Amino acid dipepetide frequency for Lepeophtheirus virus LS24

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.881AlaAla: 4.881 ± 1.59
1.284AlaCys: 1.284 ± 0.903
2.312AlaAsp: 2.312 ± 0.385
3.082AlaGlu: 3.082 ± 0.808
1.541AlaPhe: 1.541 ± 0.591
3.853AlaGly: 3.853 ± 0.689
1.541AlaHis: 1.541 ± 0.459
7.449AlaIle: 7.449 ± 1.826
3.082AlaLys: 3.082 ± 0.646
7.706AlaLeu: 7.706 ± 2.268
1.798AlaMet: 1.798 ± 0.549
2.826AlaAsn: 2.826 ± 0.607
1.798AlaPro: 1.798 ± 0.131
2.569AlaGln: 2.569 ± 1.103
5.651AlaArg: 5.651 ± 1.08
6.936AlaSer: 6.936 ± 1.02
3.853AlaThr: 3.853 ± 1.072
3.082AlaVal: 3.082 ± 0.503
0.771AlaTrp: 0.771 ± 0.282
2.569AlaTyr: 2.569 ± 0.513
0.0AlaXaa: 0.0 ± 0.0
Cys
0.771CysAla: 0.771 ± 0.282
0.514CysCys: 0.514 ± 0.314
1.541CysAsp: 1.541 ± 0.977
2.569CysGlu: 2.569 ± 1.076
0.257CysPhe: 0.257 ± 0.377
0.257CysGly: 0.257 ± 0.147
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.771CysLys: 0.771 ± 0.314
1.798CysLeu: 1.798 ± 0.549
0.0CysMet: 0.0 ± 0.0
0.514CysAsn: 0.514 ± 0.295
0.771CysPro: 0.771 ± 0.282
0.257CysGln: 0.257 ± 0.377
1.027CysArg: 1.027 ± 0.35
1.284CysSer: 1.284 ± 0.611
1.027CysThr: 1.027 ± 0.376
0.771CysVal: 0.771 ± 0.314
0.257CysTrp: 0.257 ± 0.27
0.257CysTyr: 0.257 ± 0.377
0.0CysXaa: 0.0 ± 0.0
Asp
2.312AspAla: 2.312 ± 0.47
0.514AspCys: 0.514 ± 0.274
1.284AspAsp: 1.284 ± 0.559
2.312AspGlu: 2.312 ± 0.391
1.284AspPhe: 1.284 ± 0.638
3.339AspGly: 3.339 ± 0.66
2.569AspHis: 2.569 ± 1.33
3.596AspIle: 3.596 ± 1.059
3.339AspLys: 3.339 ± 1.006
4.881AspLeu: 4.881 ± 0.327
1.798AspMet: 1.798 ± 0.34
2.569AspAsn: 2.569 ± 0.756
1.798AspPro: 1.798 ± 1.298
1.284AspGln: 1.284 ± 0.58
3.853AspArg: 3.853 ± 1.157
3.082AspSer: 3.082 ± 0.821
4.11AspThr: 4.11 ± 1.679
2.312AspVal: 2.312 ± 0.622
1.027AspTrp: 1.027 ± 0.589
1.798AspTyr: 1.798 ± 1.031
0.0AspXaa: 0.0 ± 0.0
Glu
3.596GluAla: 3.596 ± 0.277
1.284GluCys: 1.284 ± 0.736
2.569GluAsp: 2.569 ± 0.656
4.367GluGlu: 4.367 ± 1.952
1.541GluPhe: 1.541 ± 0.565
2.569GluGly: 2.569 ± 0.895
1.284GluHis: 1.284 ± 0.478
3.339GluIle: 3.339 ± 0.54
2.569GluLys: 2.569 ± 0.358
5.137GluLeu: 5.137 ± 0.65
1.284GluMet: 1.284 ± 0.518
2.055GluAsn: 2.055 ± 0.518
1.798GluPro: 1.798 ± 0.57
1.798GluGln: 1.798 ± 0.549
2.312GluArg: 2.312 ± 0.946
4.367GluSer: 4.367 ± 1.15
2.569GluThr: 2.569 ± 1.282
2.312GluVal: 2.312 ± 0.67
1.284GluTrp: 1.284 ± 0.355
2.569GluTyr: 2.569 ± 0.358
0.0GluXaa: 0.0 ± 0.0
Phe
1.798PheAla: 1.798 ± 0.353
0.771PheCys: 0.771 ± 0.678
2.055PheAsp: 2.055 ± 0.247
1.284PheGlu: 1.284 ± 0.176
1.541PhePhe: 1.541 ± 0.598
1.284PheGly: 1.284 ± 0.355
1.798PheHis: 1.798 ± 0.714
1.027PheIle: 1.027 ± 0.589
2.055PheLys: 2.055 ± 0.582
5.394PheLeu: 5.394 ± 0.851
0.0PheMet: 0.0 ± 0.0
2.312PheAsn: 2.312 ± 0.65
0.514PhePro: 0.514 ± 0.284
2.312PheGln: 2.312 ± 0.47
2.055PheArg: 2.055 ± 0.629
4.11PheSer: 4.11 ± 0.721
3.853PheThr: 3.853 ± 0.53
2.569PheVal: 2.569 ± 0.709
0.514PheTrp: 0.514 ± 0.295
1.541PheTyr: 1.541 ± 0.511
0.0PheXaa: 0.0 ± 0.0
Gly
3.339GlyAla: 3.339 ± 0.525
1.027GlyCys: 1.027 ± 0.628
3.339GlyAsp: 3.339 ± 1.283
2.312GlyGlu: 2.312 ± 0.722
1.541GlyPhe: 1.541 ± 0.565
2.826GlyGly: 2.826 ± 1.034
1.541GlyHis: 1.541 ± 0.474
2.826GlyIle: 2.826 ± 0.897
2.312GlyLys: 2.312 ± 0.817
5.394GlyLeu: 5.394 ± 0.464
1.284GlyMet: 1.284 ± 0.509
2.569GlyAsn: 2.569 ± 0.257
2.055GlyPro: 2.055 ± 0.669
3.082GlyGln: 3.082 ± 0.257
2.312GlyArg: 2.312 ± 1.039
4.624GlySer: 4.624 ± 1.301
4.11GlyThr: 4.11 ± 1.751
2.826GlyVal: 2.826 ± 0.575
0.257GlyTrp: 0.257 ± 0.147
2.055GlyTyr: 2.055 ± 0.753
0.0GlyXaa: 0.0 ± 0.0
His
2.826HisAla: 2.826 ± 0.93
0.257HisCys: 0.257 ± 0.147
0.257HisAsp: 0.257 ± 0.147
0.771HisGlu: 0.771 ± 0.282
1.541HisPhe: 1.541 ± 0.228
1.284HisGly: 1.284 ± 0.611
1.284HisHis: 1.284 ± 0.478
1.284HisIle: 1.284 ± 0.58
2.055HisLys: 2.055 ± 0.533
3.082HisLeu: 3.082 ± 1.622
0.771HisMet: 0.771 ± 0.282
1.027HisAsn: 1.027 ± 0.589
1.541HisPro: 1.541 ± 0.228
1.284HisGln: 1.284 ± 0.478
1.027HisArg: 1.027 ± 0.505
3.339HisSer: 3.339 ± 0.874
2.055HisThr: 2.055 ± 1.276
1.284HisVal: 1.284 ± 1.026
0.771HisTrp: 0.771 ± 0.314
1.541HisTyr: 1.541 ± 0.581
0.0HisXaa: 0.0 ± 0.0
Ile
4.367IleAla: 4.367 ± 0.438
1.027IleCys: 1.027 ± 0.376
2.312IleAsp: 2.312 ± 0.725
4.11IleGlu: 4.11 ± 0.702
1.541IlePhe: 1.541 ± 0.438
3.853IleGly: 3.853 ± 0.413
1.284IleHis: 1.284 ± 0.176
5.137IleIle: 5.137 ± 1.452
2.569IleLys: 2.569 ± 0.697
7.449IleLeu: 7.449 ± 0.817
1.541IleMet: 1.541 ± 0.91
1.798IleAsn: 1.798 ± 0.382
5.137IlePro: 5.137 ± 0.419
3.082IleGln: 3.082 ± 0.887
4.881IleArg: 4.881 ± 1.507
5.394IleSer: 5.394 ± 0.948
3.339IleThr: 3.339 ± 1.293
3.853IleVal: 3.853 ± 0.943
0.771IleTrp: 0.771 ± 0.282
1.798IleTyr: 1.798 ± 0.824
0.0IleXaa: 0.0 ± 0.0
Lys
4.11LysAla: 4.11 ± 1.126
0.0LysCys: 0.0 ± 0.0
1.798LysAsp: 1.798 ± 1.384
2.569LysGlu: 2.569 ± 1.058
1.541LysPhe: 1.541 ± 0.511
2.312LysGly: 2.312 ± 0.708
1.284LysHis: 1.284 ± 0.509
3.339LysIle: 3.339 ± 0.814
1.798LysLys: 1.798 ± 1.025
5.651LysLeu: 5.651 ± 1.25
2.055LysMet: 2.055 ± 0.641
2.312LysAsn: 2.312 ± 0.406
1.027LysPro: 1.027 ± 0.589
1.541LysGln: 1.541 ± 0.128
2.312LysArg: 2.312 ± 1.004
4.881LysSer: 4.881 ± 1.888
3.596LysThr: 3.596 ± 0.77
2.312LysVal: 2.312 ± 1.096
0.257LysTrp: 0.257 ± 0.147
1.541LysTyr: 1.541 ± 0.628
0.0LysXaa: 0.0 ± 0.0
Leu
11.302LeuAla: 11.302 ± 0.634
1.027LeuCys: 1.027 ± 0.376
8.477LeuAsp: 8.477 ± 0.838
5.394LeuGlu: 5.394 ± 1.339
5.651LeuPhe: 5.651 ± 1.347
4.881LeuGly: 4.881 ± 1.717
2.569LeuHis: 2.569 ± 0.499
5.908LeuIle: 5.908 ± 0.501
4.11LeuLys: 4.11 ± 0.787
11.559LeuLeu: 11.559 ± 2.867
2.569LeuMet: 2.569 ± 1.048
4.367LeuAsn: 4.367 ± 0.843
6.679LeuPro: 6.679 ± 1.283
3.853LeuGln: 3.853 ± 0.858
6.165LeuArg: 6.165 ± 1.279
10.018LeuSer: 10.018 ± 1.663
5.651LeuThr: 5.651 ± 0.973
6.422LeuVal: 6.422 ± 0.52
0.771LeuTrp: 0.771 ± 0.346
3.339LeuTyr: 3.339 ± 0.754
0.0LeuXaa: 0.0 ± 0.0
Met
2.826MetAla: 2.826 ± 0.896
0.771MetCys: 0.771 ± 0.346
1.798MetAsp: 1.798 ± 0.919
1.284MetGlu: 1.284 ± 0.736
2.055MetPhe: 2.055 ± 0.699
1.027MetGly: 1.027 ± 0.35
0.257MetHis: 0.257 ± 0.27
2.055MetIle: 2.055 ± 1.057
1.541MetLys: 1.541 ± 0.451
2.826MetLeu: 2.826 ± 1.054
0.0MetMet: 0.0 ± 0.0
0.771MetAsn: 0.771 ± 0.442
0.771MetPro: 0.771 ± 0.282
0.771MetGln: 0.771 ± 0.282
1.284MetArg: 1.284 ± 0.58
1.027MetSer: 1.027 ± 0.973
2.312MetThr: 2.312 ± 0.59
1.027MetVal: 1.027 ± 0.568
0.514MetTrp: 0.514 ± 0.444
1.027MetTyr: 1.027 ± 0.337
0.0MetXaa: 0.0 ± 0.0
Asn
1.541AsnAla: 1.541 ± 0.693
0.257AsnCys: 0.257 ± 0.147
2.826AsnAsp: 2.826 ± 1.462
1.798AsnGlu: 1.798 ± 1.034
1.541AsnPhe: 1.541 ± 0.128
1.284AsnGly: 1.284 ± 1.026
2.055AsnHis: 2.055 ± 0.533
2.312AsnIle: 2.312 ± 0.611
2.055AsnLys: 2.055 ± 0.913
5.394AsnLeu: 5.394 ± 1.484
1.284AsnMet: 1.284 ± 0.176
2.055AsnAsn: 2.055 ± 0.423
3.596AsnPro: 3.596 ± 0.493
2.312AsnGln: 2.312 ± 1.039
3.339AsnArg: 3.339 ± 1.221
2.055AsnSer: 2.055 ± 0.951
2.312AsnThr: 2.312 ± 1.407
2.055AsnVal: 2.055 ± 0.802
0.771AsnTrp: 0.771 ± 0.442
1.798AsnTyr: 1.798 ± 0.748
0.0AsnXaa: 0.0 ± 0.0
Pro
2.569ProAla: 2.569 ± 1.094
1.027ProCys: 1.027 ± 1.509
2.312ProAsp: 2.312 ± 0.391
2.569ProGlu: 2.569 ± 0.606
1.284ProPhe: 1.284 ± 0.606
3.596ProGly: 3.596 ± 0.334
2.055ProHis: 2.055 ± 0.663
3.339ProIle: 3.339 ± 0.972
1.798ProLys: 1.798 ± 0.385
5.908ProLeu: 5.908 ± 1.616
0.771ProMet: 0.771 ± 0.534
2.312ProAsn: 2.312 ± 0.847
2.312ProPro: 2.312 ± 1.01
2.055ProGln: 2.055 ± 0.669
2.055ProArg: 2.055 ± 0.472
3.082ProSer: 3.082 ± 0.583
3.853ProThr: 3.853 ± 0.716
3.082ProVal: 3.082 ± 0.499
0.514ProTrp: 0.514 ± 0.284
1.541ProTyr: 1.541 ± 0.474
0.0ProXaa: 0.0 ± 0.0
Gln
4.881GlnAla: 4.881 ± 0.891
0.0GlnCys: 0.0 ± 0.0
1.541GlnAsp: 1.541 ± 1.186
1.541GlnGlu: 1.541 ± 0.581
2.826GlnPhe: 2.826 ± 0.911
0.771GlnGly: 0.771 ± 0.314
1.027GlnHis: 1.027 ± 1.137
2.569GlnIle: 2.569 ± 0.358
1.027GlnLys: 1.027 ± 0.376
6.936GlnLeu: 6.936 ± 1.043
1.027GlnMet: 1.027 ± 0.625
1.541GlnAsn: 1.541 ± 0.438
1.284GlnPro: 1.284 ± 0.533
1.541GlnGln: 1.541 ± 0.505
0.771GlnArg: 0.771 ± 0.442
4.11GlnSer: 4.11 ± 1.151
1.284GlnThr: 1.284 ± 0.58
3.853GlnVal: 3.853 ± 0.657
1.284GlnTrp: 1.284 ± 0.547
1.284GlnTyr: 1.284 ± 0.547
0.0GlnXaa: 0.0 ± 0.0
Arg
3.339ArgAla: 3.339 ± 0.316
0.257ArgCys: 0.257 ± 0.147
2.055ArgAsp: 2.055 ± 0.472
3.853ArgGlu: 3.853 ± 0.266
3.596ArgPhe: 3.596 ± 1.333
0.771ArgGly: 0.771 ± 0.442
0.771ArgHis: 0.771 ± 0.442
3.596ArgIle: 3.596 ± 0.602
1.798ArgLys: 1.798 ± 0.131
4.624ArgLeu: 4.624 ± 0.771
1.798ArgMet: 1.798 ± 0.715
2.569ArgAsn: 2.569 ± 0.773
2.826ArgPro: 2.826 ± 0.493
2.826ArgGln: 2.826 ± 0.683
3.082ArgArg: 3.082 ± 0.665
5.394ArgSer: 5.394 ± 0.719
3.082ArgThr: 3.082 ± 0.866
5.908ArgVal: 5.908 ± 1.829
1.284ArgTrp: 1.284 ± 0.478
3.082ArgTyr: 3.082 ± 0.556
0.0ArgXaa: 0.0 ± 0.0
Ser
4.367SerAla: 4.367 ± 1.952
1.027SerCys: 1.027 ± 0.337
4.11SerAsp: 4.11 ± 1.104
2.826SerGlu: 2.826 ± 1.172
3.082SerPhe: 3.082 ± 1.431
5.394SerGly: 5.394 ± 1.409
2.826SerHis: 2.826 ± 0.9
6.679SerIle: 6.679 ± 1.073
3.853SerLys: 3.853 ± 0.747
10.018SerLeu: 10.018 ± 1.857
3.339SerMet: 3.339 ± 0.927
3.082SerAsn: 3.082 ± 0.433
4.367SerPro: 4.367 ± 1.273
4.11SerGln: 4.11 ± 0.75
4.624SerArg: 4.624 ± 1.366
10.275SerSer: 10.275 ± 2.568
4.881SerThr: 4.881 ± 0.889
4.624SerVal: 4.624 ± 1.169
0.514SerTrp: 0.514 ± 0.424
4.367SerTyr: 4.367 ± 0.84
0.0SerXaa: 0.0 ± 0.0
Thr
3.082ThrAla: 3.082 ± 0.87
1.027ThrCys: 1.027 ± 0.628
2.826ThrAsp: 2.826 ± 0.626
2.569ThrGlu: 2.569 ± 1.094
2.826ThrPhe: 2.826 ± 0.66
4.881ThrGly: 4.881 ± 0.889
1.541ThrHis: 1.541 ± 0.925
4.881ThrIle: 4.881 ± 0.837
2.569ThrLys: 2.569 ± 0.625
6.679ThrLeu: 6.679 ± 2.202
1.798ThrMet: 1.798 ± 0.53
2.312ThrAsn: 2.312 ± 1.509
3.596ThrPro: 3.596 ± 0.989
2.569ThrGln: 2.569 ± 1.357
4.11ThrArg: 4.11 ± 0.3
4.624ThrSer: 4.624 ± 1.306
3.596ThrThr: 3.596 ± 2.225
3.596ThrVal: 3.596 ± 0.472
0.771ThrTrp: 0.771 ± 0.442
2.312ThrTyr: 2.312 ± 0.628
0.0ThrXaa: 0.0 ± 0.0
Val
3.339ValAla: 3.339 ± 0.975
0.514ValCys: 0.514 ± 0.707
2.826ValAsp: 2.826 ± 0.809
3.082ValGlu: 3.082 ± 0.257
1.541ValPhe: 1.541 ± 1.077
3.853ValGly: 3.853 ± 0.943
1.027ValHis: 1.027 ± 0.376
4.367ValIle: 4.367 ± 1.798
5.137ValLys: 5.137 ± 0.695
5.394ValLeu: 5.394 ± 1.503
1.541ValMet: 1.541 ± 0.581
3.596ValAsn: 3.596 ± 1.104
2.569ValPro: 2.569 ± 1.282
1.027ValGln: 1.027 ± 0.547
2.826ValArg: 2.826 ± 1.073
4.624ValSer: 4.624 ± 0.56
3.596ValThr: 3.596 ± 0.277
4.624ValVal: 4.624 ± 1.514
1.027ValTrp: 1.027 ± 0.376
2.055ValTyr: 2.055 ± 0.552
0.0ValXaa: 0.0 ± 0.0
Trp
1.027TrpAla: 1.027 ± 0.35
0.514TrpCys: 0.514 ± 0.295
0.771TrpAsp: 0.771 ± 0.352
1.027TrpGlu: 1.027 ± 0.337
0.0TrpPhe: 0.0 ± 0.0
1.541TrpGly: 1.541 ± 0.884
0.514TrpHis: 0.514 ± 0.314
0.0TrpIle: 0.0 ± 0.0
0.514TrpLys: 0.514 ± 0.314
0.771TrpLeu: 0.771 ± 0.282
0.257TrpMet: 0.257 ± 0.147
0.514TrpAsn: 0.514 ± 0.295
1.541TrpPro: 1.541 ± 0.228
0.514TrpGln: 0.514 ± 0.284
1.027TrpArg: 1.027 ± 0.568
2.055TrpSer: 2.055 ± 0.865
0.771TrpThr: 0.771 ± 0.314
0.771TrpVal: 0.771 ± 0.537
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.312TyrAla: 2.312 ± 1.277
1.541TyrCys: 1.541 ± 0.628
2.055TyrAsp: 2.055 ± 0.284
1.284TyrGlu: 1.284 ± 0.736
2.055TyrPhe: 2.055 ± 0.422
2.055TyrGly: 2.055 ± 0.464
2.055TyrHis: 2.055 ± 0.423
1.541TyrIle: 1.541 ± 0.884
1.284TyrLys: 1.284 ± 0.547
4.11TyrLeu: 4.11 ± 1.058
0.771TyrMet: 0.771 ± 0.346
1.541TyrAsn: 1.541 ± 0.228
2.055TyrPro: 2.055 ± 0.657
2.312TyrGln: 2.312 ± 0.406
2.055TyrArg: 2.055 ± 1.136
3.082TyrSer: 3.082 ± 1.85
2.312TyrThr: 2.312 ± 0.406
1.284TyrVal: 1.284 ± 0.626
0.771TyrTrp: 0.771 ± 0.314
1.284TyrTyr: 1.284 ± 0.176
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (3894 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski