Amino acid dipepetide frequency for Mameliella alba

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.196AlaAla: 16.196 ± 0.137
1.201AlaCys: 1.201 ± 0.029
6.987AlaAsp: 6.987 ± 0.074
8.634AlaGlu: 8.634 ± 0.092
4.158AlaPhe: 4.158 ± 0.057
10.637AlaGly: 10.637 ± 0.091
2.367AlaHis: 2.367 ± 0.04
5.362AlaIle: 5.362 ± 0.062
3.382AlaLys: 3.382 ± 0.057
14.285AlaLeu: 14.285 ± 0.115
3.628AlaMet: 3.628 ± 0.049
2.456AlaAsn: 2.456 ± 0.038
6.282AlaPro: 6.282 ± 0.081
4.607AlaGln: 4.607 ± 0.053
9.522AlaArg: 9.522 ± 0.093
5.384AlaSer: 5.384 ± 0.052
5.708AlaThr: 5.708 ± 0.061
8.351AlaVal: 8.351 ± 0.08
1.546AlaTrp: 1.546 ± 0.03
2.488AlaTyr: 2.488 ± 0.04
0.0AlaXaa: 0.0 ± 0.0
Cys
1.137CysAla: 1.137 ± 0.027
0.121CysCys: 0.121 ± 0.009
0.645CysAsp: 0.645 ± 0.021
0.48CysGlu: 0.48 ± 0.018
0.357CysPhe: 0.357 ± 0.014
1.002CysGly: 1.002 ± 0.025
0.295CysHis: 0.295 ± 0.014
0.42CysIle: 0.42 ± 0.016
0.225CysLys: 0.225 ± 0.011
0.945CysLeu: 0.945 ± 0.025
0.203CysMet: 0.203 ± 0.011
0.215CysAsn: 0.215 ± 0.012
0.553CysPro: 0.553 ± 0.02
0.25CysGln: 0.25 ± 0.01
0.627CysArg: 0.627 ± 0.019
0.463CysSer: 0.463 ± 0.017
0.508CysThr: 0.508 ± 0.019
0.637CysVal: 0.637 ± 0.023
0.147CysTrp: 0.147 ± 0.009
0.226CysTyr: 0.226 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.177AspAla: 7.177 ± 0.073
0.564AspCys: 0.564 ± 0.022
3.47AspAsp: 3.47 ± 0.061
3.652AspGlu: 3.652 ± 0.045
2.356AspPhe: 2.356 ± 0.039
5.96AspGly: 5.96 ± 0.104
1.416AspHis: 1.416 ± 0.031
2.839AspIle: 2.839 ± 0.037
1.709AspLys: 1.709 ± 0.036
6.808AspLeu: 6.808 ± 0.072
1.832AspMet: 1.832 ± 0.033
1.344AspAsn: 1.344 ± 0.031
4.098AspPro: 4.098 ± 0.051
1.841AspGln: 1.841 ± 0.035
4.799AspArg: 4.799 ± 0.058
2.377AspSer: 2.377 ± 0.044
3.194AspThr: 3.194 ± 0.059
4.184AspVal: 4.184 ± 0.051
1.341AspTrp: 1.341 ± 0.028
1.613AspTyr: 1.613 ± 0.028
0.0AspXaa: 0.0 ± 0.0
Glu
8.665GluAla: 8.665 ± 0.075
0.385GluCys: 0.385 ± 0.015
3.589GluAsp: 3.589 ± 0.053
3.725GluGlu: 3.725 ± 0.059
1.783GluPhe: 1.783 ± 0.036
5.257GluGly: 5.257 ± 0.06
1.117GluHis: 1.117 ± 0.028
3.644GluIle: 3.644 ± 0.046
2.045GluLys: 2.045 ± 0.037
5.004GluLeu: 5.004 ± 0.056
1.868GluMet: 1.868 ± 0.041
1.592GluAsn: 1.592 ± 0.03
2.628GluPro: 2.628 ± 0.042
1.838GluGln: 1.838 ± 0.033
4.215GluArg: 4.215 ± 0.059
2.212GluSer: 2.212 ± 0.037
4.053GluThr: 4.053 ± 0.051
4.634GluVal: 4.634 ± 0.062
0.74GluTrp: 0.74 ± 0.017
1.054GluTyr: 1.054 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.368PheAla: 4.368 ± 0.057
0.443PheCys: 0.443 ± 0.016
2.888PheAsp: 2.888 ± 0.045
2.195PheGlu: 2.195 ± 0.04
1.383PhePhe: 1.383 ± 0.034
3.631PheGly: 3.631 ± 0.039
0.769PheHis: 0.769 ± 0.021
1.512PheIle: 1.512 ± 0.028
0.837PheLys: 0.837 ± 0.023
3.412PheLeu: 3.412 ± 0.052
0.806PheMet: 0.806 ± 0.021
0.938PheAsn: 0.938 ± 0.025
1.585PhePro: 1.585 ± 0.033
0.98PheGln: 0.98 ± 0.023
2.246PheArg: 2.246 ± 0.032
2.011PheSer: 2.011 ± 0.035
2.04PheThr: 2.04 ± 0.037
2.659PheVal: 2.659 ± 0.041
0.583PheTrp: 0.583 ± 0.02
0.894PheTyr: 0.894 ± 0.025
0.0PheXaa: 0.0 ± 0.0
Gly
10.24GlyAla: 10.24 ± 0.085
0.944GlyCys: 0.944 ± 0.027
5.128GlyAsp: 5.128 ± 0.08
4.986GlyGlu: 4.986 ± 0.059
3.747GlyPhe: 3.747 ± 0.046
7.921GlyGly: 7.921 ± 0.093
2.055GlyHis: 2.055 ± 0.039
4.477GlyIle: 4.477 ± 0.053
3.059GlyLys: 3.059 ± 0.045
9.487GlyLeu: 9.487 ± 0.087
2.706GlyMet: 2.706 ± 0.046
2.273GlyAsn: 2.273 ± 0.049
4.017GlyPro: 4.017 ± 0.047
3.262GlyGln: 3.262 ± 0.049
5.985GlyArg: 5.985 ± 0.066
4.194GlySer: 4.194 ± 0.057
5.08GlyThr: 5.08 ± 0.063
6.282GlyVal: 6.282 ± 0.064
1.524GlyTrp: 1.524 ± 0.032
2.348GlyTyr: 2.348 ± 0.038
0.0GlyXaa: 0.0 ± 0.0
His
2.333HisAla: 2.333 ± 0.039
0.26HisCys: 0.26 ± 0.013
1.32HisAsp: 1.32 ± 0.031
1.07HisGlu: 1.07 ± 0.029
0.836HisPhe: 0.836 ± 0.026
2.034HisGly: 2.034 ± 0.041
0.571HisHis: 0.571 ± 0.022
0.892HisIle: 0.892 ± 0.026
0.485HisLys: 0.485 ± 0.017
2.136HisLeu: 2.136 ± 0.038
0.581HisMet: 0.581 ± 0.021
0.445HisAsn: 0.445 ± 0.015
1.418HisPro: 1.418 ± 0.027
0.562HisGln: 0.562 ± 0.019
1.41HisArg: 1.41 ± 0.028
0.923HisSer: 0.923 ± 0.026
0.809HisThr: 0.809 ± 0.026
1.677HisVal: 1.677 ± 0.034
0.37HisTrp: 0.37 ± 0.014
0.544HisTyr: 0.544 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
6.535IleAla: 6.535 ± 0.071
0.605IleCys: 0.605 ± 0.019
3.372IleAsp: 3.372 ± 0.047
3.39IleGlu: 3.39 ± 0.045
1.659IlePhe: 1.659 ± 0.035
4.648IleGly: 4.648 ± 0.055
0.915IleHis: 0.915 ± 0.022
1.86IleIle: 1.86 ± 0.038
1.22IleLys: 1.22 ± 0.025
4.565IleLeu: 4.565 ± 0.064
0.982IleMet: 0.982 ± 0.024
1.206IleAsn: 1.206 ± 0.03
2.272IlePro: 2.272 ± 0.037
1.136IleGln: 1.136 ± 0.027
3.082IleArg: 3.082 ± 0.045
2.642IleSer: 2.642 ± 0.041
2.77IleThr: 2.77 ± 0.043
3.531IleVal: 3.531 ± 0.05
0.654IleTrp: 0.654 ± 0.021
1.102IleTyr: 1.102 ± 0.028
0.0IleXaa: 0.0 ± 0.0
Lys
3.711LysAla: 3.711 ± 0.048
0.196LysCys: 0.196 ± 0.011
1.66LysAsp: 1.66 ± 0.038
1.441LysGlu: 1.441 ± 0.033
0.82LysPhe: 0.82 ± 0.026
2.614LysGly: 2.614 ± 0.045
0.546LysHis: 0.546 ± 0.018
1.382LysIle: 1.382 ± 0.034
1.029LysLys: 1.029 ± 0.027
2.721LysLeu: 2.721 ± 0.038
0.778LysMet: 0.778 ± 0.022
0.651LysAsn: 0.651 ± 0.021
1.789LysPro: 1.789 ± 0.039
0.832LysGln: 0.832 ± 0.024
2.11LysArg: 2.11 ± 0.043
1.579LysSer: 1.579 ± 0.035
1.805LysThr: 1.805 ± 0.035
2.163LysVal: 2.163 ± 0.042
0.366LysTrp: 0.366 ± 0.015
0.587LysTyr: 0.587 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
13.185LeuAla: 13.185 ± 0.108
1.062LeuCys: 1.062 ± 0.029
6.598LeuAsp: 6.598 ± 0.073
5.395LeuGlu: 5.395 ± 0.053
3.419LeuPhe: 3.419 ± 0.05
8.699LeuGly: 8.699 ± 0.092
1.898LeuHis: 1.898 ± 0.033
4.718LeuIle: 4.718 ± 0.064
2.962LeuLys: 2.962 ± 0.047
8.808LeuLeu: 8.808 ± 0.107
2.701LeuMet: 2.701 ± 0.046
2.579LeuAsn: 2.579 ± 0.046
5.821LeuPro: 5.821 ± 0.058
2.84LeuGln: 2.84 ± 0.041
7.349LeuArg: 7.349 ± 0.079
6.439LeuSer: 6.439 ± 0.074
6.023LeuThr: 6.023 ± 0.06
7.165LeuVal: 7.165 ± 0.074
1.363LeuTrp: 1.363 ± 0.029
2.015LeuTyr: 2.015 ± 0.037
0.0LeuXaa: 0.0 ± 0.0
Met
3.335MetAla: 3.335 ± 0.042
0.18MetCys: 0.18 ± 0.011
1.507MetAsp: 1.507 ± 0.028
1.356MetGlu: 1.356 ± 0.028
0.773MetPhe: 0.773 ± 0.024
2.239MetGly: 2.239 ± 0.041
0.465MetHis: 0.465 ± 0.017
1.509MetIle: 1.509 ± 0.031
1.026MetLys: 1.026 ± 0.026
2.536MetLeu: 2.536 ± 0.044
0.806MetMet: 0.806 ± 0.023
0.78MetAsn: 0.78 ± 0.019
1.581MetPro: 1.581 ± 0.029
0.988MetGln: 0.988 ± 0.021
1.968MetArg: 1.968 ± 0.033
1.806MetSer: 1.806 ± 0.034
2.231MetThr: 2.231 ± 0.036
1.792MetVal: 1.792 ± 0.034
0.225MetTrp: 0.225 ± 0.013
0.364MetTyr: 0.364 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
2.993AsnAla: 2.993 ± 0.045
0.269AsnCys: 0.269 ± 0.014
1.429AsnAsp: 1.429 ± 0.036
1.106AsnGlu: 1.106 ± 0.026
0.887AsnPhe: 0.887 ± 0.025
2.395AsnGly: 2.395 ± 0.048
0.49AsnHis: 0.49 ± 0.016
1.251AsnIle: 1.251 ± 0.032
0.602AsnLys: 0.602 ± 0.02
2.392AsnLeu: 2.392 ± 0.04
0.671AsnMet: 0.671 ± 0.02
0.601AsnAsn: 0.601 ± 0.023
1.72AsnPro: 1.72 ± 0.033
0.643AsnGln: 0.643 ± 0.02
1.74AsnArg: 1.74 ± 0.033
1.097AsnSer: 1.097 ± 0.032
1.285AsnThr: 1.285 ± 0.029
1.71AsnVal: 1.71 ± 0.031
0.432AsnTrp: 0.432 ± 0.015
0.62AsnTyr: 0.62 ± 0.02
0.0AsnXaa: 0.0 ± 0.0
Pro
6.012ProAla: 6.012 ± 0.06
0.402ProCys: 0.402 ± 0.014
4.43ProAsp: 4.43 ± 0.058
4.541ProGlu: 4.541 ± 0.054
1.93ProPhe: 1.93 ± 0.035
5.092ProGly: 5.092 ± 0.062
1.083ProHis: 1.083 ± 0.026
2.066ProIle: 2.066 ± 0.032
1.512ProLys: 1.512 ± 0.04
4.824ProLeu: 4.824 ± 0.061
1.315ProMet: 1.315 ± 0.029
1.237ProAsn: 1.237 ± 0.028
2.501ProPro: 2.501 ± 0.048
1.739ProGln: 1.739 ± 0.03
3.206ProArg: 3.206 ± 0.053
2.406ProSer: 2.406 ± 0.035
2.35ProThr: 2.35 ± 0.038
4.569ProVal: 4.569 ± 0.063
0.737ProTrp: 0.737 ± 0.019
1.131ProTyr: 1.131 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
4.274GlnAla: 4.274 ± 0.048
0.236GlnCys: 0.236 ± 0.011
1.94GlnAsp: 1.94 ± 0.034
1.699GlnGlu: 1.699 ± 0.033
1.039GlnPhe: 1.039 ± 0.024
2.796GlnGly: 2.796 ± 0.037
0.582GlnHis: 0.582 ± 0.018
1.793GlnIle: 1.793 ± 0.035
0.947GlnLys: 0.947 ± 0.024
2.802GlnLeu: 2.802 ± 0.04
1.028GlnMet: 1.028 ± 0.022
0.836GlnAsn: 0.836 ± 0.022
1.608GlnPro: 1.608 ± 0.032
1.049GlnGln: 1.049 ± 0.025
2.121GlnArg: 2.121 ± 0.042
1.679GlnSer: 1.679 ± 0.03
1.663GlnThr: 1.663 ± 0.029
2.533GlnVal: 2.533 ± 0.03
0.402GlnTrp: 0.402 ± 0.015
0.6GlnTyr: 0.6 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
8.61ArgAla: 8.61 ± 0.082
0.519ArgCys: 0.519 ± 0.02
4.597ArgAsp: 4.597 ± 0.054
4.009ArgGlu: 4.009 ± 0.053
2.766ArgPhe: 2.766 ± 0.041
4.956ArgGly: 4.956 ± 0.056
1.616ArgHis: 1.616 ± 0.033
3.938ArgIle: 3.938 ± 0.051
2.209ArgLys: 2.209 ± 0.034
7.783ArgLeu: 7.783 ± 0.077
2.04ArgMet: 2.04 ± 0.033
1.778ArgAsn: 1.778 ± 0.034
3.524ArgPro: 3.524 ± 0.049
2.44ArgGln: 2.44 ± 0.043
5.26ArgArg: 5.26 ± 0.07
3.182ArgSer: 3.182 ± 0.043
3.156ArgThr: 3.156 ± 0.044
4.898ArgVal: 4.898 ± 0.056
1.045ArgTrp: 1.045 ± 0.028
1.601ArgTyr: 1.601 ± 0.03
0.0ArgXaa: 0.0 ± 0.0
Ser
5.689SerAla: 5.689 ± 0.062
0.438SerCys: 0.438 ± 0.017
3.238SerAsp: 3.238 ± 0.05
2.777SerGlu: 2.777 ± 0.042
2.117SerPhe: 2.117 ± 0.035
5.591SerGly: 5.591 ± 0.061
1.045SerHis: 1.045 ± 0.027
2.29SerIle: 2.29 ± 0.044
1.336SerLys: 1.336 ± 0.032
4.858SerLeu: 4.858 ± 0.057
1.239SerMet: 1.239 ± 0.026
1.183SerAsn: 1.183 ± 0.028
2.572SerPro: 2.572 ± 0.037
1.479SerGln: 1.479 ± 0.029
3.233SerArg: 3.233 ± 0.038
2.398SerSer: 2.398 ± 0.037
2.402SerThr: 2.402 ± 0.041
3.703SerVal: 3.703 ± 0.049
0.733SerTrp: 0.733 ± 0.024
1.26SerTyr: 1.26 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
6.146ThrAla: 6.146 ± 0.059
0.547ThrCys: 0.547 ± 0.017
3.202ThrAsp: 3.202 ± 0.044
3.11ThrGlu: 3.11 ± 0.041
1.902ThrPhe: 1.902 ± 0.037
5.735ThrGly: 5.735 ± 0.068
1.16ThrHis: 1.16 ± 0.029
2.514ThrIle: 2.514 ± 0.044
1.241ThrLys: 1.241 ± 0.029
6.031ThrLeu: 6.031 ± 0.074
1.201ThrMet: 1.201 ± 0.027
1.264ThrAsn: 1.264 ± 0.028
3.494ThrPro: 3.494 ± 0.043
1.593ThrGln: 1.593 ± 0.029
3.811ThrArg: 3.811 ± 0.051
2.653ThrSer: 2.653 ± 0.045
2.689ThrThr: 2.689 ± 0.044
4.308ThrVal: 4.308 ± 0.051
0.768ThrTrp: 0.768 ± 0.019
1.294ThrTyr: 1.294 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
8.528ValAla: 8.528 ± 0.081
0.685ValCys: 0.685 ± 0.023
4.14ValAsp: 4.14 ± 0.054
4.483ValGlu: 4.483 ± 0.06
2.825ValPhe: 2.825 ± 0.041
5.3ValGly: 5.3 ± 0.055
1.371ValHis: 1.371 ± 0.03
4.052ValIle: 4.052 ± 0.051
1.97ValLys: 1.97 ± 0.04
7.714ValLeu: 7.714 ± 0.077
2.158ValMet: 2.158 ± 0.037
1.952ValAsn: 1.952 ± 0.041
3.808ValPro: 3.808 ± 0.054
2.214ValGln: 2.214 ± 0.032
4.448ValArg: 4.448 ± 0.054
4.203ValSer: 4.203 ± 0.054
4.935ValThr: 4.935 ± 0.061
5.591ValVal: 5.591 ± 0.062
0.959ValTrp: 0.959 ± 0.021
1.52ValTyr: 1.52 ± 0.031
0.0ValXaa: 0.0 ± 0.0
Trp
1.467TrpAla: 1.467 ± 0.028
0.153TrpCys: 0.153 ± 0.008
0.809TrpAsp: 0.809 ± 0.023
0.724TrpGlu: 0.724 ± 0.02
0.529TrpPhe: 0.529 ± 0.016
1.053TrpGly: 1.053 ± 0.025
0.393TrpHis: 0.393 ± 0.014
0.713TrpIle: 0.713 ± 0.021
0.435TrpLys: 0.435 ± 0.017
1.704TrpLeu: 1.704 ± 0.036
0.443TrpMet: 0.443 ± 0.016
0.429TrpAsn: 0.429 ± 0.014
0.724TrpPro: 0.724 ± 0.022
0.667TrpGln: 0.667 ± 0.022
1.188TrpArg: 1.188 ± 0.027
0.79TrpSer: 0.79 ± 0.024
0.848TrpThr: 0.848 ± 0.023
0.938TrpVal: 0.938 ± 0.023
0.226TrpTrp: 0.226 ± 0.012
0.296TrpTyr: 0.296 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.578TyrAla: 2.578 ± 0.043
0.249TyrCys: 0.249 ± 0.012
1.622TyrAsp: 1.622 ± 0.032
1.275TyrGlu: 1.275 ± 0.028
0.892TyrPhe: 0.892 ± 0.023
2.156TyrGly: 2.156 ± 0.035
0.522TyrHis: 0.522 ± 0.018
0.912TyrIle: 0.912 ± 0.022
0.549TyrLys: 0.549 ± 0.018
2.223TyrLeu: 2.223 ± 0.037
0.481TyrMet: 0.481 ± 0.016
0.574TyrAsn: 0.574 ± 0.019
1.09TyrPro: 1.09 ± 0.023
0.668TyrGln: 0.668 ± 0.02
1.607TyrArg: 1.607 ± 0.031
1.143TyrSer: 1.143 ± 0.028
1.115TyrThr: 1.115 ± 0.029
1.533TyrVal: 1.533 ± 0.028
0.368TyrTrp: 0.368 ± 0.015
0.576TyrTyr: 0.576 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5714 proteins (1739916 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski