Amino acid dipepetide frequency for Runella sp. SP2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.164AlaAla: 6.164 ± 0.067
0.771AlaCys: 0.771 ± 0.021
3.896AlaAsp: 3.896 ± 0.052
4.205AlaGlu: 4.205 ± 0.06
3.726AlaPhe: 3.726 ± 0.042
5.638AlaGly: 5.638 ± 0.085
1.265AlaHis: 1.265 ± 0.024
4.683AlaIle: 4.683 ± 0.048
4.52AlaLys: 4.52 ± 0.052
7.311AlaLeu: 7.311 ± 0.07
1.57AlaMet: 1.57 ± 0.027
4.008AlaAsn: 4.008 ± 0.065
3.035AlaPro: 3.035 ± 0.051
3.577AlaGln: 3.577 ± 0.043
2.74AlaArg: 2.74 ± 0.04
5.052AlaSer: 5.052 ± 0.054
5.302AlaThr: 5.302 ± 0.097
4.838AlaVal: 4.838 ± 0.051
0.904AlaTrp: 0.904 ± 0.022
2.745AlaTyr: 2.745 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.649CysAla: 0.649 ± 0.026
0.136CysCys: 0.136 ± 0.008
0.453CysAsp: 0.453 ± 0.02
0.467CysGlu: 0.467 ± 0.021
0.456CysPhe: 0.456 ± 0.015
0.661CysGly: 0.661 ± 0.022
0.21CysHis: 0.21 ± 0.01
0.537CysIle: 0.537 ± 0.016
0.452CysLys: 0.452 ± 0.021
0.812CysLeu: 0.812 ± 0.021
0.158CysMet: 0.158 ± 0.009
0.406CysAsn: 0.406 ± 0.015
0.451CysPro: 0.451 ± 0.021
0.399CysGln: 0.399 ± 0.016
0.347CysArg: 0.347 ± 0.011
0.704CysSer: 0.704 ± 0.035
0.608CysThr: 0.608 ± 0.034
0.666CysVal: 0.666 ± 0.024
0.107CysTrp: 0.107 ± 0.007
0.318CysTyr: 0.318 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
4.042AspAla: 4.042 ± 0.051
0.415AspCys: 0.415 ± 0.013
2.299AspAsp: 2.299 ± 0.036
3.078AspGlu: 3.078 ± 0.05
3.039AspPhe: 3.039 ± 0.042
3.868AspGly: 3.868 ± 0.057
0.699AspHis: 0.699 ± 0.019
3.207AspIle: 3.207 ± 0.043
3.186AspLys: 3.186 ± 0.052
4.594AspLeu: 4.594 ± 0.056
1.003AspMet: 1.003 ± 0.023
2.428AspAsn: 2.428 ± 0.037
1.998AspPro: 1.998 ± 0.039
1.455AspGln: 1.455 ± 0.028
1.946AspArg: 1.946 ± 0.035
2.747AspSer: 2.747 ± 0.039
2.656AspThr: 2.656 ± 0.047
3.276AspVal: 3.276 ± 0.047
0.875AspTrp: 0.875 ± 0.02
2.288AspTyr: 2.288 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
4.602GluAla: 4.602 ± 0.061
0.325GluCys: 0.325 ± 0.013
2.365GluAsp: 2.365 ± 0.038
3.512GluGlu: 3.512 ± 0.058
2.357GluPhe: 2.357 ± 0.035
3.707GluGly: 3.707 ± 0.045
0.969GluHis: 0.969 ± 0.026
3.923GluIle: 3.923 ± 0.048
4.417GluLys: 4.417 ± 0.056
5.636GluLeu: 5.636 ± 0.059
1.416GluMet: 1.416 ± 0.025
3.065GluAsn: 3.065 ± 0.041
1.712GluPro: 1.712 ± 0.037
2.382GluGln: 2.382 ± 0.035
2.817GluArg: 2.817 ± 0.042
2.927GluSer: 2.927 ± 0.036
3.183GluThr: 3.183 ± 0.04
4.138GluVal: 4.138 ± 0.044
0.769GluTrp: 0.769 ± 0.019
2.061GluTyr: 2.061 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.221PheAla: 3.221 ± 0.04
0.487PheCys: 0.487 ± 0.016
2.928PheAsp: 2.928 ± 0.045
2.954PheGlu: 2.954 ± 0.044
2.482PhePhe: 2.482 ± 0.039
3.565PheGly: 3.565 ± 0.043
0.792PheHis: 0.792 ± 0.016
2.762PheIle: 2.762 ± 0.042
2.768PheLys: 2.768 ± 0.041
4.478PheLeu: 4.478 ± 0.054
1.033PheMet: 1.033 ± 0.024
2.616PheAsn: 2.616 ± 0.044
1.811PhePro: 1.811 ± 0.032
1.774PheGln: 1.774 ± 0.029
2.17PheArg: 2.17 ± 0.036
3.721PheSer: 3.721 ± 0.043
3.251PheThr: 3.251 ± 0.047
3.418PheVal: 3.418 ± 0.043
0.762PheTrp: 0.762 ± 0.02
1.963PheTyr: 1.963 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
4.964GlyAla: 4.964 ± 0.059
0.91GlyCys: 0.91 ± 0.038
3.202GlyAsp: 3.202 ± 0.05
3.439GlyGlu: 3.439 ± 0.038
3.553GlyPhe: 3.553 ± 0.045
5.802GlyGly: 5.802 ± 0.111
1.144GlyHis: 1.144 ± 0.025
4.914GlyIle: 4.914 ± 0.054
4.794GlyLys: 4.794 ± 0.052
6.548GlyLeu: 6.548 ± 0.068
1.692GlyMet: 1.692 ± 0.028
3.773GlyAsn: 3.773 ± 0.07
1.601GlyPro: 1.601 ± 0.032
2.726GlyGln: 2.726 ± 0.042
2.754GlyArg: 2.754 ± 0.043
4.707GlySer: 4.707 ± 0.089
5.365GlyThr: 5.365 ± 0.136
5.196GlyVal: 5.196 ± 0.059
1.1GlyTrp: 1.1 ± 0.026
2.838GlyTyr: 2.838 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
1.132HisAla: 1.132 ± 0.024
0.201HisCys: 0.201 ± 0.01
0.798HisAsp: 0.798 ± 0.022
0.96HisGlu: 0.96 ± 0.023
1.183HisPhe: 1.183 ± 0.022
1.096HisGly: 1.096 ± 0.025
0.491HisHis: 0.491 ± 0.015
1.11HisIle: 1.11 ± 0.026
0.849HisLys: 0.849 ± 0.024
1.916HisLeu: 1.916 ± 0.033
0.251HisMet: 0.251 ± 0.011
0.782HisAsn: 0.782 ± 0.016
1.029HisPro: 1.029 ± 0.021
0.81HisGln: 0.81 ± 0.022
0.908HisArg: 0.908 ± 0.021
1.053HisSer: 1.053 ± 0.025
0.952HisThr: 0.952 ± 0.019
0.966HisVal: 0.966 ± 0.023
0.294HisTrp: 0.294 ± 0.012
0.813HisTyr: 0.813 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
4.986IleAla: 4.986 ± 0.057
0.634IleCys: 0.634 ± 0.019
3.513IleAsp: 3.513 ± 0.042
3.991IleGlu: 3.991 ± 0.048
2.626IlePhe: 2.626 ± 0.039
4.552IleGly: 4.552 ± 0.051
1.2IleHis: 1.2 ± 0.027
3.468IleIle: 3.468 ± 0.053
3.64IleLys: 3.64 ± 0.044
5.096IleLeu: 5.096 ± 0.057
1.037IleMet: 1.037 ± 0.021
3.368IleAsn: 3.368 ± 0.047
2.877IlePro: 2.877 ± 0.04
2.359IleGln: 2.359 ± 0.033
2.845IleArg: 2.845 ± 0.038
4.385IleSer: 4.385 ± 0.053
4.142IleThr: 4.142 ± 0.073
4.126IleVal: 4.126 ± 0.045
0.721IleTrp: 0.721 ± 0.019
2.185IleTyr: 2.185 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
4.836LysAla: 4.836 ± 0.063
0.35LysCys: 0.35 ± 0.017
3.277LysAsp: 3.277 ± 0.052
3.953LysGlu: 3.953 ± 0.056
2.142LysPhe: 2.142 ± 0.039
4.244LysGly: 4.244 ± 0.051
1.091LysHis: 1.091 ± 0.027
4.266LysIle: 4.266 ± 0.053
4.511LysLys: 4.511 ± 0.061
5.386LysLeu: 5.386 ± 0.062
1.681LysMet: 1.681 ± 0.027
3.644LysAsn: 3.644 ± 0.051
2.673LysPro: 2.673 ± 0.043
2.424LysGln: 2.424 ± 0.038
2.692LysArg: 2.692 ± 0.041
3.633LysSer: 3.633 ± 0.042
3.878LysThr: 3.878 ± 0.051
4.336LysVal: 4.336 ± 0.047
0.841LysTrp: 0.841 ± 0.023
2.399LysTyr: 2.399 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
7.167LeuAla: 7.167 ± 0.063
0.83LeuCys: 0.83 ± 0.02
4.394LeuAsp: 4.394 ± 0.047
5.14LeuGlu: 5.14 ± 0.061
4.595LeuPhe: 4.595 ± 0.062
6.246LeuGly: 6.246 ± 0.061
1.679LeuHis: 1.679 ± 0.034
5.41LeuIle: 5.41 ± 0.068
6.43LeuLys: 6.43 ± 0.064
9.498LeuLeu: 9.498 ± 0.098
2.09LeuMet: 2.09 ± 0.037
4.733LeuAsn: 4.733 ± 0.053
4.632LeuPro: 4.632 ± 0.056
3.873LeuGln: 3.873 ± 0.052
4.387LeuArg: 4.387 ± 0.05
6.999LeuSer: 6.999 ± 0.062
6.509LeuThr: 6.509 ± 0.067
6.046LeuVal: 6.046 ± 0.059
1.139LeuTrp: 1.139 ± 0.026
3.267LeuTyr: 3.267 ± 0.041
0.0LeuXaa: 0.0 ± 0.0
Met
1.719MetAla: 1.719 ± 0.03
0.143MetCys: 0.143 ± 0.008
0.938MetAsp: 0.938 ± 0.023
1.072MetGlu: 1.072 ± 0.024
0.786MetPhe: 0.786 ± 0.022
1.644MetGly: 1.644 ± 0.03
0.328MetHis: 0.328 ± 0.013
1.148MetIle: 1.148 ± 0.023
1.76MetLys: 1.76 ± 0.031
1.996MetLeu: 1.996 ± 0.028
0.54MetMet: 0.54 ± 0.015
1.094MetAsn: 1.094 ± 0.025
1.014MetPro: 1.014 ± 0.023
0.803MetGln: 0.803 ± 0.02
0.987MetArg: 0.987 ± 0.02
1.342MetSer: 1.342 ± 0.026
1.327MetThr: 1.327 ± 0.027
1.381MetVal: 1.381 ± 0.026
0.204MetTrp: 0.204 ± 0.009
0.72MetTyr: 0.72 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
4.176AsnAla: 4.176 ± 0.062
0.553AsnCys: 0.553 ± 0.029
2.726AsnAsp: 2.726 ± 0.046
2.782AsnGlu: 2.782 ± 0.039
2.459AsnPhe: 2.459 ± 0.04
4.285AsnGly: 4.285 ± 0.082
0.984AsnHis: 0.984 ± 0.022
3.055AsnIle: 3.055 ± 0.045
2.604AsnLys: 2.604 ± 0.039
4.597AsnLeu: 4.597 ± 0.048
0.884AsnMet: 0.884 ± 0.02
3.001AsnAsn: 3.001 ± 0.06
2.998AsnPro: 2.998 ± 0.05
2.354AsnGln: 2.354 ± 0.045
2.429AsnArg: 2.429 ± 0.041
3.213AsnSer: 3.213 ± 0.06
3.316AsnThr: 3.316 ± 0.057
3.616AsnVal: 3.616 ± 0.049
0.741AsnTrp: 0.741 ± 0.021
2.3AsnTyr: 2.3 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
3.358ProAla: 3.358 ± 0.044
0.267ProCys: 0.267 ± 0.015
2.382ProAsp: 2.382 ± 0.038
2.704ProGlu: 2.704 ± 0.038
2.11ProPhe: 2.11 ± 0.036
1.851ProGly: 1.851 ± 0.033
0.799ProHis: 0.799 ± 0.018
2.628ProIle: 2.628 ± 0.034
2.514ProLys: 2.514 ± 0.039
3.659ProLeu: 3.659 ± 0.046
0.847ProMet: 0.847 ± 0.021
2.545ProAsn: 2.545 ± 0.041
1.388ProPro: 1.388 ± 0.033
1.753ProGln: 1.753 ± 0.03
1.378ProArg: 1.378 ± 0.029
3.101ProSer: 3.101 ± 0.067
3.315ProThr: 3.315 ± 0.068
3.072ProVal: 3.072 ± 0.047
0.466ProTrp: 0.466 ± 0.016
1.639ProTyr: 1.639 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
2.98GlnAla: 2.98 ± 0.041
0.224GlnCys: 0.224 ± 0.011
1.537GlnAsp: 1.537 ± 0.033
2.168GlnGlu: 2.168 ± 0.035
1.841GlnPhe: 1.841 ± 0.03
2.371GlnGly: 2.371 ± 0.035
0.769GlnHis: 0.769 ± 0.021
2.524GlnIle: 2.524 ± 0.037
3.062GlnLys: 3.062 ± 0.049
4.41GlnLeu: 4.41 ± 0.056
0.892GlnMet: 0.892 ± 0.02
2.375GlnAsn: 2.375 ± 0.038
1.777GlnPro: 1.777 ± 0.036
2.151GlnGln: 2.151 ± 0.04
2.006GlnArg: 2.006 ± 0.033
2.464GlnSer: 2.464 ± 0.036
2.792GlnThr: 2.792 ± 0.05
2.61GlnVal: 2.61 ± 0.04
0.648GlnTrp: 0.648 ± 0.018
1.43GlnTyr: 1.43 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
2.794ArgAla: 2.794 ± 0.04
0.315ArgCys: 0.315 ± 0.012
1.978ArgAsp: 1.978 ± 0.033
2.428ArgGlu: 2.428 ± 0.039
2.431ArgPhe: 2.431 ± 0.037
2.479ArgGly: 2.479 ± 0.036
0.774ArgHis: 0.774 ± 0.018
2.932ArgIle: 2.932 ± 0.037
2.747ArgLys: 2.747 ± 0.039
4.431ArgLeu: 4.431 ± 0.059
1.047ArgMet: 1.047 ± 0.021
2.242ArgAsn: 2.242 ± 0.04
1.664ArgPro: 1.664 ± 0.033
1.968ArgGln: 1.968 ± 0.033
2.056ArgArg: 2.056 ± 0.037
2.36ArgSer: 2.36 ± 0.033
2.48ArgThr: 2.48 ± 0.031
2.867ArgVal: 2.867 ± 0.034
0.721ArgTrp: 0.721 ± 0.019
1.956ArgTyr: 1.956 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
4.741SerAla: 4.741 ± 0.081
0.664SerCys: 0.664 ± 0.023
3.134SerAsp: 3.134 ± 0.038
3.348SerGlu: 3.348 ± 0.043
3.643SerPhe: 3.643 ± 0.046
5.203SerGly: 5.203 ± 0.118
1.086SerHis: 1.086 ± 0.025
4.092SerIle: 4.092 ± 0.051
3.536SerLys: 3.536 ± 0.042
6.57SerLeu: 6.57 ± 0.074
1.33SerMet: 1.33 ± 0.024
3.322SerAsn: 3.322 ± 0.066
2.94SerPro: 2.94 ± 0.044
2.616SerGln: 2.616 ± 0.038
2.38SerArg: 2.38 ± 0.033
4.507SerSer: 4.507 ± 0.08
4.271SerThr: 4.271 ± 0.086
4.705SerVal: 4.705 ± 0.064
0.895SerTrp: 0.895 ± 0.025
2.636SerTyr: 2.636 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
5.172ThrAla: 5.172 ± 0.109
0.541ThrCys: 0.541 ± 0.028
3.367ThrAsp: 3.367 ± 0.049
3.156ThrGlu: 3.156 ± 0.04
3.364ThrPhe: 3.364 ± 0.056
5.082ThrGly: 5.082 ± 0.106
1.155ThrHis: 1.155 ± 0.026
4.303ThrIle: 4.303 ± 0.069
3.301ThrLys: 3.301 ± 0.038
6.609ThrLeu: 6.609 ± 0.068
1.036ThrMet: 1.036 ± 0.024
3.471ThrAsn: 3.471 ± 0.068
3.441ThrPro: 3.441 ± 0.059
2.526ThrGln: 2.526 ± 0.039
2.125ThrArg: 2.125 ± 0.032
4.271ThrSer: 4.271 ± 0.086
4.865ThrThr: 4.865 ± 0.099
4.936ThrVal: 4.936 ± 0.107
0.799ThrTrp: 0.799 ± 0.021
2.755ThrTyr: 2.755 ± 0.065
0.0ThrXaa: 0.0 ± 0.0
Val
5.523ValAla: 5.523 ± 0.062
0.745ValCys: 0.745 ± 0.027
3.135ValAsp: 3.135 ± 0.044
4.025ValGlu: 4.025 ± 0.043
3.255ValPhe: 3.255 ± 0.039
5.044ValGly: 5.044 ± 0.063
1.057ValHis: 1.057 ± 0.023
4.136ValIle: 4.136 ± 0.047
4.174ValLys: 4.174 ± 0.055
6.288ValLeu: 6.288 ± 0.06
1.416ValMet: 1.416 ± 0.03
3.478ValAsn: 3.478 ± 0.054
2.754ValPro: 2.754 ± 0.039
2.413ValGln: 2.413 ± 0.038
2.929ValArg: 2.929 ± 0.04
5.058ValSer: 5.058 ± 0.062
4.766ValThr: 4.766 ± 0.116
5.34ValVal: 5.34 ± 0.061
0.894ValTrp: 0.894 ± 0.021
2.43ValTyr: 2.43 ± 0.029
0.0ValXaa: 0.0 ± 0.0
Trp
0.968TrpAla: 0.968 ± 0.021
0.112TrpCys: 0.112 ± 0.007
0.661TrpAsp: 0.661 ± 0.018
0.754TrpGlu: 0.754 ± 0.02
0.646TrpPhe: 0.646 ± 0.016
1.056TrpGly: 1.056 ± 0.026
0.289TrpHis: 0.289 ± 0.013
0.719TrpIle: 0.719 ± 0.017
0.892TrpLys: 0.892 ± 0.022
1.407TrpLeu: 1.407 ± 0.03
0.372TrpMet: 0.372 ± 0.013
0.769TrpAsn: 0.769 ± 0.019
0.349TrpPro: 0.349 ± 0.014
0.696TrpGln: 0.696 ± 0.018
0.623TrpArg: 0.623 ± 0.018
0.856TrpSer: 0.856 ± 0.028
0.828TrpThr: 0.828 ± 0.024
0.98TrpVal: 0.98 ± 0.027
0.248TrpTrp: 0.248 ± 0.012
0.561TrpTyr: 0.561 ± 0.017
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.756TyrAla: 2.756 ± 0.038
0.373TyrCys: 0.373 ± 0.021
2.116TyrAsp: 2.116 ± 0.03
2.147TyrGlu: 2.147 ± 0.032
2.262TyrPhe: 2.262 ± 0.035
2.628TyrGly: 2.628 ± 0.037
0.813TyrHis: 0.813 ± 0.02
1.936TyrIle: 1.936 ± 0.037
2.098TyrLys: 2.098 ± 0.035
3.821TyrLeu: 3.821 ± 0.049
0.651TyrMet: 0.651 ± 0.019
1.951TyrAsn: 1.951 ± 0.033
1.63TyrPro: 1.63 ± 0.029
1.976TyrGln: 1.976 ± 0.038
2.153TyrArg: 2.153 ± 0.031
2.517TyrSer: 2.517 ± 0.035
2.47TyrThr: 2.47 ± 0.057
2.348TyrVal: 2.348 ± 0.032
0.659TyrTrp: 0.659 ± 0.019
1.684TyrTyr: 1.684 ± 0.034
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5998 proteins (2298142 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski