Amino acid dipepetide frequency for Limnoglobus roseus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.872AlaAla: 16.872 ± 0.146	1.165AlaCys: 1.165 ± 0.025	8.01AlaAsp: 8.01 ± 0.071	7.19AlaGlu: 7.19 ± 0.076	4.296AlaPhe: 4.296 ± 0.049	10.358AlaGly: 10.358 ± 0.09	1.884AlaHis: 1.884 ± 0.03	4.64AlaIle: 4.64 ± 0.043	5.739AlaLys: 5.739 ± 0.073	9.548AlaLeu: 9.548 ± 0.082	2.356AlaMet: 2.356 ± 0.034	3.444AlaAsn: 3.444 ± 0.059	4.788AlaPro: 4.788 ± 0.063	2.84AlaGln: 2.84 ± 0.039	6.849AlaArg: 6.849 ± 0.077	5.071AlaSer: 5.071 ± 0.053	7.071AlaThr: 7.071 ± 0.08	10.504AlaVal: 10.504 ± 0.082	1.628AlaTrp: 1.628 ± 0.027	2.354AlaTyr: 2.354 ± 0.033	0.0AlaXaa: 0.0 ± 0.0
Cys	0.765CysAla: 0.765 ± 0.018	0.184CysCys: 0.184 ± 0.01	0.588CysAsp: 0.588 ± 0.018	0.532CysGlu: 0.532 ± 0.015	0.316CysPhe: 0.316 ± 0.011	1.014CysGly: 1.014 ± 0.023	0.366CysHis: 0.366 ± 0.013	0.272CysIle: 0.272 ± 0.01	0.31CysLys: 0.31 ± 0.011	0.932CysLeu: 0.932 ± 0.019	0.137CysMet: 0.137 ± 0.007	0.212CysAsn: 0.212 ± 0.009	0.659CysPro: 0.659 ± 0.018	0.315CysGln: 0.315 ± 0.011	0.841CysArg: 0.841 ± 0.018	0.498CysSer: 0.498 ± 0.017	0.483CysThr: 0.483 ± 0.015	0.796CysVal: 0.796 ± 0.018	0.192CysTrp: 0.192 ± 0.009	0.267CysTyr: 0.267 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.282AspAla: 7.282 ± 0.062	0.457AspCys: 0.457 ± 0.015	3.645AspAsp: 3.645 ± 0.052	3.488AspGlu: 3.488 ± 0.042	2.121AspPhe: 2.121 ± 0.028	6.153AspGly: 6.153 ± 0.073	1.238AspHis: 1.238 ± 0.024	1.928AspIle: 1.928 ± 0.031	2.193AspLys: 2.193 ± 0.037	5.889AspLeu: 5.889 ± 0.06	0.792AspMet: 0.792 ± 0.017	1.331AspAsn: 1.331 ± 0.026	4.057AspPro: 4.057 ± 0.046	1.719AspGln: 1.719 ± 0.024	4.714AspArg: 4.714 ± 0.05	2.37AspSer: 2.37 ± 0.032	2.849AspThr: 2.849 ± 0.047	4.661AspVal: 4.661 ± 0.049	0.951AspTrp: 0.951 ± 0.018	1.401AspTyr: 1.401 ± 0.025	0.0AspXaa: 0.0 ± 0.0
Glu	6.219GluAla: 6.219 ± 0.066	0.479GluCys: 0.479 ± 0.014	2.401GluAsp: 2.401 ± 0.032	2.85GluGlu: 2.85 ± 0.042	2.096GluPhe: 2.096 ± 0.028	3.407GluGly: 3.407 ± 0.038	1.048GluHis: 1.048 ± 0.021	2.336GluIle: 2.336 ± 0.034	3.011GluLys: 3.011 ± 0.052	6.013GluLeu: 6.013 ± 0.062	1.281GluMet: 1.281 ± 0.024	1.351GluAsn: 1.351 ± 0.023	2.865GluPro: 2.865 ± 0.041	2.338GluGln: 2.338 ± 0.038	4.001GluArg: 4.001 ± 0.051	2.823GluSer: 2.823 ± 0.038	2.905GluThr: 2.905 ± 0.036	4.206GluVal: 4.206 ± 0.052	0.879GluTrp: 0.879 ± 0.02	1.372GluTyr: 1.372 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.486PheAla: 4.486 ± 0.047	0.389PheCys: 0.389 ± 0.011	2.777PheAsp: 2.777 ± 0.04	2.07PheGlu: 2.07 ± 0.03	1.371PhePhe: 1.371 ± 0.028	3.466PheGly: 3.466 ± 0.038	0.809PheHis: 0.809 ± 0.017	1.132PheIle: 1.132 ± 0.023	1.125PheLys: 1.125 ± 0.021	3.618PheLeu: 3.618 ± 0.049	0.441PheMet: 0.441 ± 0.013	1.139PheAsn: 1.139 ± 0.024	1.849PhePro: 1.849 ± 0.029	1.15PheGln: 1.15 ± 0.018	2.605PheArg: 2.605 ± 0.034	1.905PheSer: 1.905 ± 0.033	2.473PheThr: 2.473 ± 0.05	3.022PheVal: 3.022 ± 0.033	0.519PheTrp: 0.519 ± 0.013	0.838PheTyr: 0.838 ± 0.019	0.0PheXaa: 0.0 ± 0.0
Gly	6.581GlyAla: 6.581 ± 0.07	0.983GlyCys: 0.983 ± 0.022	4.824GlyAsp: 4.824 ± 0.058	4.625GlyGlu: 4.625 ± 0.04	3.186GlyPhe: 3.186 ± 0.036	8.289GlyGly: 8.289 ± 0.11	1.717GlyHis: 1.717 ± 0.03	3.259GlyIle: 3.259 ± 0.041	4.329GlyLys: 4.329 ± 0.051	7.782GlyLeu: 7.782 ± 0.062	1.827GlyMet: 1.827 ± 0.027	2.526GlyAsn: 2.526 ± 0.057	4.231GlyPro: 4.231 ± 0.047	2.948GlyGln: 2.948 ± 0.04	6.215GlyArg: 6.215 ± 0.065	4.658GlySer: 4.658 ± 0.057	5.891GlyThr: 5.891 ± 0.112	6.8GlyVal: 6.8 ± 0.063	1.532GlyTrp: 1.532 ± 0.024	2.261GlyTyr: 2.261 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.159HisAla: 2.159 ± 0.033	0.289HisCys: 0.289 ± 0.011	1.189HisAsp: 1.189 ± 0.019	1.046HisGlu: 1.046 ± 0.024	0.825HisPhe: 0.825 ± 0.017	1.759HisGly: 1.759 ± 0.032	0.597HisHis: 0.597 ± 0.016	0.621HisIle: 0.621 ± 0.015	0.625HisLys: 0.625 ± 0.017	2.146HisLeu: 2.146 ± 0.033	0.278HisMet: 0.278 ± 0.009	0.502HisAsn: 0.502 ± 0.015	1.441HisPro: 1.441 ± 0.023	0.57HisGln: 0.57 ± 0.015	1.536HisArg: 1.536 ± 0.027	0.855HisSer: 0.855 ± 0.019	1.059HisThr: 1.059 ± 0.023	1.529HisVal: 1.529 ± 0.027	0.358HisTrp: 0.358 ± 0.01	0.552HisTyr: 0.552 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.69IleAla: 4.69 ± 0.042	0.384IleCys: 0.384 ± 0.013	2.781IleAsp: 2.781 ± 0.039	2.384IleGlu: 2.384 ± 0.035	1.154IlePhe: 1.154 ± 0.023	3.497IleGly: 3.497 ± 0.053	0.739IleHis: 0.739 ± 0.016	1.28IleIle: 1.28 ± 0.025	1.254IleLys: 1.254 ± 0.026	3.66IleLeu: 3.66 ± 0.043	0.449IleMet: 0.449 ± 0.013	1.083IleAsn: 1.083 ± 0.024	2.257IlePro: 2.257 ± 0.033	1.09IleGln: 1.09 ± 0.023	2.798IleArg: 2.798 ± 0.034	1.865IleSer: 1.865 ± 0.031	2.388IleThr: 2.388 ± 0.049	3.28IleVal: 3.28 ± 0.04	0.445IleTrp: 0.445 ± 0.014	0.856IleTyr: 0.856 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	5.027LysAla: 5.027 ± 0.071	0.348LysCys: 0.348 ± 0.013	2.456LysAsp: 2.456 ± 0.042	2.234LysGlu: 2.234 ± 0.041	1.419LysPhe: 1.419 ± 0.026	2.934LysGly: 2.934 ± 0.044	0.822LysHis: 0.822 ± 0.019	1.611LysIle: 1.611 ± 0.027	2.606LysLys: 2.606 ± 0.054	4.68LysLeu: 4.68 ± 0.051	1.149LysMet: 1.149 ± 0.023	1.211LysAsn: 1.211 ± 0.028	3.161LysPro: 3.161 ± 0.046	1.557LysGln: 1.557 ± 0.032	2.513LysArg: 2.513 ± 0.038	2.106LysSer: 2.106 ± 0.031	2.413LysThr: 2.413 ± 0.036	3.3LysVal: 3.3 ± 0.045	0.626LysTrp: 0.626 ± 0.018	1.016LysTyr: 1.016 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	12.639LeuAla: 12.639 ± 0.096	0.894LeuCys: 0.894 ± 0.019	5.782LeuAsp: 5.782 ± 0.057	4.556LeuGlu: 4.556 ± 0.051	3.602LeuPhe: 3.602 ± 0.04	7.548LeuGly: 7.548 ± 0.065	1.844LeuHis: 1.844 ± 0.028	3.851LeuIle: 3.851 ± 0.043	4.222LeuLys: 4.222 ± 0.052	9.561LeuLeu: 9.561 ± 0.1	1.64LeuMet: 1.64 ± 0.027	2.791LeuAsn: 2.791 ± 0.036	6.135LeuPro: 6.135 ± 0.052	2.654LeuGln: 2.654 ± 0.033	6.76LeuArg: 6.76 ± 0.071	5.301LeuSer: 5.301 ± 0.052	6.812LeuThr: 6.812 ± 0.064	7.088LeuVal: 7.088 ± 0.06	1.167LeuTrp: 1.167 ± 0.026	1.99LeuTyr: 1.99 ± 0.03	0.0LeuXaa: 0.0 ± 0.0
Met	2.2MetAla: 2.2 ± 0.032	0.153MetCys: 0.153 ± 0.009	0.816MetAsp: 0.816 ± 0.019	0.774MetGlu: 0.774 ± 0.017	0.597MetPhe: 0.597 ± 0.016	1.258MetGly: 1.258 ± 0.022	0.325MetHis: 0.325 ± 0.011	0.792MetIle: 0.792 ± 0.017	0.988MetLys: 0.988 ± 0.02	1.791MetLeu: 1.791 ± 0.029	0.435MetMet: 0.435 ± 0.014	0.676MetAsn: 0.676 ± 0.016	1.37MetPro: 1.37 ± 0.022	0.517MetGln: 0.517 ± 0.015	1.273MetArg: 1.273 ± 0.023	1.165MetSer: 1.165 ± 0.022	1.523MetThr: 1.523 ± 0.028	1.237MetVal: 1.237 ± 0.024	0.198MetTrp: 0.198 ± 0.01	0.317MetTyr: 0.317 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.019AsnAla: 3.019 ± 0.042	0.298AsnCys: 0.298 ± 0.012	1.656AsnAsp: 1.656 ± 0.036	1.311AsnGlu: 1.311 ± 0.024	1.09AsnPhe: 1.09 ± 0.024	2.953AsnGly: 2.953 ± 0.071	0.588AsnHis: 0.588 ± 0.014	0.974AsnIle: 0.974 ± 0.024	0.984AsnLys: 0.984 ± 0.02	2.852AsnLeu: 2.852 ± 0.038	0.426AsnMet: 0.426 ± 0.014	0.971AsnAsn: 0.971 ± 0.036	2.289AsnPro: 2.289 ± 0.036	0.905AsnGln: 0.905 ± 0.02	2.062AsnArg: 2.062 ± 0.028	1.358AsnSer: 1.358 ± 0.032	1.537AsnThr: 1.537 ± 0.034	2.154AsnVal: 2.154 ± 0.044	0.443AsnTrp: 0.443 ± 0.013	0.773AsnTyr: 0.773 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.796ProAla: 7.796 ± 0.074	0.415ProCys: 0.415 ± 0.016	4.253ProAsp: 4.253 ± 0.045	3.459ProGlu: 3.459 ± 0.046	2.175ProPhe: 2.175 ± 0.03	4.905ProGly: 4.905 ± 0.043	1.202ProHis: 1.202 ± 0.023	2.245ProIle: 2.245 ± 0.03	2.748ProLys: 2.748 ± 0.045	4.812ProLeu: 4.812 ± 0.043	1.077ProMet: 1.077 ± 0.022	1.915ProAsn: 1.915 ± 0.033	4.89ProPro: 4.89 ± 0.073	1.657ProGln: 1.657 ± 0.03	3.332ProArg: 3.332 ± 0.045	3.159ProSer: 3.159 ± 0.039	4.462ProThr: 4.462 ± 0.044	4.826ProVal: 4.826 ± 0.053	0.759ProTrp: 0.759 ± 0.018	1.144ProTyr: 1.144 ± 0.023	0.0ProXaa: 0.0 ± 0.0
Gln	3.531GlnAla: 3.531 ± 0.044	0.258GlnCys: 0.258 ± 0.009	1.335GlnAsp: 1.335 ± 0.026	1.514GlnGlu: 1.514 ± 0.024	1.383GlnPhe: 1.383 ± 0.024	1.973GlnGly: 1.973 ± 0.03	0.649GlnHis: 0.649 ± 0.017	1.469GlnIle: 1.469 ± 0.026	1.495GlnLys: 1.495 ± 0.035	3.421GlnLeu: 3.421 ± 0.042	0.652GlnMet: 0.652 ± 0.016	0.904GlnAsn: 0.904 ± 0.022	2.048GlnPro: 2.048 ± 0.035	1.373GlnGln: 1.373 ± 0.033	2.017GlnArg: 2.017 ± 0.03	1.673GlnSer: 1.673 ± 0.026	1.938GlnThr: 1.938 ± 0.029	2.358GlnVal: 2.358 ± 0.029	0.435GlnTrp: 0.435 ± 0.014	0.726GlnTyr: 0.726 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	6.601ArgAla: 6.601 ± 0.074	0.666ArgCys: 0.666 ± 0.015	4.02ArgAsp: 4.02 ± 0.046	4.163ArgGlu: 4.163 ± 0.048	2.844ArgPhe: 2.844 ± 0.032	4.901ArgGly: 4.901 ± 0.051	1.589ArgHis: 1.589 ± 0.031	2.89ArgIle: 2.89 ± 0.037	2.812ArgLys: 2.812 ± 0.041	7.28ArgLeu: 7.28 ± 0.072	1.53ArgMet: 1.53 ± 0.024	1.806ArgAsn: 1.806 ± 0.028	4.209ArgPro: 4.209 ± 0.049	2.503ArgGln: 2.503 ± 0.036	5.626ArgArg: 5.626 ± 0.065	3.412ArgSer: 3.412 ± 0.038	4.042ArgThr: 4.042 ± 0.042	5.629ArgVal: 5.629 ± 0.057	1.195ArgTrp: 1.195 ± 0.026	1.779ArgTyr: 1.779 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	5.339SerAla: 5.339 ± 0.055	0.467SerCys: 0.467 ± 0.014	2.786SerAsp: 2.786 ± 0.036	2.358SerGlu: 2.358 ± 0.033	1.914SerPhe: 1.914 ± 0.032	4.758SerGly: 4.758 ± 0.07	1.03SerHis: 1.03 ± 0.023	1.962SerIle: 1.962 ± 0.029	1.858SerLys: 1.858 ± 0.03	4.999SerLeu: 4.999 ± 0.047	0.915SerMet: 0.915 ± 0.021	1.518SerAsn: 1.518 ± 0.031	3.631SerPro: 3.631 ± 0.042	1.531SerGln: 1.531 ± 0.026	3.421SerArg: 3.421 ± 0.037	2.798SerSer: 2.798 ± 0.047	2.899SerThr: 2.899 ± 0.043	3.995SerVal: 3.995 ± 0.044	0.738SerTrp: 0.738 ± 0.016	1.162SerTyr: 1.162 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	8.028ThrAla: 8.028 ± 0.097	0.504ThrCys: 0.504 ± 0.016	3.665ThrAsp: 3.665 ± 0.05	2.82ThrGlu: 2.82 ± 0.037	2.487ThrPhe: 2.487 ± 0.051	5.972ThrGly: 5.972 ± 0.097	1.117ThrHis: 1.117 ± 0.018	2.776ThrIle: 2.776 ± 0.057	2.217ThrLys: 2.217 ± 0.036	6.061ThrLeu: 6.061 ± 0.064	0.959ThrMet: 0.959 ± 0.021	1.792ThrAsn: 1.792 ± 0.04	4.634ThrPro: 4.634 ± 0.056	1.576ThrGln: 1.576 ± 0.028	3.547ThrArg: 3.547 ± 0.04	2.845ThrSer: 2.845 ± 0.049	4.039ThrThr: 4.039 ± 0.078	5.546ThrVal: 5.546 ± 0.097	0.838ThrTrp: 0.838 ± 0.021	1.358ThrTyr: 1.358 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.358ValAla: 9.358 ± 0.082	0.89ValCys: 0.89 ± 0.023	3.855ValAsp: 3.855 ± 0.04	4.524ValGlu: 4.524 ± 0.043	2.802ValPhe: 2.802 ± 0.033	6.485ValGly: 6.485 ± 0.057	1.413ValHis: 1.413 ± 0.026	3.194ValIle: 3.194 ± 0.035	3.228ValLys: 3.228 ± 0.043	7.585ValLeu: 7.585 ± 0.066	1.442ValMet: 1.442 ± 0.024	2.374ValAsn: 2.374 ± 0.048	4.736ValPro: 4.736 ± 0.052	2.404ValGln: 2.404 ± 0.03	6.299ValArg: 6.299 ± 0.059	4.185ValSer: 4.185 ± 0.05	5.775ValThr: 5.775 ± 0.109	7.07ValVal: 7.07 ± 0.072	1.27ValTrp: 1.27 ± 0.027	1.964ValTyr: 1.964 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.556TrpAla: 1.556 ± 0.03	0.176TrpCys: 0.176 ± 0.008	0.922TrpAsp: 0.922 ± 0.022	0.723TrpGlu: 0.723 ± 0.02	0.554TrpPhe: 0.554 ± 0.015	0.975TrpGly: 0.975 ± 0.024	0.388TrpHis: 0.388 ± 0.013	0.47TrpIle: 0.47 ± 0.013	0.698TrpLys: 0.698 ± 0.017	1.713TrpLeu: 1.713 ± 0.026	0.306TrpMet: 0.306 ± 0.011	0.474TrpAsn: 0.474 ± 0.015	0.778TrpPro: 0.778 ± 0.023	0.648TrpGln: 0.648 ± 0.014	1.054TrpArg: 1.054 ± 0.023	0.76TrpSer: 0.76 ± 0.018	0.816TrpThr: 0.816 ± 0.017	1.168TrpVal: 1.168 ± 0.023	0.295TrpTrp: 0.295 ± 0.011	0.365TrpTyr: 0.365 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.46TyrAla: 2.46 ± 0.029	0.283TyrCys: 0.283 ± 0.011	1.48TyrAsp: 1.48 ± 0.029	1.259TyrGlu: 1.259 ± 0.022	0.949TyrPhe: 0.949 ± 0.019	1.859TyrGly: 1.859 ± 0.031	0.57TyrHis: 0.57 ± 0.015	0.63TyrIle: 0.63 ± 0.016	0.747TyrLys: 0.747 ± 0.018	2.493TyrLeu: 2.493 ± 0.035	0.312TyrMet: 0.312 ± 0.011	0.625TyrAsn: 0.625 ± 0.018	1.203TyrPro: 1.203 ± 0.023	0.858TyrGln: 0.858 ± 0.019	2.035TyrArg: 2.035 ± 0.026	1.272TyrSer: 1.272 ± 0.026	1.405TyrThr: 1.405 ± 0.034	1.684TyrVal: 1.684 ± 0.028	0.373TyrTrp: 0.373 ± 0.012	0.667TyrTyr: 0.667 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7819 proteins (2678873 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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