Amino acid dipepetide frequency for Methylocystis bryophila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.29AlaAla: 18.29 ± 0.184
1.25AlaCys: 1.25 ± 0.038
5.807AlaAsp: 5.807 ± 0.062
7.955AlaGlu: 7.955 ± 0.101
4.915AlaPhe: 4.915 ± 0.065
10.137AlaGly: 10.137 ± 0.112
2.516AlaHis: 2.516 ± 0.046
6.136AlaIle: 6.136 ± 0.085
4.828AlaLys: 4.828 ± 0.075
15.493AlaLeu: 15.493 ± 0.148
2.923AlaMet: 2.923 ± 0.055
3.063AlaAsn: 3.063 ± 0.056
7.625AlaPro: 7.625 ± 0.102
4.751AlaGln: 4.751 ± 0.068
10.333AlaArg: 10.333 ± 0.128
7.546AlaSer: 7.546 ± 0.079
6.235AlaThr: 6.235 ± 0.082
7.732AlaVal: 7.732 ± 0.09
1.455AlaTrp: 1.455 ± 0.035
2.801AlaTyr: 2.801 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
1.41CysAla: 1.41 ± 0.04
0.15CysCys: 0.15 ± 0.01
0.583CysAsp: 0.583 ± 0.024
0.594CysGlu: 0.594 ± 0.023
0.367CysPhe: 0.367 ± 0.018
1.043CysGly: 1.043 ± 0.03
0.324CysHis: 0.324 ± 0.051
0.334CysIle: 0.334 ± 0.014
0.265CysLys: 0.265 ± 0.016
0.877CysLeu: 0.877 ± 0.028
0.151CysMet: 0.151 ± 0.01
0.259CysAsn: 0.259 ± 0.016
0.519CysPro: 0.519 ± 0.021
0.227CysGln: 0.227 ± 0.012
0.681CysArg: 0.681 ± 0.026
0.55CysSer: 0.55 ± 0.024
0.319CysThr: 0.319 ± 0.015
0.811CysVal: 0.811 ± 0.026
0.127CysTrp: 0.127 ± 0.011
0.208CysTyr: 0.208 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
7.029AspAla: 7.029 ± 0.077
0.587AspCys: 0.587 ± 0.025
2.73AspAsp: 2.73 ± 0.048
3.389AspGlu: 3.389 ± 0.063
2.368AspPhe: 2.368 ± 0.052
4.403AspGly: 4.403 ± 0.065
1.173AspHis: 1.173 ± 0.033
2.388AspIle: 2.388 ± 0.046
1.619AspLys: 1.619 ± 0.034
5.719AspLeu: 5.719 ± 0.075
0.977AspMet: 0.977 ± 0.029
1.213AspAsn: 1.213 ± 0.033
3.321AspPro: 3.321 ± 0.054
1.438AspGln: 1.438 ± 0.04
3.827AspArg: 3.827 ± 0.057
2.309AspSer: 2.309 ± 0.046
1.811AspThr: 1.811 ± 0.041
3.622AspVal: 3.622 ± 0.049
0.888AspTrp: 0.888 ± 0.027
1.469AspTyr: 1.469 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
8.757GluAla: 8.757 ± 0.109
0.406GluCys: 0.406 ± 0.02
2.767GluAsp: 2.767 ± 0.054
3.834GluGlu: 3.834 ± 0.064
1.944GluPhe: 1.944 ± 0.038
4.487GluGly: 4.487 ± 0.064
1.197GluHis: 1.197 ± 0.034
3.864GluIle: 3.864 ± 0.066
2.709GluLys: 2.709 ± 0.052
5.771GluLeu: 5.771 ± 0.082
1.313GluMet: 1.313 ± 0.032
1.685GluAsn: 1.685 ± 0.037
3.04GluPro: 3.04 ± 0.054
1.877GluGln: 1.877 ± 0.046
5.667GluArg: 5.667 ± 0.095
3.031GluSer: 3.031 ± 0.05
3.701GluThr: 3.701 ± 0.056
3.351GluVal: 3.351 ± 0.052
0.754GluTrp: 0.754 ± 0.024
0.967GluTyr: 0.967 ± 0.031
0.0GluXaa: 0.0 ± 0.0
Phe
5.105PheAla: 5.105 ± 0.064
0.504PheCys: 0.504 ± 0.022
2.792PheAsp: 2.792 ± 0.05
2.457PheGlu: 2.457 ± 0.042
1.742PhePhe: 1.742 ± 0.047
3.787PheGly: 3.787 ± 0.063
0.789PheHis: 0.789 ± 0.027
1.56PheIle: 1.56 ± 0.036
1.056PheLys: 1.056 ± 0.03
3.892PheLeu: 3.892 ± 0.057
0.723PheMet: 0.723 ± 0.023
1.096PheAsn: 1.096 ± 0.032
1.788PhePro: 1.788 ± 0.041
1.02PheGln: 1.02 ± 0.025
2.37PheArg: 2.37 ± 0.042
2.686PheSer: 2.686 ± 0.051
1.868PheThr: 1.868 ± 0.039
3.092PheVal: 3.092 ± 0.053
0.606PheTrp: 0.606 ± 0.026
1.022PheTyr: 1.022 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
11.378GlyAla: 11.378 ± 0.123
0.91GlyCys: 0.91 ± 0.032
4.125GlyAsp: 4.125 ± 0.064
5.2GlyGlu: 5.2 ± 0.074
3.834GlyPhe: 3.834 ± 0.061
7.691GlyGly: 7.691 ± 0.14
1.695GlyHis: 1.695 ± 0.051
2.787GlyIle: 2.787 ± 0.051
3.102GlyLys: 3.102 ± 0.051
8.933GlyLeu: 8.933 ± 0.094
1.7GlyMet: 1.7 ± 0.039
1.841GlyAsn: 1.841 ± 0.053
3.608GlyPro: 3.608 ± 0.064
2.403GlyGln: 2.403 ± 0.041
5.983GlyArg: 5.983 ± 0.082
4.542GlySer: 4.542 ± 0.081
3.208GlyThr: 3.208 ± 0.083
7.151GlyVal: 7.151 ± 0.081
1.28GlyTrp: 1.28 ± 0.037
2.22GlyTyr: 2.22 ± 0.045
0.0GlyXaa: 0.0 ± 0.0
His
2.393HisAla: 2.393 ± 0.043
0.243HisCys: 0.243 ± 0.014
1.099HisAsp: 1.099 ± 0.035
1.183HisGlu: 1.183 ± 0.03
0.92HisPhe: 0.92 ± 0.026
1.841HisGly: 1.841 ± 0.04
0.549HisHis: 0.549 ± 0.027
0.877HisIle: 0.877 ± 0.032
0.592HisLys: 0.592 ± 0.024
1.891HisLeu: 1.891 ± 0.038
0.429HisMet: 0.429 ± 0.021
0.521HisAsn: 0.521 ± 0.028
1.253HisPro: 1.253 ± 0.034
0.482HisGln: 0.482 ± 0.02
1.352HisArg: 1.352 ± 0.037
1.017HisSer: 1.017 ± 0.028
0.68HisThr: 0.68 ± 0.025
1.504HisVal: 1.504 ± 0.035
0.361HisTrp: 0.361 ± 0.017
0.581HisTyr: 0.581 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
6.601IleAla: 6.601 ± 0.091
0.539IleCys: 0.539 ± 0.022
3.343IleAsp: 3.343 ± 0.048
3.693IleGlu: 3.693 ± 0.063
1.781IlePhe: 1.781 ± 0.039
4.719IleGly: 4.719 ± 0.067
0.834IleHis: 0.834 ± 0.026
1.755IleIle: 1.755 ± 0.04
1.354IleLys: 1.354 ± 0.031
4.205IleLeu: 4.205 ± 0.055
0.725IleMet: 0.725 ± 0.027
1.27IleAsn: 1.27 ± 0.037
2.104IlePro: 2.104 ± 0.043
1.093IleGln: 1.093 ± 0.032
2.616IleArg: 2.616 ± 0.041
2.65IleSer: 2.65 ± 0.049
1.968IleThr: 1.968 ± 0.041
4.268IleVal: 4.268 ± 0.063
0.551IleTrp: 0.551 ± 0.021
1.099IleTyr: 1.099 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
4.252LysAla: 4.252 ± 0.062
0.215LysCys: 0.215 ± 0.013
1.686LysAsp: 1.686 ± 0.038
1.949LysGlu: 1.949 ± 0.045
1.076LysPhe: 1.076 ± 0.028
2.797LysGly: 2.797 ± 0.053
0.62LysHis: 0.62 ± 0.026
2.081LysIle: 2.081 ± 0.037
1.409LysLys: 1.409 ± 0.04
3.528LysLeu: 3.528 ± 0.059
0.674LysMet: 0.674 ± 0.022
1.0LysAsn: 1.0 ± 0.026
2.18LysPro: 2.18 ± 0.042
0.954LysGln: 0.954 ± 0.027
2.635LysArg: 2.635 ± 0.044
2.145LysSer: 2.145 ± 0.048
1.999LysThr: 1.999 ± 0.042
2.067LysVal: 2.067 ± 0.047
0.382LysTrp: 0.382 ± 0.016
0.64LysTyr: 0.64 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
15.116LeuAla: 15.116 ± 0.143
1.139LeuCys: 1.139 ± 0.029
6.007LeuAsp: 6.007 ± 0.08
6.135LeuGlu: 6.135 ± 0.081
3.91LeuPhe: 3.91 ± 0.068
8.413LeuGly: 8.413 ± 0.093
1.934LeuHis: 1.934 ± 0.039
4.792LeuIle: 4.792 ± 0.071
3.458LeuLys: 3.458 ± 0.054
10.441LeuLeu: 10.441 ± 0.119
1.978LeuMet: 1.978 ± 0.043
2.535LeuAsn: 2.535 ± 0.047
5.624LeuPro: 5.624 ± 0.08
2.851LeuGln: 2.851 ± 0.05
7.977LeuArg: 7.977 ± 0.104
6.881LeuSer: 6.881 ± 0.076
5.311LeuThr: 5.311 ± 0.075
7.256LeuVal: 7.256 ± 0.075
1.269LeuTrp: 1.269 ± 0.033
2.235LeuTyr: 2.235 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
2.261MetAla: 2.261 ± 0.045
0.155MetCys: 0.155 ± 0.012
0.836MetAsp: 0.836 ± 0.026
0.947MetGlu: 0.947 ± 0.028
0.617MetPhe: 0.617 ± 0.025
1.45MetGly: 1.45 ± 0.041
0.381MetHis: 0.381 ± 0.018
1.133MetIle: 1.133 ± 0.032
0.846MetLys: 0.846 ± 0.026
2.168MetLeu: 2.168 ± 0.041
0.429MetMet: 0.429 ± 0.019
0.62MetAsn: 0.62 ± 0.02
1.084MetPro: 1.084 ± 0.028
0.71MetGln: 0.71 ± 0.027
1.863MetArg: 1.863 ± 0.04
1.473MetSer: 1.473 ± 0.034
1.486MetThr: 1.486 ± 0.032
1.104MetVal: 1.104 ± 0.031
0.171MetTrp: 0.171 ± 0.011
0.227MetTyr: 0.227 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
3.329AsnAla: 3.329 ± 0.059
0.29AsnCys: 0.29 ± 0.018
1.36AsnAsp: 1.36 ± 0.039
1.345AsnGlu: 1.345 ± 0.031
1.153AsnPhe: 1.153 ± 0.03
2.292AsnGly: 2.292 ± 0.056
0.486AsnHis: 0.486 ± 0.021
1.316AsnIle: 1.316 ± 0.042
0.668AsnLys: 0.668 ± 0.024
2.673AsnLeu: 2.673 ± 0.047
0.466AsnMet: 0.466 ± 0.019
0.71AsnAsn: 0.71 ± 0.03
1.79AsnPro: 1.79 ± 0.042
0.75AsnGln: 0.75 ± 0.029
1.594AsnArg: 1.594 ± 0.037
1.316AsnSer: 1.316 ± 0.041
1.08AsnThr: 1.08 ± 0.033
1.934AsnVal: 1.934 ± 0.047
0.439AsnTrp: 0.439 ± 0.019
0.783AsnTyr: 0.783 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
6.512ProAla: 6.512 ± 0.088
0.405ProCys: 0.405 ± 0.019
2.942ProAsp: 2.942 ± 0.055
3.646ProGlu: 3.646 ± 0.06
2.18ProPhe: 2.18 ± 0.04
4.509ProGly: 4.509 ± 0.067
1.123ProHis: 1.123 ± 0.031
2.534ProIle: 2.534 ± 0.044
1.984ProLys: 1.984 ± 0.043
5.279ProLeu: 5.279 ± 0.074
1.044ProMet: 1.044 ± 0.03
1.442ProAsn: 1.442 ± 0.032
3.514ProPro: 3.514 ± 0.075
1.998ProGln: 1.998 ± 0.04
3.528ProArg: 3.528 ± 0.056
3.401ProSer: 3.401 ± 0.062
2.666ProThr: 2.666 ± 0.047
3.509ProVal: 3.509 ± 0.054
0.744ProTrp: 0.744 ± 0.024
1.243ProTyr: 1.243 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
4.093GlnAla: 4.093 ± 0.062
0.221GlnCys: 0.221 ± 0.016
1.379GlnAsp: 1.379 ± 0.034
1.64GlnGlu: 1.64 ± 0.038
1.073GlnPhe: 1.073 ± 0.03
2.45GlnGly: 2.45 ± 0.044
0.554GlnHis: 0.554 ± 0.021
1.735GlnIle: 1.735 ± 0.043
1.201GlnLys: 1.201 ± 0.037
2.723GlnLeu: 2.723 ± 0.048
0.667GlnMet: 0.667 ± 0.021
0.916GlnAsn: 0.916 ± 0.03
1.589GlnPro: 1.589 ± 0.034
1.08GlnGln: 1.08 ± 0.033
2.449GlnArg: 2.449 ± 0.042
1.835GlnSer: 1.835 ± 0.038
1.705GlnThr: 1.705 ± 0.042
1.748GlnVal: 1.748 ± 0.041
0.401GlnTrp: 0.401 ± 0.019
0.594GlnTyr: 0.594 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
9.375ArgAla: 9.375 ± 0.112
0.647ArgCys: 0.647 ± 0.026
4.019ArgAsp: 4.019 ± 0.057
5.0ArgGlu: 5.0 ± 0.072
3.274ArgPhe: 3.274 ± 0.057
5.12ArgGly: 5.12 ± 0.062
1.622ArgHis: 1.622 ± 0.038
3.683ArgIle: 3.683 ± 0.053
2.437ArgLys: 2.437 ± 0.044
9.09ArgLeu: 9.09 ± 0.117
1.598ArgMet: 1.598 ± 0.037
1.801ArgAsn: 1.801 ± 0.038
3.644ArgPro: 3.644 ± 0.055
2.331ArgGln: 2.331 ± 0.047
6.659ArgArg: 6.659 ± 0.096
3.967ArgSer: 3.967 ± 0.058
2.776ArgThr: 2.776 ± 0.045
4.845ArgVal: 4.845 ± 0.061
0.97ArgTrp: 0.97 ± 0.031
1.72ArgTyr: 1.72 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
7.083SerAla: 7.083 ± 0.074
0.666SerCys: 0.666 ± 0.034
2.836SerAsp: 2.836 ± 0.044
3.202SerGlu: 3.202 ± 0.054
2.701SerPhe: 2.701 ± 0.053
5.626SerGly: 5.626 ± 0.091
1.081SerHis: 1.081 ± 0.028
2.636SerIle: 2.636 ± 0.05
1.743SerLys: 1.743 ± 0.039
6.222SerLeu: 6.222 ± 0.075
1.133SerMet: 1.133 ± 0.03
1.499SerAsn: 1.499 ± 0.038
3.391SerPro: 3.391 ± 0.054
1.713SerGln: 1.713 ± 0.038
4.116SerArg: 4.116 ± 0.057
3.445SerSer: 3.445 ± 0.073
2.723SerThr: 2.723 ± 0.054
3.899SerVal: 3.899 ± 0.058
0.823SerTrp: 0.823 ± 0.022
1.453SerTyr: 1.453 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
5.515ThrAla: 5.515 ± 0.076
0.382ThrCys: 0.382 ± 0.017
2.096ThrAsp: 2.096 ± 0.037
2.22ThrGlu: 2.22 ± 0.042
1.782ThrPhe: 1.782 ± 0.039
4.383ThrGly: 4.383 ± 0.09
0.962ThrHis: 0.962 ± 0.029
2.69ThrIle: 2.69 ± 0.058
1.532ThrLys: 1.532 ± 0.036
5.764ThrLeu: 5.764 ± 0.071
0.902ThrMet: 0.902 ± 0.026
1.304ThrAsn: 1.304 ± 0.042
3.563ThrPro: 3.563 ± 0.048
1.597ThrGln: 1.597 ± 0.042
3.268ThrArg: 3.268 ± 0.054
2.666ThrSer: 2.666 ± 0.052
2.593ThrThr: 2.593 ± 0.054
3.104ThrVal: 3.104 ± 0.049
0.474ThrTrp: 0.474 ± 0.017
1.005ThrTyr: 1.005 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
9.435ValAla: 9.435 ± 0.095
0.68ValCys: 0.68 ± 0.023
3.94ValAsp: 3.94 ± 0.06
4.849ValGlu: 4.849 ± 0.059
2.795ValPhe: 2.795 ± 0.049
5.337ValGly: 5.337 ± 0.069
1.213ValHis: 1.213 ± 0.031
3.398ValIle: 3.398 ± 0.053
2.44ValLys: 2.44 ± 0.045
6.596ValLeu: 6.596 ± 0.081
1.403ValMet: 1.403 ± 0.033
1.959ValAsn: 1.959 ± 0.049
2.753ValPro: 2.753 ± 0.053
1.728ValGln: 1.728 ± 0.039
4.26ValArg: 4.26 ± 0.06
4.362ValSer: 4.362 ± 0.064
3.9ValThr: 3.9 ± 0.061
5.542ValVal: 5.542 ± 0.084
0.819ValTrp: 0.819 ± 0.023
1.475ValTyr: 1.475 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.203TrpAla: 1.203 ± 0.029
0.137TrpCys: 0.137 ± 0.011
0.525TrpAsp: 0.525 ± 0.022
0.551TrpGlu: 0.551 ± 0.021
0.497TrpPhe: 0.497 ± 0.02
0.978TrpGly: 0.978 ± 0.032
0.238TrpHis: 0.238 ± 0.014
0.658TrpIle: 0.658 ± 0.024
0.443TrpLys: 0.443 ± 0.017
1.6TrpLeu: 1.6 ± 0.036
0.316TrpMet: 0.316 ± 0.017
0.41TrpAsn: 0.41 ± 0.02
0.707TrpPro: 0.707 ± 0.025
0.377TrpGln: 0.377 ± 0.02
1.606TrpArg: 1.606 ± 0.041
0.943TrpSer: 0.943 ± 0.027
0.813TrpThr: 0.813 ± 0.029
0.671TrpVal: 0.671 ± 0.024
0.204TrpTrp: 0.204 ± 0.014
0.231TrpTyr: 0.231 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.656TyrAla: 2.656 ± 0.048
0.273TyrCys: 0.273 ± 0.012
1.407TyrAsp: 1.407 ± 0.036
1.332TyrGlu: 1.332 ± 0.036
1.023TyrPhe: 1.023 ± 0.029
2.13TyrGly: 2.13 ± 0.048
0.477TyrHis: 0.477 ± 0.022
0.807TyrIle: 0.807 ± 0.029
0.605TyrLys: 0.605 ± 0.023
2.396TyrLeu: 2.396 ± 0.041
0.411TyrMet: 0.411 ± 0.017
0.628TyrAsn: 0.628 ± 0.027
1.107TyrPro: 1.107 ± 0.031
0.674TyrGln: 0.674 ± 0.025
1.792TyrArg: 1.792 ± 0.039
1.227TyrSer: 1.227 ± 0.036
0.961TyrThr: 0.961 ± 0.037
1.675TyrVal: 1.675 ± 0.037
0.39TyrTrp: 0.39 ± 0.018
0.65TyrTyr: 0.65 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4267 proteins (1300618 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski