Amino acid dipepetide frequency for Desulfovibrio sp. X2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.532AlaAla: 17.532 ± 0.207	1.75AlaCys: 1.75 ± 0.048	6.15AlaAsp: 6.15 ± 0.074	8.113AlaGlu: 8.113 ± 0.1	4.103AlaPhe: 4.103 ± 0.073	10.574AlaGly: 10.574 ± 0.11	2.184AlaHis: 2.184 ± 0.048	3.961AlaIle: 3.961 ± 0.065	4.149AlaLys: 4.149 ± 0.071	13.089AlaLeu: 13.089 ± 0.124	3.358AlaMet: 3.358 ± 0.044	2.161AlaAsn: 2.161 ± 0.045	5.746AlaPro: 5.746 ± 0.091	3.769AlaGln: 3.769 ± 0.08	9.459AlaArg: 9.459 ± 0.117	5.853AlaSer: 5.853 ± 0.078	4.715AlaThr: 4.715 ± 0.065	9.239AlaVal: 9.239 ± 0.104	1.478AlaTrp: 1.478 ± 0.04	2.453AlaTyr: 2.453 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.513CysAla: 1.513 ± 0.04	0.274CysCys: 0.274 ± 0.016	0.641CysAsp: 0.641 ± 0.022	0.699CysGlu: 0.699 ± 0.026	0.456CysPhe: 0.456 ± 0.019	1.496CysGly: 1.496 ± 0.045	0.397CysHis: 0.397 ± 0.024	0.524CysIle: 0.524 ± 0.024	0.364CysLys: 0.364 ± 0.018	1.592CysLeu: 1.592 ± 0.04	0.3CysMet: 0.3 ± 0.016	0.292CysAsn: 0.292 ± 0.017	0.925CysPro: 0.925 ± 0.034	0.262CysGln: 0.262 ± 0.015	1.074CysArg: 1.074 ± 0.033	0.714CysSer: 0.714 ± 0.027	0.555CysThr: 0.555 ± 0.023	0.899CysVal: 0.899 ± 0.03	0.165CysTrp: 0.165 ± 0.011	0.3CysTyr: 0.3 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	6.096AspAla: 6.096 ± 0.078	0.648AspCys: 0.648 ± 0.029	2.824AspAsp: 2.824 ± 0.053	3.901AspGlu: 3.901 ± 0.072	2.39AspPhe: 2.39 ± 0.047	4.639AspGly: 4.639 ± 0.07	1.033AspHis: 1.033 ± 0.033	2.687AspIle: 2.687 ± 0.052	2.121AspLys: 2.121 ± 0.042	5.922AspLeu: 5.922 ± 0.069	1.552AspMet: 1.552 ± 0.034	1.132AspAsn: 1.132 ± 0.033	3.134AspPro: 3.134 ± 0.047	1.403AspGln: 1.403 ± 0.042	3.275AspArg: 3.275 ± 0.058	2.392AspSer: 2.392 ± 0.043	2.301AspThr: 2.301 ± 0.046	4.28AspVal: 4.28 ± 0.068	0.741AspTrp: 0.741 ± 0.028	1.588AspTyr: 1.588 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	8.139GluAla: 8.139 ± 0.092	0.616GluCys: 0.616 ± 0.025	3.32GluAsp: 3.32 ± 0.054	4.827GluGlu: 4.827 ± 0.091	2.034GluPhe: 2.034 ± 0.044	4.696GluGly: 4.696 ± 0.066	1.441GluHis: 1.441 ± 0.042	3.488GluIle: 3.488 ± 0.06	3.12GluLys: 3.12 ± 0.061	6.584GluLeu: 6.584 ± 0.083	1.803GluMet: 1.803 ± 0.043	1.859GluAsn: 1.859 ± 0.041	2.734GluPro: 2.734 ± 0.057	2.286GluGln: 2.286 ± 0.044	5.57GluArg: 5.57 ± 0.089	2.988GluSer: 2.988 ± 0.044	3.042GluThr: 3.042 ± 0.056	4.388GluVal: 4.388 ± 0.064	0.638GluTrp: 0.638 ± 0.026	1.36GluTyr: 1.36 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.234PheAla: 4.234 ± 0.062	0.671PheCys: 0.671 ± 0.027	2.166PheAsp: 2.166 ± 0.048	2.156PheGlu: 2.156 ± 0.044	1.667PhePhe: 1.667 ± 0.046	3.327PheGly: 3.327 ± 0.06	0.775PheHis: 0.775 ± 0.025	1.523PheIle: 1.523 ± 0.044	1.236PheLys: 1.236 ± 0.032	4.532PheLeu: 4.532 ± 0.076	0.878PheMet: 0.878 ± 0.029	0.931PheAsn: 0.931 ± 0.031	1.777PhePro: 1.777 ± 0.043	0.935PheGln: 0.935 ± 0.031	2.23PheArg: 2.23 ± 0.043	2.488PheSer: 2.488 ± 0.054	2.12PheThr: 2.12 ± 0.047	2.874PheVal: 2.874 ± 0.049	0.6PheTrp: 0.6 ± 0.028	1.047PheTyr: 1.047 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	8.499GlyAla: 8.499 ± 0.088	1.248GlyCys: 1.248 ± 0.037	4.041GlyAsp: 4.041 ± 0.058	5.678GlyGlu: 5.678 ± 0.081	3.41GlyPhe: 3.41 ± 0.061	7.385GlyGly: 7.385 ± 0.084	1.94GlyHis: 1.94 ± 0.051	3.956GlyIle: 3.956 ± 0.059	3.795GlyLys: 3.795 ± 0.066	10.375GlyLeu: 10.375 ± 0.106	2.579GlyMet: 2.579 ± 0.05	1.981GlyAsn: 1.981 ± 0.045	3.622GlyPro: 3.622 ± 0.063	2.947GlyGln: 2.947 ± 0.058	7.056GlyArg: 7.056 ± 0.087	4.433GlySer: 4.433 ± 0.062	4.268GlyThr: 4.268 ± 0.063	6.07GlyVal: 6.07 ± 0.081	1.011GlyTrp: 1.011 ± 0.033	2.226GlyTyr: 2.226 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.199HisAla: 2.199 ± 0.041	0.322HisCys: 0.322 ± 0.018	1.2HisAsp: 1.2 ± 0.036	1.31HisGlu: 1.31 ± 0.032	0.882HisPhe: 0.882 ± 0.031	2.014HisGly: 2.014 ± 0.05	0.517HisHis: 0.517 ± 0.027	0.859HisIle: 0.859 ± 0.026	0.647HisLys: 0.647 ± 0.026	2.219HisLeu: 2.219 ± 0.046	0.507HisMet: 0.507 ± 0.022	0.474HisAsn: 0.474 ± 0.022	1.336HisPro: 1.336 ± 0.038	0.491HisGln: 0.491 ± 0.021	1.196HisArg: 1.196 ± 0.035	0.94HisSer: 0.94 ± 0.032	0.891HisThr: 0.891 ± 0.034	1.509HisVal: 1.509 ± 0.035	0.251HisTrp: 0.251 ± 0.014	0.508HisTyr: 0.508 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	4.582IleAla: 4.582 ± 0.07	0.64IleCys: 0.64 ± 0.023	2.293IleAsp: 2.293 ± 0.044	2.788IleGlu: 2.788 ± 0.054	1.773IlePhe: 1.773 ± 0.046	3.505IleGly: 3.505 ± 0.064	0.807IleHis: 0.807 ± 0.026	2.053IleIle: 2.053 ± 0.051	1.617IleLys: 1.617 ± 0.047	4.688IleLeu: 4.688 ± 0.081	1.133IleMet: 1.133 ± 0.031	1.122IleAsn: 1.122 ± 0.035	2.301IlePro: 2.301 ± 0.046	1.107IleGln: 1.107 ± 0.03	2.77IleArg: 2.77 ± 0.052	2.486IleSer: 2.486 ± 0.053	2.126IleThr: 2.126 ± 0.038	3.426IleVal: 3.426 ± 0.054	0.424IleTrp: 0.424 ± 0.02	1.067IleTyr: 1.067 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	4.597LysAla: 4.597 ± 0.084	0.316LysCys: 0.316 ± 0.017	2.221LysAsp: 2.221 ± 0.052	2.44LysGlu: 2.44 ± 0.055	0.984LysPhe: 0.984 ± 0.033	3.219LysGly: 3.219 ± 0.06	0.593LysHis: 0.593 ± 0.025	1.798LysIle: 1.798 ± 0.041	1.992LysLys: 1.992 ± 0.053	3.422LysLeu: 3.422 ± 0.066	0.918LysMet: 0.918 ± 0.03	1.158LysAsn: 1.158 ± 0.034	1.989LysPro: 1.989 ± 0.042	0.972LysGln: 0.972 ± 0.033	2.473LysArg: 2.473 ± 0.051	1.972LysSer: 1.972 ± 0.051	2.034LysThr: 2.034 ± 0.045	2.549LysVal: 2.549 ± 0.053	0.33LysTrp: 0.33 ± 0.016	0.804LysTyr: 0.804 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	15.513LeuAla: 15.513 ± 0.16	1.639LeuCys: 1.639 ± 0.04	6.463LeuAsp: 6.463 ± 0.073	6.148LeuGlu: 6.148 ± 0.071	4.199LeuPhe: 4.199 ± 0.078	9.341LeuGly: 9.341 ± 0.101	2.193LeuHis: 2.193 ± 0.043	3.721LeuIle: 3.721 ± 0.068	3.682LeuLys: 3.682 ± 0.064	12.383LeuLeu: 12.383 ± 0.14	2.265LeuMet: 2.265 ± 0.043	2.345LeuAsn: 2.345 ± 0.049	6.493LeuPro: 6.493 ± 0.081	2.613LeuGln: 2.613 ± 0.049	8.076LeuArg: 8.076 ± 0.104	7.192LeuSer: 7.192 ± 0.091	5.49LeuThr: 5.49 ± 0.068	7.786LeuVal: 7.786 ± 0.104	1.199LeuTrp: 1.199 ± 0.033	2.219LeuTyr: 2.219 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.234MetAla: 3.234 ± 0.051	0.236MetCys: 0.236 ± 0.015	1.565MetAsp: 1.565 ± 0.037	1.538MetGlu: 1.538 ± 0.044	0.674MetPhe: 0.674 ± 0.023	2.099MetGly: 2.099 ± 0.046	0.55MetHis: 0.55 ± 0.021	0.98MetIle: 0.98 ± 0.032	0.993MetLys: 0.993 ± 0.027	2.548MetLeu: 2.548 ± 0.044	0.439MetMet: 0.439 ± 0.02	0.778MetAsn: 0.778 ± 0.03	1.459MetPro: 1.459 ± 0.036	0.848MetGln: 0.848 ± 0.029	2.006MetArg: 2.006 ± 0.04	1.583MetSer: 1.583 ± 0.037	1.371MetThr: 1.371 ± 0.034	1.768MetVal: 1.768 ± 0.04	0.202MetTrp: 0.202 ± 0.014	0.455MetTyr: 0.455 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.474AsnAla: 2.474 ± 0.048	0.301AsnCys: 0.301 ± 0.015	1.156AsnAsp: 1.156 ± 0.038	1.211AsnGlu: 1.211 ± 0.035	1.002AsnPhe: 1.002 ± 0.031	1.912AsnGly: 1.912 ± 0.044	0.435AsnHis: 0.435 ± 0.021	1.286AsnIle: 1.286 ± 0.038	0.793AsnLys: 0.793 ± 0.028	2.691AsnLeu: 2.691 ± 0.057	0.669AsnMet: 0.669 ± 0.026	0.577AsnAsn: 0.577 ± 0.026	1.662AsnPro: 1.662 ± 0.042	0.632AsnGln: 0.632 ± 0.025	1.488AsnArg: 1.488 ± 0.031	1.085AsnSer: 1.085 ± 0.03	1.107AsnThr: 1.107 ± 0.037	1.887AsnVal: 1.887 ± 0.04	0.297AsnTrp: 0.297 ± 0.013	0.611AsnTyr: 0.611 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.186ProAla: 6.186 ± 0.088	0.627ProCys: 0.627 ± 0.027	3.602ProAsp: 3.602 ± 0.061	4.582ProGlu: 4.582 ± 0.064	2.017ProPhe: 2.017 ± 0.045	5.628ProGly: 5.628 ± 0.08	1.085ProHis: 1.085 ± 0.032	1.617ProIle: 1.617 ± 0.038	1.699ProLys: 1.699 ± 0.04	5.196ProLeu: 5.196 ± 0.073	1.099ProMet: 1.099 ± 0.037	0.922ProAsn: 0.922 ± 0.026	2.64ProPro: 2.64 ± 0.061	1.451ProGln: 1.451 ± 0.042	3.299ProArg: 3.299 ± 0.055	2.715ProSer: 2.715 ± 0.048	2.019ProThr: 2.019 ± 0.043	3.979ProVal: 3.979 ± 0.055	0.739ProTrp: 0.739 ± 0.026	1.167ProTyr: 1.167 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.261GlnAla: 4.261 ± 0.083	0.323GlnCys: 0.323 ± 0.015	1.647GlnAsp: 1.647 ± 0.043	1.895GlnGlu: 1.895 ± 0.042	0.784GlnPhe: 0.784 ± 0.024	2.826GlnGly: 2.826 ± 0.051	0.526GlnHis: 0.526 ± 0.021	1.467GlnIle: 1.467 ± 0.039	1.242GlnLys: 1.242 ± 0.035	2.241GlnLeu: 2.241 ± 0.048	0.796GlnMet: 0.796 ± 0.024	0.831GlnAsn: 0.831 ± 0.026	1.211GlnPro: 1.211 ± 0.031	1.02GlnGln: 1.02 ± 0.039	1.899GlnArg: 1.899 ± 0.041	1.579GlnSer: 1.579 ± 0.043	1.47GlnThr: 1.47 ± 0.038	2.039GlnVal: 2.039 ± 0.043	0.319GlnTrp: 0.319 ± 0.018	0.577GlnTyr: 0.577 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.798ArgAla: 7.798 ± 0.099	0.828ArgCys: 0.828 ± 0.029	3.82ArgAsp: 3.82 ± 0.064	5.715ArgGlu: 5.715 ± 0.087	3.022ArgPhe: 3.022 ± 0.052	5.147ArgGly: 5.147 ± 0.065	1.685ArgHis: 1.685 ± 0.041	3.708ArgIle: 3.708 ± 0.058	2.648ArgLys: 2.648 ± 0.059	9.087ArgLeu: 9.087 ± 0.112	2.028ArgMet: 2.028 ± 0.039	1.624ArgAsn: 1.624 ± 0.041	3.601ArgPro: 3.601 ± 0.061	2.365ArgGln: 2.365 ± 0.052	5.909ArgArg: 5.909 ± 0.085	3.42ArgSer: 3.42 ± 0.049	3.494ArgThr: 3.494 ± 0.052	4.875ArgVal: 4.875 ± 0.064	0.757ArgTrp: 0.757 ± 0.027	1.678ArgTyr: 1.678 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.643SerAla: 5.643 ± 0.071	0.746SerCys: 0.746 ± 0.027	2.533SerAsp: 2.533 ± 0.049	2.987SerGlu: 2.987 ± 0.051	2.325SerPhe: 2.325 ± 0.045	5.813SerGly: 5.813 ± 0.07	1.024SerHis: 1.024 ± 0.034	2.343SerIle: 2.343 ± 0.047	1.558SerLys: 1.558 ± 0.038	6.472SerLeu: 6.472 ± 0.086	1.412SerMet: 1.412 ± 0.033	1.086SerAsn: 1.086 ± 0.03	2.96SerPro: 2.96 ± 0.053	1.479SerGln: 1.479 ± 0.036	3.863SerArg: 3.863 ± 0.054	2.979SerSer: 2.979 ± 0.07	2.319SerThr: 2.319 ± 0.049	3.949SerVal: 3.949 ± 0.06	0.704SerTrp: 0.704 ± 0.026	1.185SerTyr: 1.185 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.622ThrAla: 5.622 ± 0.08	0.633ThrCys: 0.633 ± 0.026	2.422ThrAsp: 2.422 ± 0.048	2.291ThrGlu: 2.291 ± 0.045	1.872ThrPhe: 1.872 ± 0.041	4.734ThrGly: 4.734 ± 0.077	0.87ThrHis: 0.87 ± 0.032	2.15ThrIle: 2.15 ± 0.045	1.401ThrLys: 1.401 ± 0.032	5.278ThrLeu: 5.278 ± 0.067	1.138ThrMet: 1.138 ± 0.028	1.064ThrAsn: 1.064 ± 0.034	3.102ThrPro: 3.102 ± 0.053	1.22ThrGln: 1.22 ± 0.036	3.13ThrArg: 3.13 ± 0.053	2.389ThrSer: 2.389 ± 0.05	2.369ThrThr: 2.369 ± 0.049	3.781ThrVal: 3.781 ± 0.06	0.579ThrTrp: 0.579 ± 0.02	1.139ThrTyr: 1.139 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	8.168ValAla: 8.168 ± 0.097	1.115ValCys: 1.115 ± 0.035	3.956ValAsp: 3.956 ± 0.064	4.591ValGlu: 4.591 ± 0.065	3.085ValPhe: 3.085 ± 0.053	5.276ValGly: 5.276 ± 0.081	1.48ValHis: 1.48 ± 0.04	3.193ValIle: 3.193 ± 0.061	2.455ValLys: 2.455 ± 0.05	8.542ValLeu: 8.542 ± 0.096	1.689ValMet: 1.689 ± 0.043	2.013ValAsn: 2.013 ± 0.041	3.797ValPro: 3.797 ± 0.068	2.079ValGln: 2.079 ± 0.045	5.799ValArg: 5.799 ± 0.071	4.29ValSer: 4.29 ± 0.057	3.715ValThr: 3.715 ± 0.058	6.178ValVal: 6.178 ± 0.083	0.882ValTrp: 0.882 ± 0.025	1.616ValTyr: 1.616 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.078TrpAla: 1.078 ± 0.035	0.16TrpCys: 0.16 ± 0.011	0.62TrpAsp: 0.62 ± 0.024	0.696TrpGlu: 0.696 ± 0.021	0.468TrpPhe: 0.468 ± 0.02	0.865TrpGly: 0.865 ± 0.024	0.269TrpHis: 0.269 ± 0.014	0.552TrpIle: 0.552 ± 0.022	0.461TrpLys: 0.461 ± 0.022	1.55TrpLeu: 1.55 ± 0.043	0.277TrpMet: 0.277 ± 0.016	0.344TrpAsn: 0.344 ± 0.018	0.682TrpPro: 0.682 ± 0.023	0.423TrpGln: 0.423 ± 0.02	1.034TrpArg: 1.034 ± 0.035	0.591TrpSer: 0.591 ± 0.02	0.617TrpThr: 0.617 ± 0.02	0.675TrpVal: 0.675 ± 0.023	0.203TrpTrp: 0.203 ± 0.012	0.284TrpTyr: 0.284 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.47TyrAla: 2.47 ± 0.046	0.35TyrCys: 0.35 ± 0.016	1.417TyrAsp: 1.417 ± 0.037	1.366TyrGlu: 1.366 ± 0.032	1.019TyrPhe: 1.019 ± 0.033	2.025TyrGly: 2.025 ± 0.046	0.469TyrHis: 0.469 ± 0.019	0.843TyrIle: 0.843 ± 0.031	0.809TyrLys: 0.809 ± 0.027	2.549TyrLeu: 2.549 ± 0.047	0.488TyrMet: 0.488 ± 0.024	0.581TyrAsn: 0.581 ± 0.023	1.095TyrPro: 1.095 ± 0.03	0.652TyrGln: 0.652 ± 0.026	1.605TyrArg: 1.605 ± 0.036	1.292TyrSer: 1.292 ± 0.036	1.16TyrThr: 1.16 ± 0.034	1.769TyrVal: 1.769 ± 0.042	0.327TyrTrp: 0.327 ± 0.017	0.668TyrTyr: 0.668 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3444 proteins (1149838 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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