Amino acid dipepetide frequency for Tepidimonas fonticaldi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.79AlaAla: 21.79 ± 0.267
1.374AlaCys: 1.374 ± 0.044
7.353AlaAsp: 7.353 ± 0.084
7.625AlaGlu: 7.625 ± 0.115
4.182AlaPhe: 4.182 ± 0.071
11.1AlaGly: 11.1 ± 0.133
3.281AlaHis: 3.281 ± 0.069
5.141AlaIle: 5.141 ± 0.09
2.853AlaLys: 2.853 ± 0.073
17.633AlaLeu: 17.633 ± 0.204
3.28AlaMet: 3.28 ± 0.058
2.252AlaAsn: 2.252 ± 0.065
7.471AlaPro: 7.471 ± 0.124
6.503AlaGln: 6.503 ± 0.106
11.493AlaArg: 11.493 ± 0.134
5.367AlaSer: 5.367 ± 0.081
6.022AlaThr: 6.022 ± 0.087
10.604AlaVal: 10.604 ± 0.133
2.735AlaTrp: 2.735 ± 0.072
2.524AlaTyr: 2.524 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
1.196CysAla: 1.196 ± 0.046
0.114CysCys: 0.114 ± 0.012
0.556CysAsp: 0.556 ± 0.025
0.474CysGlu: 0.474 ± 0.026
0.213CysPhe: 0.213 ± 0.016
0.965CysGly: 0.965 ± 0.046
0.313CysHis: 0.313 ± 0.022
0.366CysIle: 0.366 ± 0.027
0.153CysLys: 0.153 ± 0.013
0.775CysLeu: 0.775 ± 0.033
0.191CysMet: 0.191 ± 0.015
0.209CysAsn: 0.209 ± 0.018
0.638CysPro: 0.638 ± 0.025
0.255CysGln: 0.255 ± 0.017
0.649CysArg: 0.649 ± 0.029
0.357CysSer: 0.357 ± 0.024
0.46CysThr: 0.46 ± 0.022
0.72CysVal: 0.72 ± 0.031
0.127CysTrp: 0.127 ± 0.012
0.183CysTyr: 0.183 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
8.135AspAla: 8.135 ± 0.124
0.411AspCys: 0.411 ± 0.025
3.114AspAsp: 3.114 ± 0.073
3.488AspGlu: 3.488 ± 0.065
1.807AspPhe: 1.807 ± 0.052
5.214AspGly: 5.214 ± 0.093
1.2AspHis: 1.2 ± 0.038
2.201AspIle: 2.201 ± 0.052
1.385AspLys: 1.385 ± 0.053
5.482AspLeu: 5.482 ± 0.087
1.038AspMet: 1.038 ± 0.038
0.954AspAsn: 0.954 ± 0.038
3.551AspPro: 3.551 ± 0.077
1.423AspGln: 1.423 ± 0.038
3.749AspArg: 3.749 ± 0.079
1.599AspSer: 1.599 ± 0.041
2.539AspThr: 2.539 ± 0.06
4.339AspVal: 4.339 ± 0.08
1.28AspTrp: 1.28 ± 0.045
1.196AspTyr: 1.196 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
8.064GluAla: 8.064 ± 0.118
0.353GluCys: 0.353 ± 0.022
2.19GluAsp: 2.19 ± 0.064
2.362GluGlu: 2.362 ± 0.063
1.54GluPhe: 1.54 ± 0.046
3.957GluGly: 3.957 ± 0.078
1.435GluHis: 1.435 ± 0.041
2.352GluIle: 2.352 ± 0.062
1.306GluLys: 1.306 ± 0.045
5.748GluLeu: 5.748 ± 0.088
1.031GluMet: 1.031 ± 0.034
0.905GluAsn: 0.905 ± 0.037
3.025GluPro: 3.025 ± 0.073
2.583GluGln: 2.583 ± 0.063
6.129GluArg: 6.129 ± 0.104
1.979GluSer: 1.979 ± 0.048
2.367GluThr: 2.367 ± 0.06
4.26GluVal: 4.26 ± 0.082
0.818GluTrp: 0.818 ± 0.034
0.974GluTyr: 0.974 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.915PheAla: 3.915 ± 0.071
0.332PheCys: 0.332 ± 0.018
2.388PheAsp: 2.388 ± 0.051
2.105PheGlu: 2.105 ± 0.055
1.102PhePhe: 1.102 ± 0.04
3.067PheGly: 3.067 ± 0.066
0.702PheHis: 0.702 ± 0.03
1.216PheIle: 1.216 ± 0.039
0.839PheLys: 0.839 ± 0.033
2.761PheLeu: 2.761 ± 0.064
0.603PheMet: 0.603 ± 0.026
0.848PheAsn: 0.848 ± 0.033
1.319PhePro: 1.319 ± 0.041
0.986PheGln: 0.986 ± 0.034
1.819PheArg: 1.819 ± 0.046
1.337PheSer: 1.337 ± 0.042
1.495PheThr: 1.495 ± 0.045
2.7PheVal: 2.7 ± 0.058
0.518PheTrp: 0.518 ± 0.029
0.77PheTyr: 0.77 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
9.937GlyAla: 9.937 ± 0.108
0.988GlyCys: 0.988 ± 0.032
4.238GlyAsp: 4.238 ± 0.064
4.529GlyGlu: 4.529 ± 0.079
2.836GlyPhe: 2.836 ± 0.063
7.19GlyGly: 7.19 ± 0.206
2.19GlyHis: 2.19 ± 0.052
3.599GlyIle: 3.599 ± 0.069
2.458GlyLys: 2.458 ± 0.067
9.611GlyLeu: 9.611 ± 0.127
2.194GlyMet: 2.194 ± 0.056
1.622GlyAsn: 1.622 ± 0.052
3.718GlyPro: 3.718 ± 0.081
3.436GlyGln: 3.436 ± 0.066
6.614GlyArg: 6.614 ± 0.09
3.585GlySer: 3.585 ± 0.059
4.119GlyThr: 4.119 ± 0.082
7.183GlyVal: 7.183 ± 0.09
1.978GlyTrp: 1.978 ± 0.052
2.108GlyTyr: 2.108 ± 0.054
0.0GlyXaa: 0.0 ± 0.0
His
3.305HisAla: 3.305 ± 0.07
0.287HisCys: 0.287 ± 0.018
1.342HisAsp: 1.342 ± 0.045
1.244HisGlu: 1.244 ± 0.039
0.811HisPhe: 0.811 ± 0.032
2.625HisGly: 2.625 ± 0.066
0.721HisHis: 0.721 ± 0.032
0.935HisIle: 0.935 ± 0.035
0.502HisLys: 0.502 ± 0.028
2.474HisLeu: 2.474 ± 0.055
0.438HisMet: 0.438 ± 0.02
0.511HisAsn: 0.511 ± 0.025
1.849HisPro: 1.849 ± 0.052
0.748HisGln: 0.748 ± 0.029
1.852HisArg: 1.852 ± 0.052
0.788HisSer: 0.788 ± 0.034
1.23HisThr: 1.23 ± 0.042
1.76HisVal: 1.76 ± 0.049
0.532HisTrp: 0.532 ± 0.026
0.668HisTyr: 0.668 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.467IleAla: 5.467 ± 0.09
0.316IleCys: 0.316 ± 0.017
2.982IleAsp: 2.982 ± 0.067
3.087IleGlu: 3.087 ± 0.068
1.024IlePhe: 1.024 ± 0.04
4.026IleGly: 4.026 ± 0.081
0.884IleHis: 0.884 ± 0.036
1.348IleIle: 1.348 ± 0.043
1.102IleLys: 1.102 ± 0.04
3.135IleLeu: 3.135 ± 0.067
0.656IleMet: 0.656 ± 0.03
1.025IleAsn: 1.025 ± 0.035
1.934IlePro: 1.934 ± 0.055
1.252IleGln: 1.252 ± 0.035
2.721IleArg: 2.721 ± 0.059
1.466IleSer: 1.466 ± 0.049
2.094IleThr: 2.094 ± 0.05
3.454IleVal: 3.454 ± 0.074
0.422IleTrp: 0.422 ± 0.025
0.841IleTyr: 0.841 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
3.364LysAla: 3.364 ± 0.071
0.13LysCys: 0.13 ± 0.014
1.243LysAsp: 1.243 ± 0.049
1.036LysGlu: 1.036 ± 0.047
0.619LysPhe: 0.619 ± 0.029
1.979LysGly: 1.979 ± 0.061
0.49LysHis: 0.49 ± 0.026
1.056LysIle: 1.056 ± 0.042
0.864LysLys: 0.864 ± 0.042
2.374LysLeu: 2.374 ± 0.066
0.562LysMet: 0.562 ± 0.025
0.612LysAsn: 0.612 ± 0.031
1.487LysPro: 1.487 ± 0.042
0.746LysGln: 0.746 ± 0.034
1.828LysArg: 1.828 ± 0.053
1.102LysSer: 1.102 ± 0.042
1.434LysThr: 1.434 ± 0.047
2.018LysVal: 2.018 ± 0.063
0.254LysTrp: 0.254 ± 0.019
0.519LysTyr: 0.519 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
16.689LeuAla: 16.689 ± 0.185
0.978LeuCys: 0.978 ± 0.039
6.356LeuAsp: 6.356 ± 0.089
5.495LeuGlu: 5.495 ± 0.08
3.014LeuPhe: 3.014 ± 0.063
9.114LeuGly: 9.114 ± 0.112
2.662LeuHis: 2.662 ± 0.058
4.174LeuIle: 4.174 ± 0.066
2.767LeuLys: 2.767 ± 0.07
11.702LeuLeu: 11.702 ± 0.192
2.33LeuMet: 2.33 ± 0.051
2.203LeuAsn: 2.203 ± 0.053
6.889LeuPro: 6.889 ± 0.098
5.038LeuGln: 5.038 ± 0.086
9.632LeuArg: 9.632 ± 0.123
4.94LeuSer: 4.94 ± 0.074
5.616LeuThr: 5.616 ± 0.09
7.911LeuVal: 7.911 ± 0.108
1.772LeuTrp: 1.772 ± 0.051
2.089LeuTyr: 2.089 ± 0.054
0.0LeuXaa: 0.0 ± 0.0
Met
3.148MetAla: 3.148 ± 0.063
0.161MetCys: 0.161 ± 0.013
1.038MetAsp: 1.038 ± 0.032
0.946MetGlu: 0.946 ± 0.038
0.576MetPhe: 0.576 ± 0.026
1.838MetGly: 1.838 ± 0.056
0.479MetHis: 0.479 ± 0.027
0.809MetIle: 0.809 ± 0.036
0.718MetLys: 0.718 ± 0.031
2.247MetLeu: 2.247 ± 0.059
0.463MetMet: 0.463 ± 0.024
0.636MetAsn: 0.636 ± 0.027
1.303MetPro: 1.303 ± 0.039
0.854MetGln: 0.854 ± 0.033
1.665MetArg: 1.665 ± 0.048
1.156MetSer: 1.156 ± 0.037
1.356MetThr: 1.356 ± 0.043
1.627MetVal: 1.627 ± 0.048
0.207MetTrp: 0.207 ± 0.015
0.31MetTyr: 0.31 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.59AsnAla: 2.59 ± 0.069
0.187AsnCys: 0.187 ± 0.015
1.047AsnAsp: 1.047 ± 0.038
0.901AsnGlu: 0.901 ± 0.03
0.642AsnPhe: 0.642 ± 0.027
1.687AsnGly: 1.687 ± 0.05
0.421AsnHis: 0.421 ± 0.021
0.908AsnIle: 0.908 ± 0.033
0.558AsnLys: 0.558 ± 0.028
2.252AsnLeu: 2.252 ± 0.053
0.38AsnMet: 0.38 ± 0.021
0.478AsnAsn: 0.478 ± 0.025
1.658AsnPro: 1.658 ± 0.042
0.651AsnGln: 0.651 ± 0.031
1.589AsnArg: 1.589 ± 0.044
0.67AsnSer: 0.67 ± 0.031
1.052AsnThr: 1.052 ± 0.036
1.546AsnVal: 1.546 ± 0.047
0.293AsnTrp: 0.293 ± 0.02
0.431AsnTyr: 0.431 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
8.715ProAla: 8.715 ± 0.145
0.414ProCys: 0.414 ± 0.024
3.899ProAsp: 3.899 ± 0.082
3.441ProGlu: 3.441 ± 0.07
1.738ProPhe: 1.738 ± 0.05
5.148ProGly: 5.148 ± 0.082
1.422ProHis: 1.422 ± 0.042
1.868ProIle: 1.868 ± 0.046
1.231ProLys: 1.231 ± 0.038
5.968ProLeu: 5.968 ± 0.094
1.296ProMet: 1.296 ± 0.042
1.156ProAsn: 1.156 ± 0.037
3.84ProPro: 3.84 ± 0.095
2.422ProGln: 2.422 ± 0.051
3.85ProArg: 3.85 ± 0.072
2.518ProSer: 2.518 ± 0.055
2.903ProThr: 2.903 ± 0.059
4.794ProVal: 4.794 ± 0.084
1.102ProTrp: 1.102 ± 0.045
1.189ProTyr: 1.189 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
6.832GlnAla: 6.832 ± 0.11
0.272GlnCys: 0.272 ± 0.017
1.577GlnAsp: 1.577 ± 0.049
1.535GlnGlu: 1.535 ± 0.049
1.041GlnPhe: 1.041 ± 0.038
3.164GlnGly: 3.164 ± 0.056
0.972GlnHis: 0.972 ± 0.035
1.567GlnIle: 1.567 ± 0.044
0.774GlnLys: 0.774 ± 0.029
3.733GlnLeu: 3.733 ± 0.066
0.828GlnMet: 0.828 ± 0.031
0.587GlnAsn: 0.587 ± 0.029
2.709GlnPro: 2.709 ± 0.053
1.838GlnGln: 1.838 ± 0.058
4.768GlnArg: 4.768 ± 0.084
1.487GlnSer: 1.487 ± 0.043
2.074GlnThr: 2.074 ± 0.053
3.01GlnVal: 3.01 ± 0.065
0.657GlnTrp: 0.657 ± 0.032
0.677GlnTyr: 0.677 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
10.569ArgAla: 10.569 ± 0.132
0.725ArgCys: 0.725 ± 0.03
4.276ArgAsp: 4.276 ± 0.079
4.852ArgGlu: 4.852 ± 0.078
2.789ArgPhe: 2.789 ± 0.06
5.546ArgGly: 5.546 ± 0.09
2.514ArgHis: 2.514 ± 0.057
3.579ArgIle: 3.579 ± 0.079
1.681ArgLys: 1.681 ± 0.047
10.705ArgLeu: 10.705 ± 0.15
1.728ArgMet: 1.728 ± 0.055
1.504ArgAsn: 1.504 ± 0.044
4.387ArgPro: 4.387 ± 0.086
3.567ArgGln: 3.567 ± 0.08
7.028ArgArg: 7.028 ± 0.104
2.896ArgSer: 2.896 ± 0.064
3.505ArgThr: 3.505 ± 0.072
6.131ArgVal: 6.131 ± 0.098
1.866ArgTrp: 1.866 ± 0.055
1.986ArgTyr: 1.986 ± 0.055
0.0ArgXaa: 0.0 ± 0.0
Ser
5.499SerAla: 5.499 ± 0.099
0.315SerCys: 0.315 ± 0.018
2.053SerAsp: 2.053 ± 0.05
1.772SerGlu: 1.772 ± 0.05
1.367SerPhe: 1.367 ± 0.045
4.037SerGly: 4.037 ± 0.069
0.969SerHis: 0.969 ± 0.036
1.617SerIle: 1.617 ± 0.04
0.86SerLys: 0.86 ± 0.035
4.267SerLeu: 4.267 ± 0.079
0.938SerMet: 0.938 ± 0.032
0.906SerAsn: 0.906 ± 0.035
2.608SerPro: 2.608 ± 0.056
1.275SerGln: 1.275 ± 0.039
2.928SerArg: 2.928 ± 0.066
1.873SerSer: 1.873 ± 0.042
2.183SerThr: 2.183 ± 0.049
3.076SerVal: 3.076 ± 0.065
0.528SerTrp: 0.528 ± 0.024
0.855SerTyr: 0.855 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
6.177ThrAla: 6.177 ± 0.089
0.388ThrCys: 0.388 ± 0.022
2.517ThrAsp: 2.517 ± 0.057
2.382ThrGlu: 2.382 ± 0.055
1.621ThrPhe: 1.621 ± 0.047
4.463ThrGly: 4.463 ± 0.086
1.127ThrHis: 1.127 ± 0.042
1.801ThrIle: 1.801 ± 0.049
0.928ThrLys: 0.928 ± 0.038
6.279ThrLeu: 6.279 ± 0.091
0.876ThrMet: 0.876 ± 0.036
0.944ThrAsn: 0.944 ± 0.036
3.945ThrPro: 3.945 ± 0.072
1.652ThrGln: 1.652 ± 0.046
3.306ThrArg: 3.306 ± 0.064
1.887ThrSer: 1.887 ± 0.05
2.402ThrThr: 2.402 ± 0.077
4.479ThrVal: 4.479 ± 0.067
0.734ThrTrp: 0.734 ± 0.036
0.985ThrTyr: 0.985 ± 0.036
0.0ThrXaa: 0.0 ± 0.0
Val
10.575ValAla: 10.575 ± 0.132
0.741ValCys: 0.741 ± 0.026
3.994ValAsp: 3.994 ± 0.075
4.42ValGlu: 4.42 ± 0.081
2.606ValPhe: 2.606 ± 0.07
5.791ValGly: 5.791 ± 0.093
1.84ValHis: 1.84 ± 0.044
3.317ValIle: 3.317 ± 0.074
1.935ValLys: 1.935 ± 0.058
9.204ValLeu: 9.204 ± 0.121
1.846ValMet: 1.846 ± 0.05
1.815ValAsn: 1.815 ± 0.046
4.469ValPro: 4.469 ± 0.075
3.182ValGln: 3.182 ± 0.074
6.508ValArg: 6.508 ± 0.101
3.323ValSer: 3.323 ± 0.067
4.156ValThr: 4.156 ± 0.074
6.806ValVal: 6.806 ± 0.101
1.322ValTrp: 1.322 ± 0.044
1.529ValTyr: 1.529 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
2.042TrpAla: 2.042 ± 0.057
0.196TrpCys: 0.196 ± 0.015
0.751TrpAsp: 0.751 ± 0.031
0.594TrpGlu: 0.594 ± 0.029
0.512TrpPhe: 0.512 ± 0.027
1.264TrpGly: 1.264 ± 0.04
0.506TrpHis: 0.506 ± 0.021
0.721TrpIle: 0.721 ± 0.028
0.341TrpLys: 0.341 ± 0.023
2.686TrpLeu: 2.686 ± 0.072
0.489TrpMet: 0.489 ± 0.024
0.314TrpAsn: 0.314 ± 0.021
1.042TrpPro: 1.042 ± 0.041
0.946TrpGln: 0.946 ± 0.036
1.924TrpArg: 1.924 ± 0.056
0.754TrpSer: 0.754 ± 0.032
0.754TrpThr: 0.754 ± 0.032
1.362TrpVal: 1.362 ± 0.046
0.454TrpTrp: 0.454 ± 0.026
0.298TrpTyr: 0.298 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.575TyrAla: 2.575 ± 0.053
0.23TyrCys: 0.23 ± 0.019
1.191TyrAsp: 1.191 ± 0.044
1.089TyrGlu: 1.089 ± 0.039
0.783TyrPhe: 0.783 ± 0.031
1.959TyrGly: 1.959 ± 0.053
0.495TyrHis: 0.495 ± 0.027
0.66TyrIle: 0.66 ± 0.031
0.464TyrLys: 0.464 ± 0.026
2.335TyrLeu: 2.335 ± 0.054
0.368TyrMet: 0.368 ± 0.023
0.46TyrAsn: 0.46 ± 0.026
1.074TyrPro: 1.074 ± 0.04
0.746TyrGln: 0.746 ± 0.031
1.781TyrArg: 1.781 ± 0.052
0.844TyrSer: 0.844 ± 0.031
1.127TyrThr: 1.127 ± 0.035
1.598TyrVal: 1.598 ± 0.052
0.353TyrTrp: 0.353 ± 0.02
0.508TyrTyr: 0.508 ± 0.029
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2430 proteins (812492 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski