Amino acid dipepetide frequency for Dysgonomonas alginatilytica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.307AlaAla: 4.307 ± 0.067	0.666AlaCys: 0.666 ± 0.025	3.819AlaAsp: 3.819 ± 0.046	3.92AlaGlu: 3.92 ± 0.068	2.917AlaPhe: 2.917 ± 0.046	4.292AlaGly: 4.292 ± 0.066	0.953AlaHis: 0.953 ± 0.028	5.131AlaIle: 5.131 ± 0.07	4.36AlaLys: 4.36 ± 0.054	5.745AlaLeu: 5.745 ± 0.07	1.479AlaMet: 1.479 ± 0.037	3.377AlaAsn: 3.377 ± 0.054	1.892AlaPro: 1.892 ± 0.033	2.385AlaGln: 2.385 ± 0.039	2.251AlaArg: 2.251 ± 0.046	4.295AlaSer: 4.295 ± 0.063	3.527AlaThr: 3.527 ± 0.052	3.715AlaVal: 3.715 ± 0.059	0.692AlaTrp: 0.692 ± 0.023	2.824AlaTyr: 2.824 ± 0.048	0.001AlaXaa: 0.001 ± 0.001
Cys	0.489CysAla: 0.489 ± 0.019	0.161CysCys: 0.161 ± 0.01	0.514CysAsp: 0.514 ± 0.017	0.53CysGlu: 0.53 ± 0.021	0.565CysPhe: 0.565 ± 0.019	0.72CysGly: 0.72 ± 0.028	0.185CysHis: 0.185 ± 0.012	0.869CysIle: 0.869 ± 0.025	0.591CysLys: 0.591 ± 0.021	0.922CysLeu: 0.922 ± 0.027	0.207CysMet: 0.207 ± 0.012	0.51CysAsn: 0.51 ± 0.021	0.397CysPro: 0.397 ± 0.018	0.256CysGln: 0.256 ± 0.016	0.35CysArg: 0.35 ± 0.014	0.706CysSer: 0.706 ± 0.025	0.489CysThr: 0.489 ± 0.016	0.552CysVal: 0.552 ± 0.018	0.115CysTrp: 0.115 ± 0.009	0.42CysTyr: 0.42 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	3.595AspAla: 3.595 ± 0.058	0.528AspCys: 0.528 ± 0.023	2.802AspAsp: 2.802 ± 0.05	3.539AspGlu: 3.539 ± 0.052	3.193AspPhe: 3.193 ± 0.051	3.942AspGly: 3.942 ± 0.06	0.799AspHis: 0.799 ± 0.022	4.958AspIle: 4.958 ± 0.074	4.886AspLys: 4.886 ± 0.067	5.142AspLeu: 5.142 ± 0.06	1.43AspMet: 1.43 ± 0.033	3.619AspAsn: 3.619 ± 0.053	1.929AspPro: 1.929 ± 0.037	1.599AspGln: 1.599 ± 0.034	2.276AspArg: 2.276 ± 0.039	3.563AspSer: 3.563 ± 0.049	2.688AspThr: 2.688 ± 0.038	3.378AspVal: 3.378 ± 0.05	0.84AspTrp: 0.84 ± 0.024	2.929AspTyr: 2.929 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	4.178GluAla: 4.178 ± 0.059	0.462GluCys: 0.462 ± 0.018	3.347GluAsp: 3.347 ± 0.053	4.224GluGlu: 4.224 ± 0.064	2.521GluPhe: 2.521 ± 0.048	3.613GluGly: 3.613 ± 0.06	0.962GluHis: 0.962 ± 0.028	5.106GluIle: 5.106 ± 0.065	5.363GluLys: 5.363 ± 0.069	5.692GluLeu: 5.692 ± 0.073	1.668GluMet: 1.668 ± 0.035	4.075GluAsn: 4.075 ± 0.055	1.572GluPro: 1.572 ± 0.039	2.251GluGln: 2.251 ± 0.047	2.656GluArg: 2.656 ± 0.055	3.685GluSer: 3.685 ± 0.057	3.202GluThr: 3.202 ± 0.045	3.824GluVal: 3.824 ± 0.058	0.804GluTrp: 0.804 ± 0.022	2.907GluTyr: 2.907 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	2.896PheAla: 2.896 ± 0.044	0.556PheCys: 0.556 ± 0.019	3.037PheAsp: 3.037 ± 0.045	2.828PheGlu: 2.828 ± 0.043	2.498PhePhe: 2.498 ± 0.051	3.137PheGly: 3.137 ± 0.043	0.763PheHis: 0.763 ± 0.02	3.934PheIle: 3.934 ± 0.06	2.996PheLys: 2.996 ± 0.045	4.279PheLeu: 4.279 ± 0.06	1.184PheMet: 1.184 ± 0.029	2.729PheAsn: 2.729 ± 0.042	1.661PhePro: 1.661 ± 0.033	1.374PheGln: 1.374 ± 0.034	1.849PheArg: 1.849 ± 0.036	3.905PheSer: 3.905 ± 0.056	2.927PheThr: 2.927 ± 0.043	2.886PheVal: 2.886 ± 0.05	0.565PheTrp: 0.565 ± 0.021	2.154PheTyr: 2.154 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	3.811GlyAla: 3.811 ± 0.063	0.671GlyCys: 0.671 ± 0.026	3.436GlyAsp: 3.436 ± 0.056	3.73GlyGlu: 3.73 ± 0.054	3.211GlyPhe: 3.211 ± 0.057	4.61GlyGly: 4.61 ± 0.081	1.101GlyHis: 1.101 ± 0.027	5.42GlyIle: 5.42 ± 0.06	5.031GlyLys: 5.031 ± 0.065	5.618GlyLeu: 5.618 ± 0.07	1.568GlyMet: 1.568 ± 0.037	3.772GlyAsn: 3.772 ± 0.06	1.069GlyPro: 1.069 ± 0.029	1.965GlyGln: 1.965 ± 0.04	2.451GlyArg: 2.451 ± 0.041	4.109GlySer: 4.109 ± 0.07	4.026GlyThr: 4.026 ± 0.068	4.333GlyVal: 4.333 ± 0.06	0.946GlyTrp: 0.946 ± 0.028	3.331GlyTyr: 3.331 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.938HisAla: 0.938 ± 0.022	0.2HisCys: 0.2 ± 0.011	0.795HisAsp: 0.795 ± 0.024	0.885HisGlu: 0.885 ± 0.026	0.991HisPhe: 0.991 ± 0.024	0.988HisGly: 0.988 ± 0.028	0.371HisHis: 0.371 ± 0.015	1.439HisIle: 1.439 ± 0.034	1.04HisLys: 1.04 ± 0.027	1.606HisLeu: 1.606 ± 0.038	0.324HisMet: 0.324 ± 0.015	0.932HisAsn: 0.932 ± 0.025	0.812HisPro: 0.812 ± 0.024	0.562HisGln: 0.562 ± 0.018	0.665HisArg: 0.665 ± 0.018	1.029HisSer: 1.029 ± 0.028	0.895HisThr: 0.895 ± 0.026	0.793HisVal: 0.793 ± 0.024	0.207HisTrp: 0.207 ± 0.012	0.8HisTyr: 0.8 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	5.344IleAla: 5.344 ± 0.065	0.873IleCys: 0.873 ± 0.024	5.062IleAsp: 5.062 ± 0.067	5.399IleGlu: 5.399 ± 0.072	3.48IlePhe: 3.48 ± 0.052	4.992IleGly: 4.992 ± 0.071	1.325IleHis: 1.325 ± 0.03	6.137IleIle: 6.137 ± 0.088	5.686IleLys: 5.686 ± 0.062	7.187IleLeu: 7.187 ± 0.083	1.487IleMet: 1.487 ± 0.032	4.759IleAsn: 4.759 ± 0.07	3.411IlePro: 3.411 ± 0.044	2.601IleGln: 2.601 ± 0.044	3.203IleArg: 3.203 ± 0.052	5.961IleSer: 5.961 ± 0.069	4.812IleThr: 4.812 ± 0.057	4.902IleVal: 4.902 ± 0.068	0.771IleTrp: 0.771 ± 0.026	3.318IleTyr: 3.318 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	4.757LysAla: 4.757 ± 0.065	0.462LysCys: 0.462 ± 0.019	4.902LysAsp: 4.902 ± 0.068	6.039LysGlu: 6.039 ± 0.074	2.55LysPhe: 2.55 ± 0.041	4.674LysGly: 4.674 ± 0.06	1.271LysHis: 1.271 ± 0.033	5.618LysIle: 5.618 ± 0.067	5.8LysLys: 5.8 ± 0.071	5.963LysLeu: 5.963 ± 0.069	2.08LysMet: 2.08 ± 0.04	4.528LysAsn: 4.528 ± 0.058	2.289LysPro: 2.289 ± 0.04	2.749LysGln: 2.749 ± 0.051	2.853LysArg: 2.853 ± 0.053	4.436LysSer: 4.436 ± 0.053	4.208LysThr: 4.208 ± 0.059	4.504LysVal: 4.504 ± 0.054	0.839LysTrp: 0.839 ± 0.024	3.634LysTyr: 3.634 ± 0.054	0.0LysXaa: 0.0 ± 0.0
Leu	5.598LeuAla: 5.598 ± 0.064	0.976LeuCys: 0.976 ± 0.024	5.021LeuAsp: 5.021 ± 0.064	5.086LeuGlu: 5.086 ± 0.063	4.822LeuPhe: 4.822 ± 0.068	5.323LeuGly: 5.323 ± 0.06	1.463LeuHis: 1.463 ± 0.033	6.817LeuIle: 6.817 ± 0.078	6.852LeuLys: 6.852 ± 0.077	8.738LeuLeu: 8.738 ± 0.111	2.061LeuMet: 2.061 ± 0.038	5.424LeuAsn: 5.424 ± 0.068	3.65LeuPro: 3.65 ± 0.057	3.06LeuGln: 3.06 ± 0.057	3.57LeuArg: 3.57 ± 0.047	7.247LeuSer: 7.247 ± 0.075	5.187LeuThr: 5.187 ± 0.054	4.837LeuVal: 4.837 ± 0.066	1.011LeuTrp: 1.011 ± 0.029	3.811LeuTyr: 3.811 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.543MetAla: 1.543 ± 0.035	0.182MetCys: 0.182 ± 0.01	1.228MetAsp: 1.228 ± 0.029	1.425MetGlu: 1.425 ± 0.029	0.947MetPhe: 0.947 ± 0.029	1.612MetGly: 1.612 ± 0.037	0.364MetHis: 0.364 ± 0.014	1.643MetIle: 1.643 ± 0.033	2.364MetLys: 2.364 ± 0.032	2.049MetLeu: 2.049 ± 0.041	0.61MetMet: 0.61 ± 0.019	1.409MetAsn: 1.409 ± 0.032	0.969MetPro: 0.969 ± 0.027	0.91MetGln: 0.91 ± 0.027	0.986MetArg: 0.986 ± 0.027	1.523MetSer: 1.523 ± 0.031	1.308MetThr: 1.308 ± 0.028	1.277MetVal: 1.277 ± 0.028	0.234MetTrp: 0.234 ± 0.013	0.887MetTyr: 0.887 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.407AsnAla: 3.407 ± 0.052	0.497AsnCys: 0.497 ± 0.019	3.062AsnAsp: 3.062 ± 0.055	3.424AsnGlu: 3.424 ± 0.048	2.585AsnPhe: 2.585 ± 0.043	3.993AsnGly: 3.993 ± 0.067	0.947AsnHis: 0.947 ± 0.023	5.321AsnIle: 5.321 ± 0.056	4.532AsnLys: 4.532 ± 0.064	5.187AsnLeu: 5.187 ± 0.061	1.392AsnMet: 1.392 ± 0.034	3.87AsnAsn: 3.87 ± 0.07	2.813AsnPro: 2.813 ± 0.042	2.0AsnGln: 2.0 ± 0.041	2.423AsnArg: 2.423 ± 0.044	3.749AsnSer: 3.749 ± 0.058	3.64AsnThr: 3.64 ± 0.051	3.336AsnVal: 3.336 ± 0.05	0.723AsnTrp: 0.723 ± 0.022	2.819AsnTyr: 2.819 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	2.21ProAla: 2.21 ± 0.046	0.266ProCys: 0.266 ± 0.014	2.37ProAsp: 2.37 ± 0.041	2.669ProGlu: 2.669 ± 0.045	1.806ProPhe: 1.806 ± 0.037	1.822ProGly: 1.822 ± 0.038	0.642ProHis: 0.642 ± 0.021	2.64ProIle: 2.64 ± 0.037	2.183ProLys: 2.183 ± 0.037	3.07ProLeu: 3.07 ± 0.05	0.793ProMet: 0.793 ± 0.024	2.02ProAsn: 2.02 ± 0.036	0.795ProPro: 0.795 ± 0.026	1.441ProGln: 1.441 ± 0.03	1.103ProArg: 1.103 ± 0.026	2.413ProSer: 2.413 ± 0.043	2.026ProThr: 2.026 ± 0.038	2.527ProVal: 2.527 ± 0.045	0.381ProTrp: 0.381 ± 0.016	1.622ProTyr: 1.622 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.204GlnAla: 2.204 ± 0.044	0.227GlnCys: 0.227 ± 0.014	1.639GlnAsp: 1.639 ± 0.039	2.121GlnGlu: 2.121 ± 0.047	1.494GlnPhe: 1.494 ± 0.032	1.894GlnGly: 1.894 ± 0.033	0.526GlnHis: 0.526 ± 0.017	2.815GlnIle: 2.815 ± 0.048	2.707GlnLys: 2.707 ± 0.041	3.168GlnLeu: 3.168 ± 0.055	0.891GlnMet: 0.891 ± 0.025	2.139GlnAsn: 2.139 ± 0.041	1.071GlnPro: 1.071 ± 0.027	1.416GlnGln: 1.416 ± 0.03	1.392GlnArg: 1.392 ± 0.034	2.178GlnSer: 2.178 ± 0.039	2.062GlnThr: 2.062 ± 0.038	1.88GlnVal: 1.88 ± 0.037	0.43GlnTrp: 0.43 ± 0.02	1.543GlnTyr: 1.543 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.183ArgAla: 2.183 ± 0.042	0.31ArgCys: 0.31 ± 0.015	2.027ArgAsp: 2.027 ± 0.041	2.423ArgGlu: 2.423 ± 0.054	1.97ArgPhe: 1.97 ± 0.042	2.158ArgGly: 2.158 ± 0.044	0.667ArgHis: 0.667 ± 0.022	3.419ArgIle: 3.419 ± 0.056	3.06ArgLys: 3.06 ± 0.049	3.691ArgLeu: 3.691 ± 0.048	1.042ArgMet: 1.042 ± 0.028	2.354ArgAsn: 2.354 ± 0.044	1.236ArgPro: 1.236 ± 0.036	1.343ArgGln: 1.343 ± 0.031	1.575ArgArg: 1.575 ± 0.036	2.235ArgSer: 2.235 ± 0.035	2.098ArgThr: 2.098 ± 0.038	2.317ArgVal: 2.317 ± 0.04	0.585ArgTrp: 0.585 ± 0.018	1.91ArgTyr: 1.91 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	3.981SerAla: 3.981 ± 0.057	0.722SerCys: 0.722 ± 0.025	4.089SerAsp: 4.089 ± 0.057	4.012SerGlu: 4.012 ± 0.051	3.823SerPhe: 3.823 ± 0.055	4.783SerGly: 4.783 ± 0.067	1.108SerHis: 1.108 ± 0.026	5.529SerIle: 5.529 ± 0.066	4.626SerLys: 4.626 ± 0.058	6.538SerLeu: 6.538 ± 0.068	1.458SerMet: 1.458 ± 0.031	3.687SerAsn: 3.687 ± 0.061	2.434SerPro: 2.434 ± 0.045	2.254SerGln: 2.254 ± 0.044	2.396SerArg: 2.396 ± 0.037	4.658SerSer: 4.658 ± 0.074	3.768SerThr: 3.768 ± 0.063	4.395SerVal: 4.395 ± 0.055	0.852SerTrp: 0.852 ± 0.028	3.015SerTyr: 3.015 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	3.746ThrAla: 3.746 ± 0.059	0.448ThrCys: 0.448 ± 0.019	3.534ThrAsp: 3.534 ± 0.044	3.24ThrGlu: 3.24 ± 0.055	2.786ThrPhe: 2.786 ± 0.051	4.095ThrGly: 4.095 ± 0.064	0.955ThrHis: 0.955 ± 0.025	4.773ThrIle: 4.773 ± 0.062	3.632ThrLys: 3.632 ± 0.053	5.278ThrLeu: 5.278 ± 0.065	1.077ThrMet: 1.077 ± 0.027	3.189ThrAsn: 3.189 ± 0.054	2.6ThrPro: 2.6 ± 0.038	1.898ThrGln: 1.898 ± 0.042	1.865ThrArg: 1.865 ± 0.037	3.872ThrSer: 3.872 ± 0.057	3.462ThrThr: 3.462 ± 0.068	3.672ThrVal: 3.672 ± 0.057	0.663ThrTrp: 0.663 ± 0.023	2.57ThrTyr: 2.57 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	3.865ValAla: 3.865 ± 0.059	0.727ValCys: 0.727 ± 0.025	3.58ValAsp: 3.58 ± 0.054	3.659ValGlu: 3.659 ± 0.057	3.053ValPhe: 3.053 ± 0.045	3.741ValGly: 3.741 ± 0.055	0.888ValHis: 0.888 ± 0.023	4.618ValIle: 4.618 ± 0.067	4.272ValLys: 4.272 ± 0.056	5.42ValLeu: 5.42 ± 0.06	1.304ValMet: 1.304 ± 0.032	3.487ValAsn: 3.487 ± 0.051	2.096ValPro: 2.096 ± 0.045	1.75ValGln: 1.75 ± 0.033	2.293ValArg: 2.293 ± 0.039	4.571ValSer: 4.571 ± 0.067	3.444ValThr: 3.444 ± 0.056	3.951ValVal: 3.951 ± 0.056	0.71ValTrp: 0.71 ± 0.023	2.642ValTyr: 2.642 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.748TrpAla: 0.748 ± 0.022	0.157TrpCys: 0.157 ± 0.01	0.772TrpAsp: 0.772 ± 0.024	0.665TrpGlu: 0.665 ± 0.023	0.569TrpPhe: 0.569 ± 0.019	0.981TrpGly: 0.981 ± 0.035	0.24TrpHis: 0.24 ± 0.014	0.914TrpIle: 0.914 ± 0.027	0.834TrpLys: 0.834 ± 0.025	1.071TrpLeu: 1.071 ± 0.025	0.364TrpMet: 0.364 ± 0.015	0.816TrpAsn: 0.816 ± 0.024	0.234TrpPro: 0.234 ± 0.013	0.468TrpGln: 0.468 ± 0.018	0.498TrpArg: 0.498 ± 0.019	0.714TrpSer: 0.714 ± 0.022	0.677TrpThr: 0.677 ± 0.025	0.757TrpVal: 0.757 ± 0.026	0.202TrpTrp: 0.202 ± 0.012	0.511TrpTyr: 0.511 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.752TyrAla: 2.752 ± 0.044	0.456TyrCys: 0.456 ± 0.019	2.599TyrAsp: 2.599 ± 0.052	2.293TyrGlu: 2.293 ± 0.044	2.378TyrPhe: 2.378 ± 0.043	2.837TyrGly: 2.837 ± 0.051	0.744TyrHis: 0.744 ± 0.023	3.607TyrIle: 3.607 ± 0.049	3.342TyrLys: 3.342 ± 0.045	4.189TyrLeu: 4.189 ± 0.062	1.05TyrMet: 1.05 ± 0.03	3.027TyrAsn: 3.027 ± 0.052	1.87TyrPro: 1.87 ± 0.039	1.514TyrGln: 1.514 ± 0.034	1.952TyrArg: 1.952 ± 0.04	3.277TyrSer: 3.277 ± 0.051	2.909TyrThr: 2.909 ± 0.051	2.232TyrVal: 2.232 ± 0.044	0.62TyrTrp: 0.62 ± 0.022	2.308TyrTyr: 2.308 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.007XaaXaa: 0.007 ± 0.008

Statistics based on 4322 proteins (1489738 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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