Amino acid dipepetide frequency for Fontibacillus panacisegetis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.762AlaAla: 6.762 ± 0.094	0.653AlaCys: 0.653 ± 0.023	3.647AlaAsp: 3.647 ± 0.054	4.988AlaGlu: 4.988 ± 0.064	2.897AlaPhe: 2.897 ± 0.046	5.664AlaGly: 5.664 ± 0.081	1.255AlaHis: 1.255 ± 0.027	5.381AlaIle: 5.381 ± 0.059	4.191AlaLys: 4.191 ± 0.054	7.366AlaLeu: 7.366 ± 0.073	1.984AlaMet: 1.984 ± 0.043	2.631AlaAsn: 2.631 ± 0.048	2.282AlaPro: 2.282 ± 0.046	2.374AlaGln: 2.374 ± 0.041	3.004AlaArg: 3.004 ± 0.048	4.727AlaSer: 4.727 ± 0.058	3.376AlaThr: 3.376 ± 0.049	5.728AlaVal: 5.728 ± 0.065	0.743AlaTrp: 0.743 ± 0.023	2.473AlaTyr: 2.473 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.451CysAla: 0.451 ± 0.018	0.116CysCys: 0.116 ± 0.01	0.442CysAsp: 0.442 ± 0.019	0.452CysGlu: 0.452 ± 0.017	0.345CysPhe: 0.345 ± 0.016	0.774CysGly: 0.774 ± 0.027	0.198CysHis: 0.198 ± 0.012	0.597CysIle: 0.597 ± 0.021	0.376CysLys: 0.376 ± 0.017	0.792CysLeu: 0.792 ± 0.024	0.207CysMet: 0.207 ± 0.011	0.351CysAsn: 0.351 ± 0.015	0.361CysPro: 0.361 ± 0.017	0.229CysGln: 0.229 ± 0.013	0.411CysArg: 0.411 ± 0.017	0.624CysSer: 0.624 ± 0.023	0.431CysThr: 0.431 ± 0.017	0.465CysVal: 0.465 ± 0.017	0.101CysTrp: 0.101 ± 0.009	0.292CysTyr: 0.292 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	3.516AspAla: 3.516 ± 0.051	0.377AspCys: 0.377 ± 0.016	2.562AspAsp: 2.562 ± 0.05	3.956AspGlu: 3.956 ± 0.056	2.292AspPhe: 2.292 ± 0.038	3.819AspGly: 3.819 ± 0.055	1.241AspHis: 1.241 ± 0.033	4.037AspIle: 4.037 ± 0.065	3.085AspLys: 3.085 ± 0.044	5.178AspLeu: 5.178 ± 0.061	1.356AspMet: 1.356 ± 0.03	2.153AspAsn: 2.153 ± 0.039	2.176AspPro: 2.176 ± 0.039	2.051AspGln: 2.051 ± 0.038	2.572AspArg: 2.572 ± 0.044	3.173AspSer: 3.173 ± 0.043	2.653AspThr: 2.653 ± 0.044	3.596AspVal: 3.596 ± 0.051	0.708AspTrp: 0.708 ± 0.023	2.221AspTyr: 2.221 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	5.462GluAla: 5.462 ± 0.076	0.446GluCys: 0.446 ± 0.016	3.395GluAsp: 3.395 ± 0.05	5.603GluGlu: 5.603 ± 0.078	2.353GluPhe: 2.353 ± 0.047	4.465GluGly: 4.465 ± 0.062	1.551GluHis: 1.551 ± 0.038	5.072GluIle: 5.072 ± 0.06	4.394GluLys: 4.394 ± 0.056	7.392GluLeu: 7.392 ± 0.088	2.163GluMet: 2.163 ± 0.042	2.899GluAsn: 2.899 ± 0.042	2.094GluPro: 2.094 ± 0.044	3.622GluGln: 3.622 ± 0.064	3.562GluArg: 3.562 ± 0.058	3.821GluSer: 3.821 ± 0.048	3.141GluThr: 3.141 ± 0.048	4.768GluVal: 4.768 ± 0.069	0.878GluTrp: 0.878 ± 0.023	2.224GluTyr: 2.224 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.007PheAla: 3.007 ± 0.042	0.393PheCys: 0.393 ± 0.015	2.39PheAsp: 2.39 ± 0.043	2.528PheGlu: 2.528 ± 0.049	1.858PhePhe: 1.858 ± 0.038	3.132PheGly: 3.132 ± 0.051	0.903PheHis: 0.903 ± 0.027	3.2PheIle: 3.2 ± 0.046	2.149PheLys: 2.149 ± 0.038	3.834PheLeu: 3.834 ± 0.058	1.21PheMet: 1.21 ± 0.032	1.854PheAsn: 1.854 ± 0.038	1.452PhePro: 1.452 ± 0.033	1.44PheGln: 1.44 ± 0.03	1.84PheArg: 1.84 ± 0.04	3.051PheSer: 3.051 ± 0.044	2.433PheThr: 2.433 ± 0.039	3.013PheVal: 3.013 ± 0.045	0.481PheTrp: 0.481 ± 0.019	1.546PheTyr: 1.546 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	4.881GlyAla: 4.881 ± 0.074	0.716GlyCys: 0.716 ± 0.022	3.571GlyAsp: 3.571 ± 0.059	4.614GlyGlu: 4.614 ± 0.062	3.082GlyPhe: 3.082 ± 0.051	5.127GlyGly: 5.127 ± 0.077	1.409GlyHis: 1.409 ± 0.031	6.027GlyIle: 6.027 ± 0.065	4.495GlyLys: 4.495 ± 0.055	6.913GlyLeu: 6.913 ± 0.082	2.161GlyMet: 2.161 ± 0.043	2.942GlyAsn: 2.942 ± 0.053	1.747GlyPro: 1.747 ± 0.035	2.575GlyGln: 2.575 ± 0.044	3.098GlyArg: 3.098 ± 0.049	4.693GlySer: 4.693 ± 0.059	4.153GlyThr: 4.153 ± 0.061	5.135GlyVal: 5.135 ± 0.067	0.929GlyTrp: 0.929 ± 0.03	3.034GlyTyr: 3.034 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.311HisAla: 1.311 ± 0.03	0.202HisCys: 0.202 ± 0.01	1.078HisAsp: 1.078 ± 0.029	1.354HisGlu: 1.354 ± 0.031	1.001HisPhe: 1.001 ± 0.027	1.413HisGly: 1.413 ± 0.033	0.649HisHis: 0.649 ± 0.024	1.478HisIle: 1.478 ± 0.032	0.951HisLys: 0.951 ± 0.026	2.149HisLeu: 2.149 ± 0.057	0.554HisMet: 0.554 ± 0.022	0.829HisAsn: 0.829 ± 0.022	1.128HisPro: 1.128 ± 0.029	0.783HisGln: 0.783 ± 0.024	1.069HisArg: 1.069 ± 0.028	1.3HisSer: 1.3 ± 0.029	1.057HisThr: 1.057 ± 0.028	1.372HisVal: 1.372 ± 0.028	0.267HisTrp: 0.267 ± 0.013	0.851HisTyr: 0.851 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.802IleAla: 5.802 ± 0.063	0.722IleCys: 0.722 ± 0.023	4.129IleAsp: 4.129 ± 0.053	4.953IleGlu: 4.953 ± 0.07	2.859IlePhe: 2.859 ± 0.052	5.48IleGly: 5.48 ± 0.072	1.653IleHis: 1.653 ± 0.038	5.148IleIle: 5.148 ± 0.068	3.752IleLys: 3.752 ± 0.05	6.552IleLeu: 6.552 ± 0.081	1.852IleMet: 1.852 ± 0.033	3.008IleAsn: 3.008 ± 0.058	3.277IlePro: 3.277 ± 0.042	2.823IleGln: 2.823 ± 0.044	3.527IleArg: 3.527 ± 0.05	5.469IleSer: 5.469 ± 0.064	4.309IleThr: 4.309 ± 0.058	5.739IleVal: 5.739 ± 0.069	0.733IleTrp: 0.733 ± 0.025	2.354IleTyr: 2.354 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.084LysAla: 4.084 ± 0.053	0.328LysCys: 0.328 ± 0.015	3.22LysAsp: 3.22 ± 0.045	4.783LysGlu: 4.783 ± 0.063	1.816LysPhe: 1.816 ± 0.037	3.842LysGly: 3.842 ± 0.056	1.076LysHis: 1.076 ± 0.028	3.844LysIle: 3.844 ± 0.051	3.787LysLys: 3.787 ± 0.055	5.907LysLeu: 5.907 ± 0.06	1.836LysMet: 1.836 ± 0.036	2.547LysAsn: 2.547 ± 0.049	2.051LysPro: 2.051 ± 0.039	2.568LysGln: 2.568 ± 0.046	2.791LysArg: 2.791 ± 0.043	3.596LysSer: 3.596 ± 0.052	2.999LysThr: 2.999 ± 0.042	4.016LysVal: 4.016 ± 0.055	0.813LysTrp: 0.813 ± 0.023	2.22LysTyr: 2.22 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	7.281LeuAla: 7.281 ± 0.084	0.866LeuCys: 0.866 ± 0.025	5.326LeuAsp: 5.326 ± 0.059	6.449LeuGlu: 6.449 ± 0.073	4.524LeuPhe: 4.524 ± 0.062	6.621LeuGly: 6.621 ± 0.066	2.085LeuHis: 2.085 ± 0.044	7.242LeuIle: 7.242 ± 0.093	5.728LeuLys: 5.728 ± 0.063	10.698LeuLeu: 10.698 ± 0.114	2.567LeuMet: 2.567 ± 0.048	4.311LeuAsn: 4.311 ± 0.057	4.272LeuPro: 4.272 ± 0.051	3.873LeuGln: 3.873 ± 0.055	4.599LeuArg: 4.599 ± 0.057	7.517LeuSer: 7.517 ± 0.084	5.551LeuThr: 5.551 ± 0.071	6.21LeuVal: 6.21 ± 0.077	0.988LeuTrp: 0.988 ± 0.025	3.293LeuTyr: 3.293 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	1.932MetAla: 1.932 ± 0.038	0.181MetCys: 0.181 ± 0.012	1.517MetAsp: 1.517 ± 0.031	1.883MetGlu: 1.883 ± 0.04	1.108MetPhe: 1.108 ± 0.025	1.743MetGly: 1.743 ± 0.039	0.464MetHis: 0.464 ± 0.018	2.174MetIle: 2.174 ± 0.043	2.064MetLys: 2.064 ± 0.035	2.916MetLeu: 2.916 ± 0.049	0.918MetMet: 0.918 ± 0.026	1.632MetAsn: 1.632 ± 0.031	1.008MetPro: 1.008 ± 0.025	0.936MetGln: 0.936 ± 0.022	1.218MetArg: 1.218 ± 0.029	1.901MetSer: 1.901 ± 0.038	1.624MetThr: 1.624 ± 0.037	1.715MetVal: 1.715 ± 0.04	0.222MetTrp: 0.222 ± 0.012	0.78MetTyr: 0.78 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.746AsnAla: 2.746 ± 0.052	0.315AsnCys: 0.315 ± 0.013	2.237AsnAsp: 2.237 ± 0.04	3.023AsnGlu: 3.023 ± 0.041	1.492AsnPhe: 1.492 ± 0.035	3.469AsnGly: 3.469 ± 0.054	0.955AsnHis: 0.955 ± 0.025	3.021AsnIle: 3.021 ± 0.044	2.656AsnLys: 2.656 ± 0.045	3.874AsnLeu: 3.874 ± 0.054	1.145AsnMet: 1.145 ± 0.028	2.116AsnAsn: 2.116 ± 0.047	2.067AsnPro: 2.067 ± 0.04	1.737AsnGln: 1.737 ± 0.038	2.145AsnArg: 2.145 ± 0.037	2.743AsnSer: 2.743 ± 0.05	2.272AsnThr: 2.272 ± 0.045	2.91AsnVal: 2.91 ± 0.048	0.524AsnTrp: 0.524 ± 0.021	1.659AsnTyr: 1.659 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	2.525ProAla: 2.525 ± 0.042	0.272ProCys: 0.272 ± 0.014	2.44ProAsp: 2.44 ± 0.043	3.169ProGlu: 3.169 ± 0.052	1.774ProPhe: 1.774 ± 0.041	2.533ProGly: 2.533 ± 0.042	0.779ProHis: 0.779 ± 0.026	2.6ProIle: 2.6 ± 0.045	1.856ProLys: 1.856 ± 0.036	3.648ProLeu: 3.648 ± 0.059	0.835ProMet: 0.835 ± 0.025	1.62ProAsn: 1.62 ± 0.035	1.021ProPro: 1.021 ± 0.031	1.296ProGln: 1.296 ± 0.03	1.277ProArg: 1.277 ± 0.031	2.516ProSer: 2.516 ± 0.046	1.87ProThr: 1.87 ± 0.035	3.04ProVal: 3.04 ± 0.047	0.455ProTrp: 0.455 ± 0.02	1.524ProTyr: 1.524 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	2.811GlnAla: 2.811 ± 0.043	0.231GlnCys: 0.231 ± 0.011	1.764GlnAsp: 1.764 ± 0.035	2.707GlnGlu: 2.707 ± 0.051	1.583GlnPhe: 1.583 ± 0.034	2.614GlnGly: 2.614 ± 0.042	0.816GlnHis: 0.816 ± 0.023	2.755GlnIle: 2.755 ± 0.043	2.151GlnLys: 2.151 ± 0.039	4.064GlnLeu: 4.064 ± 0.055	1.194GlnMet: 1.194 ± 0.029	1.604GlnAsn: 1.604 ± 0.034	1.324GlnPro: 1.324 ± 0.03	1.815GlnGln: 1.815 ± 0.035	1.858GlnArg: 1.858 ± 0.04	2.442GlnSer: 2.442 ± 0.048	1.812GlnThr: 1.812 ± 0.031	2.473GlnVal: 2.473 ± 0.038	0.456GlnTrp: 0.456 ± 0.018	1.434GlnTyr: 1.434 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.78ArgAla: 2.78 ± 0.046	0.334ArgCys: 0.334 ± 0.015	2.477ArgAsp: 2.477 ± 0.042	3.445ArgGlu: 3.445 ± 0.057	2.001ArgPhe: 2.001 ± 0.038	2.823ArgGly: 2.823 ± 0.051	1.007ArgHis: 1.007 ± 0.026	3.505ArgIle: 3.505 ± 0.056	3.098ArgLys: 3.098 ± 0.047	4.721ArgLeu: 4.721 ± 0.063	1.448ArgMet: 1.448 ± 0.031	2.089ArgAsn: 2.089 ± 0.037	1.499ArgPro: 1.499 ± 0.039	1.809ArgGln: 1.809 ± 0.034	2.415ArgArg: 2.415 ± 0.049	2.989ArgSer: 2.989 ± 0.044	2.417ArgThr: 2.417 ± 0.04	2.914ArgVal: 2.914 ± 0.038	0.558ArgTrp: 0.558 ± 0.02	1.852ArgTyr: 1.852 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	4.494SerAla: 4.494 ± 0.062	0.478SerCys: 0.478 ± 0.019	3.446SerAsp: 3.446 ± 0.051	4.279SerGlu: 4.279 ± 0.052	3.178SerPhe: 3.178 ± 0.05	5.564SerGly: 5.564 ± 0.069	1.33SerHis: 1.33 ± 0.031	5.202SerIle: 5.202 ± 0.07	3.797SerLys: 3.797 ± 0.058	6.811SerLeu: 6.811 ± 0.076	1.831SerMet: 1.831 ± 0.034	2.934SerAsn: 2.934 ± 0.05	2.38SerPro: 2.38 ± 0.046	2.182SerGln: 2.182 ± 0.039	3.081SerArg: 3.081 ± 0.048	5.141SerSer: 5.141 ± 0.066	3.541SerThr: 3.541 ± 0.051	4.6SerVal: 4.6 ± 0.061	0.8SerTrp: 0.8 ± 0.026	2.534SerTyr: 2.534 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.223ThrAla: 4.223 ± 0.062	0.344ThrCys: 0.344 ± 0.016	2.706ThrAsp: 2.706 ± 0.049	3.43ThrGlu: 3.43 ± 0.053	2.286ThrPhe: 2.286 ± 0.039	4.305ThrGly: 4.305 ± 0.059	0.981ThrHis: 0.981 ± 0.026	4.077ThrIle: 4.077 ± 0.056	2.801ThrLys: 2.801 ± 0.048	5.403ThrLeu: 5.403 ± 0.064	1.35ThrMet: 1.35 ± 0.03	2.165ThrAsn: 2.165 ± 0.042	2.334ThrPro: 2.334 ± 0.038	1.541ThrGln: 1.541 ± 0.033	2.154ThrArg: 2.154 ± 0.042	3.565ThrSer: 3.565 ± 0.054	3.028ThrThr: 3.028 ± 0.054	4.327ThrVal: 4.327 ± 0.055	0.588ThrTrp: 0.588 ± 0.023	1.924ThrTyr: 1.924 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	4.99ValAla: 4.99 ± 0.06	0.598ValCys: 0.598 ± 0.02	3.683ValAsp: 3.683 ± 0.054	4.51ValGlu: 4.51 ± 0.058	2.98ValPhe: 2.98 ± 0.049	4.496ValGly: 4.496 ± 0.067	1.387ValHis: 1.387 ± 0.035	5.383ValIle: 5.383 ± 0.06	4.133ValLys: 4.133 ± 0.061	7.005ValLeu: 7.005 ± 0.066	1.998ValMet: 1.998 ± 0.037	3.125ValAsn: 3.125 ± 0.046	2.736ValPro: 2.736 ± 0.049	2.555ValGln: 2.555 ± 0.046	3.0ValArg: 3.0 ± 0.045	4.99ValSer: 4.99 ± 0.055	4.356ValThr: 4.356 ± 0.064	5.088ValVal: 5.088 ± 0.065	0.8ValTrp: 0.8 ± 0.024	2.403ValTyr: 2.403 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	0.671TrpAla: 0.671 ± 0.023	0.093TrpCys: 0.093 ± 0.008	0.675TrpAsp: 0.675 ± 0.023	0.729TrpGlu: 0.729 ± 0.021	0.534TrpPhe: 0.534 ± 0.019	0.759TrpGly: 0.759 ± 0.024	0.228TrpHis: 0.228 ± 0.014	0.96TrpIle: 0.96 ± 0.028	0.722TrpLys: 0.722 ± 0.024	1.234TrpLeu: 1.234 ± 0.03	0.392TrpMet: 0.392 ± 0.014	0.692TrpAsn: 0.692 ± 0.02	0.278TrpPro: 0.278 ± 0.013	0.426TrpGln: 0.426 ± 0.017	0.542TrpArg: 0.542 ± 0.02	0.88TrpSer: 0.88 ± 0.026	0.561TrpThr: 0.561 ± 0.023	0.696TrpVal: 0.696 ± 0.025	0.165TrpTrp: 0.165 ± 0.011	0.418TrpTyr: 0.418 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.399TyrAla: 2.399 ± 0.039	0.351TyrCys: 0.351 ± 0.016	2.019TyrAsp: 2.019 ± 0.038	2.448TyrGlu: 2.448 ± 0.04	1.751TyrPhe: 1.751 ± 0.034	2.663TyrGly: 2.663 ± 0.046	0.827TyrHis: 0.827 ± 0.024	2.438TyrIle: 2.438 ± 0.049	1.936TyrLys: 1.936 ± 0.042	3.545TyrLeu: 3.545 ± 0.056	0.936TyrMet: 0.936 ± 0.029	1.606TyrAsn: 1.606 ± 0.036	1.563TyrPro: 1.563 ± 0.03	1.274TyrGln: 1.274 ± 0.026	2.018TyrArg: 2.018 ± 0.041	2.463TyrSer: 2.463 ± 0.043	1.946TyrThr: 1.946 ± 0.041	2.41TyrVal: 2.41 ± 0.045	0.444TyrTrp: 0.444 ± 0.019	1.542TyrTyr: 1.542 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4786 proteins (1512109 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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