Amino acid dipepetide frequency for Reinekea blandensis MED297

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.247AlaAla: 8.247 ± 0.104	0.855AlaCys: 0.855 ± 0.025	5.891AlaAsp: 5.891 ± 0.08	6.247AlaGlu: 6.247 ± 0.082	3.773AlaPhe: 3.773 ± 0.057	6.707AlaGly: 6.707 ± 0.073	1.878AlaHis: 1.878 ± 0.037	5.491AlaIle: 5.491 ± 0.062	3.373AlaLys: 3.373 ± 0.07	10.883AlaLeu: 10.883 ± 0.119	2.804AlaMet: 2.804 ± 0.05	3.156AlaAsn: 3.156 ± 0.049	3.228AlaPro: 3.228 ± 0.052	4.293AlaGln: 4.293 ± 0.062	4.856AlaArg: 4.856 ± 0.058	5.366AlaSer: 5.366 ± 0.066	4.629AlaThr: 4.629 ± 0.056	6.483AlaVal: 6.483 ± 0.076	1.206AlaTrp: 1.206 ± 0.03	2.433AlaTyr: 2.433 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.777CysAla: 0.777 ± 0.023	0.123CysCys: 0.123 ± 0.01	0.529CysAsp: 0.529 ± 0.023	0.495CysGlu: 0.495 ± 0.021	0.384CysPhe: 0.384 ± 0.018	0.757CysGly: 0.757 ± 0.025	0.329CysHis: 0.329 ± 0.018	0.415CysIle: 0.415 ± 0.017	0.244CysLys: 0.244 ± 0.014	0.947CysLeu: 0.947 ± 0.028	0.169CysMet: 0.169 ± 0.012	0.295CysAsn: 0.295 ± 0.014	0.424CysPro: 0.424 ± 0.021	0.451CysGln: 0.451 ± 0.02	0.582CysArg: 0.582 ± 0.02	0.569CysSer: 0.569 ± 0.022	0.439CysThr: 0.439 ± 0.018	0.592CysVal: 0.592 ± 0.022	0.109CysTrp: 0.109 ± 0.009	0.27CysTyr: 0.27 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.781AspAla: 5.781 ± 0.071	0.562AspCys: 0.562 ± 0.021	4.148AspAsp: 4.148 ± 0.065	4.188AspGlu: 4.188 ± 0.064	2.406AspPhe: 2.406 ± 0.044	4.424AspGly: 4.424 ± 0.081	1.45AspHis: 1.45 ± 0.038	3.793AspIle: 3.793 ± 0.059	1.912AspLys: 1.912 ± 0.044	6.085AspLeu: 6.085 ± 0.067	1.423AspMet: 1.423 ± 0.032	2.074AspAsn: 2.074 ± 0.049	2.577AspPro: 2.577 ± 0.044	2.851AspGln: 2.851 ± 0.049	3.612AspArg: 3.612 ± 0.053	3.435AspSer: 3.435 ± 0.055	3.099AspThr: 3.099 ± 0.052	4.493AspVal: 4.493 ± 0.067	1.156AspTrp: 1.156 ± 0.029	2.074AspTyr: 2.074 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.904GluAla: 5.904 ± 0.088	0.418GluCys: 0.418 ± 0.016	3.154GluAsp: 3.154 ± 0.051	3.257GluGlu: 3.257 ± 0.071	2.338GluPhe: 2.338 ± 0.037	3.518GluGly: 3.518 ± 0.06	1.701GluHis: 1.701 ± 0.037	3.029GluIle: 3.029 ± 0.054	2.636GluLys: 2.636 ± 0.056	6.887GluLeu: 6.887 ± 0.074	1.468GluMet: 1.468 ± 0.037	2.286GluAsn: 2.286 ± 0.045	2.636GluPro: 2.636 ± 0.05	4.052GluGln: 4.052 ± 0.06	3.996GluArg: 3.996 ± 0.064	3.848GluSer: 3.848 ± 0.063	3.632GluThr: 3.632 ± 0.048	4.056GluVal: 4.056 ± 0.062	0.835GluTrp: 0.835 ± 0.028	1.59GluTyr: 1.59 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.536PheAla: 3.536 ± 0.061	0.428PheCys: 0.428 ± 0.018	2.795PheAsp: 2.795 ± 0.05	2.526PheGlu: 2.526 ± 0.045	1.697PhePhe: 1.697 ± 0.048	3.265PheGly: 3.265 ± 0.057	0.87PheHis: 0.87 ± 0.026	2.268PheIle: 2.268 ± 0.045	1.443PheLys: 1.443 ± 0.033	3.699PheLeu: 3.699 ± 0.061	0.98PheMet: 0.98 ± 0.032	1.721PheAsn: 1.721 ± 0.038	1.481PhePro: 1.481 ± 0.033	1.596PheGln: 1.596 ± 0.033	2.113PheArg: 2.113 ± 0.038	2.942PheSer: 2.942 ± 0.051	2.166PheThr: 2.166 ± 0.047	2.802PheVal: 2.802 ± 0.049	0.688PheTrp: 0.688 ± 0.024	1.309PheTyr: 1.309 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	5.681GlyAla: 5.681 ± 0.08	0.801GlyCys: 0.801 ± 0.027	4.065GlyAsp: 4.065 ± 0.071	4.238GlyGlu: 4.238 ± 0.055	3.456GlyPhe: 3.456 ± 0.054	4.822GlyGly: 4.822 ± 0.081	1.746GlyHis: 1.746 ± 0.04	4.246GlyIle: 4.246 ± 0.064	2.772GlyLys: 2.772 ± 0.05	7.772GlyLeu: 7.772 ± 0.095	1.946GlyMet: 1.946 ± 0.04	2.318GlyAsn: 2.318 ± 0.048	1.963GlyPro: 1.963 ± 0.037	3.374GlyGln: 3.374 ± 0.05	3.699GlyArg: 3.699 ± 0.053	4.029GlySer: 4.029 ± 0.066	3.653GlyThr: 3.653 ± 0.052	5.249GlyVal: 5.249 ± 0.073	1.187GlyTrp: 1.187 ± 0.032	2.56GlyTyr: 2.56 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	1.79HisAla: 1.79 ± 0.039	0.338HisCys: 0.338 ± 0.015	1.281HisAsp: 1.281 ± 0.031	1.261HisGlu: 1.261 ± 0.031	1.023HisPhe: 1.023 ± 0.029	1.592HisGly: 1.592 ± 0.039	0.78HisHis: 0.78 ± 0.025	1.187HisIle: 1.187 ± 0.033	0.692HisLys: 0.692 ± 0.021	2.536HisLeu: 2.536 ± 0.051	0.454HisMet: 0.454 ± 0.019	0.76HisAsn: 0.76 ± 0.023	1.363HisPro: 1.363 ± 0.035	1.31HisGln: 1.31 ± 0.034	1.571HisArg: 1.571 ± 0.034	1.388HisSer: 1.388 ± 0.034	1.081HisThr: 1.081 ± 0.027	1.246HisVal: 1.246 ± 0.032	0.527HisTrp: 0.527 ± 0.019	0.844HisTyr: 0.844 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.89IleAla: 5.89 ± 0.072	0.511IleCys: 0.511 ± 0.022	4.148IleAsp: 4.148 ± 0.056	4.147IleGlu: 4.147 ± 0.058	1.761IlePhe: 1.761 ± 0.038	4.4IleGly: 4.4 ± 0.064	1.175IleHis: 1.175 ± 0.029	2.746IleIle: 2.746 ± 0.051	1.925IleLys: 1.925 ± 0.039	4.894IleLeu: 4.894 ± 0.066	1.164IleMet: 1.164 ± 0.03	2.303IleAsn: 2.303 ± 0.042	2.53IlePro: 2.53 ± 0.047	2.339IleGln: 2.339 ± 0.041	3.459IleArg: 3.459 ± 0.059	3.574IleSer: 3.574 ± 0.059	2.995IleThr: 2.995 ± 0.048	3.774IleVal: 3.774 ± 0.06	0.652IleTrp: 0.652 ± 0.021	1.313IleTyr: 1.313 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.038LysAla: 4.038 ± 0.077	0.189LysCys: 0.189 ± 0.013	2.147LysAsp: 2.147 ± 0.047	2.041LysGlu: 2.041 ± 0.048	0.942LysPhe: 0.942 ± 0.027	2.4LysGly: 2.4 ± 0.048	0.877LysHis: 0.877 ± 0.028	1.822LysIle: 1.822 ± 0.041	1.804LysLys: 1.804 ± 0.054	3.561LysLeu: 3.561 ± 0.063	0.835LysMet: 0.835 ± 0.027	1.35LysAsn: 1.35 ± 0.033	1.991LysPro: 1.991 ± 0.039	1.892LysGln: 1.892 ± 0.046	2.286LysArg: 2.286 ± 0.044	2.219LysSer: 2.219 ± 0.046	2.557LysThr: 2.557 ± 0.046	2.612LysVal: 2.612 ± 0.05	0.372LysTrp: 0.372 ± 0.016	0.847LysTyr: 0.847 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	10.308LeuAla: 10.308 ± 0.104	0.951LeuCys: 0.951 ± 0.026	6.237LeuAsp: 6.237 ± 0.068	5.881LeuGlu: 5.881 ± 0.08	4.227LeuPhe: 4.227 ± 0.065	6.942LeuGly: 6.942 ± 0.088	2.04LeuHis: 2.04 ± 0.038	6.345LeuIle: 6.345 ± 0.08	4.739LeuLys: 4.739 ± 0.069	10.957LeuLeu: 10.957 ± 0.137	2.96LeuMet: 2.96 ± 0.046	4.797LeuAsn: 4.797 ± 0.065	5.147LeuPro: 5.147 ± 0.063	4.328LeuGln: 4.328 ± 0.064	5.114LeuArg: 5.114 ± 0.069	8.422LeuSer: 8.422 ± 0.083	7.142LeuThr: 7.142 ± 0.075	7.2LeuVal: 7.2 ± 0.094	1.349LeuTrp: 1.349 ± 0.034	2.698LeuTyr: 2.698 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.667MetAla: 2.667 ± 0.048	0.153MetCys: 0.153 ± 0.012	1.328MetAsp: 1.328 ± 0.028	1.19MetGlu: 1.19 ± 0.033	0.812MetPhe: 0.812 ± 0.028	1.612MetGly: 1.612 ± 0.043	0.47MetHis: 0.47 ± 0.017	1.448MetIle: 1.448 ± 0.033	1.229MetLys: 1.229 ± 0.032	2.501MetLeu: 2.501 ± 0.041	0.736MetMet: 0.736 ± 0.024	1.174MetAsn: 1.174 ± 0.029	1.232MetPro: 1.232 ± 0.033	1.052MetGln: 1.052 ± 0.027	1.189MetArg: 1.189 ± 0.03	1.941MetSer: 1.941 ± 0.043	1.982MetThr: 1.982 ± 0.038	1.806MetVal: 1.806 ± 0.039	0.203MetTrp: 0.203 ± 0.012	0.471MetTyr: 0.471 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.522AsnAla: 3.522 ± 0.051	0.337AsnCys: 0.337 ± 0.019	2.431AsnAsp: 2.431 ± 0.051	2.188AsnGlu: 2.188 ± 0.042	1.177AsnPhe: 1.177 ± 0.026	2.896AsnGly: 2.896 ± 0.057	0.867AsnHis: 0.867 ± 0.025	1.948AsnIle: 1.948 ± 0.041	1.142AsnLys: 1.142 ± 0.029	3.682AsnLeu: 3.682 ± 0.052	0.79AsnMet: 0.79 ± 0.025	1.376AsnAsn: 1.376 ± 0.041	2.122AsnPro: 2.122 ± 0.04	1.75AsnGln: 1.75 ± 0.035	2.483AsnArg: 2.483 ± 0.046	2.009AsnSer: 2.009 ± 0.04	1.985AsnThr: 1.985 ± 0.048	2.281AsnVal: 2.281 ± 0.048	0.595AsnTrp: 0.595 ± 0.024	1.05AsnTyr: 1.05 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	3.88ProAla: 3.88 ± 0.064	0.281ProCys: 0.281 ± 0.015	3.37ProAsp: 3.37 ± 0.046	3.731ProGlu: 3.731 ± 0.06	1.858ProPhe: 1.858 ± 0.043	3.064ProGly: 3.064 ± 0.043	0.838ProHis: 0.838 ± 0.028	2.381ProIle: 2.381 ± 0.045	1.613ProLys: 1.613 ± 0.042	4.278ProLeu: 4.278 ± 0.055	1.191ProMet: 1.191 ± 0.03	1.582ProAsn: 1.582 ± 0.034	1.397ProPro: 1.397 ± 0.035	1.627ProGln: 1.627 ± 0.033	1.493ProArg: 1.493 ± 0.035	2.632ProSer: 2.632 ± 0.042	2.375ProThr: 2.375 ± 0.047	3.645ProVal: 3.645 ± 0.055	0.651ProTrp: 0.651 ± 0.024	1.21ProTyr: 1.21 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.901GlnAla: 4.901 ± 0.08	0.416GlnCys: 0.416 ± 0.018	2.148GlnAsp: 2.148 ± 0.042	2.275GlnGlu: 2.275 ± 0.047	1.743GlnPhe: 1.743 ± 0.035	3.192GlnGly: 3.192 ± 0.042	1.169GlnHis: 1.169 ± 0.032	2.474GlnIle: 2.474 ± 0.051	1.788GlnLys: 1.788 ± 0.044	5.181GlnLeu: 5.181 ± 0.084	1.262GlnMet: 1.262 ± 0.033	1.555GlnAsn: 1.555 ± 0.034	2.252GlnPro: 2.252 ± 0.043	3.099GlnGln: 3.099 ± 0.066	2.983GlnArg: 2.983 ± 0.049	3.256GlnSer: 3.256 ± 0.048	2.966GlnThr: 2.966 ± 0.046	3.334GlnVal: 3.334 ± 0.048	1.008GlnTrp: 1.008 ± 0.03	1.335GlnTyr: 1.335 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	4.367ArgAla: 4.367 ± 0.06	0.479ArgCys: 0.479 ± 0.017	3.026ArgAsp: 3.026 ± 0.044	3.406ArgGlu: 3.406 ± 0.058	2.804ArgPhe: 2.804 ± 0.051	2.952ArgGly: 2.952 ± 0.05	1.517ArgHis: 1.517 ± 0.037	3.295ArgIle: 3.295 ± 0.049	2.151ArgLys: 2.151 ± 0.051	6.926ArgLeu: 6.926 ± 0.081	1.457ArgMet: 1.457 ± 0.035	1.94ArgAsn: 1.94 ± 0.044	2.236ArgPro: 2.236 ± 0.04	3.125ArgGln: 3.125 ± 0.058	3.267ArgArg: 3.267 ± 0.062	3.322ArgSer: 3.322 ± 0.052	2.758ArgThr: 2.758 ± 0.04	3.865ArgVal: 3.865 ± 0.053	0.97ArgTrp: 0.97 ± 0.025	2.045ArgTyr: 2.045 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.934SerAla: 5.934 ± 0.073	0.464SerCys: 0.464 ± 0.021	4.265SerAsp: 4.265 ± 0.063	4.121SerGlu: 4.121 ± 0.057	2.646SerPhe: 2.646 ± 0.045	5.124SerGly: 5.124 ± 0.072	1.435SerHis: 1.435 ± 0.033	3.422SerIle: 3.422 ± 0.058	2.085SerLys: 2.085 ± 0.047	7.001SerLeu: 7.001 ± 0.074	1.69SerMet: 1.69 ± 0.034	2.092SerAsn: 2.092 ± 0.051	2.546SerPro: 2.546 ± 0.043	2.903SerGln: 2.903 ± 0.048	3.374SerArg: 3.374 ± 0.057	3.886SerSer: 3.886 ± 0.066	3.447SerThr: 3.447 ± 0.053	4.94SerVal: 4.94 ± 0.073	0.894SerTrp: 0.894 ± 0.026	1.61SerTyr: 1.61 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	4.967ThrAla: 4.967 ± 0.065	0.413ThrCys: 0.413 ± 0.018	3.681ThrAsp: 3.681 ± 0.066	3.592ThrGlu: 3.592 ± 0.053	2.231ThrPhe: 2.231 ± 0.047	4.456ThrGly: 4.456 ± 0.061	1.279ThrHis: 1.279 ± 0.028	2.989ThrIle: 2.989 ± 0.046	1.495ThrLys: 1.495 ± 0.041	7.237ThrLeu: 7.237 ± 0.077	1.128ThrMet: 1.128 ± 0.031	1.747ThrAsn: 1.747 ± 0.039	2.869ThrPro: 2.869 ± 0.055	2.529ThrGln: 2.529 ± 0.049	2.911ThrArg: 2.911 ± 0.05	3.144ThrSer: 3.144 ± 0.051	3.134ThrThr: 3.134 ± 0.058	4.315ThrVal: 4.315 ± 0.062	0.748ThrTrp: 0.748 ± 0.026	1.488ThrTyr: 1.488 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	6.332ValAla: 6.332 ± 0.086	0.675ValCys: 0.675 ± 0.023	4.445ValAsp: 4.445 ± 0.059	4.234ValGlu: 4.234 ± 0.06	3.064ValPhe: 3.064 ± 0.05	4.59ValGly: 4.59 ± 0.065	1.49ValHis: 1.49 ± 0.034	4.367ValIle: 4.367 ± 0.059	2.552ValLys: 2.552 ± 0.051	7.372ValLeu: 7.372 ± 0.084	1.835ValMet: 1.835 ± 0.041	2.713ValAsn: 2.713 ± 0.051	3.021ValPro: 3.021 ± 0.047	2.843ValGln: 2.843 ± 0.056	3.898ValArg: 3.898 ± 0.054	5.198ValSer: 5.198 ± 0.067	4.241ValThr: 4.241 ± 0.063	5.217ValVal: 5.217 ± 0.071	0.887ValTrp: 0.887 ± 0.024	1.873ValTyr: 1.873 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	1.057TrpAla: 1.057 ± 0.03	0.161TrpCys: 0.161 ± 0.009	0.652TrpAsp: 0.652 ± 0.022	0.596TrpGlu: 0.596 ± 0.023	0.693TrpPhe: 0.693 ± 0.027	0.808TrpGly: 0.808 ± 0.026	0.424TrpHis: 0.424 ± 0.017	0.752TrpIle: 0.752 ± 0.025	0.415TrpLys: 0.415 ± 0.017	2.13TrpLeu: 2.13 ± 0.052	0.401TrpMet: 0.401 ± 0.018	0.499TrpAsn: 0.499 ± 0.018	0.711TrpPro: 0.711 ± 0.023	1.129TrpGln: 1.129 ± 0.033	0.864TrpArg: 0.864 ± 0.027	0.912TrpSer: 0.912 ± 0.028	0.739TrpThr: 0.739 ± 0.026	1.177TrpVal: 1.177 ± 0.03	0.248TrpTrp: 0.248 ± 0.016	0.426TrpTyr: 0.426 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.219TyrAla: 2.219 ± 0.043	0.345TyrCys: 0.345 ± 0.014	1.8TyrAsp: 1.8 ± 0.045	1.623TyrGlu: 1.623 ± 0.041	1.292TyrPhe: 1.292 ± 0.03	2.052TyrGly: 2.052 ± 0.04	0.688TyrHis: 0.688 ± 0.024	1.283TyrIle: 1.283 ± 0.031	0.774TyrLys: 0.774 ± 0.024	3.255TyrLeu: 3.255 ± 0.047	0.502TyrMet: 0.502 ± 0.02	0.896TyrAsn: 0.896 ± 0.024	1.372TyrPro: 1.372 ± 0.031	1.794TyrGln: 1.794 ± 0.04	2.158TyrArg: 2.158 ± 0.047	1.788TyrSer: 1.788 ± 0.037	1.335TyrThr: 1.335 ± 0.035	1.762TyrVal: 1.762 ± 0.034	0.508TyrTrp: 0.508 ± 0.019	0.843TyrTyr: 0.843 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4236 proteins (1345410 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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