Amino acid dipepetide frequency for Erysipelatoclostridium sp. AM42-17

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.301AlaAla: 3.301 ± 0.106	0.976AlaCys: 0.976 ± 0.038	2.43AlaAsp: 2.43 ± 0.072	1.971AlaGlu: 1.971 ± 0.075	2.514AlaPhe: 2.514 ± 0.072	3.937AlaGly: 3.937 ± 0.091	1.31AlaHis: 1.31 ± 0.045	5.677AlaIle: 5.677 ± 0.104	5.066AlaLys: 5.066 ± 0.098	6.323AlaLeu: 6.323 ± 0.116	1.935AlaMet: 1.935 ± 0.058	2.619AlaAsn: 2.619 ± 0.075	1.387AlaPro: 1.387 ± 0.056	1.746AlaGln: 1.746 ± 0.054	2.071AlaArg: 2.071 ± 0.059	3.745AlaSer: 3.745 ± 0.067	3.091AlaThr: 3.091 ± 0.071	3.657AlaVal: 3.657 ± 0.088	0.373AlaTrp: 0.373 ± 0.024	2.527AlaTyr: 2.527 ± 0.067	0.0AlaXaa: 0.0 ± 0.0
Cys	0.77CysAla: 0.77 ± 0.037	0.25CysCys: 0.25 ± 0.022	0.862CysAsp: 0.862 ± 0.035	0.567CysGlu: 0.567 ± 0.032	0.771CysPhe: 0.771 ± 0.032	1.103CysGly: 1.103 ± 0.05	0.525CysHis: 0.525 ± 0.032	1.267CysIle: 1.267 ± 0.046	0.982CysLys: 0.982 ± 0.039	1.498CysLeu: 1.498 ± 0.048	0.395CysMet: 0.395 ± 0.025	0.543CysAsn: 0.543 ± 0.029	0.498CysPro: 0.498 ± 0.034	0.682CysGln: 0.682 ± 0.034	0.454CysArg: 0.454 ± 0.026	0.875CysSer: 0.875 ± 0.038	0.6CysThr: 0.6 ± 0.03	0.889CysVal: 0.889 ± 0.04	0.094CysTrp: 0.094 ± 0.012	0.634CysTyr: 0.634 ± 0.037	0.0CysXaa: 0.0 ± 0.0
Asp	3.208AspAla: 3.208 ± 0.076	0.867AspCys: 0.867 ± 0.039	3.801AspAsp: 3.801 ± 0.09	4.905AspGlu: 4.905 ± 0.101	2.9AspPhe: 2.9 ± 0.066	3.728AspGly: 3.728 ± 0.108	1.815AspHis: 1.815 ± 0.064	5.446AspIle: 5.446 ± 0.101	3.934AspLys: 3.934 ± 0.094	5.739AspLeu: 5.739 ± 0.091	1.727AspMet: 1.727 ± 0.056	2.574AspAsn: 2.574 ± 0.073	1.555AspPro: 1.555 ± 0.047	2.961AspGln: 2.961 ± 0.067	1.86AspArg: 1.86 ± 0.054	2.913AspSer: 2.913 ± 0.064	2.58AspThr: 2.58 ± 0.056	4.103AspVal: 4.103 ± 0.081	0.394AspTrp: 0.394 ± 0.028	3.69AspTyr: 3.69 ± 0.085	0.0AspXaa: 0.0 ± 0.0
Glu	3.99GluAla: 3.99 ± 0.091	0.723GluCys: 0.723 ± 0.037	3.609GluAsp: 3.609 ± 0.083	4.76GluGlu: 4.76 ± 0.117	2.428GluPhe: 2.428 ± 0.056	3.398GluGly: 3.398 ± 0.09	1.349GluHis: 1.349 ± 0.043	5.489GluIle: 5.489 ± 0.103	5.994GluLys: 5.994 ± 0.108	6.016GluLeu: 6.016 ± 0.114	2.199GluMet: 2.199 ± 0.061	4.259GluAsn: 4.259 ± 0.073	1.385GluPro: 1.385 ± 0.052	2.378GluGln: 2.378 ± 0.069	2.275GluArg: 2.275 ± 0.063	2.975GluSer: 2.975 ± 0.064	3.264GluThr: 3.264 ± 0.073	4.338GluVal: 4.338 ± 0.091	0.359GluTrp: 0.359 ± 0.026	2.977GluTyr: 2.977 ± 0.073	0.0GluXaa: 0.0 ± 0.0
Phe	2.336PheAla: 2.336 ± 0.061	0.592PheCys: 0.592 ± 0.034	3.161PheAsp: 3.161 ± 0.074	2.536PheGlu: 2.536 ± 0.07	1.918PhePhe: 1.918 ± 0.058	2.61PheGly: 2.61 ± 0.077	0.895PheHis: 0.895 ± 0.041	4.268PheIle: 4.268 ± 0.116	3.437PheLys: 3.437 ± 0.073	3.625PheLeu: 3.625 ± 0.088	1.113PheMet: 1.113 ± 0.045	2.488PheAsn: 2.488 ± 0.069	1.113PhePro: 1.113 ± 0.043	1.251PheGln: 1.251 ± 0.046	1.024PheArg: 1.024 ± 0.048	2.749PheSer: 2.749 ± 0.069	2.004PheThr: 2.004 ± 0.066	3.106PheVal: 3.106 ± 0.077	0.228PheTrp: 0.228 ± 0.019	2.049PheTyr: 2.049 ± 0.065	0.0PheXaa: 0.0 ± 0.0
Gly	3.786GlyAla: 3.786 ± 0.112	1.053GlyCys: 1.053 ± 0.048	3.084GlyAsp: 3.084 ± 0.073	3.064GlyGlu: 3.064 ± 0.077	2.917GlyPhe: 2.917 ± 0.084	3.951GlyGly: 3.951 ± 0.111	1.59GlyHis: 1.59 ± 0.051	5.772GlyIle: 5.772 ± 0.104	5.027GlyLys: 5.027 ± 0.094	5.655GlyLeu: 5.655 ± 0.103	1.949GlyMet: 1.949 ± 0.056	2.755GlyAsn: 2.755 ± 0.07	1.188GlyPro: 1.188 ± 0.05	2.31GlyGln: 2.31 ± 0.072	1.943GlyArg: 1.943 ± 0.058	3.467GlySer: 3.467 ± 0.079	3.465GlyThr: 3.465 ± 0.092	4.217GlyVal: 4.217 ± 0.097	0.484GlyTrp: 0.484 ± 0.03	3.373GlyTyr: 3.373 ± 0.075	0.0GlyXaa: 0.0 ± 0.0
His	1.124HisAla: 1.124 ± 0.043	0.481HisCys: 0.481 ± 0.028	1.63HisAsp: 1.63 ± 0.054	1.345HisGlu: 1.345 ± 0.045	1.26HisPhe: 1.26 ± 0.046	1.432HisGly: 1.432 ± 0.05	1.168HisHis: 1.168 ± 0.037	2.166HisIle: 2.166 ± 0.061	1.165HisLys: 1.165 ± 0.05	2.502HisLeu: 2.502 ± 0.062	0.542HisMet: 0.542 ± 0.031	0.94HisAsn: 0.94 ± 0.038	1.087HisPro: 1.087 ± 0.044	1.46HisGln: 1.46 ± 0.061	0.829HisArg: 0.829 ± 0.036	1.245HisSer: 1.245 ± 0.045	1.065HisThr: 1.065 ± 0.043	1.663HisVal: 1.663 ± 0.05	0.134HisTrp: 0.134 ± 0.016	1.446HisTyr: 1.446 ± 0.052	0.0HisXaa: 0.0 ± 0.0
Ile	5.299IleAla: 5.299 ± 0.094	1.551IleCys: 1.551 ± 0.045	6.069IleAsp: 6.069 ± 0.11	6.125IleGlu: 6.125 ± 0.104	3.528IlePhe: 3.528 ± 0.105	5.296IleGly: 5.296 ± 0.12	1.997IleHis: 1.997 ± 0.061	7.652IleIle: 7.652 ± 0.164	7.349IleLys: 7.349 ± 0.106	7.655IleLeu: 7.655 ± 0.155	2.222IleMet: 2.222 ± 0.065	4.482IleAsn: 4.482 ± 0.077	2.903IlePro: 2.903 ± 0.075	3.237IleGln: 3.237 ± 0.081	2.571IleArg: 2.571 ± 0.075	5.318IleSer: 5.318 ± 0.112	4.323IleThr: 4.323 ± 0.084	6.1IleVal: 6.1 ± 0.11	0.431IleTrp: 0.431 ± 0.028	3.714IleTyr: 3.714 ± 0.077	0.0IleXaa: 0.0 ± 0.0
Lys	4.619LysAla: 4.619 ± 0.106	0.697LysCys: 0.697 ± 0.03	5.638LysAsp: 5.638 ± 0.1	7.968LysGlu: 7.968 ± 0.133	1.949LysPhe: 1.949 ± 0.06	4.462LysGly: 4.462 ± 0.085	1.499LysHis: 1.499 ± 0.049	6.253LysIle: 6.253 ± 0.113	8.085LysLys: 8.085 ± 0.139	6.013LysLeu: 6.013 ± 0.099	2.849LysMet: 2.849 ± 0.063	4.96LysAsn: 4.96 ± 0.107	2.033LysPro: 2.033 ± 0.053	3.865LysGln: 3.865 ± 0.075	3.142LysArg: 3.142 ± 0.075	3.568LysSer: 3.568 ± 0.08	4.273LysThr: 4.273 ± 0.087	5.115LysVal: 5.115 ± 0.099	0.547LysTrp: 0.547 ± 0.03	3.675LysTyr: 3.675 ± 0.086	0.0LysXaa: 0.0 ± 0.0
Leu	5.647LeuAla: 5.647 ± 0.109	1.326LeuCys: 1.326 ± 0.045	6.039LeuAsp: 6.039 ± 0.108	5.841LeuGlu: 5.841 ± 0.107	4.218LeuPhe: 4.218 ± 0.091	5.538LeuGly: 5.538 ± 0.106	1.768LeuHis: 1.768 ± 0.058	7.445LeuIle: 7.445 ± 0.135	8.532LeuLys: 8.532 ± 0.109	8.586LeuLeu: 8.586 ± 0.162	2.617LeuMet: 2.617 ± 0.057	5.503LeuAsn: 5.503 ± 0.095	3.073LeuPro: 3.073 ± 0.074	3.228LeuGln: 3.228 ± 0.075	2.724LeuArg: 2.724 ± 0.073	6.573LeuSer: 6.573 ± 0.118	5.008LeuThr: 5.008 ± 0.104	5.741LeuVal: 5.741 ± 0.104	0.531LeuTrp: 0.531 ± 0.032	3.792LeuTyr: 3.792 ± 0.094	0.0LeuXaa: 0.0 ± 0.0
Met	1.944MetAla: 1.944 ± 0.056	0.325MetCys: 0.325 ± 0.021	1.577MetAsp: 1.577 ± 0.051	1.679MetGlu: 1.679 ± 0.061	1.103MetPhe: 1.103 ± 0.051	1.644MetGly: 1.644 ± 0.055	0.476MetHis: 0.476 ± 0.03	3.201MetIle: 3.201 ± 0.072	2.966MetLys: 2.966 ± 0.064	2.466MetLeu: 2.466 ± 0.067	1.265MetMet: 1.265 ± 0.052	1.976MetAsn: 1.976 ± 0.056	0.95MetPro: 0.95 ± 0.042	0.956MetGln: 0.956 ± 0.037	0.784MetArg: 0.784 ± 0.039	1.812MetSer: 1.812 ± 0.052	1.548MetThr: 1.548 ± 0.049	1.698MetVal: 1.698 ± 0.054	0.169MetTrp: 0.169 ± 0.017	0.973MetTyr: 0.973 ± 0.036	0.0MetXaa: 0.0 ± 0.0
Asn	2.689AsnAla: 2.689 ± 0.08	0.637AsnCys: 0.637 ± 0.035	3.256AsnAsp: 3.256 ± 0.084	4.048AsnGlu: 4.048 ± 0.075	1.59AsnPhe: 1.59 ± 0.049	3.192AsnGly: 3.192 ± 0.083	1.721AsnHis: 1.721 ± 0.061	4.362AsnIle: 4.362 ± 0.078	4.612AsnLys: 4.612 ± 0.108	3.975AsnLeu: 3.975 ± 0.073	1.396AsnMet: 1.396 ± 0.043	2.909AsnAsn: 2.909 ± 0.092	1.833AsnPro: 1.833 ± 0.056	3.292AsnGln: 3.292 ± 0.093	1.822AsnArg: 1.822 ± 0.06	2.439AsnSer: 2.439 ± 0.069	2.422AsnThr: 2.422 ± 0.066	3.1AsnVal: 3.1 ± 0.076	0.389AsnTrp: 0.389 ± 0.027	2.527AsnTyr: 2.527 ± 0.069	0.0AsnXaa: 0.0 ± 0.0
Pro	1.52ProAla: 1.52 ± 0.058	0.386ProCys: 0.386 ± 0.024	1.677ProAsp: 1.677 ± 0.052	2.06ProGlu: 2.06 ± 0.072	1.434ProPhe: 1.434 ± 0.045	1.685ProGly: 1.685 ± 0.06	0.831ProHis: 0.831 ± 0.04	2.382ProIle: 2.382 ± 0.063	1.691ProLys: 1.691 ± 0.057	2.794ProLeu: 2.794 ± 0.073	0.801ProMet: 0.801 ± 0.036	1.21ProAsn: 1.21 ± 0.042	0.465ProPro: 0.465 ± 0.027	1.338ProGln: 1.338 ± 0.041	0.959ProArg: 0.959 ± 0.042	1.638ProSer: 1.638 ± 0.041	1.666ProThr: 1.666 ± 0.058	2.133ProVal: 2.133 ± 0.069	0.194ProTrp: 0.194 ± 0.017	1.546ProTyr: 1.546 ± 0.051	0.0ProXaa: 0.0 ± 0.0
Gln	2.578GlnAla: 2.578 ± 0.072	0.533GlnCys: 0.533 ± 0.031	2.578GlnAsp: 2.578 ± 0.072	3.078GlnGlu: 3.078 ± 0.075	1.752GlnPhe: 1.752 ± 0.057	2.343GlnGly: 2.343 ± 0.068	0.876GlnHis: 0.876 ± 0.036	3.464GlnIle: 3.464 ± 0.072	3.045GlnLys: 3.045 ± 0.079	4.16GlnLeu: 4.16 ± 0.099	1.21GlnMet: 1.21 ± 0.052	2.297GlnAsn: 2.297 ± 0.069	0.998GlnPro: 0.998 ± 0.037	1.594GlnGln: 1.594 ± 0.051	1.462GlnArg: 1.462 ± 0.048	2.211GlnSer: 2.211 ± 0.067	2.083GlnThr: 2.083 ± 0.058	2.678GlnVal: 2.678 ± 0.067	0.283GlnTrp: 0.283 ± 0.021	2.335GlnTyr: 2.335 ± 0.074	0.0GlnXaa: 0.0 ± 0.0
Arg	1.612ArgAla: 1.612 ± 0.056	0.483ArgCys: 0.483 ± 0.029	1.74ArgAsp: 1.74 ± 0.053	2.058ArgGlu: 2.058 ± 0.065	1.516ArgPhe: 1.516 ± 0.054	1.827ArgGly: 1.827 ± 0.058	0.828ArgHis: 0.828 ± 0.031	2.906ArgIle: 2.906 ± 0.073	2.774ArgLys: 2.774 ± 0.073	3.173ArgLeu: 3.173 ± 0.075	1.02ArgMet: 1.02 ± 0.04	1.619ArgAsn: 1.619 ± 0.054	0.931ArgPro: 0.931 ± 0.038	1.354ArgGln: 1.354 ± 0.048	1.285ArgArg: 1.285 ± 0.046	1.619ArgSer: 1.619 ± 0.047	1.479ArgThr: 1.479 ± 0.048	2.182ArgVal: 2.182 ± 0.059	0.231ArgTrp: 0.231 ± 0.021	1.994ArgTyr: 1.994 ± 0.06	0.0ArgXaa: 0.0 ± 0.0
Ser	2.731SerAla: 2.731 ± 0.067	0.695SerCys: 0.695 ± 0.038	3.22SerAsp: 3.22 ± 0.072	2.824SerGlu: 2.824 ± 0.067	2.966SerPhe: 2.966 ± 0.075	3.846SerGly: 3.846 ± 0.092	1.599SerHis: 1.599 ± 0.048	4.991SerIle: 4.991 ± 0.098	4.351SerLys: 4.351 ± 0.09	6.27SerLeu: 6.27 ± 0.1	1.71SerMet: 1.71 ± 0.053	2.72SerAsn: 2.72 ± 0.069	1.449SerPro: 1.449 ± 0.049	2.795SerGln: 2.795 ± 0.077	1.961SerArg: 1.961 ± 0.057	3.864SerSer: 3.864 ± 0.097	2.889SerThr: 2.889 ± 0.074	3.511SerVal: 3.511 ± 0.081	0.469SerTrp: 0.469 ± 0.035	2.758SerTyr: 2.758 ± 0.073	0.0SerXaa: 0.0 ± 0.0
Thr	2.611ThrAla: 2.611 ± 0.08	0.69ThrCys: 0.69 ± 0.033	2.36ThrAsp: 2.36 ± 0.078	2.077ThrGlu: 2.077 ± 0.062	2.241ThrPhe: 2.241 ± 0.065	3.692ThrGly: 3.692 ± 0.091	1.137ThrHis: 1.137 ± 0.042	4.954ThrIle: 4.954 ± 0.094	3.731ThrLys: 3.731 ± 0.081	5.236ThrLeu: 5.236 ± 0.105	1.39ThrMet: 1.39 ± 0.054	2.452ThrAsn: 2.452 ± 0.063	1.829ThrPro: 1.829 ± 0.063	1.64ThrGln: 1.64 ± 0.052	1.557ThrArg: 1.557 ± 0.052	3.262ThrSer: 3.262 ± 0.072	2.906ThrThr: 2.906 ± 0.067	3.715ThrVal: 3.715 ± 0.096	0.35ThrTrp: 0.35 ± 0.034	2.647ThrTyr: 2.647 ± 0.072	0.0ThrXaa: 0.0 ± 0.0
Val	4.104ValAla: 4.104 ± 0.085	1.121ValCys: 1.121 ± 0.044	4.385ValAsp: 4.385 ± 0.089	4.362ValGlu: 4.362 ± 0.091	2.831ValPhe: 2.831 ± 0.078	4.064ValGly: 4.064 ± 0.093	1.321ValHis: 1.321 ± 0.052	5.87ValIle: 5.87 ± 0.102	5.094ValLys: 5.094 ± 0.103	6.358ValLeu: 6.358 ± 0.105	1.78ValMet: 1.78 ± 0.048	3.287ValAsn: 3.287 ± 0.067	2.002ValPro: 2.002 ± 0.058	1.843ValGln: 1.843 ± 0.057	1.893ValArg: 1.893 ± 0.054	4.349ValSer: 4.349 ± 0.091	3.362ValThr: 3.362 ± 0.079	4.724ValVal: 4.724 ± 0.102	0.355ValTrp: 0.355 ± 0.026	2.906ValTyr: 2.906 ± 0.071	0.0ValXaa: 0.0 ± 0.0
Trp	0.365TrpAla: 0.365 ± 0.023	0.117TrpCys: 0.117 ± 0.013	0.308TrpAsp: 0.308 ± 0.023	0.27TrpGlu: 0.27 ± 0.027	0.333TrpPhe: 0.333 ± 0.024	0.433TrpGly: 0.433 ± 0.028	0.187TrpHis: 0.187 ± 0.018	0.579TrpIle: 0.579 ± 0.033	0.459TrpLys: 0.459 ± 0.03	0.712TrpLeu: 0.712 ± 0.032	0.233TrpMet: 0.233 ± 0.018	0.378TrpAsn: 0.378 ± 0.026	0.148TrpPro: 0.148 ± 0.014	0.32TrpGln: 0.32 ± 0.019	0.208TrpArg: 0.208 ± 0.019	0.381TrpSer: 0.381 ± 0.024	0.275TrpThr: 0.275 ± 0.025	0.342TrpVal: 0.342 ± 0.024	0.084TrpTrp: 0.084 ± 0.012	0.305TrpTyr: 0.305 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.421TyrAla: 2.421 ± 0.056	0.757TyrCys: 0.757 ± 0.037	3.273TyrAsp: 3.273 ± 0.079	2.63TyrGlu: 2.63 ± 0.068	2.333TyrPhe: 2.333 ± 0.062	2.87TyrGly: 2.87 ± 0.067	1.793TyrHis: 1.793 ± 0.057	3.678TyrIle: 3.678 ± 0.092	2.916TyrLys: 2.916 ± 0.075	4.974TyrLeu: 4.974 ± 0.103	1.154TyrMet: 1.154 ± 0.042	2.239TyrAsn: 2.239 ± 0.067	1.58TyrPro: 1.58 ± 0.054	3.308TyrGln: 3.308 ± 0.083	1.807TyrArg: 1.807 ± 0.053	2.617TyrSer: 2.617 ± 0.066	2.174TyrThr: 2.174 ± 0.072	3.002TyrVal: 3.002 ± 0.07	0.34TyrTrp: 0.34 ± 0.029	2.483TyrTyr: 2.483 ± 0.083	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2067 proteins (640331 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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