Amino acid dipepetide frequency for Amycolatopsis methanolica 239

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.753AlaAla: 20.753 ± 0.141	1.052AlaCys: 1.052 ± 0.023	8.397AlaAsp: 8.397 ± 0.065	9.567AlaGlu: 9.567 ± 0.081	3.65AlaPhe: 3.65 ± 0.044	13.845AlaGly: 13.845 ± 0.08	2.586AlaHis: 2.586 ± 0.04	4.398AlaIle: 4.398 ± 0.052	3.025AlaLys: 3.025 ± 0.047	13.974AlaLeu: 13.974 ± 0.101	2.629AlaMet: 2.629 ± 0.036	2.207AlaAsn: 2.207 ± 0.036	6.459AlaPro: 6.459 ± 0.074	3.716AlaGln: 3.716 ± 0.046	10.205AlaArg: 10.205 ± 0.086	5.578AlaSer: 5.578 ± 0.057	6.841AlaThr: 6.841 ± 0.057	12.098AlaVal: 12.098 ± 0.087	1.778AlaTrp: 1.778 ± 0.03	2.275AlaTyr: 2.275 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	1.046CysAla: 1.046 ± 0.026	0.114CysCys: 0.114 ± 0.008	0.425CysAsp: 0.425 ± 0.016	0.403CysGlu: 0.403 ± 0.015	0.239CysPhe: 0.239 ± 0.011	0.993CysGly: 0.993 ± 0.025	0.182CysHis: 0.182 ± 0.011	0.17CysIle: 0.17 ± 0.009	0.091CysLys: 0.091 ± 0.007	0.718CysLeu: 0.718 ± 0.019	0.112CysMet: 0.112 ± 0.007	0.122CysAsn: 0.122 ± 0.008	0.491CysPro: 0.491 ± 0.015	0.18CysGln: 0.18 ± 0.009	0.606CysArg: 0.606 ± 0.016	0.427CysSer: 0.427 ± 0.015	0.485CysThr: 0.485 ± 0.018	0.652CysVal: 0.652 ± 0.016	0.139CysTrp: 0.139 ± 0.008	0.182CysTyr: 0.182 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.312AspAla: 7.312 ± 0.064	0.378AspCys: 0.378 ± 0.013	3.553AspAsp: 3.553 ± 0.045	4.275AspGlu: 4.275 ± 0.047	1.64AspPhe: 1.64 ± 0.024	5.919AspGly: 5.919 ± 0.062	1.365AspHis: 1.365 ± 0.028	1.864AspIle: 1.864 ± 0.031	1.089AspLys: 1.089 ± 0.024	6.452AspLeu: 6.452 ± 0.063	0.717AspMet: 0.717 ± 0.019	1.016AspAsn: 1.016 ± 0.024	4.391AspPro: 4.391 ± 0.038	1.654AspGln: 1.654 ± 0.031	4.816AspArg: 4.816 ± 0.052	2.324AspSer: 2.324 ± 0.035	2.859AspThr: 2.859 ± 0.038	5.297AspVal: 5.297 ± 0.052	0.916AspTrp: 0.916 ± 0.021	1.164AspTyr: 1.164 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	7.015GluAla: 7.015 ± 0.06	0.37GluCys: 0.37 ± 0.015	2.633GluAsp: 2.633 ± 0.039	3.137GluGlu: 3.137 ± 0.047	1.826GluPhe: 1.826 ± 0.031	3.782GluGly: 3.782 ± 0.05	1.709GluHis: 1.709 ± 0.028	2.53GluIle: 2.53 ± 0.028	1.354GluLys: 1.354 ± 0.029	7.581GluLeu: 7.581 ± 0.073	0.961GluMet: 0.961 ± 0.024	1.094GluAsn: 1.094 ± 0.024	3.64GluPro: 3.64 ± 0.052	2.328GluGln: 2.328 ± 0.03	5.461GluArg: 5.461 ± 0.056	2.453GluSer: 2.453 ± 0.038	2.893GluThr: 2.893 ± 0.038	5.397GluVal: 5.397 ± 0.055	0.866GluTrp: 0.866 ± 0.021	1.06GluTyr: 1.06 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	4.262PheAla: 4.262 ± 0.047	0.285PheCys: 0.285 ± 0.012	2.16PheAsp: 2.16 ± 0.037	1.548PheGlu: 1.548 ± 0.03	0.903PhePhe: 0.903 ± 0.02	3.48PheGly: 3.48 ± 0.042	0.634PheHis: 0.634 ± 0.016	0.734PheIle: 0.734 ± 0.019	0.415PheLys: 0.415 ± 0.014	2.739PheLeu: 2.739 ± 0.038	0.339PheMet: 0.339 ± 0.013	0.573PheAsn: 0.573 ± 0.018	1.446PhePro: 1.446 ± 0.027	0.665PheGln: 0.665 ± 0.017	1.943PheArg: 1.943 ± 0.027	1.424PheSer: 1.424 ± 0.029	2.063PheThr: 2.063 ± 0.032	2.571PheVal: 2.571 ± 0.034	0.411PheTrp: 0.411 ± 0.016	0.613PheTyr: 0.613 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	10.816GlyAla: 10.816 ± 0.064	0.8GlyCys: 0.8 ± 0.022	5.03GlyAsp: 5.03 ± 0.054	5.424GlyGlu: 5.424 ± 0.053	3.183GlyPhe: 3.183 ± 0.047	8.487GlyGly: 8.487 ± 0.084	2.07GlyHis: 2.07 ± 0.035	3.676GlyIle: 3.676 ± 0.047	2.418GlyLys: 2.418 ± 0.035	9.672GlyLeu: 9.672 ± 0.083	2.019GlyMet: 2.019 ± 0.032	1.792GlyAsn: 1.792 ± 0.03	4.782GlyPro: 4.782 ± 0.051	2.881GlyGln: 2.881 ± 0.051	7.493GlyArg: 7.493 ± 0.073	4.995GlySer: 4.995 ± 0.06	5.493GlyThr: 5.493 ± 0.059	8.259GlyVal: 8.259 ± 0.062	1.789GlyTrp: 1.789 ± 0.027	2.344GlyTyr: 2.344 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.655HisAla: 2.655 ± 0.037	0.204HisCys: 0.204 ± 0.011	1.314HisAsp: 1.314 ± 0.025	1.24HisGlu: 1.24 ± 0.024	0.64HisPhe: 0.64 ± 0.019	2.315HisGly: 2.315 ± 0.034	0.636HisHis: 0.636 ± 0.018	0.618HisIle: 0.618 ± 0.016	0.318HisLys: 0.318 ± 0.014	2.364HisLeu: 2.364 ± 0.037	0.28HisMet: 0.28 ± 0.011	0.382HisAsn: 0.382 ± 0.014	1.678HisPro: 1.678 ± 0.026	0.618HisGln: 0.618 ± 0.019	1.973HisArg: 1.973 ± 0.034	0.912HisSer: 0.912 ± 0.022	1.081HisThr: 1.081 ± 0.021	1.793HisVal: 1.793 ± 0.033	0.35HisTrp: 0.35 ± 0.012	0.499HisTyr: 0.499 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	5.474IleAla: 5.474 ± 0.054	0.318IleCys: 0.318 ± 0.014	2.318IleAsp: 2.318 ± 0.035	2.154IleGlu: 2.154 ± 0.033	0.792IlePhe: 0.792 ± 0.022	3.949IleGly: 3.949 ± 0.053	0.607IleHis: 0.607 ± 0.017	1.0IleIle: 1.0 ± 0.024	0.658IleLys: 0.658 ± 0.02	2.506IleLeu: 2.506 ± 0.043	0.46IleMet: 0.46 ± 0.017	0.779IleAsn: 0.779 ± 0.021	1.931IlePro: 1.931 ± 0.031	0.742IleGln: 0.742 ± 0.021	2.376IleArg: 2.376 ± 0.032	1.805IleSer: 1.805 ± 0.029	2.447IleThr: 2.447 ± 0.033	3.204IleVal: 3.204 ± 0.047	0.402IleTrp: 0.402 ± 0.014	0.622IleTyr: 0.622 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	2.65LysAla: 2.65 ± 0.041	0.108LysCys: 0.108 ± 0.008	0.998LysAsp: 0.998 ± 0.025	0.961LysGlu: 0.961 ± 0.027	0.528LysPhe: 0.528 ± 0.017	1.413LysGly: 1.413 ± 0.024	0.462LysHis: 0.462 ± 0.014	0.951LysIle: 0.951 ± 0.024	0.586LysLys: 0.586 ± 0.023	2.294LysLeu: 2.294 ± 0.038	0.392LysMet: 0.392 ± 0.013	0.427LysAsn: 0.427 ± 0.015	1.469LysPro: 1.469 ± 0.033	0.717LysGln: 0.717 ± 0.021	1.566LysArg: 1.566 ± 0.032	0.984LysSer: 0.984 ± 0.021	1.21LysThr: 1.21 ± 0.027	1.934LysVal: 1.934 ± 0.027	0.273LysTrp: 0.273 ± 0.011	0.439LysTyr: 0.439 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	16.067LeuAla: 16.067 ± 0.118	0.776LeuCys: 0.776 ± 0.02	6.989LeuAsp: 6.989 ± 0.066	4.804LeuGlu: 4.804 ± 0.06	2.732LeuPhe: 2.732 ± 0.036	9.733LeuGly: 9.733 ± 0.082	2.184LeuHis: 2.184 ± 0.035	3.402LeuIle: 3.402 ± 0.046	1.75LeuLys: 1.75 ± 0.028	10.801LeuLeu: 10.801 ± 0.094	1.489LeuMet: 1.489 ± 0.027	1.757LeuAsn: 1.757 ± 0.031	6.473LeuPro: 6.473 ± 0.064	2.145LeuGln: 2.145 ± 0.036	8.871LeuArg: 8.871 ± 0.075	5.504LeuSer: 5.504 ± 0.054	6.565LeuThr: 6.565 ± 0.066	9.837LeuVal: 9.837 ± 0.084	1.197LeuTrp: 1.197 ± 0.022	1.586LeuTyr: 1.586 ± 0.028	0.0LeuXaa: 0.0 ± 0.0
Met	2.182MetAla: 2.182 ± 0.029	0.124MetCys: 0.124 ± 0.008	0.814MetAsp: 0.814 ± 0.022	0.605MetGlu: 0.605 ± 0.017	0.504MetPhe: 0.504 ± 0.016	1.223MetGly: 1.223 ± 0.025	0.351MetHis: 0.351 ± 0.012	0.764MetIle: 0.764 ± 0.019	0.375MetLys: 0.375 ± 0.012	1.816MetLeu: 1.816 ± 0.034	0.297MetMet: 0.297 ± 0.013	0.393MetAsn: 0.393 ± 0.015	1.148MetPro: 1.148 ± 0.024	0.426MetGln: 0.426 ± 0.014	1.522MetArg: 1.522 ± 0.028	1.239MetSer: 1.239 ± 0.025	1.631MetThr: 1.631 ± 0.025	1.342MetVal: 1.342 ± 0.024	0.204MetTrp: 0.204 ± 0.01	0.255MetTyr: 0.255 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.337AsnAla: 2.337 ± 0.036	0.159AsnCys: 0.159 ± 0.009	0.955AsnAsp: 0.955 ± 0.022	0.827AsnGlu: 0.827 ± 0.019	0.526AsnPhe: 0.526 ± 0.016	1.746AsnGly: 1.746 ± 0.029	0.4AsnHis: 0.4 ± 0.015	0.667AsnIle: 0.667 ± 0.017	0.361AsnLys: 0.361 ± 0.013	1.908AsnLeu: 1.908 ± 0.028	0.304AsnMet: 0.304 ± 0.01	0.423AsnAsn: 0.423 ± 0.015	1.531AsnPro: 1.531 ± 0.025	0.558AsnGln: 0.558 ± 0.016	1.353AsnArg: 1.353 ± 0.028	0.929AsnSer: 0.929 ± 0.022	1.115AsnThr: 1.115 ± 0.024	1.491AsnVal: 1.491 ± 0.027	0.299AsnTrp: 0.299 ± 0.012	0.44AsnTyr: 0.44 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.395ProAla: 8.395 ± 0.074	0.347ProCys: 0.347 ± 0.014	4.423ProAsp: 4.423 ± 0.055	4.385ProGlu: 4.385 ± 0.057	1.59ProPhe: 1.59 ± 0.03	6.73ProGly: 6.73 ± 0.064	1.238ProHis: 1.238 ± 0.027	1.571ProIle: 1.571 ± 0.026	1.225ProLys: 1.225 ± 0.027	5.222ProLeu: 5.222 ± 0.052	0.993ProMet: 0.993 ± 0.022	1.008ProAsn: 1.008 ± 0.025	3.513ProPro: 3.513 ± 0.065	1.556ProGln: 1.556 ± 0.039	4.033ProArg: 4.033 ± 0.047	3.048ProSer: 3.048 ± 0.036	2.788ProThr: 2.788 ± 0.04	5.846ProVal: 5.846 ± 0.06	0.881ProTrp: 0.881 ± 0.019	1.16ProTyr: 1.16 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	3.787GlnAla: 3.787 ± 0.05	0.169GlnCys: 0.169 ± 0.009	1.193GlnAsp: 1.193 ± 0.025	1.209GlnGlu: 1.209 ± 0.025	0.77GlnPhe: 0.77 ± 0.022	2.091GlnGly: 2.091 ± 0.041	0.65GlnHis: 0.65 ± 0.018	1.15GlnIle: 1.15 ± 0.025	0.518GlnLys: 0.518 ± 0.017	3.25GlnLeu: 3.25 ± 0.041	0.461GlnMet: 0.461 ± 0.015	0.522GlnAsn: 0.522 ± 0.015	1.874GlnPro: 1.874 ± 0.04	1.257GlnGln: 1.257 ± 0.042	2.618GlnArg: 2.618 ± 0.036	1.194GlnSer: 1.194 ± 0.024	1.276GlnThr: 1.276 ± 0.028	2.59GlnVal: 2.59 ± 0.036	0.455GlnTrp: 0.455 ± 0.013	0.542GlnTyr: 0.542 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	9.929ArgAla: 9.929 ± 0.077	0.627ArgCys: 0.627 ± 0.02	4.507ArgAsp: 4.507 ± 0.05	5.082ArgGlu: 5.082 ± 0.056	2.537ArgPhe: 2.537 ± 0.038	6.083ArgGly: 6.083 ± 0.066	1.985ArgHis: 1.985 ± 0.035	3.26ArgIle: 3.26 ± 0.037	1.893ArgLys: 1.893 ± 0.03	8.627ArgLeu: 8.627 ± 0.072	1.879ArgMet: 1.879 ± 0.026	1.498ArgAsn: 1.498 ± 0.025	4.816ArgPro: 4.816 ± 0.047	2.335ArgGln: 2.335 ± 0.037	8.07ArgArg: 8.07 ± 0.083	3.824ArgSer: 3.824 ± 0.041	4.701ArgThr: 4.701 ± 0.049	6.265ArgVal: 6.265 ± 0.063	1.46ArgTrp: 1.46 ± 0.028	1.872ArgTyr: 1.872 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.561SerAla: 6.561 ± 0.067	0.406SerCys: 0.406 ± 0.014	2.536SerAsp: 2.536 ± 0.037	2.415SerGlu: 2.415 ± 0.037	1.491SerPhe: 1.491 ± 0.024	5.573SerGly: 5.573 ± 0.06	0.852SerHis: 0.852 ± 0.023	1.634SerIle: 1.634 ± 0.032	0.937SerLys: 0.937 ± 0.021	4.599SerLeu: 4.599 ± 0.044	1.132SerMet: 1.132 ± 0.022	0.87SerAsn: 0.87 ± 0.021	3.001SerPro: 3.001 ± 0.044	1.174SerGln: 1.174 ± 0.026	3.752SerArg: 3.752 ± 0.043	2.717SerSer: 2.717 ± 0.047	2.987SerThr: 2.987 ± 0.038	4.16SerVal: 4.16 ± 0.051	0.936SerTrp: 0.936 ± 0.021	1.088SerTyr: 1.088 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	7.883ThrAla: 7.883 ± 0.065	0.431ThrCys: 0.431 ± 0.015	3.255ThrAsp: 3.255 ± 0.043	3.276ThrGlu: 3.276 ± 0.039	1.703ThrPhe: 1.703 ± 0.031	6.41ThrGly: 6.41 ± 0.053	1.089ThrHis: 1.089 ± 0.026	2.052ThrIle: 2.052 ± 0.033	1.152ThrLys: 1.152 ± 0.024	5.375ThrLeu: 5.375 ± 0.046	0.948ThrMet: 0.948 ± 0.02	0.983ThrAsn: 0.983 ± 0.022	3.71ThrPro: 3.71 ± 0.052	1.323ThrGln: 1.323 ± 0.027	3.882ThrArg: 3.882 ± 0.04	3.061ThrSer: 3.061 ± 0.038	3.728ThrThr: 3.728 ± 0.046	5.664ThrVal: 5.664 ± 0.049	0.876ThrTrp: 0.876 ± 0.02	1.134ThrTyr: 1.134 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	11.929ValAla: 11.929 ± 0.081	0.766ValCys: 0.766 ± 0.02	5.462ValAsp: 5.462 ± 0.05	5.076ValGlu: 5.076 ± 0.048	2.731ValPhe: 2.731 ± 0.036	6.677ValGly: 6.677 ± 0.062	2.034ValHis: 2.034 ± 0.032	3.096ValIle: 3.096 ± 0.04	1.637ValLys: 1.637 ± 0.031	10.637ValLeu: 10.637 ± 0.083	1.305ValMet: 1.305 ± 0.025	1.758ValAsn: 1.758 ± 0.032	5.565ValPro: 5.565 ± 0.051	2.076ValGln: 2.076 ± 0.032	7.441ValArg: 7.441 ± 0.073	4.584ValSer: 4.584 ± 0.045	5.698ValThr: 5.698 ± 0.054	9.313ValVal: 9.313 ± 0.089	1.121ValTrp: 1.121 ± 0.024	1.491ValTyr: 1.491 ± 0.028	0.0ValXaa: 0.0 ± 0.0
Trp	1.639TrpAla: 1.639 ± 0.028	0.166TrpCys: 0.166 ± 0.009	0.739TrpAsp: 0.739 ± 0.018	0.642TrpGlu: 0.642 ± 0.018	0.564TrpPhe: 0.564 ± 0.016	1.007TrpGly: 1.007 ± 0.023	0.376TrpHis: 0.376 ± 0.013	0.576TrpIle: 0.576 ± 0.017	0.274TrpLys: 0.274 ± 0.012	1.899TrpLeu: 1.899 ± 0.031	0.303TrpMet: 0.303 ± 0.011	0.339TrpAsn: 0.339 ± 0.014	0.856TrpPro: 0.856 ± 0.022	0.592TrpGln: 0.592 ± 0.018	1.425TrpArg: 1.425 ± 0.027	0.88TrpSer: 0.88 ± 0.02	0.988TrpThr: 0.988 ± 0.023	1.107TrpVal: 1.107 ± 0.022	0.33TrpTrp: 0.33 ± 0.014	0.307TrpTyr: 0.307 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.342TyrAla: 2.342 ± 0.034	0.179TyrCys: 0.179 ± 0.01	1.299TyrAsp: 1.299 ± 0.026	1.058TyrGlu: 1.058 ± 0.02	0.659TyrPhe: 0.659 ± 0.019	1.969TyrGly: 1.969 ± 0.03	0.46TyrHis: 0.46 ± 0.015	0.434TyrIle: 0.434 ± 0.016	0.285TyrLys: 0.285 ± 0.012	2.228TyrLeu: 2.228 ± 0.033	0.194TyrMet: 0.194 ± 0.01	0.386TyrAsn: 0.386 ± 0.014	1.175TyrPro: 1.175 ± 0.025	0.633TyrGln: 0.633 ± 0.016	1.844TyrArg: 1.844 ± 0.032	0.94TyrSer: 0.94 ± 0.024	1.086TyrThr: 1.086 ± 0.022	1.577TyrVal: 1.577 ± 0.025	0.326TyrTrp: 0.326 ± 0.012	0.469TyrTyr: 0.469 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7005 proteins (2109989 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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