Amino acid dipepetide frequency for Rhodococcus phage Jace

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.998AlaAla: 16.998 ± 1.203
1.014AlaCys: 1.014 ± 0.299
7.813AlaAsp: 7.813 ± 0.809
7.395AlaGlu: 7.395 ± 0.793
3.161AlaPhe: 3.161 ± 0.464
10.318AlaGly: 10.318 ± 1.196
2.743AlaHis: 2.743 ± 0.412
4.95AlaIle: 4.95 ± 0.447
5.248AlaLys: 5.248 ± 0.887
10.974AlaLeu: 10.974 ± 1.03
3.519AlaMet: 3.519 ± 0.386
3.221AlaAsn: 3.221 ± 0.379
5.726AlaPro: 5.726 ± 0.666
5.547AlaGln: 5.547 ± 0.82
8.767AlaArg: 8.767 ± 0.94
5.368AlaSer: 5.368 ± 0.51
7.634AlaThr: 7.634 ± 0.646
6.441AlaVal: 6.441 ± 0.734
1.849AlaTrp: 1.849 ± 0.376
2.624AlaTyr: 2.624 ± 0.426
0.0AlaXaa: 0.0 ± 0.0
Cys
1.193CysAla: 1.193 ± 0.294
0.0CysCys: 0.0 ± 0.0
0.358CysAsp: 0.358 ± 0.157
0.358CysGlu: 0.358 ± 0.13
0.119CysPhe: 0.119 ± 0.079
1.193CysGly: 1.193 ± 0.319
0.239CysHis: 0.239 ± 0.106
0.477CysIle: 0.477 ± 0.179
0.358CysLys: 0.358 ± 0.156
0.835CysLeu: 0.835 ± 0.205
0.179CysMet: 0.179 ± 0.09
0.239CysAsn: 0.239 ± 0.109
0.537CysPro: 0.537 ± 0.181
0.179CysGln: 0.179 ± 0.108
0.716CysArg: 0.716 ± 0.202
0.656CysSer: 0.656 ± 0.298
0.596CysThr: 0.596 ± 0.198
0.537CysVal: 0.537 ± 0.19
0.179CysTrp: 0.179 ± 0.098
0.119CysTyr: 0.119 ± 0.084
0.0CysXaa: 0.0 ± 0.0
Asp
9.185AspAla: 9.185 ± 0.803
0.477AspCys: 0.477 ± 0.2
5.666AspAsp: 5.666 ± 0.76
5.666AspGlu: 5.666 ± 0.703
2.028AspPhe: 2.028 ± 0.352
5.904AspGly: 5.904 ± 0.622
1.372AspHis: 1.372 ± 0.311
3.042AspIle: 3.042 ± 0.401
2.326AspLys: 2.326 ± 0.415
5.964AspLeu: 5.964 ± 0.742
0.835AspMet: 0.835 ± 0.24
2.147AspAsn: 2.147 ± 0.295
3.936AspPro: 3.936 ± 0.519
1.849AspGln: 1.849 ± 0.288
4.831AspArg: 4.831 ± 0.539
2.982AspSer: 2.982 ± 0.417
3.28AspThr: 3.28 ± 0.474
5.308AspVal: 5.308 ± 0.571
1.968AspTrp: 1.968 ± 0.35
1.431AspTyr: 1.431 ± 0.308
0.0AspXaa: 0.0 ± 0.0
Glu
6.143GluAla: 6.143 ± 0.636
0.775GluCys: 0.775 ± 0.219
2.445GluAsp: 2.445 ± 0.323
1.61GluGlu: 1.61 ± 0.304
1.909GluPhe: 1.909 ± 0.326
3.698GluGly: 3.698 ± 0.443
1.849GluHis: 1.849 ± 0.395
3.34GluIle: 3.34 ± 0.447
2.207GluLys: 2.207 ± 0.447
5.189GluLeu: 5.189 ± 0.635
1.789GluMet: 1.789 ± 0.306
1.789GluAsn: 1.789 ± 0.346
3.757GluPro: 3.757 ± 0.602
3.519GluGln: 3.519 ± 0.564
4.712GluArg: 4.712 ± 0.55
2.565GluSer: 2.565 ± 0.446
4.235GluThr: 4.235 ± 0.543
3.4GluVal: 3.4 ± 0.448
1.193GluTrp: 1.193 ± 0.309
1.193GluTyr: 1.193 ± 0.247
0.0GluXaa: 0.0 ± 0.0
Phe
3.161PheAla: 3.161 ± 0.547
0.358PheCys: 0.358 ± 0.148
2.684PheAsp: 2.684 ± 0.439
2.386PheGlu: 2.386 ± 0.406
0.298PhePhe: 0.298 ± 0.139
2.207PheGly: 2.207 ± 0.469
0.537PheHis: 0.537 ± 0.168
0.775PheIle: 0.775 ± 0.197
1.074PheLys: 1.074 ± 0.252
1.133PheLeu: 1.133 ± 0.306
0.537PheMet: 0.537 ± 0.17
0.895PheAsn: 0.895 ± 0.206
1.431PhePro: 1.431 ± 0.333
0.835PheGln: 0.835 ± 0.21
1.431PheArg: 1.431 ± 0.244
0.895PheSer: 0.895 ± 0.245
2.445PheThr: 2.445 ± 0.333
2.445PheVal: 2.445 ± 0.315
0.716PheTrp: 0.716 ± 0.252
0.179PheTyr: 0.179 ± 0.083
0.0PheXaa: 0.0 ± 0.0
Gly
7.873GlyAla: 7.873 ± 1.42
0.119GlyCys: 0.119 ± 0.09
5.01GlyAsp: 5.01 ± 0.506
4.473GlyGlu: 4.473 ± 0.49
2.386GlyPhe: 2.386 ± 0.427
7.992GlyGly: 7.992 ± 2.21
2.803GlyHis: 2.803 ± 0.532
3.757GlyIle: 3.757 ± 0.569
3.936GlyLys: 3.936 ± 0.529
6.501GlyLeu: 6.501 ± 0.593
1.968GlyMet: 1.968 ± 0.381
2.445GlyAsn: 2.445 ± 0.421
2.147GlyPro: 2.147 ± 0.304
3.638GlyGln: 3.638 ± 0.453
6.262GlyArg: 6.262 ± 0.568
4.891GlySer: 4.891 ± 0.854
6.143GlyThr: 6.143 ± 0.624
6.62GlyVal: 6.62 ± 0.814
1.372GlyTrp: 1.372 ± 0.328
2.087GlyTyr: 2.087 ± 0.421
0.0GlyXaa: 0.0 ± 0.0
His
2.743HisAla: 2.743 ± 0.542
0.298HisCys: 0.298 ± 0.145
1.968HisAsp: 1.968 ± 0.451
1.67HisGlu: 1.67 ± 0.349
0.716HisPhe: 0.716 ± 0.253
2.087HisGly: 2.087 ± 0.453
0.417HisHis: 0.417 ± 0.143
0.895HisIle: 0.895 ± 0.253
0.835HisLys: 0.835 ± 0.243
2.445HisLeu: 2.445 ± 0.44
0.537HisMet: 0.537 ± 0.19
0.895HisAsn: 0.895 ± 0.263
1.67HisPro: 1.67 ± 0.319
1.133HisGln: 1.133 ± 0.254
1.372HisArg: 1.372 ± 0.421
0.895HisSer: 0.895 ± 0.281
1.67HisThr: 1.67 ± 0.369
2.386HisVal: 2.386 ± 0.414
0.537HisTrp: 0.537 ± 0.149
0.895HisTyr: 0.895 ± 0.223
0.0HisXaa: 0.0 ± 0.0
Ile
5.487IleAla: 5.487 ± 0.543
0.596IleCys: 0.596 ± 0.192
3.4IleAsp: 3.4 ± 0.367
3.28IleGlu: 3.28 ± 0.474
1.193IlePhe: 1.193 ± 0.261
3.757IleGly: 3.757 ± 0.419
1.193IleHis: 1.193 ± 0.271
1.431IleIle: 1.431 ± 0.315
1.252IleLys: 1.252 ± 0.229
2.624IleLeu: 2.624 ± 0.386
1.133IleMet: 1.133 ± 0.255
1.431IleAsn: 1.431 ± 0.296
2.087IlePro: 2.087 ± 0.318
0.716IleGln: 0.716 ± 0.222
3.459IleArg: 3.459 ± 0.526
1.61IleSer: 1.61 ± 0.283
3.757IleThr: 3.757 ± 0.465
3.877IleVal: 3.877 ± 0.399
0.119IleTrp: 0.119 ± 0.071
1.193IleTyr: 1.193 ± 0.275
0.0IleXaa: 0.0 ± 0.0
Lys
4.354LysAla: 4.354 ± 0.492
0.239LysCys: 0.239 ± 0.146
1.491LysAsp: 1.491 ± 0.385
1.312LysGlu: 1.312 ± 0.33
1.014LysPhe: 1.014 ± 0.251
2.087LysGly: 2.087 ± 0.37
0.895LysHis: 0.895 ± 0.273
2.028LysIle: 2.028 ± 0.39
0.656LysLys: 0.656 ± 0.186
3.28LysLeu: 3.28 ± 0.54
1.252LysMet: 1.252 ± 0.3
1.193LysAsn: 1.193 ± 0.289
2.565LysPro: 2.565 ± 0.48
1.133LysGln: 1.133 ± 0.221
2.922LysArg: 2.922 ± 0.572
1.67LysSer: 1.67 ± 0.317
2.982LysThr: 2.982 ± 0.489
2.565LysVal: 2.565 ± 0.365
0.596LysTrp: 0.596 ± 0.24
0.954LysTyr: 0.954 ± 0.218
0.0LysXaa: 0.0 ± 0.0
Leu
10.378LeuAla: 10.378 ± 0.944
0.895LeuCys: 0.895 ± 0.24
7.813LeuAsp: 7.813 ± 0.68
3.459LeuGlu: 3.459 ± 0.428
1.491LeuPhe: 1.491 ± 0.352
7.992LeuGly: 7.992 ± 0.787
2.207LeuHis: 2.207 ± 0.381
2.743LeuIle: 2.743 ± 0.385
1.968LeuLys: 1.968 ± 0.384
6.68LeuLeu: 6.68 ± 0.728
1.252LeuMet: 1.252 ± 0.322
3.161LeuAsn: 3.161 ± 0.43
5.01LeuPro: 5.01 ± 0.509
2.803LeuGln: 2.803 ± 0.419
7.157LeuArg: 7.157 ± 0.714
5.01LeuSer: 5.01 ± 0.674
5.248LeuThr: 5.248 ± 0.727
6.083LeuVal: 6.083 ± 0.653
1.551LeuTrp: 1.551 ± 0.295
0.716LeuTyr: 0.716 ± 0.182
0.0LeuXaa: 0.0 ± 0.0
Met
2.863MetAla: 2.863 ± 0.38
0.179MetCys: 0.179 ± 0.096
0.775MetAsp: 0.775 ± 0.208
0.835MetGlu: 0.835 ± 0.245
0.835MetPhe: 0.835 ± 0.206
0.954MetGly: 0.954 ± 0.236
0.775MetHis: 0.775 ± 0.189
0.835MetIle: 0.835 ± 0.204
0.358MetLys: 0.358 ± 0.123
2.326MetLeu: 2.326 ± 0.398
0.537MetMet: 0.537 ± 0.176
0.775MetAsn: 0.775 ± 0.251
1.551MetPro: 1.551 ± 0.301
0.656MetGln: 0.656 ± 0.235
2.147MetArg: 2.147 ± 0.309
2.028MetSer: 2.028 ± 0.366
2.684MetThr: 2.684 ± 0.351
1.312MetVal: 1.312 ± 0.3
0.358MetTrp: 0.358 ± 0.139
0.477MetTyr: 0.477 ± 0.194
0.0MetXaa: 0.0 ± 0.0
Asn
4.056AsnAla: 4.056 ± 0.516
0.179AsnCys: 0.179 ± 0.094
3.519AsnAsp: 3.519 ± 0.485
1.491AsnGlu: 1.491 ± 0.303
0.537AsnPhe: 0.537 ± 0.177
3.578AsnGly: 3.578 ± 0.607
0.716AsnHis: 0.716 ± 0.191
1.014AsnIle: 1.014 ± 0.255
0.775AsnLys: 0.775 ± 0.229
2.565AsnLeu: 2.565 ± 0.418
0.596AsnMet: 0.596 ± 0.149
1.014AsnAsn: 1.014 ± 0.266
2.505AsnPro: 2.505 ± 0.308
1.312AsnGln: 1.312 ± 0.299
1.73AsnArg: 1.73 ± 0.339
1.431AsnSer: 1.431 ± 0.277
1.968AsnThr: 1.968 ± 0.335
2.863AsnVal: 2.863 ± 0.37
0.298AsnTrp: 0.298 ± 0.15
0.298AsnTyr: 0.298 ± 0.143
0.0AsnXaa: 0.0 ± 0.0
Pro
6.262ProAla: 6.262 ± 0.833
0.477ProCys: 0.477 ± 0.152
5.01ProAsp: 5.01 ± 0.724
2.922ProGlu: 2.922 ± 0.477
1.849ProPhe: 1.849 ± 0.284
4.473ProGly: 4.473 ± 0.483
1.491ProHis: 1.491 ± 0.349
2.505ProIle: 2.505 ± 0.355
2.207ProLys: 2.207 ± 0.465
3.877ProLeu: 3.877 ± 0.477
1.61ProMet: 1.61 ± 0.294
2.028ProAsn: 2.028 ± 0.416
2.326ProPro: 2.326 ± 0.338
0.895ProGln: 0.895 ± 0.242
3.042ProArg: 3.042 ± 0.481
2.028ProSer: 2.028 ± 0.338
2.624ProThr: 2.624 ± 0.382
3.638ProVal: 3.638 ± 0.52
0.656ProTrp: 0.656 ± 0.194
0.954ProTyr: 0.954 ± 0.223
0.0ProXaa: 0.0 ± 0.0
Gln
3.877GlnAla: 3.877 ± 0.596
0.417GlnCys: 0.417 ± 0.158
1.252GlnAsp: 1.252 ± 0.282
1.372GlnGlu: 1.372 ± 0.301
0.656GlnPhe: 0.656 ± 0.2
2.803GlnGly: 2.803 ± 0.495
1.074GlnHis: 1.074 ± 0.241
1.67GlnIle: 1.67 ± 0.309
0.895GlnLys: 0.895 ± 0.215
4.831GlnLeu: 4.831 ± 0.561
1.193GlnMet: 1.193 ± 0.2
1.372GlnAsn: 1.372 ± 0.352
1.67GlnPro: 1.67 ± 0.29
2.565GlnGln: 2.565 ± 0.617
3.638GlnArg: 3.638 ± 0.504
1.849GlnSer: 1.849 ± 0.347
2.565GlnThr: 2.565 ± 0.358
1.968GlnVal: 1.968 ± 0.374
0.895GlnTrp: 0.895 ± 0.253
0.596GlnTyr: 0.596 ± 0.173
0.0GlnXaa: 0.0 ± 0.0
Arg
8.887ArgAla: 8.887 ± 0.749
0.537ArgCys: 0.537 ± 0.204
5.785ArgAsp: 5.785 ± 0.658
6.561ArgGlu: 6.561 ± 0.71
1.849ArgPhe: 1.849 ± 0.335
4.294ArgGly: 4.294 ± 0.443
2.326ArgHis: 2.326 ± 0.484
3.459ArgIle: 3.459 ± 0.533
3.101ArgLys: 3.101 ± 0.442
6.322ArgLeu: 6.322 ± 0.602
1.372ArgMet: 1.372 ± 0.269
2.386ArgAsn: 2.386 ± 0.401
3.042ArgPro: 3.042 ± 0.408
3.4ArgGln: 3.4 ± 0.473
5.487ArgArg: 5.487 ± 0.621
4.115ArgSer: 4.115 ± 0.466
4.473ArgThr: 4.473 ± 0.544
3.936ArgVal: 3.936 ± 0.557
1.61ArgTrp: 1.61 ± 0.367
2.147ArgTyr: 2.147 ± 0.338
0.0ArgXaa: 0.0 ± 0.0
Ser
5.785SerAla: 5.785 ± 0.735
0.596SerCys: 0.596 ± 0.205
2.207SerAsp: 2.207 ± 0.37
1.968SerGlu: 1.968 ± 0.374
1.67SerPhe: 1.67 ± 0.347
4.712SerGly: 4.712 ± 0.721
1.133SerHis: 1.133 ± 0.273
2.087SerIle: 2.087 ± 0.331
2.147SerLys: 2.147 ± 0.645
4.056SerLeu: 4.056 ± 0.375
1.372SerMet: 1.372 ± 0.255
2.147SerAsn: 2.147 ± 0.366
2.505SerPro: 2.505 ± 0.369
1.312SerGln: 1.312 ± 0.251
3.757SerArg: 3.757 ± 0.439
3.34SerSer: 3.34 ± 0.526
3.578SerThr: 3.578 ± 0.464
3.161SerVal: 3.161 ± 0.475
1.133SerTrp: 1.133 ± 0.274
1.193SerTyr: 1.193 ± 0.217
0.0SerXaa: 0.0 ± 0.0
Thr
9.96ThrAla: 9.96 ± 0.771
1.014ThrCys: 1.014 ± 0.288
4.175ThrAsp: 4.175 ± 0.45
3.101ThrGlu: 3.101 ± 0.43
2.266ThrPhe: 2.266 ± 0.323
5.666ThrGly: 5.666 ± 0.664
1.193ThrHis: 1.193 ± 0.338
3.519ThrIle: 3.519 ± 0.476
2.445ThrLys: 2.445 ± 0.385
5.845ThrLeu: 5.845 ± 0.633
1.133ThrMet: 1.133 ± 0.25
2.087ThrAsn: 2.087 ± 0.348
3.459ThrPro: 3.459 ± 0.437
1.67ThrGln: 1.67 ± 0.347
4.771ThrArg: 4.771 ± 0.574
3.817ThrSer: 3.817 ± 0.475
5.368ThrThr: 5.368 ± 0.613
4.712ThrVal: 4.712 ± 0.432
0.895ThrTrp: 0.895 ± 0.211
1.61ThrTyr: 1.61 ± 0.257
0.0ThrXaa: 0.0 ± 0.0
Val
8.171ValAla: 8.171 ± 0.869
0.716ValCys: 0.716 ± 0.201
6.083ValAsp: 6.083 ± 0.686
5.308ValGlu: 5.308 ± 0.553
1.61ValPhe: 1.61 ± 0.408
5.069ValGly: 5.069 ± 0.562
1.968ValHis: 1.968 ± 0.362
3.638ValIle: 3.638 ± 0.449
2.147ValLys: 2.147 ± 0.407
4.354ValLeu: 4.354 ± 0.522
1.014ValMet: 1.014 ± 0.254
2.087ValAsn: 2.087 ± 0.508
3.34ValPro: 3.34 ± 0.44
2.743ValGln: 2.743 ± 0.422
5.01ValArg: 5.01 ± 0.576
3.161ValSer: 3.161 ± 0.44
4.95ValThr: 4.95 ± 0.517
5.069ValVal: 5.069 ± 0.518
0.895ValTrp: 0.895 ± 0.27
1.551ValTyr: 1.551 ± 0.29
0.0ValXaa: 0.0 ± 0.0
Trp
1.431TrpAla: 1.431 ± 0.321
0.0TrpCys: 0.0 ± 0.0
1.074TrpAsp: 1.074 ± 0.313
1.074TrpGlu: 1.074 ± 0.26
0.596TrpPhe: 0.596 ± 0.197
1.372TrpGly: 1.372 ± 0.354
0.716TrpHis: 0.716 ± 0.249
0.477TrpIle: 0.477 ± 0.18
0.537TrpLys: 0.537 ± 0.185
1.849TrpLeu: 1.849 ± 0.386
0.596TrpMet: 0.596 ± 0.187
0.417TrpAsn: 0.417 ± 0.14
0.895TrpPro: 0.895 ± 0.234
0.835TrpGln: 0.835 ± 0.185
1.551TrpArg: 1.551 ± 0.329
0.775TrpSer: 0.775 ± 0.287
0.954TrpThr: 0.954 ± 0.243
1.61TrpVal: 1.61 ± 0.289
0.239TrpTrp: 0.239 ± 0.118
0.477TrpTyr: 0.477 ± 0.168
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.565TyrAla: 2.565 ± 0.391
0.179TyrCys: 0.179 ± 0.12
1.67TyrAsp: 1.67 ± 0.36
1.074TyrGlu: 1.074 ± 0.258
0.239TyrPhe: 0.239 ± 0.113
2.266TyrGly: 2.266 ± 0.381
0.417TyrHis: 0.417 ± 0.15
0.954TyrIle: 0.954 ± 0.199
0.716TyrLys: 0.716 ± 0.196
1.968TyrLeu: 1.968 ± 0.386
0.775TyrMet: 0.775 ± 0.196
0.716TyrAsn: 0.716 ± 0.199
0.716TyrPro: 0.716 ± 0.281
0.417TyrGln: 0.417 ± 0.164
2.326TyrArg: 2.326 ± 0.395
0.775TyrSer: 0.775 ± 0.209
1.551TyrThr: 1.551 ± 0.295
0.954TyrVal: 0.954 ± 0.238
0.417TyrTrp: 0.417 ± 0.17
0.358TyrTyr: 0.358 ± 0.18
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 93 proteins (16768 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski