 1.544 ± 0.031	1.54TyrGln: 1.54 ± 0.03	1.714TyrArg: 1.714 ± 0.033	2.603TyrSer: 2.603 ± 0.039	1.781TyrThr: 1.781 ± 0.033	1.735TyrVal: 1.735 ± 0.036	0.53TyrTrp: 0.53 ± 0.019	1.449TyrTyr: 1.449 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4982 proteins (1741385 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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