Amino acid dipepetide frequency for Burkholderiales bacterium PBB6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.766AlaAla: 19.766 ± 0.228	1.334AlaCys: 1.334 ± 0.032	7.186AlaAsp: 7.186 ± 0.085	6.812AlaGlu: 6.812 ± 0.09	3.856AlaPhe: 3.856 ± 0.059	11.28AlaGly: 11.28 ± 0.095	2.87AlaHis: 2.87 ± 0.049	4.347AlaIle: 4.347 ± 0.06	3.578AlaLys: 3.578 ± 0.071	16.113AlaLeu: 16.113 ± 0.241	3.673AlaMet: 3.673 ± 0.053	3.018AlaAsn: 3.018 ± 0.061	6.838AlaPro: 6.838 ± 0.108	6.039AlaGln: 6.039 ± 0.103	9.121AlaArg: 9.121 ± 0.1	7.342AlaSer: 7.342 ± 0.101	6.895AlaThr: 6.895 ± 0.079	9.623AlaVal: 9.623 ± 0.085	2.338AlaTrp: 2.338 ± 0.049	2.206AlaTyr: 2.206 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.112CysAla: 1.112 ± 0.029	0.109CysCys: 0.109 ± 0.01	0.543CysAsp: 0.543 ± 0.02	0.47CysGlu: 0.47 ± 0.019	0.291CysPhe: 0.291 ± 0.017	0.921CysGly: 0.921 ± 0.026	0.26CysHis: 0.26 ± 0.015	0.343CysIle: 0.343 ± 0.017	0.205CysLys: 0.205 ± 0.013	0.893CysLeu: 0.893 ± 0.027	0.185CysMet: 0.185 ± 0.012	0.206CysAsn: 0.206 ± 0.012	0.466CysPro: 0.466 ± 0.021	0.304CysGln: 0.304 ± 0.017	0.555CysArg: 0.555 ± 0.019	0.496CysSer: 0.496 ± 0.019	0.497CysThr: 0.497 ± 0.018	0.689CysVal: 0.689 ± 0.024	0.131CysTrp: 0.131 ± 0.011	0.156CysTyr: 0.156 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.619AspAla: 7.619 ± 0.086	0.411AspCys: 0.411 ± 0.018	3.123AspAsp: 3.123 ± 0.046	3.169AspGlu: 3.169 ± 0.05	1.793AspPhe: 1.793 ± 0.043	4.904AspGly: 4.904 ± 0.079	1.219AspHis: 1.219 ± 0.034	2.171AspIle: 2.171 ± 0.047	1.617AspLys: 1.617 ± 0.04	5.391AspLeu: 5.391 ± 0.065	1.322AspMet: 1.322 ± 0.033	1.27AspAsn: 1.27 ± 0.035	2.713AspPro: 2.713 ± 0.045	1.901AspGln: 1.901 ± 0.039	3.209AspArg: 3.209 ± 0.061	2.331AspSer: 2.331 ± 0.041	2.899AspThr: 2.899 ± 0.056	4.358AspVal: 4.358 ± 0.07	1.034AspTrp: 1.034 ± 0.033	1.172AspTyr: 1.172 ± 0.032	0.0AspXaa: 0.0 ± 0.0
Glu	7.053GluAla: 7.053 ± 0.079	0.34GluCys: 0.34 ± 0.016	2.077GluAsp: 2.077 ± 0.044	2.143GluGlu: 2.143 ± 0.051	1.649GluPhe: 1.649 ± 0.041	3.649GluGly: 3.649 ± 0.058	1.276GluHis: 1.276 ± 0.034	2.08GluIle: 2.08 ± 0.046	1.407GluLys: 1.407 ± 0.037	5.867GluLeu: 5.867 ± 0.077	1.153GluMet: 1.153 ± 0.029	0.982GluAsn: 0.982 ± 0.032	2.436GluPro: 2.436 ± 0.045	2.637GluGln: 2.637 ± 0.049	4.425GluArg: 4.425 ± 0.082	2.142GluSer: 2.142 ± 0.042	2.168GluThr: 2.168 ± 0.039	4.115GluVal: 4.115 ± 0.06	0.67GluTrp: 0.67 ± 0.024	0.844GluTyr: 0.844 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.739PheAla: 3.739 ± 0.056	0.344PheCys: 0.344 ± 0.017	2.343PheAsp: 2.343 ± 0.051	1.98PheGlu: 1.98 ± 0.039	1.239PhePhe: 1.239 ± 0.035	3.219PheGly: 3.219 ± 0.057	0.732PheHis: 0.732 ± 0.026	1.333PheIle: 1.333 ± 0.031	1.132PheLys: 1.132 ± 0.033	2.709PheLeu: 2.709 ± 0.05	0.762PheMet: 0.762 ± 0.025	1.147PheAsn: 1.147 ± 0.03	1.343PhePro: 1.343 ± 0.031	1.067PheGln: 1.067 ± 0.028	1.781PheArg: 1.781 ± 0.036	1.992PheSer: 1.992 ± 0.039	2.009PheThr: 2.009 ± 0.045	2.476PheVal: 2.476 ± 0.042	0.529PheTrp: 0.529 ± 0.019	0.739PheTyr: 0.739 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.456GlyAla: 9.456 ± 0.086	0.892GlyCys: 0.892 ± 0.028	4.174GlyAsp: 4.174 ± 0.066	4.322GlyGlu: 4.322 ± 0.063	3.138GlyPhe: 3.138 ± 0.055	6.922GlyGly: 6.922 ± 0.104	2.092GlyHis: 2.092 ± 0.047	3.236GlyIle: 3.236 ± 0.055	2.85GlyLys: 2.85 ± 0.056	9.841GlyLeu: 9.841 ± 0.094	2.22GlyMet: 2.22 ± 0.044	2.014GlyAsn: 2.014 ± 0.047	3.338GlyPro: 3.338 ± 0.061	3.964GlyGln: 3.964 ± 0.061	5.479GlyArg: 5.479 ± 0.061	4.659GlySer: 4.659 ± 0.072	4.604GlyThr: 4.604 ± 0.091	6.776GlyVal: 6.776 ± 0.067	1.639GlyTrp: 1.639 ± 0.042	1.971GlyTyr: 1.971 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.969HisAla: 2.969 ± 0.052	0.279HisCys: 0.279 ± 0.015	1.254HisAsp: 1.254 ± 0.028	1.075HisGlu: 1.075 ± 0.033	0.877HisPhe: 0.877 ± 0.024	2.195HisGly: 2.195 ± 0.043	0.734HisHis: 0.734 ± 0.028	0.895HisIle: 0.895 ± 0.027	0.511HisLys: 0.511 ± 0.017	2.557HisLeu: 2.557 ± 0.053	0.45HisMet: 0.45 ± 0.019	0.492HisAsn: 0.492 ± 0.019	1.521HisPro: 1.521 ± 0.033	0.898HisGln: 0.898 ± 0.024	1.613HisArg: 1.613 ± 0.038	1.002HisSer: 1.002 ± 0.027	1.217HisThr: 1.217 ± 0.033	1.632HisVal: 1.632 ± 0.037	0.512HisTrp: 0.512 ± 0.021	0.558HisTyr: 0.558 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	4.798IleAla: 4.798 ± 0.066	0.358IleCys: 0.358 ± 0.016	3.037IleAsp: 3.037 ± 0.045	2.71IleGlu: 2.71 ± 0.05	1.059IlePhe: 1.059 ± 0.032	3.736IleGly: 3.736 ± 0.061	0.764IleHis: 0.764 ± 0.025	1.327IleIle: 1.327 ± 0.037	1.308IleLys: 1.308 ± 0.035	2.515IleLeu: 2.515 ± 0.05	0.583IleMet: 0.583 ± 0.027	1.327IleAsn: 1.327 ± 0.039	1.575IlePro: 1.575 ± 0.04	1.174IleGln: 1.174 ± 0.033	2.221IleArg: 2.221 ± 0.041	2.221IleSer: 2.221 ± 0.043	2.516IleThr: 2.516 ± 0.045	2.821IleVal: 2.821 ± 0.054	0.477IleTrp: 0.477 ± 0.021	0.773IleTyr: 0.773 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	4.086LysAla: 4.086 ± 0.067	0.147LysCys: 0.147 ± 0.012	1.464LysAsp: 1.464 ± 0.039	1.173LysGlu: 1.173 ± 0.033	0.845LysPhe: 0.845 ± 0.026	2.244LysGly: 2.244 ± 0.048	0.594LysHis: 0.594 ± 0.02	1.156LysIle: 1.156 ± 0.033	1.114LysLys: 1.114 ± 0.039	3.244LysLeu: 3.244 ± 0.056	0.666LysMet: 0.666 ± 0.025	0.738LysAsn: 0.738 ± 0.028	2.008LysPro: 2.008 ± 0.047	1.15LysGln: 1.15 ± 0.032	2.001LysArg: 2.001 ± 0.046	1.561LysSer: 1.561 ± 0.034	1.59LysThr: 1.59 ± 0.037	2.503LysVal: 2.503 ± 0.054	0.277LysTrp: 0.277 ± 0.014	0.519LysTyr: 0.519 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	15.789LeuAla: 15.789 ± 0.143	0.979LeuCys: 0.979 ± 0.027	5.96LeuAsp: 5.96 ± 0.068	4.698LeuGlu: 4.698 ± 0.068	3.199LeuPhe: 3.199 ± 0.056	8.994LeuGly: 8.994 ± 0.093	2.531LeuHis: 2.531 ± 0.048	3.927LeuIle: 3.927 ± 0.068	3.625LeuLys: 3.625 ± 0.06	11.676LeuLeu: 11.676 ± 0.148	2.805LeuMet: 2.805 ± 0.05	3.026LeuAsn: 3.026 ± 0.047	6.783LeuPro: 6.783 ± 0.078	4.891LeuGln: 4.891 ± 0.065	7.842LeuArg: 7.842 ± 0.083	6.717LeuSer: 6.717 ± 0.098	6.067LeuThr: 6.067 ± 0.133	8.148LeuVal: 8.148 ± 0.088	1.456LeuTrp: 1.456 ± 0.036	1.829LeuTyr: 1.829 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	3.376MetAla: 3.376 ± 0.046	0.169MetCys: 0.169 ± 0.011	1.15MetAsp: 1.15 ± 0.029	0.869MetGlu: 0.869 ± 0.028	0.676MetPhe: 0.676 ± 0.024	1.907MetGly: 1.907 ± 0.041	0.559MetHis: 0.559 ± 0.021	0.886MetIle: 0.886 ± 0.023	0.9MetLys: 0.9 ± 0.028	2.678MetLeu: 2.678 ± 0.044	0.523MetMet: 0.523 ± 0.021	0.842MetAsn: 0.842 ± 0.025	1.615MetPro: 1.615 ± 0.036	1.073MetGln: 1.073 ± 0.025	1.717MetArg: 1.717 ± 0.037	1.756MetSer: 1.756 ± 0.037	1.533MetThr: 1.533 ± 0.032	1.809MetVal: 1.809 ± 0.038	0.212MetTrp: 0.212 ± 0.014	0.321MetTyr: 0.321 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.325AsnAla: 3.325 ± 0.057	0.233AsnCys: 0.233 ± 0.012	1.383AsnAsp: 1.383 ± 0.038	1.176AsnGlu: 1.176 ± 0.032	0.904AsnPhe: 0.904 ± 0.028	2.278AsnGly: 2.278 ± 0.051	0.53AsnHis: 0.53 ± 0.021	1.049AsnIle: 1.049 ± 0.029	0.746AsnLys: 0.746 ± 0.03	2.616AsnLeu: 2.616 ± 0.05	0.524AsnMet: 0.524 ± 0.017	0.734AsnAsn: 0.734 ± 0.029	1.7AsnPro: 1.7 ± 0.037	0.961AsnGln: 0.961 ± 0.031	1.557AsnArg: 1.557 ± 0.037	1.169AsnSer: 1.169 ± 0.032	1.518AsnThr: 1.518 ± 0.038	1.875AsnVal: 1.875 ± 0.039	0.413AsnTrp: 0.413 ± 0.018	0.606AsnTyr: 0.606 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	8.25ProAla: 8.25 ± 0.112	0.364ProCys: 0.364 ± 0.019	3.471ProAsp: 3.471 ± 0.059	3.301ProGlu: 3.301 ± 0.053	1.681ProPhe: 1.681 ± 0.039	4.821ProGly: 4.821 ± 0.069	1.142ProHis: 1.142 ± 0.033	1.619ProIle: 1.619 ± 0.039	1.414ProLys: 1.414 ± 0.035	5.418ProLeu: 5.418 ± 0.072	1.445ProMet: 1.445 ± 0.03	1.235ProAsn: 1.235 ± 0.035	2.775ProPro: 2.775 ± 0.066	2.025ProGln: 2.025 ± 0.043	3.041ProArg: 3.041 ± 0.048	2.652ProSer: 2.652 ± 0.046	2.732ProThr: 2.732 ± 0.045	4.838ProVal: 4.838 ± 0.073	0.916ProTrp: 0.916 ± 0.028	0.978ProTyr: 0.978 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	6.754GlnAla: 6.754 ± 0.089	0.295GlnCys: 0.295 ± 0.014	1.533GlnAsp: 1.533 ± 0.032	1.349GlnGlu: 1.349 ± 0.04	1.262GlnPhe: 1.262 ± 0.032	3.361GlnGly: 3.361 ± 0.052	1.105GlnHis: 1.105 ± 0.028	1.687GlnIle: 1.687 ± 0.048	0.939GlnLys: 0.939 ± 0.028	4.871GlnLeu: 4.871 ± 0.07	1.024GlnMet: 1.024 ± 0.031	0.743GlnAsn: 0.743 ± 0.021	2.702GlnPro: 2.702 ± 0.054	2.3GlnGln: 2.3 ± 0.052	4.077GlnArg: 4.077 ± 0.068	1.958GlnSer: 1.958 ± 0.039	2.106GlnThr: 2.106 ± 0.044	3.604GlnVal: 3.604 ± 0.084	0.72GlnTrp: 0.72 ± 0.026	0.641GlnTyr: 0.641 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.774ArgAla: 7.774 ± 0.086	0.643ArgCys: 0.643 ± 0.023	3.663ArgAsp: 3.663 ± 0.053	3.835ArgGlu: 3.835 ± 0.063	2.62ArgPhe: 2.62 ± 0.042	4.542ArgGly: 4.542 ± 0.071	1.948ArgHis: 1.948 ± 0.043	2.931ArgIle: 2.931 ± 0.05	1.856ArgLys: 1.856 ± 0.045	8.316ArgLeu: 8.316 ± 0.097	1.932ArgMet: 1.932 ± 0.037	1.658ArgAsn: 1.658 ± 0.037	3.364ArgPro: 3.364 ± 0.063	3.48ArgGln: 3.48 ± 0.058	4.948ArgArg: 4.948 ± 0.082	3.723ArgSer: 3.723 ± 0.055	3.289ArgThr: 3.289 ± 0.05	5.227ArgVal: 5.227 ± 0.067	1.44ArgTrp: 1.44 ± 0.033	1.552ArgTyr: 1.552 ± 0.031	0.0ArgXaa: 0.0 ± 0.0
Ser	7.074SerAla: 7.074 ± 0.098	0.412SerCys: 0.412 ± 0.019	2.546SerAsp: 2.546 ± 0.045	2.37SerGlu: 2.37 ± 0.049	2.01SerPhe: 2.01 ± 0.039	5.045SerGly: 5.045 ± 0.062	1.231SerHis: 1.231 ± 0.031	2.088SerIle: 2.088 ± 0.042	1.37SerLys: 1.37 ± 0.031	5.992SerLeu: 5.992 ± 0.075	1.279SerMet: 1.279 ± 0.027	1.364SerAsn: 1.364 ± 0.034	3.033SerPro: 3.033 ± 0.05	2.137SerGln: 2.137 ± 0.04	3.593SerArg: 3.593 ± 0.055	3.169SerSer: 3.169 ± 0.062	3.257SerThr: 3.257 ± 0.078	4.139SerVal: 4.139 ± 0.062	0.843SerTrp: 0.843 ± 0.026	1.117SerTyr: 1.117 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.875ThrAla: 6.875 ± 0.16	0.432ThrCys: 0.432 ± 0.019	2.91ThrAsp: 2.91 ± 0.064	2.504ThrGlu: 2.504 ± 0.041	1.664ThrPhe: 1.664 ± 0.041	5.049ThrGly: 5.049 ± 0.069	1.149ThrHis: 1.149 ± 0.029	1.83ThrIle: 1.83 ± 0.04	1.202ThrLys: 1.202 ± 0.036	6.689ThrLeu: 6.689 ± 0.086	1.114ThrMet: 1.114 ± 0.029	1.259ThrAsn: 1.259 ± 0.037	3.78ThrPro: 3.78 ± 0.063	1.978ThrGln: 1.978 ± 0.046	3.364ThrArg: 3.364 ± 0.048	2.869ThrSer: 2.869 ± 0.062	3.135ThrThr: 3.135 ± 0.097	4.405ThrVal: 4.405 ± 0.089	0.784ThrTrp: 0.784 ± 0.025	0.987ThrTyr: 0.987 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	10.396ValAla: 10.396 ± 0.118	0.686ValCys: 0.686 ± 0.022	4.163ValAsp: 4.163 ± 0.065	3.757ValGlu: 3.757 ± 0.062	2.582ValPhe: 2.582 ± 0.045	5.744ValGly: 5.744 ± 0.066	1.714ValHis: 1.714 ± 0.04	3.181ValIle: 3.181 ± 0.051	2.385ValLys: 2.385 ± 0.046	8.955ValLeu: 8.955 ± 0.09	2.099ValMet: 2.099 ± 0.041	2.266ValAsn: 2.266 ± 0.047	4.278ValPro: 4.278 ± 0.063	3.17ValGln: 3.17 ± 0.052	5.202ValArg: 5.202 ± 0.067	4.486ValSer: 4.486 ± 0.057	4.099ValThr: 4.099 ± 0.07	6.715ValVal: 6.715 ± 0.086	1.131ValTrp: 1.131 ± 0.029	1.34ValTyr: 1.34 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.697TrpAla: 1.697 ± 0.04	0.213TrpCys: 0.213 ± 0.011	0.657TrpAsp: 0.657 ± 0.024	0.495TrpGlu: 0.495 ± 0.021	0.512TrpPhe: 0.512 ± 0.021	1.046TrpGly: 1.046 ± 0.027	0.434TrpHis: 0.434 ± 0.02	0.539TrpIle: 0.539 ± 0.02	0.364TrpLys: 0.364 ± 0.015	2.507TrpLeu: 2.507 ± 0.061	0.461TrpMet: 0.461 ± 0.017	0.401TrpAsn: 0.401 ± 0.018	0.953TrpPro: 0.953 ± 0.029	1.062TrpGln: 1.062 ± 0.026	1.547TrpArg: 1.547 ± 0.042	0.8TrpSer: 0.8 ± 0.026	0.742TrpThr: 0.742 ± 0.025	1.164TrpVal: 1.164 ± 0.029	0.387TrpTrp: 0.387 ± 0.017	0.262TrpTyr: 0.262 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.326TyrAla: 2.326 ± 0.042	0.194TyrCys: 0.194 ± 0.012	0.987TyrAsp: 0.987 ± 0.03	0.904TyrGlu: 0.904 ± 0.026	0.757TyrPhe: 0.757 ± 0.024	1.729TyrGly: 1.729 ± 0.04	0.353TyrHis: 0.353 ± 0.015	0.675TyrIle: 0.675 ± 0.023	0.558TyrLys: 0.558 ± 0.022	2.095TyrLeu: 2.095 ± 0.049	0.351TyrMet: 0.351 ± 0.017	0.575TyrAsn: 0.575 ± 0.022	0.9TyrPro: 0.9 ± 0.028	0.819TyrGln: 0.819 ± 0.023	1.449TyrArg: 1.449 ± 0.033	1.025TyrSer: 1.025 ± 0.028	1.108TyrThr: 1.108 ± 0.034	1.432TyrVal: 1.432 ± 0.025	0.334TyrTrp: 0.334 ± 0.016	0.466TyrTyr: 0.466 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3916 proteins (1336967 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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