Amino acid dipepetide frequency for Legionella beliardensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.752AlaAla: 6.752 ± 0.108
1.097AlaCys: 1.097 ± 0.04
3.568AlaAsp: 3.568 ± 0.056
4.311AlaGlu: 4.311 ± 0.077
3.307AlaPhe: 3.307 ± 0.065
5.003AlaGly: 5.003 ± 0.091
1.835AlaHis: 1.835 ± 0.045
6.681AlaIle: 6.681 ± 0.089
5.04AlaLys: 5.04 ± 0.078
9.503AlaLeu: 9.503 ± 0.12
2.015AlaMet: 2.015 ± 0.05
3.951AlaAsn: 3.951 ± 0.072
2.53AlaPro: 2.53 ± 0.05
3.631AlaGln: 3.631 ± 0.067
3.456AlaArg: 3.456 ± 0.071
4.752AlaSer: 4.752 ± 0.064
4.3AlaThr: 4.3 ± 0.077
4.615AlaVal: 4.615 ± 0.076
0.875AlaTrp: 0.875 ± 0.032
2.809AlaTyr: 2.809 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.825CysAla: 0.825 ± 0.031
0.218CysCys: 0.218 ± 0.016
0.548CysAsp: 0.548 ± 0.024
0.591CysGlu: 0.591 ± 0.024
0.693CysPhe: 0.693 ± 0.029
0.803CysGly: 0.803 ± 0.029
0.37CysHis: 0.37 ± 0.021
0.809CysIle: 0.809 ± 0.03
0.593CysLys: 0.593 ± 0.024
1.503CysLeu: 1.503 ± 0.049
0.251CysMet: 0.251 ± 0.016
0.521CysAsn: 0.521 ± 0.024
0.523CysPro: 0.523 ± 0.024
0.605CysGln: 0.605 ± 0.025
0.49CysArg: 0.49 ± 0.024
0.777CysSer: 0.777 ± 0.029
0.498CysThr: 0.498 ± 0.024
0.647CysVal: 0.647 ± 0.025
0.141CysTrp: 0.141 ± 0.014
0.462CysTyr: 0.462 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.431AspAla: 3.431 ± 0.055
0.634AspCys: 0.634 ± 0.024
2.397AspAsp: 2.397 ± 0.058
3.287AspGlu: 3.287 ± 0.056
2.339AspPhe: 2.339 ± 0.052
2.415AspGly: 2.415 ± 0.058
0.85AspHis: 0.85 ± 0.029
3.845AspIle: 3.845 ± 0.063
3.596AspLys: 3.596 ± 0.062
5.087AspLeu: 5.087 ± 0.083
0.999AspMet: 0.999 ± 0.031
2.68AspAsn: 2.68 ± 0.059
1.69AspPro: 1.69 ± 0.037
1.4AspGln: 1.4 ± 0.039
1.7AspArg: 1.7 ± 0.042
2.854AspSer: 2.854 ± 0.06
2.247AspThr: 2.247 ± 0.05
2.849AspVal: 2.849 ± 0.051
0.669AspTrp: 0.669 ± 0.023
2.232AspTyr: 2.232 ± 0.045
0.0AspXaa: 0.0 ± 0.0
Glu
4.544GluAla: 4.544 ± 0.078
0.565GluCys: 0.565 ± 0.024
2.473GluAsp: 2.473 ± 0.06
3.982GluGlu: 3.982 ± 0.082
2.173GluPhe: 2.173 ± 0.047
2.778GluGly: 2.778 ± 0.058
1.456GluHis: 1.456 ± 0.04
4.262GluIle: 4.262 ± 0.068
4.518GluLys: 4.518 ± 0.086
6.659GluLeu: 6.659 ± 0.084
1.245GluMet: 1.245 ± 0.033
2.821GluAsn: 2.821 ± 0.051
1.927GluPro: 1.927 ± 0.041
3.63GluGln: 3.63 ± 0.068
2.854GluArg: 2.854 ± 0.064
2.922GluSer: 2.922 ± 0.066
2.695GluThr: 2.695 ± 0.055
3.417GluVal: 3.417 ± 0.064
0.537GluTrp: 0.537 ± 0.022
1.545GluTyr: 1.545 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
3.497PheAla: 3.497 ± 0.067
0.627PheCys: 0.627 ± 0.029
2.253PheAsp: 2.253 ± 0.047
2.076PheGlu: 2.076 ± 0.051
2.562PhePhe: 2.562 ± 0.066
2.515PheGly: 2.515 ± 0.052
0.992PheHis: 0.992 ± 0.031
3.92PheIle: 3.92 ± 0.084
2.817PheLys: 2.817 ± 0.054
4.777PheLeu: 4.777 ± 0.082
0.907PheMet: 0.907 ± 0.031
2.832PheAsn: 2.832 ± 0.056
1.725PhePro: 1.725 ± 0.052
1.433PheGln: 1.433 ± 0.034
1.453PheArg: 1.453 ± 0.037
3.397PheSer: 3.397 ± 0.073
2.571PheThr: 2.571 ± 0.054
2.273PheVal: 2.273 ± 0.049
0.568PheTrp: 0.568 ± 0.027
1.874PheTyr: 1.874 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
4.249GlyAla: 4.249 ± 0.097
0.84GlyCys: 0.84 ± 0.032
2.537GlyAsp: 2.537 ± 0.053
3.009GlyGlu: 3.009 ± 0.061
3.072GlyPhe: 3.072 ± 0.063
3.912GlyGly: 3.912 ± 0.138
1.488GlyHis: 1.488 ± 0.038
4.764GlyIle: 4.764 ± 0.075
3.573GlyLys: 3.573 ± 0.063
6.432GlyLeu: 6.432 ± 0.09
1.464GlyMet: 1.464 ± 0.039
2.531GlyAsn: 2.531 ± 0.064
1.643GlyPro: 1.643 ± 0.046
2.582GlyGln: 2.582 ± 0.061
2.463GlyArg: 2.463 ± 0.053
3.445GlySer: 3.445 ± 0.066
2.993GlyThr: 2.993 ± 0.087
3.733GlyVal: 3.733 ± 0.081
0.765GlyTrp: 0.765 ± 0.026
2.395GlyTyr: 2.395 ± 0.052
0.0GlyXaa: 0.0 ± 0.0
His
1.896HisAla: 1.896 ± 0.046
0.401HisCys: 0.401 ± 0.021
1.151HisAsp: 1.151 ± 0.037
1.309HisGlu: 1.309 ± 0.038
1.297HisPhe: 1.297 ± 0.037
1.425HisGly: 1.425 ± 0.043
0.861HisHis: 0.861 ± 0.031
1.539HisIle: 1.539 ± 0.042
1.127HisLys: 1.127 ± 0.04
2.811HisLeu: 2.811 ± 0.056
0.509HisMet: 0.509 ± 0.025
0.993HisAsn: 0.993 ± 0.03
1.154HisPro: 1.154 ± 0.038
1.24HisGln: 1.24 ± 0.037
1.007HisArg: 1.007 ± 0.03
1.4HisSer: 1.4 ± 0.034
1.179HisThr: 1.179 ± 0.034
1.344HisVal: 1.344 ± 0.033
0.396HisTrp: 0.396 ± 0.02
1.209HisTyr: 1.209 ± 0.039
0.0HisXaa: 0.0 ± 0.0
Ile
6.478IleAla: 6.478 ± 0.094
0.837IleCys: 0.837 ± 0.032
4.209IleAsp: 4.209 ± 0.073
4.592IleGlu: 4.592 ± 0.074
2.895IlePhe: 2.895 ± 0.069
4.685IleGly: 4.685 ± 0.087
1.694IleHis: 1.694 ± 0.038
5.873IleIle: 5.873 ± 0.092
5.281IleLys: 5.281 ± 0.092
7.166IleLeu: 7.166 ± 0.108
1.436IleMet: 1.436 ± 0.042
4.783IleAsn: 4.783 ± 0.071
3.397IlePro: 3.397 ± 0.068
2.709IleGln: 2.709 ± 0.058
2.915IleArg: 2.915 ± 0.055
5.015IleSer: 5.015 ± 0.067
4.461IleThr: 4.461 ± 0.077
3.99IleVal: 3.99 ± 0.069
0.644IleTrp: 0.644 ± 0.024
2.568IleTyr: 2.568 ± 0.058
0.0IleXaa: 0.0 ± 0.0
Lys
4.881LysAla: 4.881 ± 0.086
0.454LysCys: 0.454 ± 0.024
3.146LysAsp: 3.146 ± 0.056
4.416LysGlu: 4.416 ± 0.083
1.996LysPhe: 1.996 ± 0.049
3.068LysGly: 3.068 ± 0.056
1.563LysHis: 1.563 ± 0.038
4.503LysIle: 4.503 ± 0.067
4.818LysLys: 4.818 ± 0.089
6.725LysLeu: 6.725 ± 0.099
1.277LysMet: 1.277 ± 0.038
3.586LysAsn: 3.586 ± 0.069
2.959LysPro: 2.959 ± 0.053
3.838LysGln: 3.838 ± 0.075
3.067LysArg: 3.067 ± 0.06
3.648LysSer: 3.648 ± 0.067
3.485LysThr: 3.485 ± 0.063
3.345LysVal: 3.345 ± 0.055
0.568LysTrp: 0.568 ± 0.027
1.695LysTyr: 1.695 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
10.024LeuAla: 10.024 ± 0.121
1.251LeuCys: 1.251 ± 0.039
5.115LeuAsp: 5.115 ± 0.078
5.662LeuGlu: 5.662 ± 0.089
5.084LeuPhe: 5.084 ± 0.096
6.463LeuGly: 6.463 ± 0.088
2.388LeuHis: 2.388 ± 0.053
8.903LeuIle: 8.903 ± 0.106
7.087LeuLys: 7.087 ± 0.093
12.356LeuLeu: 12.356 ± 0.18
2.478LeuMet: 2.478 ± 0.053
6.051LeuAsn: 6.051 ± 0.081
5.322LeuPro: 5.322 ± 0.084
4.794LeuGln: 4.794 ± 0.078
4.348LeuArg: 4.348 ± 0.075
7.914LeuSer: 7.914 ± 0.091
6.835LeuThr: 6.835 ± 0.089
6.015LeuVal: 6.015 ± 0.09
1.036LeuTrp: 1.036 ± 0.038
3.459LeuTyr: 3.459 ± 0.066
0.0LeuXaa: 0.0 ± 0.0
Met
1.96MetAla: 1.96 ± 0.048
0.162MetCys: 0.162 ± 0.012
0.947MetAsp: 0.947 ± 0.031
0.976MetGlu: 0.976 ± 0.031
0.662MetPhe: 0.662 ± 0.028
1.292MetGly: 1.292 ± 0.035
0.581MetHis: 0.581 ± 0.027
1.39MetIle: 1.39 ± 0.039
1.381MetLys: 1.381 ± 0.037
2.382MetLeu: 2.382 ± 0.051
0.602MetMet: 0.602 ± 0.028
1.043MetAsn: 1.043 ± 0.034
1.102MetPro: 1.102 ± 0.036
1.212MetGln: 1.212 ± 0.033
1.093MetArg: 1.093 ± 0.031
1.502MetSer: 1.502 ± 0.041
1.408MetThr: 1.408 ± 0.041
1.257MetVal: 1.257 ± 0.032
0.16MetTrp: 0.16 ± 0.012
0.536MetTyr: 0.536 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.418AsnAla: 3.418 ± 0.072
0.622AsnCys: 0.622 ± 0.029
2.456AsnAsp: 2.456 ± 0.053
3.074AsnGlu: 3.074 ± 0.061
2.374AsnPhe: 2.374 ± 0.056
2.454AsnGly: 2.454 ± 0.061
1.483AsnHis: 1.483 ± 0.034
3.497AsnIle: 3.497 ± 0.068
3.594AsnLys: 3.594 ± 0.073
5.749AsnLeu: 5.749 ± 0.087
0.995AsnMet: 0.995 ± 0.03
3.228AsnAsn: 3.228 ± 0.074
2.72AsnPro: 2.72 ± 0.051
2.954AsnGln: 2.954 ± 0.059
2.175AsnArg: 2.175 ± 0.052
3.141AsnSer: 3.141 ± 0.066
2.816AsnThr: 2.816 ± 0.06
2.36AsnVal: 2.36 ± 0.051
0.694AsnTrp: 0.694 ± 0.029
2.43AsnTyr: 2.43 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
3.239ProAla: 3.239 ± 0.067
0.424ProCys: 0.424 ± 0.022
2.038ProAsp: 2.038 ± 0.038
2.731ProGlu: 2.731 ± 0.054
1.936ProPhe: 1.936 ± 0.046
2.46ProGly: 2.46 ± 0.059
0.941ProHis: 0.941 ± 0.033
3.126ProIle: 3.126 ± 0.064
2.285ProLys: 2.285 ± 0.048
4.603ProLeu: 4.603 ± 0.073
0.847ProMet: 0.847 ± 0.032
2.238ProAsn: 2.238 ± 0.053
1.57ProPro: 1.57 ± 0.046
1.666ProGln: 1.666 ± 0.047
1.332ProArg: 1.332 ± 0.042
2.569ProSer: 2.569 ± 0.054
2.428ProThr: 2.428 ± 0.05
2.696ProVal: 2.696 ± 0.059
0.517ProTrp: 0.517 ± 0.02
1.476ProTyr: 1.476 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
4.725GlnAla: 4.725 ± 0.078
0.501GlnCys: 0.501 ± 0.026
1.997GlnAsp: 1.997 ± 0.047
2.996GlnGlu: 2.996 ± 0.063
2.148GlnPhe: 2.148 ± 0.044
2.826GlnGly: 2.826 ± 0.063
1.179GlnHis: 1.179 ± 0.034
2.949GlnIle: 2.949 ± 0.051
2.709GlnLys: 2.709 ± 0.056
5.613GlnLeu: 5.613 ± 0.092
0.832GlnMet: 0.832 ± 0.033
1.972GlnAsn: 1.972 ± 0.049
1.69GlnPro: 1.69 ± 0.042
3.057GlnGln: 3.057 ± 0.073
1.997GlnArg: 1.997 ± 0.047
2.567GlnSer: 2.567 ± 0.05
2.572GlnThr: 2.572 ± 0.051
2.979GlnVal: 2.979 ± 0.066
0.593GlnTrp: 0.593 ± 0.025
1.557GlnTyr: 1.557 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
3.173ArgAla: 3.173 ± 0.065
0.47ArgCys: 0.47 ± 0.02
2.031ArgAsp: 2.031 ± 0.047
2.629ArgGlu: 2.629 ± 0.076
2.194ArgPhe: 2.194 ± 0.049
2.208ArgGly: 2.208 ± 0.058
1.154ArgHis: 1.154 ± 0.032
2.908ArgIle: 2.908 ± 0.06
2.399ArgLys: 2.399 ± 0.058
5.037ArgLeu: 5.037 ± 0.085
0.953ArgMet: 0.953 ± 0.031
1.856ArgAsn: 1.856 ± 0.039
1.479ArgPro: 1.479 ± 0.041
2.182ArgGln: 2.182 ± 0.047
1.903ArgArg: 1.903 ± 0.052
2.196ArgSer: 2.196 ± 0.053
1.869ArgThr: 1.869 ± 0.049
2.48ArgVal: 2.48 ± 0.051
0.515ArgTrp: 0.515 ± 0.025
1.737ArgTyr: 1.737 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
4.569SerAla: 4.569 ± 0.077
0.76SerCys: 0.76 ± 0.029
2.772SerAsp: 2.772 ± 0.056
3.269SerGlu: 3.269 ± 0.059
3.103SerPhe: 3.103 ± 0.063
3.823SerGly: 3.823 ± 0.079
1.625SerHis: 1.625 ± 0.038
4.516SerIle: 4.516 ± 0.08
3.551SerLys: 3.551 ± 0.063
7.839SerLeu: 7.839 ± 0.095
1.443SerMet: 1.443 ± 0.033
3.062SerAsn: 3.062 ± 0.065
2.687SerPro: 2.687 ± 0.055
2.981SerGln: 2.981 ± 0.067
2.405SerArg: 2.405 ± 0.046
4.415SerSer: 4.415 ± 0.082
3.383SerThr: 3.383 ± 0.061
3.314SerVal: 3.314 ± 0.06
0.729SerTrp: 0.729 ± 0.026
2.389SerTyr: 2.389 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
4.461ThrAla: 4.461 ± 0.079
0.636ThrCys: 0.636 ± 0.026
2.511ThrAsp: 2.511 ± 0.058
2.688ThrGlu: 2.688 ± 0.051
2.212ThrPhe: 2.212 ± 0.047
3.492ThrGly: 3.492 ± 0.091
1.395ThrHis: 1.395 ± 0.036
4.406ThrIle: 4.406 ± 0.081
2.896ThrLys: 2.896 ± 0.054
6.402ThrLeu: 6.402 ± 0.076
1.161ThrMet: 1.161 ± 0.033
2.721ThrAsn: 2.721 ± 0.062
2.693ThrPro: 2.693 ± 0.059
2.307ThrGln: 2.307 ± 0.05
2.158ThrArg: 2.158 ± 0.053
3.419ThrSer: 3.419 ± 0.068
3.417ThrThr: 3.417 ± 0.097
3.303ThrVal: 3.303 ± 0.089
0.608ThrTrp: 0.608 ± 0.026
1.969ThrTyr: 1.969 ± 0.047
0.0ThrXaa: 0.0 ± 0.0
Val
4.644ValAla: 4.644 ± 0.071
0.692ValCys: 0.692 ± 0.029
2.912ValAsp: 2.912 ± 0.061
2.988ValGlu: 2.988 ± 0.064
2.569ValPhe: 2.569 ± 0.048
3.534ValGly: 3.534 ± 0.064
1.075ValHis: 1.075 ± 0.035
4.838ValIle: 4.838 ± 0.072
3.415ValLys: 3.415 ± 0.064
5.809ValLeu: 5.809 ± 0.077
1.383ValMet: 1.383 ± 0.037
3.296ValAsn: 3.296 ± 0.065
2.227ValPro: 2.227 ± 0.053
2.029ValGln: 2.029 ± 0.052
2.225ValArg: 2.225 ± 0.047
3.798ValSer: 3.798 ± 0.069
3.35ValThr: 3.35 ± 0.097
3.664ValVal: 3.664 ± 0.082
0.571ValTrp: 0.571 ± 0.025
1.767ValTyr: 1.767 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.741TrpAla: 0.741 ± 0.03
0.125TrpCys: 0.125 ± 0.011
0.49TrpAsp: 0.49 ± 0.023
0.517TrpGlu: 0.517 ± 0.018
0.53TrpPhe: 0.53 ± 0.025
0.651TrpGly: 0.651 ± 0.027
0.39TrpHis: 0.39 ± 0.021
0.707TrpIle: 0.707 ± 0.029
0.447TrpLys: 0.447 ± 0.026
1.671TrpLeu: 1.671 ± 0.045
0.252TrpMet: 0.252 ± 0.015
0.451TrpAsn: 0.451 ± 0.021
0.483TrpPro: 0.483 ± 0.021
0.925TrpGln: 0.925 ± 0.032
0.559TrpArg: 0.559 ± 0.028
0.6TrpSer: 0.6 ± 0.025
0.485TrpThr: 0.485 ± 0.024
0.692TrpVal: 0.692 ± 0.025
0.166TrpTrp: 0.166 ± 0.013
0.398TrpTyr: 0.398 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.525TyrAla: 2.525 ± 0.054
0.55TyrCys: 0.55 ± 0.023
1.649TyrAsp: 1.649 ± 0.04
1.899TyrGlu: 1.899 ± 0.044
1.925TyrPhe: 1.925 ± 0.047
2.082TyrGly: 2.082 ± 0.046
0.929TyrHis: 0.929 ± 0.032
2.196TyrIle: 2.196 ± 0.051
1.911TyrLys: 1.911 ± 0.046
4.458TyrLeu: 4.458 ± 0.069
0.597TyrMet: 0.597 ± 0.029
1.619TyrAsn: 1.619 ± 0.042
1.601TyrPro: 1.601 ± 0.045
2.284TyrGln: 2.284 ± 0.057
1.77TyrArg: 1.77 ± 0.041
2.302TyrSer: 2.302 ± 0.052
1.866TyrThr: 1.866 ± 0.052
1.814TyrVal: 1.814 ± 0.047
0.529TyrTrp: 0.529 ± 0.022
1.536TyrTyr: 1.536 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3101 proteins (1004299 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski