Amino acid dipepetide frequency for Burkholderiales bacterium PBB1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.379AlaAla: 18.379 ± 0.213	1.29AlaCys: 1.29 ± 0.04	7.082AlaAsp: 7.082 ± 0.087	6.606AlaGlu: 6.606 ± 0.116	3.612AlaPhe: 3.612 ± 0.059	10.093AlaGly: 10.093 ± 0.165	2.761AlaHis: 2.761 ± 0.062	5.115AlaIle: 5.115 ± 0.083	3.53AlaLys: 3.53 ± 0.086	14.996AlaLeu: 14.996 ± 0.183	3.37AlaMet: 3.37 ± 0.063	2.736AlaAsn: 2.736 ± 0.062	6.51AlaPro: 6.51 ± 0.111	5.696AlaGln: 5.696 ± 0.085	9.044AlaArg: 9.044 ± 0.124	7.663AlaSer: 7.663 ± 0.12	6.554AlaThr: 6.554 ± 0.118	9.603AlaVal: 9.603 ± 0.118	1.835AlaTrp: 1.835 ± 0.051	2.431AlaTyr: 2.431 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	1.241CysAla: 1.241 ± 0.036	0.115CysCys: 0.115 ± 0.011	0.555CysAsp: 0.555 ± 0.023	0.49CysGlu: 0.49 ± 0.023	0.315CysPhe: 0.315 ± 0.017	0.989CysGly: 0.989 ± 0.039	0.248CysHis: 0.248 ± 0.019	0.389CysIle: 0.389 ± 0.02	0.221CysLys: 0.221 ± 0.015	0.848CysLeu: 0.848 ± 0.032	0.156CysMet: 0.156 ± 0.014	0.231CysAsn: 0.231 ± 0.015	0.499CysPro: 0.499 ± 0.026	0.295CysGln: 0.295 ± 0.017	0.627CysArg: 0.627 ± 0.027	0.543CysSer: 0.543 ± 0.025	0.513CysThr: 0.513 ± 0.029	0.735CysVal: 0.735 ± 0.031	0.12CysTrp: 0.12 ± 0.011	0.179CysTyr: 0.179 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.858AspAla: 7.858 ± 0.115	0.445AspCys: 0.445 ± 0.023	3.143AspAsp: 3.143 ± 0.067	3.254AspGlu: 3.254 ± 0.074	1.94AspPhe: 1.94 ± 0.041	4.756AspGly: 4.756 ± 0.093	1.227AspHis: 1.227 ± 0.041	2.475AspIle: 2.475 ± 0.052	1.555AspLys: 1.555 ± 0.04	5.465AspLeu: 5.465 ± 0.077	1.09AspMet: 1.09 ± 0.036	1.183AspAsn: 1.183 ± 0.047	3.061AspPro: 3.061 ± 0.058	1.703AspGln: 1.703 ± 0.042	3.915AspArg: 3.915 ± 0.074	2.488AspSer: 2.488 ± 0.058	2.988AspThr: 2.988 ± 0.072	4.277AspVal: 4.277 ± 0.076	0.906AspTrp: 0.906 ± 0.028	1.31AspTyr: 1.31 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	6.739GluAla: 6.739 ± 0.121	0.386GluCys: 0.386 ± 0.018	2.031GluAsp: 2.031 ± 0.05	2.084GluGlu: 2.084 ± 0.059	1.769GluPhe: 1.769 ± 0.047	3.507GluGly: 3.507 ± 0.07	1.37GluHis: 1.37 ± 0.042	2.509GluIle: 2.509 ± 0.056	1.578GluLys: 1.578 ± 0.051	5.825GluLeu: 5.825 ± 0.105	1.174GluMet: 1.174 ± 0.041	1.068GluAsn: 1.068 ± 0.033	2.687GluPro: 2.687 ± 0.06	2.387GluGln: 2.387 ± 0.063	4.669GluArg: 4.669 ± 0.097	2.701GluSer: 2.701 ± 0.052	2.352GluThr: 2.352 ± 0.051	4.332GluVal: 4.332 ± 0.075	0.66GluTrp: 0.66 ± 0.027	0.923GluTyr: 0.923 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.843PheAla: 3.843 ± 0.073	0.371PheCys: 0.371 ± 0.021	2.641PheAsp: 2.641 ± 0.06	2.115PheGlu: 2.115 ± 0.047	1.255PhePhe: 1.255 ± 0.041	3.149PheGly: 3.149 ± 0.061	0.724PheHis: 0.724 ± 0.029	1.454PheIle: 1.454 ± 0.046	1.173PheLys: 1.173 ± 0.034	2.687PheLeu: 2.687 ± 0.057	0.717PheMet: 0.717 ± 0.03	1.109PheAsn: 1.109 ± 0.038	1.323PhePro: 1.323 ± 0.038	1.039PheGln: 1.039 ± 0.036	1.86PheArg: 1.86 ± 0.041	2.051PheSer: 2.051 ± 0.045	1.798PheThr: 1.798 ± 0.043	2.602PheVal: 2.602 ± 0.057	0.464PheTrp: 0.464 ± 0.025	0.761PheTyr: 0.761 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	9.101GlyAla: 9.101 ± 0.154	0.922GlyCys: 0.922 ± 0.031	4.3GlyAsp: 4.3 ± 0.107	4.106GlyGlu: 4.106 ± 0.068	3.092GlyPhe: 3.092 ± 0.058	6.645GlyGly: 6.645 ± 0.176	1.956GlyHis: 1.956 ± 0.055	3.648GlyIle: 3.648 ± 0.072	2.824GlyLys: 2.824 ± 0.068	8.865GlyLeu: 8.865 ± 0.104	1.986GlyMet: 1.986 ± 0.047	2.146GlyAsn: 2.146 ± 0.094	3.009GlyPro: 3.009 ± 0.051	3.143GlyGln: 3.143 ± 0.062	5.641GlyArg: 5.641 ± 0.082	4.853GlySer: 4.853 ± 0.121	4.657GlyThr: 4.657 ± 0.105	6.678GlyVal: 6.678 ± 0.099	1.453GlyTrp: 1.453 ± 0.047	2.083GlyTyr: 2.083 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.969HisAla: 2.969 ± 0.071	0.276HisCys: 0.276 ± 0.019	1.272HisAsp: 1.272 ± 0.041	1.19HisGlu: 1.19 ± 0.041	0.837HisPhe: 0.837 ± 0.031	2.182HisGly: 2.182 ± 0.057	0.73HisHis: 0.73 ± 0.031	0.913HisIle: 0.913 ± 0.033	0.463HisLys: 0.463 ± 0.023	2.4HisLeu: 2.4 ± 0.058	0.447HisMet: 0.447 ± 0.024	0.438HisAsn: 0.438 ± 0.025	1.553HisPro: 1.553 ± 0.046	0.755HisGln: 0.755 ± 0.03	1.77HisArg: 1.77 ± 0.045	1.101HisSer: 1.101 ± 0.035	1.115HisThr: 1.115 ± 0.032	1.522HisVal: 1.522 ± 0.041	0.366HisTrp: 0.366 ± 0.02	0.589HisTyr: 0.589 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.089IleAla: 6.089 ± 0.098	0.381IleCys: 0.381 ± 0.023	3.723IleAsp: 3.723 ± 0.063	3.417IleGlu: 3.417 ± 0.063	1.136IlePhe: 1.136 ± 0.041	4.254IleGly: 4.254 ± 0.075	0.843IleHis: 0.843 ± 0.032	1.37IleIle: 1.37 ± 0.045	1.406IleLys: 1.406 ± 0.051	2.721IleLeu: 2.721 ± 0.063	0.608IleMet: 0.608 ± 0.025	1.416IleAsn: 1.416 ± 0.04	1.851IlePro: 1.851 ± 0.047	1.233IleGln: 1.233 ± 0.034	2.506IleArg: 2.506 ± 0.057	2.452IleSer: 2.452 ± 0.057	2.626IleThr: 2.626 ± 0.061	3.495IleVal: 3.495 ± 0.067	0.389IleTrp: 0.389 ± 0.021	0.899IleTyr: 0.899 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	3.763LysAla: 3.763 ± 0.082	0.184LysCys: 0.184 ± 0.014	1.426LysAsp: 1.426 ± 0.045	1.332LysGlu: 1.332 ± 0.047	0.851LysPhe: 0.851 ± 0.033	2.119LysGly: 2.119 ± 0.059	0.61LysHis: 0.61 ± 0.025	1.306LysIle: 1.306 ± 0.05	1.221LysLys: 1.221 ± 0.053	3.239LysLeu: 3.239 ± 0.071	0.7LysMet: 0.7 ± 0.025	0.899LysAsn: 0.899 ± 0.031	1.988LysPro: 1.988 ± 0.058	1.165LysGln: 1.165 ± 0.04	2.216LysArg: 2.216 ± 0.061	1.691LysSer: 1.691 ± 0.044	1.688LysThr: 1.688 ± 0.049	2.503LysVal: 2.503 ± 0.056	0.291LysTrp: 0.291 ± 0.021	0.608LysTyr: 0.608 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	14.258LeuAla: 14.258 ± 0.163	1.035LeuCys: 1.035 ± 0.038	5.943LeuAsp: 5.943 ± 0.093	4.94LeuGlu: 4.94 ± 0.086	3.227LeuPhe: 3.227 ± 0.066	8.386LeuGly: 8.386 ± 0.095	2.436LeuHis: 2.436 ± 0.058	4.615LeuIle: 4.615 ± 0.073	3.696LeuLys: 3.696 ± 0.079	11.39LeuLeu: 11.39 ± 0.174	2.7LeuMet: 2.7 ± 0.067	2.885LeuAsn: 2.885 ± 0.066	6.198LeuPro: 6.198 ± 0.1	4.214LeuGln: 4.214 ± 0.072	8.175LeuArg: 8.175 ± 0.127	6.888LeuSer: 6.888 ± 0.093	5.859LeuThr: 5.859 ± 0.091	7.719LeuVal: 7.719 ± 0.093	1.398LeuTrp: 1.398 ± 0.04	2.039LeuTyr: 2.039 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.964MetAla: 2.964 ± 0.063	0.174MetCys: 0.174 ± 0.014	1.009MetAsp: 1.009 ± 0.031	0.887MetGlu: 0.887 ± 0.033	0.688MetPhe: 0.688 ± 0.031	1.719MetGly: 1.719 ± 0.05	0.489MetHis: 0.489 ± 0.023	0.879MetIle: 0.879 ± 0.032	0.948MetLys: 0.948 ± 0.031	2.566MetLeu: 2.566 ± 0.056	0.505MetMet: 0.505 ± 0.027	0.847MetAsn: 0.847 ± 0.029	1.462MetPro: 1.462 ± 0.041	0.956MetGln: 0.956 ± 0.035	1.656MetArg: 1.656 ± 0.042	1.621MetSer: 1.621 ± 0.043	1.459MetThr: 1.459 ± 0.043	1.663MetVal: 1.663 ± 0.043	0.214MetTrp: 0.214 ± 0.015	0.354MetTyr: 0.354 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.224AsnAla: 3.224 ± 0.087	0.243AsnCys: 0.243 ± 0.017	1.386AsnAsp: 1.386 ± 0.059	1.209AsnGlu: 1.209 ± 0.034	0.894AsnPhe: 0.894 ± 0.031	2.128AsnGly: 2.128 ± 0.072	0.54AsnHis: 0.54 ± 0.026	1.066AsnIle: 1.066 ± 0.038	0.724AsnLys: 0.724 ± 0.031	2.678AsnLeu: 2.678 ± 0.06	0.464AsnMet: 0.464 ± 0.023	0.703AsnAsn: 0.703 ± 0.042	1.785AsnPro: 1.785 ± 0.045	0.862AsnGln: 0.862 ± 0.036	1.633AsnArg: 1.633 ± 0.041	1.282AsnSer: 1.282 ± 0.052	1.462AsnThr: 1.462 ± 0.058	1.91AsnVal: 1.91 ± 0.056	0.359AsnTrp: 0.359 ± 0.017	0.634AsnTyr: 0.634 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	7.098ProAla: 7.098 ± 0.115	0.393ProCys: 0.393 ± 0.021	3.222ProAsp: 3.222 ± 0.055	3.156ProGlu: 3.156 ± 0.059	1.689ProPhe: 1.689 ± 0.043	4.519ProGly: 4.519 ± 0.072	1.14ProHis: 1.14 ± 0.045	1.962ProIle: 1.962 ± 0.041	1.552ProLys: 1.552 ± 0.044	5.339ProLeu: 5.339 ± 0.082	1.297ProMet: 1.297 ± 0.037	1.381ProAsn: 1.381 ± 0.042	2.869ProPro: 2.869 ± 0.077	2.12ProGln: 2.12 ± 0.051	3.079ProArg: 3.079 ± 0.067	3.067ProSer: 3.067 ± 0.057	2.985ProThr: 2.985 ± 0.064	4.426ProVal: 4.426 ± 0.076	0.821ProTrp: 0.821 ± 0.031	1.099ProTyr: 1.099 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	5.572GlnAla: 5.572 ± 0.1	0.286GlnCys: 0.286 ± 0.018	1.432GlnAsp: 1.432 ± 0.038	1.353GlnGlu: 1.353 ± 0.046	1.192GlnPhe: 1.192 ± 0.034	2.918GlnGly: 2.918 ± 0.063	0.898GlnHis: 0.898 ± 0.032	1.844GlnIle: 1.844 ± 0.043	0.956GlnLys: 0.956 ± 0.038	4.367GlnLeu: 4.367 ± 0.062	0.896GlnMet: 0.896 ± 0.034	0.686GlnAsn: 0.686 ± 0.028	2.271GlnPro: 2.271 ± 0.063	1.879GlnGln: 1.879 ± 0.053	3.787GlnArg: 3.787 ± 0.081	2.098GlnSer: 2.098 ± 0.055	1.997GlnThr: 1.997 ± 0.048	3.149GlnVal: 3.149 ± 0.061	0.629GlnTrp: 0.629 ± 0.024	0.674GlnTyr: 0.674 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	8.03ArgAla: 8.03 ± 0.111	0.689ArgCys: 0.689 ± 0.029	3.91ArgAsp: 3.91 ± 0.075	3.99ArgGlu: 3.99 ± 0.085	2.72ArgPhe: 2.72 ± 0.059	4.849ArgGly: 4.849 ± 0.068	1.986ArgHis: 1.986 ± 0.051	3.463ArgIle: 3.463 ± 0.065	1.856ArgLys: 1.856 ± 0.057	8.454ArgLeu: 8.454 ± 0.134	1.851ArgMet: 1.851 ± 0.054	1.671ArgAsn: 1.671 ± 0.047	3.451ArgPro: 3.451 ± 0.074	3.042ArgGln: 3.042 ± 0.072	5.422ArgArg: 5.422 ± 0.107	4.122ArgSer: 4.122 ± 0.071	3.339ArgThr: 3.339 ± 0.056	5.386ArgVal: 5.386 ± 0.075	1.291ArgTrp: 1.291 ± 0.042	1.947ArgTyr: 1.947 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	7.594SerAla: 7.594 ± 0.117	0.518SerCys: 0.518 ± 0.025	3.031SerAsp: 3.031 ± 0.072	2.584SerGlu: 2.584 ± 0.054	2.113SerPhe: 2.113 ± 0.052	5.632SerGly: 5.632 ± 0.12	1.236SerHis: 1.236 ± 0.033	2.613SerIle: 2.613 ± 0.056	1.499SerLys: 1.499 ± 0.05	6.079SerLeu: 6.079 ± 0.092	1.336SerMet: 1.336 ± 0.042	1.372SerAsn: 1.372 ± 0.046	3.109SerPro: 3.109 ± 0.061	1.968SerGln: 1.968 ± 0.05	3.842SerArg: 3.842 ± 0.07	3.424SerSer: 3.424 ± 0.087	3.32SerThr: 3.32 ± 0.083	4.553SerVal: 4.553 ± 0.082	0.754SerTrp: 0.754 ± 0.035	1.21SerTyr: 1.21 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.56ThrAla: 6.56 ± 0.12	0.415ThrCys: 0.415 ± 0.025	2.855ThrAsp: 2.855 ± 0.078	2.48ThrGlu: 2.48 ± 0.045	1.685ThrPhe: 1.685 ± 0.051	4.763ThrGly: 4.763 ± 0.111	1.24ThrHis: 1.24 ± 0.036	2.098ThrIle: 2.098 ± 0.055	1.219ThrLys: 1.219 ± 0.04	6.805ThrLeu: 6.805 ± 0.091	1.09ThrMet: 1.09 ± 0.035	1.289ThrAsn: 1.289 ± 0.054	3.794ThrPro: 3.794 ± 0.081	2.065ThrGln: 2.065 ± 0.05	3.422ThrArg: 3.422 ± 0.065	3.016ThrSer: 3.016 ± 0.072	3.112ThrThr: 3.112 ± 0.092	4.698ThrVal: 4.698 ± 0.113	0.72ThrTrp: 0.72 ± 0.032	1.108ThrTyr: 1.108 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	9.629ValAla: 9.629 ± 0.123	0.791ValCys: 0.791 ± 0.032	4.328ValAsp: 4.328 ± 0.069	4.061ValGlu: 4.061 ± 0.073	2.726ValPhe: 2.726 ± 0.054	5.755ValGly: 5.755 ± 0.09	1.698ValHis: 1.698 ± 0.046	3.704ValIle: 3.704 ± 0.058	2.411ValLys: 2.411 ± 0.059	8.86ValLeu: 8.86 ± 0.127	1.912ValMet: 1.912 ± 0.053	2.164ValAsn: 2.164 ± 0.064	4.036ValPro: 4.036 ± 0.072	2.834ValGln: 2.834 ± 0.056	5.258ValArg: 5.258 ± 0.075	4.672ValSer: 4.672 ± 0.076	4.509ValThr: 4.509 ± 0.093	6.831ValVal: 6.831 ± 0.107	1.01ValTrp: 1.01 ± 0.036	1.537ValTyr: 1.537 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.383TrpAla: 1.383 ± 0.041	0.161TrpCys: 0.161 ± 0.013	0.577TrpAsp: 0.577 ± 0.028	0.478TrpGlu: 0.478 ± 0.025	0.528TrpPhe: 0.528 ± 0.023	0.891TrpGly: 0.891 ± 0.031	0.359TrpHis: 0.359 ± 0.018	0.623TrpIle: 0.623 ± 0.027	0.427TrpLys: 0.427 ± 0.02	2.116TrpLeu: 2.116 ± 0.049	0.398TrpMet: 0.398 ± 0.022	0.377TrpAsn: 0.377 ± 0.02	0.724TrpPro: 0.724 ± 0.032	0.782TrpGln: 0.782 ± 0.032	1.257TrpArg: 1.257 ± 0.041	0.862TrpSer: 0.862 ± 0.033	0.755TrpThr: 0.755 ± 0.041	1.047TrpVal: 1.047 ± 0.032	0.314TrpTrp: 0.314 ± 0.019	0.265TrpTyr: 0.265 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.615TyrAla: 2.615 ± 0.056	0.234TyrCys: 0.234 ± 0.016	1.173TyrAsp: 1.173 ± 0.034	1.021TyrGlu: 1.021 ± 0.035	0.863TyrPhe: 0.863 ± 0.033	1.857TyrGly: 1.857 ± 0.047	0.396TyrHis: 0.396 ± 0.02	0.769TyrIle: 0.769 ± 0.029	0.544TyrLys: 0.544 ± 0.027	2.299TyrLeu: 2.299 ± 0.053	0.363TyrMet: 0.363 ± 0.02	0.585TyrAsn: 0.585 ± 0.026	1.035TyrPro: 1.035 ± 0.034	0.748TyrGln: 0.748 ± 0.031	1.688TyrArg: 1.688 ± 0.043	1.19TyrSer: 1.19 ± 0.042	1.344TyrThr: 1.344 ± 0.05	1.598TyrVal: 1.598 ± 0.039	0.328TyrTrp: 0.328 ± 0.017	0.517TyrTyr: 0.517 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2893 proteins (996319 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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