Amino acid dipepetide frequency for Syntrophomonas wolfei subsp. wolfei (strain DSM 2245B / Goettingen)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.462AlaAla: 7.462 ± 0.123	1.138AlaCys: 1.138 ± 0.039	3.9AlaAsp: 3.9 ± 0.066	5.556AlaGlu: 5.556 ± 0.098	2.973AlaPhe: 2.973 ± 0.067	6.667AlaGly: 6.667 ± 0.102	1.214AlaHis: 1.214 ± 0.039	5.827AlaIle: 5.827 ± 0.096	3.382AlaLys: 3.382 ± 0.071	8.208AlaLeu: 8.208 ± 0.121	2.132AlaMet: 2.132 ± 0.054	2.629AlaAsn: 2.629 ± 0.068	2.179AlaPro: 2.179 ± 0.056	2.758AlaGln: 2.758 ± 0.06	5.013AlaArg: 5.013 ± 0.073	4.427AlaSer: 4.427 ± 0.072	3.281AlaThr: 3.281 ± 0.078	5.929AlaVal: 5.929 ± 0.098	0.719AlaTrp: 0.719 ± 0.034	2.542AlaTyr: 2.542 ± 0.066	0.0AlaXaa: 0.0 ± 0.0
Cys	0.725CysAla: 0.725 ± 0.034	0.211CysCys: 0.211 ± 0.018	0.572CysAsp: 0.572 ± 0.031	0.652CysGlu: 0.652 ± 0.034	0.533CysPhe: 0.533 ± 0.028	1.096CysGly: 1.096 ± 0.043	0.267CysHis: 0.267 ± 0.022	0.796CysIle: 0.796 ± 0.036	0.527CysLys: 0.527 ± 0.026	1.256CysLeu: 1.256 ± 0.038	0.293CysMet: 0.293 ± 0.019	0.449CysAsn: 0.449 ± 0.024	0.737CysPro: 0.737 ± 0.038	0.544CysGln: 0.544 ± 0.026	0.733CysArg: 0.733 ± 0.033	0.948CysSer: 0.948 ± 0.035	0.465CysThr: 0.465 ± 0.026	0.52CysVal: 0.52 ± 0.028	0.129CysTrp: 0.129 ± 0.014	0.381CysTyr: 0.381 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.245AspAla: 3.245 ± 0.066	0.621AspCys: 0.621 ± 0.031	2.296AspAsp: 2.296 ± 0.056	3.988AspGlu: 3.988 ± 0.071	2.635AspPhe: 2.635 ± 0.061	3.403AspGly: 3.403 ± 0.072	0.769AspHis: 0.769 ± 0.032	4.921AspIle: 4.921 ± 0.094	3.325AspLys: 3.325 ± 0.066	5.527AspLeu: 5.527 ± 0.086	1.486AspMet: 1.486 ± 0.042	2.254AspAsn: 2.254 ± 0.055	2.039AspPro: 2.039 ± 0.051	1.257AspGln: 1.257 ± 0.041	2.511AspArg: 2.511 ± 0.057	3.083AspSer: 3.083 ± 0.068	2.108AspThr: 2.108 ± 0.053	2.815AspVal: 2.815 ± 0.06	0.578AspTrp: 0.578 ± 0.027	2.387AspTyr: 2.387 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	6.045GluAla: 6.045 ± 0.094	0.632GluCys: 0.632 ± 0.03	3.455GluAsp: 3.455 ± 0.064	6.906GluGlu: 6.906 ± 0.129	2.494GluPhe: 2.494 ± 0.057	4.448GluGly: 4.448 ± 0.088	1.201GluHis: 1.201 ± 0.037	6.512GluIle: 6.512 ± 0.103	6.036GluLys: 6.036 ± 0.102	7.982GluLeu: 7.982 ± 0.121	2.333GluMet: 2.333 ± 0.056	3.477GluAsn: 3.477 ± 0.075	2.043GluPro: 2.043 ± 0.059	3.226GluGln: 3.226 ± 0.072	3.831GluArg: 3.831 ± 0.071	3.516GluSer: 3.516 ± 0.073	2.799GluThr: 2.799 ± 0.067	5.069GluVal: 5.069 ± 0.09	0.676GluTrp: 0.676 ± 0.03	2.331GluTyr: 2.331 ± 0.057	0.0GluXaa: 0.0 ± 0.0
Phe	2.976PheAla: 2.976 ± 0.067	0.606PheCys: 0.606 ± 0.03	2.204PheAsp: 2.204 ± 0.058	2.195PheGlu: 2.195 ± 0.056	1.834PhePhe: 1.834 ± 0.053	2.46PheGly: 2.46 ± 0.053	0.645PheHis: 0.645 ± 0.034	2.986PheIle: 2.986 ± 0.061	2.242PheLys: 2.242 ± 0.055	4.204PheLeu: 4.204 ± 0.09	1.027PheMet: 1.027 ± 0.037	1.885PheAsn: 1.885 ± 0.049	1.609PhePro: 1.609 ± 0.049	1.35PheGln: 1.35 ± 0.051	1.774PheArg: 1.774 ± 0.049	2.947PheSer: 2.947 ± 0.062	2.107PheThr: 2.107 ± 0.056	2.111PheVal: 2.111 ± 0.055	0.445PheTrp: 0.445 ± 0.025	1.583PheTyr: 1.583 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.804GlyAla: 4.804 ± 0.097	0.943GlyCys: 0.943 ± 0.035	3.391GlyAsp: 3.391 ± 0.074	5.126GlyGlu: 5.126 ± 0.093	3.002GlyPhe: 3.002 ± 0.065	5.053GlyGly: 5.053 ± 0.119	1.34GlyHis: 1.34 ± 0.043	6.167GlyIle: 6.167 ± 0.09	5.202GlyLys: 5.202 ± 0.081	7.009GlyLeu: 7.009 ± 0.107	2.066GlyMet: 2.066 ± 0.054	2.815GlyAsn: 2.815 ± 0.068	1.863GlyPro: 1.863 ± 0.047	3.03GlyGln: 3.03 ± 0.067	3.719GlyArg: 3.719 ± 0.071	4.366GlySer: 4.366 ± 0.091	3.477GlyThr: 3.477 ± 0.098	4.537GlyVal: 4.537 ± 0.073	0.776GlyTrp: 0.776 ± 0.032	2.799GlyTyr: 2.799 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	0.933HisAla: 0.933 ± 0.035	0.27HisCys: 0.27 ± 0.018	0.786HisAsp: 0.786 ± 0.032	1.051HisGlu: 1.051 ± 0.035	0.792HisPhe: 0.792 ± 0.034	1.13HisGly: 1.13 ± 0.038	0.482HisHis: 0.482 ± 0.025	1.384HisIle: 1.384 ± 0.046	0.891HisLys: 0.891 ± 0.033	1.871HisLeu: 1.871 ± 0.059	0.38HisMet: 0.38 ± 0.018	0.758HisAsn: 0.758 ± 0.031	1.045HisPro: 1.045 ± 0.039	0.625HisGln: 0.625 ± 0.031	0.925HisArg: 0.925 ± 0.039	1.15HisSer: 1.15 ± 0.04	0.712HisThr: 0.712 ± 0.029	0.753HisVal: 0.753 ± 0.03	0.229HisTrp: 0.229 ± 0.017	0.723HisTyr: 0.723 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.085IleAla: 6.085 ± 0.097	1.001IleCys: 1.001 ± 0.042	4.365IleAsp: 4.365 ± 0.07	5.249IleGlu: 5.249 ± 0.092	2.812IlePhe: 2.812 ± 0.071	4.723IleGly: 4.723 ± 0.08	1.11IleHis: 1.11 ± 0.04	6.37IleIle: 6.37 ± 0.121	5.538IleLys: 5.538 ± 0.093	7.362IleLeu: 7.362 ± 0.123	2.113IleMet: 2.113 ± 0.045	3.871IleAsn: 3.871 ± 0.083	3.525IlePro: 3.525 ± 0.059	2.194IleGln: 2.194 ± 0.054	3.704IleArg: 3.704 ± 0.077	5.273IleSer: 5.273 ± 0.086	3.773IleThr: 3.773 ± 0.089	4.676IleVal: 4.676 ± 0.092	0.631IleTrp: 0.631 ± 0.029	2.436IleTyr: 2.436 ± 0.061	0.0IleXaa: 0.0 ± 0.0
Lys	4.989LysAla: 4.989 ± 0.09	0.478LysCys: 0.478 ± 0.03	3.22LysAsp: 3.22 ± 0.068	5.147LysGlu: 5.147 ± 0.089	1.663LysPhe: 1.663 ± 0.052	3.92LysGly: 3.92 ± 0.078	0.976LysHis: 0.976 ± 0.035	4.662LysIle: 4.662 ± 0.077	4.552LysLys: 4.552 ± 0.086	5.647LysLeu: 5.647 ± 0.083	1.765LysMet: 1.765 ± 0.043	2.838LysAsn: 2.838 ± 0.062	2.279LysPro: 2.279 ± 0.052	2.387LysGln: 2.387 ± 0.062	3.127LysArg: 3.127 ± 0.062	3.415LysSer: 3.415 ± 0.073	3.037LysThr: 3.037 ± 0.056	4.007LysVal: 4.007 ± 0.076	0.57LysTrp: 0.57 ± 0.025	2.084LysTyr: 2.084 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	9.078LeuAla: 9.078 ± 0.13	1.178LeuCys: 1.178 ± 0.042	5.631LeuAsp: 5.631 ± 0.088	7.963LeuGlu: 7.963 ± 0.116	4.012LeuPhe: 4.012 ± 0.094	7.421LeuGly: 7.421 ± 0.115	1.737LeuHis: 1.737 ± 0.048	6.729LeuIle: 6.729 ± 0.123	6.431LeuLys: 6.431 ± 0.102	12.076LeuLeu: 12.076 ± 0.226	2.621LeuMet: 2.621 ± 0.055	4.536LeuAsn: 4.536 ± 0.069	4.488LeuPro: 4.488 ± 0.076	4.298LeuGln: 4.298 ± 0.089	5.085LeuArg: 5.085 ± 0.094	7.001LeuSer: 7.001 ± 0.101	4.225LeuThr: 4.225 ± 0.082	6.585LeuVal: 6.585 ± 0.103	0.918LeuTrp: 0.918 ± 0.034	3.088LeuTyr: 3.088 ± 0.075	0.0LeuXaa: 0.0 ± 0.0
Met	2.536MetAla: 2.536 ± 0.062	0.172MetCys: 0.172 ± 0.017	1.495MetAsp: 1.495 ± 0.046	2.304MetGlu: 2.304 ± 0.063	0.746MetPhe: 0.746 ± 0.03	2.154MetGly: 2.154 ± 0.051	0.412MetHis: 0.412 ± 0.025	1.687MetIle: 1.687 ± 0.048	1.776MetLys: 1.776 ± 0.048	2.775MetLeu: 2.775 ± 0.062	0.666MetMet: 0.666 ± 0.031	1.152MetAsn: 1.152 ± 0.042	1.09MetPro: 1.09 ± 0.041	1.139MetGln: 1.139 ± 0.036	1.194MetArg: 1.194 ± 0.041	1.473MetSer: 1.473 ± 0.043	1.109MetThr: 1.109 ± 0.04	2.088MetVal: 2.088 ± 0.052	0.155MetTrp: 0.155 ± 0.016	0.527MetTyr: 0.527 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.77AsnAla: 2.77 ± 0.061	0.624AsnCys: 0.624 ± 0.029	1.981AsnAsp: 1.981 ± 0.056	2.624AsnGlu: 2.624 ± 0.061	1.607AsnPhe: 1.607 ± 0.042	2.697AsnGly: 2.697 ± 0.074	0.763AsnHis: 0.763 ± 0.029	3.635AsnIle: 3.635 ± 0.069	2.452AsnLys: 2.452 ± 0.062	4.488AsnLeu: 4.488 ± 0.084	1.155AsnMet: 1.155 ± 0.036	2.057AsnAsn: 2.057 ± 0.06	2.321AsnPro: 2.321 ± 0.058	1.781AsnGln: 1.781 ± 0.041	2.489AsnArg: 2.489 ± 0.061	2.619AsnSer: 2.619 ± 0.058	1.984AsnThr: 1.984 ± 0.05	2.206AsnVal: 2.206 ± 0.058	0.527AsnTrp: 0.527 ± 0.027	1.838AsnTyr: 1.838 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	3.255ProAla: 3.255 ± 0.072	0.405ProCys: 0.405 ± 0.025	2.444ProAsp: 2.444 ± 0.057	3.691ProGlu: 3.691 ± 0.069	1.543ProPhe: 1.543 ± 0.043	3.572ProGly: 3.572 ± 0.078	0.752ProHis: 0.752 ± 0.031	2.205ProIle: 2.205 ± 0.051	1.289ProLys: 1.289 ± 0.044	4.056ProLeu: 4.056 ± 0.087	0.756ProMet: 0.756 ± 0.032	1.235ProAsn: 1.235 ± 0.041	1.516ProPro: 1.516 ± 0.063	1.563ProGln: 1.563 ± 0.045	2.126ProArg: 2.126 ± 0.053	2.149ProSer: 2.149 ± 0.055	1.481ProThr: 1.481 ± 0.043	3.34ProVal: 3.34 ± 0.063	0.444ProTrp: 0.444 ± 0.028	1.394ProTyr: 1.394 ± 0.05	0.0ProXaa: 0.0 ± 0.0
Gln	3.533GlnAla: 3.533 ± 0.071	0.324GlnCys: 0.324 ± 0.019	1.883GlnAsp: 1.883 ± 0.047	3.549GlnGlu: 3.549 ± 0.075	1.072GlnPhe: 1.072 ± 0.036	2.819GlnGly: 2.819 ± 0.056	0.632GlnHis: 0.632 ± 0.03	2.532GlnIle: 2.532 ± 0.056	2.547GlnLys: 2.547 ± 0.073	3.853GlnLeu: 3.853 ± 0.074	0.966GlnMet: 0.966 ± 0.035	1.597GlnAsn: 1.597 ± 0.046	1.306GlnPro: 1.306 ± 0.042	1.735GlnGln: 1.735 ± 0.053	1.993GlnArg: 1.993 ± 0.054	1.952GlnSer: 1.952 ± 0.054	1.445GlnThr: 1.445 ± 0.047	2.941GlnVal: 2.941 ± 0.073	0.341GlnTrp: 0.341 ± 0.024	1.129GlnTyr: 1.129 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.359ArgAla: 3.359 ± 0.068	0.586ArgCys: 0.586 ± 0.028	2.697ArgAsp: 2.697 ± 0.065	4.756ArgGlu: 4.756 ± 0.089	2.088ArgPhe: 2.088 ± 0.055	3.31ArgGly: 3.31 ± 0.068	0.904ArgHis: 0.904 ± 0.041	4.17ArgIle: 4.17 ± 0.074	3.211ArgLys: 3.211 ± 0.072	5.718ArgLeu: 5.718 ± 0.098	1.517ArgMet: 1.517 ± 0.042	2.196ArgAsn: 2.196 ± 0.056	1.822ArgPro: 1.822 ± 0.055	2.535ArgGln: 2.535 ± 0.069	2.81ArgArg: 2.81 ± 0.065	2.83ArgSer: 2.83 ± 0.059	1.976ArgThr: 1.976 ± 0.049	3.699ArgVal: 3.699 ± 0.076	0.531ArgTrp: 0.531 ± 0.024	1.843ArgTyr: 1.843 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	3.889SerAla: 3.889 ± 0.076	0.821SerCys: 0.821 ± 0.03	2.851SerAsp: 2.851 ± 0.065	3.752SerGlu: 3.752 ± 0.063	2.836SerPhe: 2.836 ± 0.057	5.158SerGly: 5.158 ± 0.099	1.042SerHis: 1.042 ± 0.035	4.571SerIle: 4.571 ± 0.074	3.152SerLys: 3.152 ± 0.062	6.799SerLeu: 6.799 ± 0.101	1.533SerMet: 1.533 ± 0.05	2.455SerAsn: 2.455 ± 0.061	2.69SerPro: 2.69 ± 0.064	2.33SerGln: 2.33 ± 0.058	3.748SerArg: 3.748 ± 0.071	4.479SerSer: 4.479 ± 0.084	2.742SerThr: 2.742 ± 0.068	3.261SerVal: 3.261 ± 0.065	0.631SerTrp: 0.631 ± 0.037	2.273SerTyr: 2.273 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	4.145ThrAla: 4.145 ± 0.08	0.449ThrCys: 0.449 ± 0.023	1.965ThrAsp: 1.965 ± 0.065	2.535ThrGlu: 2.535 ± 0.058	1.638ThrPhe: 1.638 ± 0.049	4.116ThrGly: 4.116 ± 0.084	0.761ThrHis: 0.761 ± 0.033	3.596ThrIle: 3.596 ± 0.088	1.588ThrLys: 1.588 ± 0.047	4.562ThrLeu: 4.562 ± 0.091	1.084ThrMet: 1.084 ± 0.038	1.575ThrAsn: 1.575 ± 0.045	2.213ThrPro: 2.213 ± 0.052	1.275ThrGln: 1.275 ± 0.035	2.369ThrArg: 2.369 ± 0.052	2.516ThrSer: 2.516 ± 0.066	2.504ThrThr: 2.504 ± 0.079	3.376ThrVal: 3.376 ± 0.087	0.375ThrTrp: 0.375 ± 0.024	1.35ThrTyr: 1.35 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	5.19ValAla: 5.19 ± 0.101	0.756ValCys: 0.756 ± 0.029	3.655ValAsp: 3.655 ± 0.07	4.976ValGlu: 4.976 ± 0.088	3.01ValPhe: 3.01 ± 0.067	4.218ValGly: 4.218 ± 0.089	0.947ValHis: 0.947 ± 0.039	4.977ValIle: 4.977 ± 0.084	4.378ValLys: 4.378 ± 0.074	6.758ValLeu: 6.758 ± 0.099	1.735ValMet: 1.735 ± 0.046	2.938ValAsn: 2.938 ± 0.057	2.379ValPro: 2.379 ± 0.057	1.939ValGln: 1.939 ± 0.049	2.897ValArg: 2.897 ± 0.069	4.061ValSer: 4.061 ± 0.073	2.82ValThr: 2.82 ± 0.081	4.78ValVal: 4.78 ± 0.078	0.493ValTrp: 0.493 ± 0.023	2.184ValTyr: 2.184 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.686TrpAla: 0.686 ± 0.029	0.099TrpCys: 0.099 ± 0.01	0.622TrpAsp: 0.622 ± 0.031	0.79TrpGlu: 0.79 ± 0.032	0.357TrpPhe: 0.357 ± 0.023	0.742TrpGly: 0.742 ± 0.033	0.186TrpHis: 0.186 ± 0.018	0.572TrpIle: 0.572 ± 0.029	0.612TrpLys: 0.612 ± 0.028	1.05TrpLeu: 1.05 ± 0.044	0.259TrpMet: 0.259 ± 0.019	0.415TrpAsn: 0.415 ± 0.025	0.388TrpPro: 0.388 ± 0.027	0.548TrpGln: 0.548 ± 0.028	0.455TrpArg: 0.455 ± 0.027	0.514TrpSer: 0.514 ± 0.024	0.383TrpThr: 0.383 ± 0.022	0.597TrpVal: 0.597 ± 0.029	0.129TrpTrp: 0.129 ± 0.012	0.312TrpTyr: 0.312 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.233TyrAla: 2.233 ± 0.059	0.522TyrCys: 0.522 ± 0.027	1.838TyrAsp: 1.838 ± 0.052	2.204TyrGlu: 2.204 ± 0.049	1.541TyrPhe: 1.541 ± 0.049	2.376TyrGly: 2.376 ± 0.062	0.749TyrHis: 0.749 ± 0.03	2.513TyrIle: 2.513 ± 0.065	1.632TyrLys: 1.632 ± 0.047	3.902TyrLeu: 3.902 ± 0.069	0.762TyrMet: 0.762 ± 0.033	1.486TyrAsn: 1.486 ± 0.048	1.681TyrPro: 1.681 ± 0.047	1.634TyrGln: 1.634 ± 0.048	2.057TyrArg: 2.057 ± 0.056	2.294TyrSer: 2.294 ± 0.053	1.56TyrThr: 1.56 ± 0.045	1.797TyrVal: 1.797 ± 0.05	0.422TyrTrp: 0.422 ± 0.026	1.526TyrTyr: 1.526 ± 0.051	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2473 proteins (795412 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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