Amino acid dipepetide frequency for Mycobacterium virus CJW1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.069AlaAla: 12.069 ± 1.337
1.097AlaCys: 1.097 ± 0.228
6.246AlaAsp: 6.246 ± 0.564
8.735AlaGlu: 8.735 ± 0.756
2.87AlaPhe: 2.87 ± 0.368
8.482AlaGly: 8.482 ± 0.815
2.321AlaHis: 2.321 ± 0.375
3.925AlaIle: 3.925 ± 0.478
5.148AlaLys: 5.148 ± 0.503
7.891AlaLeu: 7.891 ± 0.629
3.038AlaMet: 3.038 ± 0.369
2.996AlaAsn: 2.996 ± 0.515
4.558AlaPro: 4.558 ± 0.457
3.123AlaGln: 3.123 ± 0.348
5.824AlaArg: 5.824 ± 0.814
5.866AlaSer: 5.866 ± 0.568
6.457AlaThr: 6.457 ± 0.432
5.655AlaVal: 5.655 ± 0.515
1.857AlaTrp: 1.857 ± 0.262
2.785AlaTyr: 2.785 ± 0.394
0.0AlaXaa: 0.0 ± 0.0
Cys
1.139CysAla: 1.139 ± 0.224
0.169CysCys: 0.169 ± 0.088
0.633CysAsp: 0.633 ± 0.209
0.675CysGlu: 0.675 ± 0.182
0.338CysPhe: 0.338 ± 0.136
1.688CysGly: 1.688 ± 0.354
0.169CysHis: 0.169 ± 0.097
0.422CysIle: 0.422 ± 0.123
0.464CysLys: 0.464 ± 0.138
1.266CysLeu: 1.266 ± 0.257
0.127CysMet: 0.127 ± 0.071
0.464CysAsn: 0.464 ± 0.151
0.549CysPro: 0.549 ± 0.179
0.506CysGln: 0.506 ± 0.173
0.633CysArg: 0.633 ± 0.184
0.802CysSer: 0.802 ± 0.221
0.464CysThr: 0.464 ± 0.137
0.633CysVal: 0.633 ± 0.184
0.253CysTrp: 0.253 ± 0.136
0.422CysTyr: 0.422 ± 0.137
0.0CysXaa: 0.0 ± 0.0
Asp
5.613AspAla: 5.613 ± 0.592
1.224AspCys: 1.224 ± 0.267
4.304AspAsp: 4.304 ± 0.433
4.6AspGlu: 4.6 ± 0.452
1.477AspPhe: 1.477 ± 0.255
7.216AspGly: 7.216 ± 0.637
1.604AspHis: 1.604 ± 0.231
3.376AspIle: 3.376 ± 0.362
2.532AspLys: 2.532 ± 0.308
4.726AspLeu: 4.726 ± 0.471
1.604AspMet: 1.604 ± 0.287
1.772AspAsn: 1.772 ± 0.3
4.009AspPro: 4.009 ± 0.338
1.688AspGln: 1.688 ± 0.368
3.967AspArg: 3.967 ± 0.509
3.165AspSer: 3.165 ± 0.389
3.418AspThr: 3.418 ± 0.303
4.473AspVal: 4.473 ± 0.449
1.519AspTrp: 1.519 ± 0.245
2.532AspTyr: 2.532 ± 0.444
0.0AspXaa: 0.0 ± 0.0
Glu
7.174GluAla: 7.174 ± 0.7
1.055GluCys: 1.055 ± 0.27
5.233GluAsp: 5.233 ± 0.541
4.726GluGlu: 4.726 ± 0.466
2.574GluPhe: 2.574 ± 0.36
4.642GluGly: 4.642 ± 0.417
1.393GluHis: 1.393 ± 0.235
2.827GluIle: 2.827 ± 0.351
2.405GluLys: 2.405 ± 0.394
7.385GluLeu: 7.385 ± 0.556
1.224GluMet: 1.224 ± 0.216
2.11GluAsn: 2.11 ± 0.281
2.743GluPro: 2.743 ± 0.305
2.532GluGln: 2.532 ± 0.314
4.051GluArg: 4.051 ± 0.425
2.912GluSer: 2.912 ± 0.335
3.46GluThr: 3.46 ± 0.375
4.558GluVal: 4.558 ± 0.473
1.266GluTrp: 1.266 ± 0.259
2.279GluTyr: 2.279 ± 0.357
0.0GluXaa: 0.0 ± 0.0
Phe
2.659PheAla: 2.659 ± 0.36
0.506PheCys: 0.506 ± 0.188
2.532PheAsp: 2.532 ± 0.319
2.026PheGlu: 2.026 ± 0.279
0.928PhePhe: 0.928 ± 0.216
2.532PheGly: 2.532 ± 0.413
0.971PheHis: 0.971 ± 0.209
1.435PheIle: 1.435 ± 0.243
1.055PheLys: 1.055 ± 0.204
1.899PheLeu: 1.899 ± 0.31
0.506PheMet: 0.506 ± 0.117
1.055PheAsn: 1.055 ± 0.246
1.35PhePro: 1.35 ± 0.247
0.76PheGln: 0.76 ± 0.179
1.35PheArg: 1.35 ± 0.227
1.941PheSer: 1.941 ± 0.321
2.194PheThr: 2.194 ± 0.344
2.026PheVal: 2.026 ± 0.36
0.295PheTrp: 0.295 ± 0.101
0.928PheTyr: 0.928 ± 0.203
0.0PheXaa: 0.0 ± 0.0
Gly
7.849GlyAla: 7.849 ± 0.814
0.717GlyCys: 0.717 ± 0.198
5.402GlyAsp: 5.402 ± 0.514
5.444GlyGlu: 5.444 ± 0.541
2.068GlyPhe: 2.068 ± 0.279
9.368GlyGly: 9.368 ± 1.814
2.11GlyHis: 2.11 ± 0.291
4.178GlyIle: 4.178 ± 0.579
4.051GlyLys: 4.051 ± 0.352
6.457GlyLeu: 6.457 ± 0.427
2.279GlyMet: 2.279 ± 0.344
3.418GlyAsn: 3.418 ± 0.389
3.756GlyPro: 3.756 ± 0.406
2.448GlyGln: 2.448 ± 0.41
4.558GlyArg: 4.558 ± 0.383
5.697GlySer: 5.697 ± 0.71
6.625GlyThr: 6.625 ± 0.676
6.33GlyVal: 6.33 ± 0.567
1.815GlyTrp: 1.815 ± 0.265
3.46GlyTyr: 3.46 ± 0.438
0.0GlyXaa: 0.0 ± 0.0
His
1.815HisAla: 1.815 ± 0.339
0.506HisCys: 0.506 ± 0.151
1.561HisAsp: 1.561 ± 0.244
1.393HisGlu: 1.393 ± 0.262
0.675HisPhe: 0.675 ± 0.184
2.194HisGly: 2.194 ± 0.314
0.971HisHis: 0.971 ± 0.186
1.013HisIle: 1.013 ± 0.153
1.055HisLys: 1.055 ± 0.194
2.448HisLeu: 2.448 ± 0.375
0.591HisMet: 0.591 ± 0.131
0.928HisAsn: 0.928 ± 0.205
1.646HisPro: 1.646 ± 0.27
0.971HisGln: 0.971 ± 0.252
1.519HisArg: 1.519 ± 0.245
1.266HisSer: 1.266 ± 0.226
1.435HisThr: 1.435 ± 0.261
1.182HisVal: 1.182 ± 0.275
0.338HisTrp: 0.338 ± 0.12
0.971HisTyr: 0.971 ± 0.202
0.0HisXaa: 0.0 ± 0.0
Ile
4.769IleAla: 4.769 ± 0.452
0.338IleCys: 0.338 ± 0.112
3.334IleAsp: 3.334 ± 0.358
3.629IleGlu: 3.629 ± 0.461
1.055IlePhe: 1.055 ± 0.237
3.165IleGly: 3.165 ± 0.426
1.266IleHis: 1.266 ± 0.247
1.646IleIle: 1.646 ± 0.262
1.815IleLys: 1.815 ± 0.266
3.207IleLeu: 3.207 ± 0.387
0.928IleMet: 0.928 ± 0.203
1.73IleAsn: 1.73 ± 0.309
2.616IlePro: 2.616 ± 0.3
1.561IleGln: 1.561 ± 0.285
2.743IleArg: 2.743 ± 0.311
2.532IleSer: 2.532 ± 0.402
2.827IleThr: 2.827 ± 0.402
3.038IleVal: 3.038 ± 0.347
0.464IleTrp: 0.464 ± 0.132
1.224IleTyr: 1.224 ± 0.257
0.0IleXaa: 0.0 ± 0.0
Lys
4.853LysAla: 4.853 ± 0.479
0.591LysCys: 0.591 ± 0.149
2.616LysAsp: 2.616 ± 0.342
2.321LysGlu: 2.321 ± 0.314
1.224LysPhe: 1.224 ± 0.234
3.249LysGly: 3.249 ± 0.382
1.182LysHis: 1.182 ± 0.204
1.688LysIle: 1.688 ± 0.26
2.194LysLys: 2.194 ± 0.278
3.84LysLeu: 3.84 ± 0.365
1.055LysMet: 1.055 ± 0.227
1.519LysAsn: 1.519 ± 0.297
2.532LysPro: 2.532 ± 0.316
1.646LysGln: 1.646 ± 0.273
3.207LysArg: 3.207 ± 0.454
3.165LysSer: 3.165 ± 0.403
1.983LysThr: 1.983 ± 0.282
3.249LysVal: 3.249 ± 0.351
1.182LysTrp: 1.182 ± 0.225
1.182LysTyr: 1.182 ± 0.255
0.0LysXaa: 0.0 ± 0.0
Leu
9.031LeuAla: 9.031 ± 0.736
0.76LeuCys: 0.76 ± 0.194
4.473LeuAsp: 4.473 ± 0.481
4.769LeuGlu: 4.769 ± 0.454
2.237LeuPhe: 2.237 ± 0.341
5.95LeuGly: 5.95 ± 0.511
1.646LeuHis: 1.646 ± 0.264
3.882LeuIle: 3.882 ± 0.333
4.136LeuLys: 4.136 ± 0.358
6.836LeuLeu: 6.836 ± 0.597
2.574LeuMet: 2.574 ± 0.304
3.207LeuAsn: 3.207 ± 0.323
3.798LeuPro: 3.798 ± 0.418
3.038LeuGln: 3.038 ± 0.372
5.697LeuArg: 5.697 ± 0.499
4.6LeuSer: 4.6 ± 0.455
6.203LeuThr: 6.203 ± 0.553
5.486LeuVal: 5.486 ± 0.499
1.266LeuTrp: 1.266 ± 0.237
1.646LeuTyr: 1.646 ± 0.28
0.0LeuXaa: 0.0 ± 0.0
Met
2.574MetAla: 2.574 ± 0.338
0.211MetCys: 0.211 ± 0.096
1.477MetAsp: 1.477 ± 0.243
1.561MetGlu: 1.561 ± 0.357
0.633MetPhe: 0.633 ± 0.177
1.688MetGly: 1.688 ± 0.299
0.422MetHis: 0.422 ± 0.128
0.844MetIle: 0.844 ± 0.159
1.604MetLys: 1.604 ± 0.274
1.604MetLeu: 1.604 ± 0.214
0.422MetMet: 0.422 ± 0.15
0.844MetAsn: 0.844 ± 0.188
1.055MetPro: 1.055 ± 0.195
0.549MetGln: 0.549 ± 0.205
1.35MetArg: 1.35 ± 0.236
2.743MetSer: 2.743 ± 0.403
1.899MetThr: 1.899 ± 0.283
1.561MetVal: 1.561 ± 0.251
0.549MetTrp: 0.549 ± 0.16
0.338MetTyr: 0.338 ± 0.114
0.0MetXaa: 0.0 ± 0.0
Asn
2.659AsnAla: 2.659 ± 0.363
0.253AsnCys: 0.253 ± 0.116
2.152AsnAsp: 2.152 ± 0.293
1.815AsnGlu: 1.815 ± 0.254
0.971AsnPhe: 0.971 ± 0.241
4.642AsnGly: 4.642 ± 0.467
0.802AsnHis: 0.802 ± 0.198
1.182AsnIle: 1.182 ± 0.35
0.928AsnLys: 0.928 ± 0.17
3.292AsnLeu: 3.292 ± 0.53
0.338AsnMet: 0.338 ± 0.159
1.013AsnAsn: 1.013 ± 0.238
2.912AsnPro: 2.912 ± 0.313
1.097AsnGln: 1.097 ± 0.197
2.152AsnArg: 2.152 ± 0.263
1.73AsnSer: 1.73 ± 0.322
1.73AsnThr: 1.73 ± 0.343
2.237AsnVal: 2.237 ± 0.34
0.591AsnTrp: 0.591 ± 0.146
0.802AsnTyr: 0.802 ± 0.185
0.0AsnXaa: 0.0 ± 0.0
Pro
5.233ProAla: 5.233 ± 0.585
0.549ProCys: 0.549 ± 0.15
3.714ProAsp: 3.714 ± 0.326
3.418ProGlu: 3.418 ± 0.347
1.815ProPhe: 1.815 ± 0.297
5.022ProGly: 5.022 ± 0.689
1.73ProHis: 1.73 ± 0.262
2.279ProIle: 2.279 ± 0.307
2.532ProLys: 2.532 ± 0.43
3.84ProLeu: 3.84 ± 0.345
1.266ProMet: 1.266 ± 0.218
1.73ProAsn: 1.73 ± 0.211
3.165ProPro: 3.165 ± 0.479
1.772ProGln: 1.772 ± 0.283
2.701ProArg: 2.701 ± 0.412
2.912ProSer: 2.912 ± 0.297
3.334ProThr: 3.334 ± 0.324
3.714ProVal: 3.714 ± 0.388
1.224ProTrp: 1.224 ± 0.229
1.561ProTyr: 1.561 ± 0.27
0.0ProXaa: 0.0 ± 0.0
Gln
3.714GlnAla: 3.714 ± 0.474
0.338GlnCys: 0.338 ± 0.139
1.815GlnAsp: 1.815 ± 0.267
1.857GlnGlu: 1.857 ± 0.264
0.717GlnPhe: 0.717 ± 0.193
2.363GlnGly: 2.363 ± 0.41
0.464GlnHis: 0.464 ± 0.133
1.604GlnIle: 1.604 ± 0.3
1.561GlnLys: 1.561 ± 0.31
3.503GlnLeu: 3.503 ± 0.527
0.844GlnMet: 0.844 ± 0.241
0.802GlnAsn: 0.802 ± 0.175
1.688GlnPro: 1.688 ± 0.288
0.928GlnGln: 0.928 ± 0.229
2.448GlnArg: 2.448 ± 0.316
2.026GlnSer: 2.026 ± 0.252
1.604GlnThr: 1.604 ± 0.202
2.363GlnVal: 2.363 ± 0.346
0.844GlnTrp: 0.844 ± 0.186
0.971GlnTyr: 0.971 ± 0.185
0.0GlnXaa: 0.0 ± 0.0
Arg
6.71ArgAla: 6.71 ± 0.712
0.802ArgCys: 0.802 ± 0.193
3.882ArgAsp: 3.882 ± 0.484
3.714ArgGlu: 3.714 ± 0.432
1.73ArgPhe: 1.73 ± 0.337
4.262ArgGly: 4.262 ± 0.425
1.899ArgHis: 1.899 ± 0.311
2.532ArgIle: 2.532 ± 0.388
3.207ArgLys: 3.207 ± 0.397
4.98ArgLeu: 4.98 ± 0.53
2.026ArgMet: 2.026 ± 0.269
1.477ArgAsn: 1.477 ± 0.194
3.038ArgPro: 3.038 ± 0.377
1.899ArgGln: 1.899 ± 0.265
4.473ArgArg: 4.473 ± 0.554
2.996ArgSer: 2.996 ± 0.367
2.659ArgThr: 2.659 ± 0.341
4.262ArgVal: 4.262 ± 0.509
1.519ArgTrp: 1.519 ± 0.271
2.279ArgTyr: 2.279 ± 0.29
0.0ArgXaa: 0.0 ± 0.0
Ser
4.98SerAla: 4.98 ± 0.551
0.464SerCys: 0.464 ± 0.139
3.249SerAsp: 3.249 ± 0.41
3.503SerGlu: 3.503 ± 0.373
1.983SerPhe: 1.983 ± 0.306
6.583SerGly: 6.583 ± 0.971
1.477SerHis: 1.477 ± 0.231
2.194SerIle: 2.194 ± 0.324
2.068SerLys: 2.068 ± 0.355
4.98SerLeu: 4.98 ± 0.473
1.097SerMet: 1.097 ± 0.188
2.068SerAsn: 2.068 ± 0.29
2.785SerPro: 2.785 ± 0.321
1.646SerGln: 1.646 ± 0.286
3.207SerArg: 3.207 ± 0.45
3.671SerSer: 3.671 ± 0.58
3.925SerThr: 3.925 ± 0.569
4.178SerVal: 4.178 ± 0.41
1.604SerTrp: 1.604 ± 0.238
1.561SerTyr: 1.561 ± 0.291
0.0SerXaa: 0.0 ± 0.0
Thr
6.668ThrAla: 6.668 ± 0.67
0.506ThrCys: 0.506 ± 0.152
3.925ThrAsp: 3.925 ± 0.441
3.925ThrGlu: 3.925 ± 0.429
1.983ThrPhe: 1.983 ± 0.262
5.359ThrGly: 5.359 ± 0.548
1.097ThrHis: 1.097 ± 0.161
3.165ThrIle: 3.165 ± 0.353
2.448ThrLys: 2.448 ± 0.355
4.937ThrLeu: 4.937 ± 0.449
1.435ThrMet: 1.435 ± 0.318
2.194ThrAsn: 2.194 ± 0.357
5.191ThrPro: 5.191 ± 0.554
1.941ThrGln: 1.941 ± 0.311
2.912ThrArg: 2.912 ± 0.35
2.87ThrSer: 2.87 ± 0.322
3.376ThrThr: 3.376 ± 0.407
5.57ThrVal: 5.57 ± 0.434
1.435ThrTrp: 1.435 ± 0.319
2.026ThrTyr: 2.026 ± 0.262
0.0ThrXaa: 0.0 ± 0.0
Val
7.174ValAla: 7.174 ± 0.518
0.971ValCys: 0.971 ± 0.213
4.811ValAsp: 4.811 ± 0.618
5.57ValGlu: 5.57 ± 0.524
2.068ValPhe: 2.068 ± 0.329
5.106ValGly: 5.106 ± 0.478
1.73ValHis: 1.73 ± 0.277
3.503ValIle: 3.503 ± 0.379
3.503ValLys: 3.503 ± 0.352
3.882ValLeu: 3.882 ± 0.399
1.646ValMet: 1.646 ± 0.251
2.49ValAsn: 2.49 ± 0.285
3.671ValPro: 3.671 ± 0.337
2.321ValGln: 2.321 ± 0.348
4.347ValArg: 4.347 ± 0.517
3.84ValSer: 3.84 ± 0.329
5.57ValThr: 5.57 ± 0.686
5.95ValVal: 5.95 ± 0.778
0.802ValTrp: 0.802 ± 0.267
1.941ValTyr: 1.941 ± 0.326
0.0ValXaa: 0.0 ± 0.0
Trp
1.604TrpAla: 1.604 ± 0.21
0.295TrpCys: 0.295 ± 0.119
1.646TrpAsp: 1.646 ± 0.242
0.844TrpGlu: 0.844 ± 0.197
0.844TrpPhe: 0.844 ± 0.211
1.139TrpGly: 1.139 ± 0.258
0.633TrpHis: 0.633 ± 0.148
1.013TrpIle: 1.013 ± 0.221
0.633TrpLys: 0.633 ± 0.141
1.688TrpLeu: 1.688 ± 0.312
0.338TrpMet: 0.338 ± 0.132
0.76TrpAsn: 0.76 ± 0.164
0.928TrpPro: 0.928 ± 0.178
0.928TrpGln: 0.928 ± 0.25
0.886TrpArg: 0.886 ± 0.229
1.097TrpSer: 1.097 ± 0.202
1.224TrpThr: 1.224 ± 0.248
2.194TrpVal: 2.194 ± 0.339
0.464TrpTrp: 0.464 ± 0.133
0.675TrpTyr: 0.675 ± 0.187
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.659TyrAla: 2.659 ± 0.304
0.464TyrCys: 0.464 ± 0.169
1.815TyrAsp: 1.815 ± 0.371
2.026TyrGlu: 2.026 ± 0.26
0.76TyrPhe: 0.76 ± 0.198
3.376TyrGly: 3.376 ± 0.422
0.591TyrHis: 0.591 ± 0.178
1.182TyrIle: 1.182 ± 0.201
1.139TyrLys: 1.139 ± 0.229
2.574TyrLeu: 2.574 ± 0.289
0.549TyrMet: 0.549 ± 0.162
0.717TyrAsn: 0.717 ± 0.164
1.519TyrPro: 1.519 ± 0.29
1.139TyrGln: 1.139 ± 0.216
2.321TyrArg: 2.321 ± 0.293
1.393TyrSer: 1.393 ± 0.211
2.574TyrThr: 2.574 ± 0.34
2.237TyrVal: 2.237 ± 0.337
0.549TyrTrp: 0.549 ± 0.181
0.802TyrTyr: 0.802 ± 0.206
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 141 proteins (23698 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski