Amino acid dipepetide frequency for Sulfitobacter sp. SK011

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.47AlaAla: 15.47 ± 0.167
1.149AlaCys: 1.149 ± 0.031
7.206AlaAsp: 7.206 ± 0.086
7.189AlaGlu: 7.189 ± 0.1
4.426AlaPhe: 4.426 ± 0.065
9.69AlaGly: 9.69 ± 0.094
2.439AlaHis: 2.439 ± 0.052
6.17AlaIle: 6.17 ± 0.088
4.326AlaLys: 4.326 ± 0.063
12.972AlaLeu: 12.972 ± 0.133
3.866AlaMet: 3.866 ± 0.056
2.885AlaAsn: 2.885 ± 0.057
5.257AlaPro: 5.257 ± 0.076
4.657AlaGln: 4.657 ± 0.057
7.669AlaArg: 7.669 ± 0.094
5.664AlaSer: 5.664 ± 0.069
5.828AlaThr: 5.828 ± 0.068
8.058AlaVal: 8.058 ± 0.076
1.41AlaTrp: 1.41 ± 0.032
2.537AlaTyr: 2.537 ± 0.056
0.0AlaXaa: 0.0 ± 0.0
Cys
1.174CysAla: 1.174 ± 0.034
0.119CysCys: 0.119 ± 0.011
0.681CysAsp: 0.681 ± 0.023
0.462CysGlu: 0.462 ± 0.018
0.366CysPhe: 0.366 ± 0.017
1.017CysGly: 1.017 ± 0.031
0.289CysHis: 0.289 ± 0.015
0.468CysIle: 0.468 ± 0.019
0.262CysLys: 0.262 ± 0.015
0.876CysLeu: 0.876 ± 0.025
0.185CysMet: 0.185 ± 0.013
0.243CysAsn: 0.243 ± 0.015
0.522CysPro: 0.522 ± 0.022
0.261CysGln: 0.261 ± 0.015
0.522CysArg: 0.522 ± 0.021
0.509CysSer: 0.509 ± 0.022
0.472CysThr: 0.472 ± 0.02
0.702CysVal: 0.702 ± 0.027
0.127CysTrp: 0.127 ± 0.01
0.245CysTyr: 0.245 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
7.823AspAla: 7.823 ± 0.082
0.566AspCys: 0.566 ± 0.02
3.659AspAsp: 3.659 ± 0.073
3.374AspGlu: 3.374 ± 0.06
2.325AspPhe: 2.325 ± 0.046
5.546AspGly: 5.546 ± 0.084
1.536AspHis: 1.536 ± 0.037
3.495AspIle: 3.495 ± 0.049
1.943AspLys: 1.943 ± 0.045
6.376AspLeu: 6.376 ± 0.081
1.892AspMet: 1.892 ± 0.041
1.452AspAsn: 1.452 ± 0.04
3.557AspPro: 3.557 ± 0.054
2.226AspGln: 2.226 ± 0.045
3.84AspArg: 3.84 ± 0.061
2.051AspSer: 2.051 ± 0.047
3.215AspThr: 3.215 ± 0.056
4.834AspVal: 4.834 ± 0.057
1.125AspTrp: 1.125 ± 0.032
1.478AspTyr: 1.478 ± 0.036
0.0AspXaa: 0.0 ± 0.0
Glu
6.862GluAla: 6.862 ± 0.1
0.395GluCys: 0.395 ± 0.02
3.056GluAsp: 3.056 ± 0.057
2.93GluGlu: 2.93 ± 0.065
1.896GluPhe: 1.896 ± 0.037
4.111GluGly: 4.111 ± 0.063
1.155GluHis: 1.155 ± 0.03
3.398GluIle: 3.398 ± 0.054
2.348GluLys: 2.348 ± 0.048
4.786GluLeu: 4.786 ± 0.066
1.943GluMet: 1.943 ± 0.038
2.009GluAsn: 2.009 ± 0.044
2.307GluPro: 2.307 ± 0.045
1.928GluGln: 1.928 ± 0.046
3.555GluArg: 3.555 ± 0.063
1.911GluSer: 1.911 ± 0.046
3.616GluThr: 3.616 ± 0.052
4.187GluVal: 4.187 ± 0.057
0.74GluTrp: 0.74 ± 0.025
1.109GluTyr: 1.109 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
4.595PheAla: 4.595 ± 0.074
0.501PheCys: 0.501 ± 0.019
3.114PheAsp: 3.114 ± 0.055
2.362PheGlu: 2.362 ± 0.05
1.514PhePhe: 1.514 ± 0.04
3.866PheGly: 3.866 ± 0.065
0.776PheHis: 0.776 ± 0.024
1.853PheIle: 1.853 ± 0.04
1.153PheLys: 1.153 ± 0.032
3.454PheLeu: 3.454 ± 0.063
0.978PheMet: 0.978 ± 0.03
1.157PheAsn: 1.157 ± 0.031
1.536PhePro: 1.536 ± 0.036
1.158PheGln: 1.158 ± 0.031
1.967PheArg: 1.967 ± 0.041
2.257PheSer: 2.257 ± 0.047
2.111PheThr: 2.111 ± 0.04
2.891PheVal: 2.891 ± 0.054
0.608PheTrp: 0.608 ± 0.021
0.995PheTyr: 0.995 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
9.205GlyAla: 9.205 ± 0.087
0.927GlyCys: 0.927 ± 0.027
4.723GlyAsp: 4.723 ± 0.075
4.023GlyGlu: 4.023 ± 0.06
3.84GlyPhe: 3.84 ± 0.06
7.126GlyGly: 7.126 ± 0.1
2.067GlyHis: 2.067 ± 0.046
4.684GlyIle: 4.684 ± 0.062
3.446GlyLys: 3.446 ± 0.062
8.769GlyLeu: 8.769 ± 0.096
2.669GlyMet: 2.669 ± 0.051
2.26GlyAsn: 2.26 ± 0.051
3.546GlyPro: 3.546 ± 0.058
3.19GlyGln: 3.19 ± 0.058
5.087GlyArg: 5.087 ± 0.069
4.208GlySer: 4.208 ± 0.057
4.714GlyThr: 4.714 ± 0.061
6.405GlyVal: 6.405 ± 0.073
1.484GlyTrp: 1.484 ± 0.039
2.352GlyTyr: 2.352 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.424HisAla: 2.424 ± 0.051
0.255HisCys: 0.255 ± 0.014
1.355HisAsp: 1.355 ± 0.035
1.009HisGlu: 1.009 ± 0.026
0.882HisPhe: 0.882 ± 0.028
1.952HisGly: 1.952 ± 0.044
0.625HisHis: 0.625 ± 0.026
1.157HisIle: 1.157 ± 0.031
0.592HisLys: 0.592 ± 0.021
2.339HisLeu: 2.339 ± 0.046
0.622HisMet: 0.622 ± 0.026
0.554HisAsn: 0.554 ± 0.021
1.387HisPro: 1.387 ± 0.036
0.682HisGln: 0.682 ± 0.022
1.273HisArg: 1.273 ± 0.03
1.007HisSer: 1.007 ± 0.025
0.986HisThr: 0.986 ± 0.033
1.617HisVal: 1.617 ± 0.037
0.343HisTrp: 0.343 ± 0.017
0.581HisTyr: 0.581 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
7.342IleAla: 7.342 ± 0.089
0.712IleCys: 0.712 ± 0.024
3.683IleAsp: 3.683 ± 0.052
3.614IleGlu: 3.614 ± 0.054
1.935IlePhe: 1.935 ± 0.043
5.125IleGly: 5.125 ± 0.07
0.935IleHis: 0.935 ± 0.03
2.743IleIle: 2.743 ± 0.057
1.936IleLys: 1.936 ± 0.041
4.975IleLeu: 4.975 ± 0.067
1.282IleMet: 1.282 ± 0.032
1.663IleAsn: 1.663 ± 0.041
2.453IlePro: 2.453 ± 0.05
1.344IleGln: 1.344 ± 0.035
3.033IleArg: 3.033 ± 0.052
3.324IleSer: 3.324 ± 0.048
3.315IleThr: 3.315 ± 0.052
3.975IleVal: 3.975 ± 0.057
0.835IleTrp: 0.835 ± 0.026
1.311IleTyr: 1.311 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
4.191LysAla: 4.191 ± 0.06
0.236LysCys: 0.236 ± 0.016
2.128LysAsp: 2.128 ± 0.046
1.701LysGlu: 1.701 ± 0.037
1.154LysPhe: 1.154 ± 0.032
3.137LysGly: 3.137 ± 0.053
0.739LysHis: 0.739 ± 0.023
2.007LysIle: 2.007 ± 0.045
1.5LysLys: 1.5 ± 0.039
3.318LysLeu: 3.318 ± 0.053
1.097LysMet: 1.097 ± 0.03
1.037LysAsn: 1.037 ± 0.025
2.02LysPro: 2.02 ± 0.043
1.104LysGln: 1.104 ± 0.029
2.402LysArg: 2.402 ± 0.044
2.217LysSer: 2.217 ± 0.045
2.203LysThr: 2.203 ± 0.045
2.53LysVal: 2.53 ± 0.056
0.458LysTrp: 0.458 ± 0.018
0.778LysTyr: 0.778 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
12.049LeuAla: 12.049 ± 0.128
0.993LeuCys: 0.993 ± 0.028
5.847LeuAsp: 5.847 ± 0.071
5.078LeuGlu: 5.078 ± 0.07
3.613LeuPhe: 3.613 ± 0.063
8.064LeuGly: 8.064 ± 0.083
1.953LeuHis: 1.953 ± 0.041
5.741LeuIle: 5.741 ± 0.074
3.594LeuLys: 3.594 ± 0.057
8.543LeuLeu: 8.543 ± 0.126
2.861LeuMet: 2.861 ± 0.047
3.026LeuAsn: 3.026 ± 0.055
5.306LeuPro: 5.306 ± 0.073
2.762LeuGln: 2.762 ± 0.049
6.468LeuArg: 6.468 ± 0.087
6.569LeuSer: 6.569 ± 0.083
5.975LeuThr: 5.975 ± 0.078
6.5LeuVal: 6.5 ± 0.084
1.283LeuTrp: 1.283 ± 0.039
1.894LeuTyr: 1.894 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
3.654MetAla: 3.654 ± 0.051
0.217MetCys: 0.217 ± 0.014
1.633MetAsp: 1.633 ± 0.033
1.265MetGlu: 1.265 ± 0.031
0.945MetPhe: 0.945 ± 0.027
2.454MetGly: 2.454 ± 0.047
0.513MetHis: 0.513 ± 0.021
1.847MetIle: 1.847 ± 0.037
1.213MetLys: 1.213 ± 0.035
2.746MetLeu: 2.746 ± 0.051
0.867MetMet: 0.867 ± 0.025
0.987MetAsn: 0.987 ± 0.027
1.623MetPro: 1.623 ± 0.039
1.096MetGln: 1.096 ± 0.032
1.981MetArg: 1.981 ± 0.041
1.828MetSer: 1.828 ± 0.038
2.157MetThr: 2.157 ± 0.037
1.972MetVal: 1.972 ± 0.036
0.272MetTrp: 0.272 ± 0.014
0.427MetTyr: 0.427 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.516AsnAla: 3.516 ± 0.056
0.283AsnCys: 0.283 ± 0.015
1.698AsnAsp: 1.698 ± 0.039
1.324AsnGlu: 1.324 ± 0.033
1.136AsnPhe: 1.136 ± 0.032
2.52AsnGly: 2.52 ± 0.051
0.59AsnHis: 0.59 ± 0.023
1.642AsnIle: 1.642 ± 0.039
0.85AsnLys: 0.85 ± 0.032
2.746AsnLeu: 2.746 ± 0.045
0.817AsnMet: 0.817 ± 0.025
0.806AsnAsn: 0.806 ± 0.025
1.974AsnPro: 1.974 ± 0.04
0.853AsnGln: 0.853 ± 0.026
1.785AsnArg: 1.785 ± 0.035
1.308AsnSer: 1.308 ± 0.033
1.523AsnThr: 1.523 ± 0.036
2.041AsnVal: 2.041 ± 0.043
0.521AsnTrp: 0.521 ± 0.024
0.732AsnTyr: 0.732 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
5.075ProAla: 5.075 ± 0.07
0.36ProCys: 0.36 ± 0.018
3.997ProAsp: 3.997 ± 0.069
3.487ProGlu: 3.487 ± 0.057
2.027ProPhe: 2.027 ± 0.04
4.006ProGly: 4.006 ± 0.059
1.1ProHis: 1.1 ± 0.027
2.463ProIle: 2.463 ± 0.049
1.983ProLys: 1.983 ± 0.052
4.481ProLeu: 4.481 ± 0.061
1.391ProMet: 1.391 ± 0.035
1.521ProAsn: 1.521 ± 0.037
2.025ProPro: 2.025 ± 0.053
1.727ProGln: 1.727 ± 0.039
2.511ProArg: 2.511 ± 0.046
2.512ProSer: 2.512 ± 0.042
2.575ProThr: 2.575 ± 0.047
3.943ProVal: 3.943 ± 0.057
0.65ProTrp: 0.65 ± 0.023
1.164ProTyr: 1.164 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
3.934GlnAla: 3.934 ± 0.063
0.22GlnCys: 0.22 ± 0.015
1.829GlnAsp: 1.829 ± 0.039
1.595GlnGlu: 1.595 ± 0.033
1.17GlnPhe: 1.17 ± 0.029
2.712GlnGly: 2.712 ± 0.05
0.718GlnHis: 0.718 ± 0.026
2.25GlnIle: 2.25 ± 0.049
1.255GlnLys: 1.255 ± 0.033
2.903GlnLeu: 2.903 ± 0.049
1.276GlnMet: 1.276 ± 0.029
1.081GlnAsn: 1.081 ± 0.03
1.566GlnPro: 1.566 ± 0.033
1.181GlnGln: 1.181 ± 0.039
2.094GlnArg: 2.094 ± 0.045
2.047GlnSer: 2.047 ± 0.042
2.121GlnThr: 2.121 ± 0.044
2.454GlnVal: 2.454 ± 0.045
0.391GlnTrp: 0.391 ± 0.018
0.652GlnTyr: 0.652 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
7.189ArgAla: 7.189 ± 0.08
0.484ArgCys: 0.484 ± 0.021
4.114ArgAsp: 4.114 ± 0.06
3.215ArgGlu: 3.215 ± 0.053
2.55ArgPhe: 2.55 ± 0.048
4.161ArgGly: 4.161 ± 0.052
1.463ArgHis: 1.463 ± 0.038
3.635ArgIle: 3.635 ± 0.063
2.37ArgLys: 2.37 ± 0.045
6.363ArgLeu: 6.363 ± 0.091
1.893ArgMet: 1.893 ± 0.042
1.851ArgAsn: 1.851 ± 0.036
2.769ArgPro: 2.769 ± 0.046
2.171ArgGln: 2.171 ± 0.045
4.224ArgArg: 4.224 ± 0.063
3.224ArgSer: 3.224 ± 0.046
2.957ArgThr: 2.957 ± 0.043
4.33ArgVal: 4.33 ± 0.065
0.898ArgTrp: 0.898 ± 0.026
1.506ArgTyr: 1.506 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
5.88SerAla: 5.88 ± 0.064
0.445SerCys: 0.445 ± 0.021
3.574SerAsp: 3.574 ± 0.054
2.876SerGlu: 2.876 ± 0.053
2.315SerPhe: 2.315 ± 0.051
5.303SerGly: 5.303 ± 0.063
1.141SerHis: 1.141 ± 0.032
2.741SerIle: 2.741 ± 0.047
1.872SerLys: 1.872 ± 0.047
4.983SerLeu: 4.983 ± 0.074
1.491SerMet: 1.491 ± 0.034
1.548SerAsn: 1.548 ± 0.039
2.432SerPro: 2.432 ± 0.043
1.736SerGln: 1.736 ± 0.04
3.036SerArg: 3.036 ± 0.05
2.711SerSer: 2.711 ± 0.044
2.643SerThr: 2.643 ± 0.043
3.97SerVal: 3.97 ± 0.061
0.682SerTrp: 0.682 ± 0.026
1.31SerTyr: 1.31 ± 0.028
0.0SerXaa: 0.0 ± 0.0
Thr
6.162ThrAla: 6.162 ± 0.074
0.555ThrCys: 0.555 ± 0.021
3.398ThrAsp: 3.398 ± 0.049
2.757ThrGlu: 2.757 ± 0.055
2.126ThrPhe: 2.126 ± 0.04
5.182ThrGly: 5.182 ± 0.073
1.243ThrHis: 1.243 ± 0.029
2.944ThrIle: 2.944 ± 0.051
1.779ThrLys: 1.779 ± 0.037
6.146ThrLeu: 6.146 ± 0.058
1.394ThrMet: 1.394 ± 0.039
1.465ThrAsn: 1.465 ± 0.035
3.44ThrPro: 3.44 ± 0.054
1.802ThrGln: 1.802 ± 0.038
3.309ThrArg: 3.309 ± 0.053
3.019ThrSer: 3.019 ± 0.046
2.976ThrThr: 2.976 ± 0.054
4.097ThrVal: 4.097 ± 0.058
0.698ThrTrp: 0.698 ± 0.027
1.338ThrTyr: 1.338 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
8.377ValAla: 8.377 ± 0.087
0.67ValCys: 0.67 ± 0.024
4.193ValAsp: 4.193 ± 0.067
4.128ValGlu: 4.128 ± 0.061
3.005ValPhe: 3.005 ± 0.062
5.556ValGly: 5.556 ± 0.072
1.423ValHis: 1.423 ± 0.036
4.525ValIle: 4.525 ± 0.058
2.402ValLys: 2.402 ± 0.047
7.375ValLeu: 7.375 ± 0.088
2.26ValMet: 2.26 ± 0.046
2.022ValAsn: 2.022 ± 0.041
3.493ValPro: 3.493 ± 0.049
2.25ValGln: 2.25 ± 0.042
4.094ValArg: 4.094 ± 0.055
4.306ValSer: 4.306 ± 0.063
4.538ValThr: 4.538 ± 0.065
5.566ValVal: 5.566 ± 0.087
1.02ValTrp: 1.02 ± 0.029
1.461ValTyr: 1.461 ± 0.033
0.0ValXaa: 0.0 ± 0.0
Trp
1.429TrpAla: 1.429 ± 0.036
0.155TrpCys: 0.155 ± 0.011
0.812TrpAsp: 0.812 ± 0.026
0.644TrpGlu: 0.644 ± 0.022
0.631TrpPhe: 0.631 ± 0.023
1.012TrpGly: 1.012 ± 0.034
0.366TrpHis: 0.366 ± 0.016
0.771TrpIle: 0.771 ± 0.028
0.449TrpLys: 0.449 ± 0.022
1.625TrpLeu: 1.625 ± 0.043
0.412TrpMet: 0.412 ± 0.017
0.477TrpAsn: 0.477 ± 0.022
0.701TrpPro: 0.701 ± 0.025
0.599TrpGln: 0.599 ± 0.024
1.003TrpArg: 1.003 ± 0.027
0.801TrpSer: 0.801 ± 0.025
0.764TrpThr: 0.764 ± 0.026
0.97TrpVal: 0.97 ± 0.028
0.224TrpTrp: 0.224 ± 0.014
0.285TrpTyr: 0.285 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.515TyrAla: 2.515 ± 0.042
0.26TyrCys: 0.26 ± 0.014
1.616TyrAsp: 1.616 ± 0.034
1.21TyrGlu: 1.21 ± 0.033
0.99TyrPhe: 0.99 ± 0.029
2.183TyrGly: 2.183 ± 0.044
0.569TyrHis: 0.569 ± 0.022
1.002TyrIle: 1.002 ± 0.026
0.683TyrLys: 0.683 ± 0.024
2.34TyrLeu: 2.34 ± 0.04
0.503TyrMet: 0.503 ± 0.02
0.62TyrAsn: 0.62 ± 0.021
1.085TyrPro: 1.085 ± 0.031
0.723TyrGln: 0.723 ± 0.022
1.514TyrArg: 1.514 ± 0.039
1.217TyrSer: 1.217 ± 0.035
1.146TyrThr: 1.146 ± 0.029
1.619TyrVal: 1.619 ± 0.038
0.361TyrTrp: 0.361 ± 0.018
0.602TyrTyr: 0.602 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4006 proteins (1234747 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski