Amino acid dipepetide frequency for Microcella alkaliphila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.538AlaAla: 20.538 ± 0.249	0.65AlaCys: 0.65 ± 0.033	8.779AlaAsp: 8.779 ± 0.128	8.63AlaGlu: 8.63 ± 0.103	3.693AlaPhe: 3.693 ± 0.07	11.781AlaGly: 11.781 ± 0.136	2.765AlaHis: 2.765 ± 0.064	6.485AlaIle: 6.485 ± 0.106	2.348AlaLys: 2.348 ± 0.065	14.654AlaLeu: 14.654 ± 0.183	2.636AlaMet: 2.636 ± 0.058	2.34AlaAsn: 2.34 ± 0.056	6.864AlaPro: 6.864 ± 0.12	3.561AlaGln: 3.561 ± 0.068	10.206AlaArg: 10.206 ± 0.158	7.149AlaSer: 7.149 ± 0.101	7.764AlaThr: 7.764 ± 0.104	11.726AlaVal: 11.726 ± 0.146	1.807AlaTrp: 1.807 ± 0.05	2.244AlaTyr: 2.244 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.62CysAla: 0.62 ± 0.03	0.046CysCys: 0.046 ± 0.009	0.361CysAsp: 0.361 ± 0.021	0.251CysGlu: 0.251 ± 0.018	0.148CysPhe: 0.148 ± 0.014	0.526CysGly: 0.526 ± 0.027	0.095CysHis: 0.095 ± 0.01	0.201CysIle: 0.201 ± 0.016	0.053CysLys: 0.053 ± 0.008	0.404CysLeu: 0.404 ± 0.026	0.071CysMet: 0.071 ± 0.009	0.11CysAsn: 0.11 ± 0.012	0.273CysPro: 0.273 ± 0.018	0.117CysGln: 0.117 ± 0.012	0.355CysArg: 0.355 ± 0.024	0.307CysSer: 0.307 ± 0.021	0.319CysThr: 0.319 ± 0.02	0.381CysVal: 0.381 ± 0.019	0.05CysTrp: 0.05 ± 0.008	0.081CysTyr: 0.081 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	9.639AspAla: 9.639 ± 0.139	0.234AspCys: 0.234 ± 0.02	4.957AspAsp: 4.957 ± 0.094	5.007AspGlu: 5.007 ± 0.089	1.621AspPhe: 1.621 ± 0.05	6.098AspGly: 6.098 ± 0.106	1.243AspHis: 1.243 ± 0.045	2.525AspIle: 2.525 ± 0.063	0.87AspLys: 0.87 ± 0.035	5.747AspLeu: 5.747 ± 0.082	0.852AspMet: 0.852 ± 0.032	1.054AspAsn: 1.054 ± 0.039	4.146AspPro: 4.146 ± 0.084	1.592AspGln: 1.592 ± 0.049	4.907AspArg: 4.907 ± 0.093	2.779AspSer: 2.779 ± 0.065	3.049AspThr: 3.049 ± 0.061	5.421AspVal: 5.421 ± 0.098	0.925AspTrp: 0.925 ± 0.036	1.277AspTyr: 1.277 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.356GluAla: 7.356 ± 0.106	0.27GluCys: 0.27 ± 0.019	2.102GluAsp: 2.102 ± 0.054	2.665GluGlu: 2.665 ± 0.067	1.806GluPhe: 1.806 ± 0.049	4.164GluGly: 4.164 ± 0.073	1.578GluHis: 1.578 ± 0.045	2.637GluIle: 2.637 ± 0.062	1.432GluLys: 1.432 ± 0.052	7.436GluLeu: 7.436 ± 0.099	0.885GluMet: 0.885 ± 0.039	1.383GluAsn: 1.383 ± 0.04	3.386GluPro: 3.386 ± 0.083	2.343GluGln: 2.343 ± 0.053	5.877GluArg: 5.877 ± 0.095	2.921GluSer: 2.921 ± 0.064	3.139GluThr: 3.139 ± 0.069	4.691GluVal: 4.691 ± 0.086	0.957GluTrp: 0.957 ± 0.037	1.09GluTyr: 1.09 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.15PheAla: 4.15 ± 0.079	0.162PheCys: 0.162 ± 0.014	2.224PheAsp: 2.224 ± 0.048	1.651PheGlu: 1.651 ± 0.05	1.074PhePhe: 1.074 ± 0.049	3.327PheGly: 3.327 ± 0.074	0.532PheHis: 0.532 ± 0.02	1.181PheIle: 1.181 ± 0.039	0.36PheLys: 0.36 ± 0.02	2.702PheLeu: 2.702 ± 0.071	0.458PheMet: 0.458 ± 0.026	0.578PheAsn: 0.578 ± 0.029	1.402PhePro: 1.402 ± 0.045	0.694PheGln: 0.694 ± 0.031	1.864PheArg: 1.864 ± 0.044	1.658PheSer: 1.658 ± 0.048	2.048PheThr: 2.048 ± 0.053	2.802PheVal: 2.802 ± 0.065	0.426PheTrp: 0.426 ± 0.022	0.591PheTyr: 0.591 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	10.867GlyAla: 10.867 ± 0.144	0.505GlyCys: 0.505 ± 0.025	5.321GlyAsp: 5.321 ± 0.091	5.075GlyGlu: 5.075 ± 0.085	3.104GlyPhe: 3.104 ± 0.058	7.502GlyGly: 7.502 ± 0.128	1.828GlyHis: 1.828 ± 0.049	4.678GlyIle: 4.678 ± 0.093	1.898GlyLys: 1.898 ± 0.05	8.713GlyLeu: 8.713 ± 0.121	1.917GlyMet: 1.917 ± 0.048	1.627GlyAsn: 1.627 ± 0.053	3.727GlyPro: 3.727 ± 0.067	2.462GlyGln: 2.462 ± 0.064	6.377GlyArg: 6.377 ± 0.106	5.149GlySer: 5.149 ± 0.077	5.082GlyThr: 5.082 ± 0.078	8.022GlyVal: 8.022 ± 0.101	1.496GlyTrp: 1.496 ± 0.042	2.075GlyTyr: 2.075 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	2.473HisAla: 2.473 ± 0.065	0.105HisCys: 0.105 ± 0.012	1.434HisAsp: 1.434 ± 0.051	1.235HisGlu: 1.235 ± 0.042	0.551HisPhe: 0.551 ± 0.024	1.931HisGly: 1.931 ± 0.052	0.595HisHis: 0.595 ± 0.032	0.754HisIle: 0.754 ± 0.029	0.283HisLys: 0.283 ± 0.017	2.045HisLeu: 2.045 ± 0.055	0.302HisMet: 0.302 ± 0.02	0.379HisAsn: 0.379 ± 0.021	1.667HisPro: 1.667 ± 0.046	0.533HisGln: 0.533 ± 0.022	1.761HisArg: 1.761 ± 0.057	0.909HisSer: 0.909 ± 0.032	1.051HisThr: 1.051 ± 0.037	1.679HisVal: 1.679 ± 0.042	0.305HisTrp: 0.305 ± 0.02	0.497HisTyr: 0.497 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	7.524IleAla: 7.524 ± 0.11	0.219IleCys: 0.219 ± 0.017	3.942IleAsp: 3.942 ± 0.075	3.08IleGlu: 3.08 ± 0.067	1.164IlePhe: 1.164 ± 0.043	4.618IleGly: 4.618 ± 0.095	0.76IleHis: 0.76 ± 0.028	2.151IleIle: 2.151 ± 0.055	0.75IleLys: 0.75 ± 0.036	3.57IleLeu: 3.57 ± 0.068	0.656IleMet: 0.656 ± 0.029	0.941IleAsn: 0.941 ± 0.037	2.486IlePro: 2.486 ± 0.061	1.031IleGln: 1.031 ± 0.036	2.836IleArg: 2.836 ± 0.053	2.259IleSer: 2.259 ± 0.054	3.006IleThr: 3.006 ± 0.063	4.936IleVal: 4.936 ± 0.084	0.497IleTrp: 0.497 ± 0.026	0.724IleTyr: 0.724 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	2.33LysAla: 2.33 ± 0.067	0.065LysCys: 0.065 ± 0.009	0.914LysAsp: 0.914 ± 0.041	0.858LysGlu: 0.858 ± 0.038	0.5LysPhe: 0.5 ± 0.026	1.38LysGly: 1.38 ± 0.048	0.44LysHis: 0.44 ± 0.028	0.754LysIle: 0.754 ± 0.035	0.83LysLys: 0.83 ± 0.045	1.777LysLeu: 1.777 ± 0.052	0.347LysMet: 0.347 ± 0.023	0.554LysAsn: 0.554 ± 0.029	1.175LysPro: 1.175 ± 0.043	0.649LysGln: 0.649 ± 0.03	1.613LysArg: 1.613 ± 0.043	1.055LysSer: 1.055 ± 0.038	1.213LysThr: 1.213 ± 0.04	1.452LysVal: 1.452 ± 0.045	0.217LysTrp: 0.217 ± 0.014	0.429LysTyr: 0.429 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	14.996LeuAla: 14.996 ± 0.172	0.459LeuCys: 0.459 ± 0.023	7.066LeuAsp: 7.066 ± 0.101	5.386LeuGlu: 5.386 ± 0.096	2.719LeuPhe: 2.719 ± 0.075	9.137LeuGly: 9.137 ± 0.127	1.79LeuHis: 1.79 ± 0.042	4.852LeuIle: 4.852 ± 0.092	1.704LeuLys: 1.704 ± 0.058	9.526LeuLeu: 9.526 ± 0.153	1.646LeuMet: 1.646 ± 0.046	1.777LeuAsn: 1.777 ± 0.043	5.412LeuPro: 5.412 ± 0.076	2.419LeuGln: 2.419 ± 0.059	7.196LeuArg: 7.196 ± 0.093	5.562LeuSer: 5.562 ± 0.092	6.447LeuThr: 6.447 ± 0.101	9.509LeuVal: 9.509 ± 0.125	1.225LeuTrp: 1.225 ± 0.037	1.648LeuTyr: 1.648 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.184MetAla: 2.184 ± 0.052	0.092MetCys: 0.092 ± 0.011	0.734MetAsp: 0.734 ± 0.034	0.664MetGlu: 0.664 ± 0.029	0.434MetPhe: 0.434 ± 0.024	1.263MetGly: 1.263 ± 0.04	0.392MetHis: 0.392 ± 0.023	0.847MetIle: 0.847 ± 0.037	0.415MetLys: 0.415 ± 0.021	2.01MetLeu: 2.01 ± 0.054	0.281MetMet: 0.281 ± 0.024	0.48MetAsn: 0.48 ± 0.024	1.16MetPro: 1.16 ± 0.038	0.461MetGln: 0.461 ± 0.023	1.46MetArg: 1.46 ± 0.038	1.37MetSer: 1.37 ± 0.04	1.795MetThr: 1.795 ± 0.049	1.435MetVal: 1.435 ± 0.046	0.191MetTrp: 0.191 ± 0.015	0.232MetTyr: 0.232 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.571AsnAla: 2.571 ± 0.056	0.125AsnCys: 0.125 ± 0.012	1.17AsnAsp: 1.17 ± 0.042	1.022AsnGlu: 1.022 ± 0.04	0.591AsnPhe: 0.591 ± 0.032	1.89AsnGly: 1.89 ± 0.056	0.373AsnHis: 0.373 ± 0.022	0.87AsnIle: 0.87 ± 0.037	0.352AsnLys: 0.352 ± 0.022	1.914AsnLeu: 1.914 ± 0.047	0.324AsnMet: 0.324 ± 0.024	0.476AsnAsn: 0.476 ± 0.027	1.734AsnPro: 1.734 ± 0.047	0.575AsnGln: 0.575 ± 0.027	1.383AsnArg: 1.383 ± 0.042	0.948AsnSer: 0.948 ± 0.036	1.065AsnThr: 1.065 ± 0.04	1.594AsnVal: 1.594 ± 0.047	0.297AsnTrp: 0.297 ± 0.019	0.426AsnTyr: 0.426 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	7.321ProAla: 7.321 ± 0.136	0.19ProCys: 0.19 ± 0.017	4.004ProAsp: 4.004 ± 0.063	3.889ProGlu: 3.889 ± 0.084	1.662ProPhe: 1.662 ± 0.039	4.968ProGly: 4.968 ± 0.091	1.213ProHis: 1.213 ± 0.049	2.326ProIle: 2.326 ± 0.047	1.024ProLys: 1.024 ± 0.038	5.063ProLeu: 5.063 ± 0.091	0.88ProMet: 0.88 ± 0.034	1.15ProAsn: 1.15 ± 0.038	2.533ProPro: 2.533 ± 0.083	1.444ProGln: 1.444 ± 0.034	3.59ProArg: 3.59 ± 0.077	3.086ProSer: 3.086 ± 0.075	3.463ProThr: 3.463 ± 0.072	4.905ProVal: 4.905 ± 0.091	0.833ProTrp: 0.833 ± 0.029	1.05ProTyr: 1.05 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	3.289GlnAla: 3.289 ± 0.061	0.133GlnCys: 0.133 ± 0.01	0.937GlnAsp: 0.937 ± 0.034	1.069GlnGlu: 1.069 ± 0.04	0.95GlnPhe: 0.95 ± 0.038	1.911GlnGly: 1.911 ± 0.053	0.657GlnHis: 0.657 ± 0.026	1.329GlnIle: 1.329 ± 0.04	0.738GlnLys: 0.738 ± 0.032	3.404GlnLeu: 3.404 ± 0.063	0.541GlnMet: 0.541 ± 0.029	0.673GlnAsn: 0.673 ± 0.032	1.495GlnPro: 1.495 ± 0.05	1.2GlnGln: 1.2 ± 0.045	2.561GlnArg: 2.561 ± 0.059	1.39GlnSer: 1.39 ± 0.041	1.45GlnThr: 1.45 ± 0.04	2.403GlnVal: 2.403 ± 0.055	0.459GlnTrp: 0.459 ± 0.025	0.651GlnTyr: 0.651 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	9.785ArgAla: 9.785 ± 0.139	0.314ArgCys: 0.314 ± 0.022	4.859ArgAsp: 4.859 ± 0.09	4.849ArgGlu: 4.849 ± 0.089	2.472ArgPhe: 2.472 ± 0.05	5.756ArgGly: 5.756 ± 0.095	1.625ArgHis: 1.625 ± 0.052	3.882ArgIle: 3.882 ± 0.076	1.308ArgLys: 1.308 ± 0.044	7.65ArgLeu: 7.65 ± 0.11	1.799ArgMet: 1.799 ± 0.05	1.352ArgAsn: 1.352 ± 0.047	3.803ArgPro: 3.803 ± 0.078	2.216ArgGln: 2.216 ± 0.053	6.859ArgArg: 6.859 ± 0.119	3.897ArgSer: 3.897 ± 0.079	4.286ArgThr: 4.286 ± 0.078	6.53ArgVal: 6.53 ± 0.097	1.251ArgTrp: 1.251 ± 0.042	1.561ArgTyr: 1.561 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	7.086SerAla: 7.086 ± 0.095	0.253SerCys: 0.253 ± 0.019	3.229SerAsp: 3.229 ± 0.066	2.71SerGlu: 2.71 ± 0.055	1.665SerPhe: 1.665 ± 0.045	5.375SerGly: 5.375 ± 0.089	1.011SerHis: 1.011 ± 0.028	2.79SerIle: 2.79 ± 0.059	0.945SerLys: 0.945 ± 0.032	5.154SerLeu: 5.154 ± 0.08	1.121SerMet: 1.121 ± 0.037	1.023SerAsn: 1.023 ± 0.038	3.044SerPro: 3.044 ± 0.075	1.329SerGln: 1.329 ± 0.041	3.829SerArg: 3.829 ± 0.067	3.054SerSer: 3.054 ± 0.068	3.481SerThr: 3.481 ± 0.067	4.64SerVal: 4.64 ± 0.078	0.801SerTrp: 0.801 ± 0.034	1.046SerTyr: 1.046 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	7.76ThrAla: 7.76 ± 0.097	0.25ThrCys: 0.25 ± 0.022	3.592ThrAsp: 3.592 ± 0.071	3.213ThrGlu: 3.213 ± 0.063	1.766ThrPhe: 1.766 ± 0.05	5.692ThrGly: 5.692 ± 0.075	1.158ThrHis: 1.158 ± 0.04	3.081ThrIle: 3.081 ± 0.071	1.098ThrLys: 1.098 ± 0.043	6.079ThrLeu: 6.079 ± 0.087	1.019ThrMet: 1.019 ± 0.036	1.173ThrAsn: 1.173 ± 0.04	4.088ThrPro: 4.088 ± 0.081	1.428ThrGln: 1.428 ± 0.042	4.111ThrArg: 4.111 ± 0.088	3.175ThrSer: 3.175 ± 0.072	3.836ThrThr: 3.836 ± 0.075	6.045ThrVal: 6.045 ± 0.097	0.775ThrTrp: 0.775 ± 0.031	1.076ThrTyr: 1.076 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	12.194ValAla: 12.194 ± 0.156	0.461ValCys: 0.461 ± 0.024	6.387ValAsp: 6.387 ± 0.097	5.107ValGlu: 5.107 ± 0.082	2.703ValPhe: 2.703 ± 0.061	7.309ValGly: 7.309 ± 0.105	1.8ValHis: 1.8 ± 0.052	4.579ValIle: 4.579 ± 0.079	1.521ValLys: 1.521 ± 0.049	8.925ValLeu: 8.925 ± 0.119	1.521ValMet: 1.521 ± 0.043	1.822ValAsn: 1.822 ± 0.044	4.508ValPro: 4.508 ± 0.09	2.048ValGln: 2.048 ± 0.048	6.342ValArg: 6.342 ± 0.103	4.967ValSer: 4.967 ± 0.079	6.123ValThr: 6.123 ± 0.087	9.046ValVal: 9.046 ± 0.135	1.089ValTrp: 1.089 ± 0.041	1.509ValTyr: 1.509 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	1.603TrpAla: 1.603 ± 0.042	0.099TrpCys: 0.099 ± 0.011	0.678TrpAsp: 0.678 ± 0.027	0.626TrpGlu: 0.626 ± 0.032	0.548TrpPhe: 0.548 ± 0.026	1.013TrpGly: 1.013 ± 0.038	0.343TrpHis: 0.343 ± 0.02	0.611TrpIle: 0.611 ± 0.029	0.31TrpLys: 0.31 ± 0.019	1.591TrpLeu: 1.591 ± 0.049	0.414TrpMet: 0.414 ± 0.024	0.415TrpAsn: 0.415 ± 0.02	0.678TrpPro: 0.678 ± 0.028	0.592TrpGln: 0.592 ± 0.026	1.288TrpArg: 1.288 ± 0.041	0.924TrpSer: 0.924 ± 0.037	0.713TrpThr: 0.713 ± 0.028	1.181TrpVal: 1.181 ± 0.039	0.383TrpTrp: 0.383 ± 0.019	0.261TrpTyr: 0.261 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.332TyrAla: 2.332 ± 0.053	0.137TyrCys: 0.137 ± 0.014	1.251TyrAsp: 1.251 ± 0.043	1.129TyrGlu: 1.129 ± 0.035	0.712TyrPhe: 0.712 ± 0.037	1.786TyrGly: 1.786 ± 0.047	0.289TyrHis: 0.289 ± 0.019	0.62TyrIle: 0.62 ± 0.027	0.314TyrLys: 0.314 ± 0.021	2.113TyrLeu: 2.113 ± 0.052	0.231TyrMet: 0.231 ± 0.017	0.394TyrAsn: 0.394 ± 0.023	1.012TyrPro: 1.012 ± 0.038	0.546TyrGln: 0.546 ± 0.023	1.641TyrArg: 1.641 ± 0.051	1.028TyrSer: 1.028 ± 0.037	1.084TyrThr: 1.084 ± 0.038	1.563TyrVal: 1.563 ± 0.042	0.286TyrTrp: 0.286 ± 0.019	0.394TyrTyr: 0.394 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2621 proteins (817268 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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