Amino acid dipepetide frequency for Litoreibacter ponti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.465AlaAla: 15.465 ± 0.164	1.228AlaCys: 1.228 ± 0.035	6.754AlaAsp: 6.754 ± 0.099	7.85AlaGlu: 7.85 ± 0.106	4.437AlaPhe: 4.437 ± 0.073	9.827AlaGly: 9.827 ± 0.1	2.33AlaHis: 2.33 ± 0.044	5.834AlaIle: 5.834 ± 0.078	4.258AlaLys: 4.258 ± 0.07	13.471AlaLeu: 13.471 ± 0.149	3.808AlaMet: 3.808 ± 0.061	2.795AlaAsn: 2.795 ± 0.055	5.849AlaPro: 5.849 ± 0.081	4.734AlaGln: 4.734 ± 0.072	8.361AlaArg: 8.361 ± 0.106	5.933AlaSer: 5.933 ± 0.078	5.996AlaThr: 5.996 ± 0.075	7.861AlaVal: 7.861 ± 0.088	1.414AlaTrp: 1.414 ± 0.037	2.562AlaTyr: 2.562 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.196CysAla: 1.196 ± 0.034	0.109CysCys: 0.109 ± 0.01	0.642CysAsp: 0.642 ± 0.027	0.482CysGlu: 0.482 ± 0.02	0.346CysPhe: 0.346 ± 0.017	0.962CysGly: 0.962 ± 0.031	0.265CysHis: 0.265 ± 0.016	0.428CysIle: 0.428 ± 0.017	0.219CysLys: 0.219 ± 0.016	0.896CysLeu: 0.896 ± 0.028	0.175CysMet: 0.175 ± 0.011	0.206CysAsn: 0.206 ± 0.015	0.469CysPro: 0.469 ± 0.022	0.232CysGln: 0.232 ± 0.013	0.51CysArg: 0.51 ± 0.021	0.462CysSer: 0.462 ± 0.022	0.484CysThr: 0.484 ± 0.021	0.698CysVal: 0.698 ± 0.024	0.108CysTrp: 0.108 ± 0.01	0.221CysTyr: 0.221 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.813AspAla: 7.813 ± 0.096	0.509AspCys: 0.509 ± 0.022	3.66AspAsp: 3.66 ± 0.109	3.787AspGlu: 3.787 ± 0.072	2.391AspPhe: 2.391 ± 0.055	6.041AspGly: 6.041 ± 0.102	1.409AspHis: 1.409 ± 0.033	3.164AspIle: 3.164 ± 0.052	1.733AspLys: 1.733 ± 0.038	6.187AspLeu: 6.187 ± 0.084	1.72AspMet: 1.72 ± 0.042	1.368AspAsn: 1.368 ± 0.037	3.591AspPro: 3.591 ± 0.059	1.987AspGln: 1.987 ± 0.039	4.054AspArg: 4.054 ± 0.06	2.063AspSer: 2.063 ± 0.048	3.445AspThr: 3.445 ± 0.094	4.584AspVal: 4.584 ± 0.082	1.16AspTrp: 1.16 ± 0.031	1.598AspTyr: 1.598 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	8.054GluAla: 8.054 ± 0.088	0.359GluCys: 0.359 ± 0.016	3.689GluAsp: 3.689 ± 0.067	3.49GluGlu: 3.49 ± 0.073	2.009GluPhe: 2.009 ± 0.046	4.834GluGly: 4.834 ± 0.076	1.166GluHis: 1.166 ± 0.035	3.653GluIle: 3.653 ± 0.057	2.241GluLys: 2.241 ± 0.047	5.631GluLeu: 5.631 ± 0.082	2.042GluMet: 2.042 ± 0.039	1.757GluAsn: 1.757 ± 0.04	2.715GluPro: 2.715 ± 0.082	2.033GluGln: 2.033 ± 0.046	4.105GluArg: 4.105 ± 0.063	2.158GluSer: 2.158 ± 0.048	4.014GluThr: 4.014 ± 0.069	4.554GluVal: 4.554 ± 0.073	0.717GluTrp: 0.717 ± 0.025	1.109GluTyr: 1.109 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.678PheAla: 4.678 ± 0.068	0.447PheCys: 0.447 ± 0.018	2.937PheAsp: 2.937 ± 0.044	2.597PheGlu: 2.597 ± 0.051	1.598PhePhe: 1.598 ± 0.05	3.869PheGly: 3.869 ± 0.064	0.71PheHis: 0.71 ± 0.025	1.789PheIle: 1.789 ± 0.041	1.204PheLys: 1.204 ± 0.038	3.557PheLeu: 3.557 ± 0.067	0.958PheMet: 0.958 ± 0.029	1.095PheAsn: 1.095 ± 0.033	1.619PhePro: 1.619 ± 0.037	1.118PheGln: 1.118 ± 0.031	2.032PheArg: 2.032 ± 0.051	2.278PheSer: 2.278 ± 0.044	2.196PheThr: 2.196 ± 0.051	2.764PheVal: 2.764 ± 0.058	0.585PheTrp: 0.585 ± 0.027	0.968PheTyr: 0.968 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.841GlyAla: 9.841 ± 0.101	0.894GlyCys: 0.894 ± 0.03	4.917GlyAsp: 4.917 ± 0.112	4.923GlyGlu: 4.923 ± 0.065	3.947GlyPhe: 3.947 ± 0.064	7.554GlyGly: 7.554 ± 0.139	1.91GlyHis: 1.91 ± 0.044	4.347GlyIle: 4.347 ± 0.068	3.157GlyLys: 3.157 ± 0.064	9.179GlyLeu: 9.179 ± 0.112	2.548GlyMet: 2.548 ± 0.049	2.232GlyAsn: 2.232 ± 0.078	3.681GlyPro: 3.681 ± 0.048	3.001GlyGln: 3.001 ± 0.055	5.215GlyArg: 5.215 ± 0.081	4.293GlySer: 4.293 ± 0.069	4.836GlyThr: 4.836 ± 0.093	6.366GlyVal: 6.366 ± 0.075	1.419GlyTrp: 1.419 ± 0.032	2.203GlyTyr: 2.203 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.203HisAla: 2.203 ± 0.047	0.236HisCys: 0.236 ± 0.016	1.266HisAsp: 1.266 ± 0.033	1.054HisGlu: 1.054 ± 0.029	0.832HisPhe: 0.832 ± 0.027	1.888HisGly: 1.888 ± 0.046	0.592HisHis: 0.592 ± 0.026	1.023HisIle: 1.023 ± 0.028	0.568HisLys: 0.568 ± 0.024	2.079HisLeu: 2.079 ± 0.049	0.573HisMet: 0.573 ± 0.022	0.487HisAsn: 0.487 ± 0.018	1.333HisPro: 1.333 ± 0.04	0.581HisGln: 0.581 ± 0.022	1.243HisArg: 1.243 ± 0.038	0.901HisSer: 0.901 ± 0.028	0.885HisThr: 0.885 ± 0.027	1.532HisVal: 1.532 ± 0.038	0.346HisTrp: 0.346 ± 0.017	0.536HisTyr: 0.536 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.922IleAla: 6.922 ± 0.083	0.624IleCys: 0.624 ± 0.022	3.526IleAsp: 3.526 ± 0.065	3.746IleGlu: 3.746 ± 0.063	1.944IlePhe: 1.944 ± 0.045	4.747IleGly: 4.747 ± 0.075	0.874IleHis: 0.874 ± 0.029	2.439IleIle: 2.439 ± 0.049	1.645IleLys: 1.645 ± 0.044	4.691IleLeu: 4.691 ± 0.074	1.171IleMet: 1.171 ± 0.033	1.558IleAsn: 1.558 ± 0.041	2.339IlePro: 2.339 ± 0.048	1.188IleGln: 1.188 ± 0.031	2.867IleArg: 2.867 ± 0.052	3.126IleSer: 3.126 ± 0.061	3.084IleThr: 3.084 ± 0.058	3.704IleVal: 3.704 ± 0.06	0.792IleTrp: 0.792 ± 0.029	1.211IleTyr: 1.211 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.08LysAla: 4.08 ± 0.077	0.198LysCys: 0.198 ± 0.014	2.023LysAsp: 2.023 ± 0.052	1.66LysGlu: 1.66 ± 0.042	1.088LysPhe: 1.088 ± 0.03	2.84LysGly: 2.84 ± 0.056	0.678LysHis: 0.678 ± 0.025	1.826LysIle: 1.826 ± 0.042	1.42LysLys: 1.42 ± 0.049	3.343LysLeu: 3.343 ± 0.06	0.984LysMet: 0.984 ± 0.033	0.851LysAsn: 0.851 ± 0.026	1.956LysPro: 1.956 ± 0.049	0.996LysGln: 0.996 ± 0.036	2.325LysArg: 2.325 ± 0.053	2.019LysSer: 2.019 ± 0.048	2.121LysThr: 2.121 ± 0.04	2.422LysVal: 2.422 ± 0.053	0.408LysTrp: 0.408 ± 0.016	0.663LysTyr: 0.663 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	12.154LeuAla: 12.154 ± 0.131	0.978LeuCys: 0.978 ± 0.033	6.22LeuAsp: 6.22 ± 0.075	5.662LeuGlu: 5.662 ± 0.073	3.698LeuPhe: 3.698 ± 0.075	8.311LeuGly: 8.311 ± 0.09	1.842LeuHis: 1.842 ± 0.04	5.391LeuIle: 5.391 ± 0.085	3.607LeuLys: 3.607 ± 0.069	8.608LeuLeu: 8.608 ± 0.124	2.687LeuMet: 2.687 ± 0.056	2.695LeuAsn: 2.695 ± 0.047	5.271LeuPro: 5.271 ± 0.064	2.835LeuGln: 2.835 ± 0.052	6.577LeuArg: 6.577 ± 0.088	6.698LeuSer: 6.698 ± 0.087	5.963LeuThr: 5.963 ± 0.088	6.632LeuVal: 6.632 ± 0.077	1.287LeuTrp: 1.287 ± 0.038	2.044LeuTyr: 2.044 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.465MetAla: 3.465 ± 0.06	0.203MetCys: 0.203 ± 0.012	1.529MetAsp: 1.529 ± 0.035	1.585MetGlu: 1.585 ± 0.037	0.875MetPhe: 0.875 ± 0.029	2.452MetGly: 2.452 ± 0.051	0.462MetHis: 0.462 ± 0.019	1.623MetIle: 1.623 ± 0.048	1.139MetLys: 1.139 ± 0.031	2.613MetLeu: 2.613 ± 0.045	0.783MetMet: 0.783 ± 0.029	0.806MetAsn: 0.806 ± 0.026	1.486MetPro: 1.486 ± 0.035	0.925MetGln: 0.925 ± 0.028	1.941MetArg: 1.941 ± 0.046	1.966MetSer: 1.966 ± 0.037	1.917MetThr: 1.917 ± 0.044	1.915MetVal: 1.915 ± 0.039	0.277MetTrp: 0.277 ± 0.017	0.371MetTyr: 0.371 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.189AsnAla: 3.189 ± 0.06	0.262AsnCys: 0.262 ± 0.014	1.54AsnAsp: 1.54 ± 0.066	1.268AsnGlu: 1.268 ± 0.037	1.095AsnPhe: 1.095 ± 0.033	2.399AsnGly: 2.399 ± 0.07	0.539AsnHis: 0.539 ± 0.023	1.455AsnIle: 1.455 ± 0.04	0.724AsnLys: 0.724 ± 0.024	2.524AsnLeu: 2.524 ± 0.053	0.75AsnMet: 0.75 ± 0.024	0.709AsnAsn: 0.709 ± 0.028	1.91AsnPro: 1.91 ± 0.04	0.74AsnGln: 0.74 ± 0.025	1.564AsnArg: 1.564 ± 0.037	1.31AsnSer: 1.31 ± 0.041	1.442AsnThr: 1.442 ± 0.051	1.848AsnVal: 1.848 ± 0.052	0.407AsnTrp: 0.407 ± 0.018	0.665AsnTyr: 0.665 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.464ProAla: 5.464 ± 0.081	0.367ProCys: 0.367 ± 0.018	4.046ProAsp: 4.046 ± 0.071	4.108ProGlu: 4.108 ± 0.089	2.053ProPhe: 2.053 ± 0.041	4.27ProGly: 4.27 ± 0.059	1.078ProHis: 1.078 ± 0.033	2.338ProIle: 2.338 ± 0.042	1.93ProLys: 1.93 ± 0.044	4.526ProLeu: 4.526 ± 0.071	1.381ProMet: 1.381 ± 0.037	1.42ProAsn: 1.42 ± 0.039	2.185ProPro: 2.185 ± 0.054	1.6ProGln: 1.6 ± 0.04	2.654ProArg: 2.654 ± 0.052	2.659ProSer: 2.659 ± 0.052	2.497ProThr: 2.497 ± 0.054	3.991ProVal: 3.991 ± 0.067	0.632ProTrp: 0.632 ± 0.025	1.131ProTyr: 1.131 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	3.934GlnAla: 3.934 ± 0.063	0.193GlnCys: 0.193 ± 0.014	1.751GlnAsp: 1.751 ± 0.043	1.62GlnGlu: 1.62 ± 0.042	1.156GlnPhe: 1.156 ± 0.035	2.621GlnGly: 2.621 ± 0.048	0.58GlnHis: 0.58 ± 0.023	2.105GlnIle: 2.105 ± 0.041	1.088GlnLys: 1.088 ± 0.03	2.945GlnLeu: 2.945 ± 0.055	1.111GlnMet: 1.111 ± 0.031	0.931GlnAsn: 0.931 ± 0.026	1.582GlnPro: 1.582 ± 0.037	1.051GlnGln: 1.051 ± 0.034	1.981GlnArg: 1.981 ± 0.044	1.787GlnSer: 1.787 ± 0.042	1.957GlnThr: 1.957 ± 0.044	2.452GlnVal: 2.452 ± 0.05	0.399GlnTrp: 0.399 ± 0.018	0.593GlnTyr: 0.593 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	7.908ArgAla: 7.908 ± 0.103	0.462ArgCys: 0.462 ± 0.02	4.294ArgAsp: 4.294 ± 0.058	3.73ArgGlu: 3.73 ± 0.058	2.587ArgPhe: 2.587 ± 0.049	4.481ArgGly: 4.481 ± 0.072	1.356ArgHis: 1.356 ± 0.032	3.455ArgIle: 3.455 ± 0.057	2.227ArgLys: 2.227 ± 0.052	6.479ArgLeu: 6.479 ± 0.092	1.817ArgMet: 1.817 ± 0.039	1.635ArgAsn: 1.635 ± 0.041	2.974ArgPro: 2.974 ± 0.056	2.079ArgGln: 2.079 ± 0.045	4.353ArgArg: 4.353 ± 0.077	3.075ArgSer: 3.075 ± 0.055	2.956ArgThr: 2.956 ± 0.056	4.598ArgVal: 4.598 ± 0.068	0.838ArgTrp: 0.838 ± 0.031	1.493ArgTyr: 1.493 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.728SerAla: 5.728 ± 0.079	0.463SerCys: 0.463 ± 0.02	3.576SerAsp: 3.576 ± 0.059	3.183SerGlu: 3.183 ± 0.056	2.387SerPhe: 2.387 ± 0.044	5.365SerGly: 5.365 ± 0.084	1.08SerHis: 1.08 ± 0.034	2.587SerIle: 2.587 ± 0.053	1.761SerLys: 1.761 ± 0.039	5.063SerLeu: 5.063 ± 0.076	1.405SerMet: 1.405 ± 0.036	1.514SerAsn: 1.514 ± 0.042	2.588SerPro: 2.588 ± 0.054	1.658SerGln: 1.658 ± 0.04	3.041SerArg: 3.041 ± 0.059	2.65SerSer: 2.65 ± 0.063	2.57SerThr: 2.57 ± 0.047	3.918SerVal: 3.918 ± 0.066	0.695SerTrp: 0.695 ± 0.025	1.383SerTyr: 1.383 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.146ThrAla: 6.146 ± 0.084	0.531ThrCys: 0.531 ± 0.031	3.225ThrAsp: 3.225 ± 0.063	3.008ThrGlu: 3.008 ± 0.049	2.097ThrPhe: 2.097 ± 0.04	5.335ThrGly: 5.335 ± 0.079	1.196ThrHis: 1.196 ± 0.036	2.87ThrIle: 2.87 ± 0.079	1.657ThrLys: 1.657 ± 0.041	6.224ThrLeu: 6.224 ± 0.08	1.377ThrMet: 1.377 ± 0.032	1.37ThrAsn: 1.37 ± 0.057	3.615ThrPro: 3.615 ± 0.063	1.756ThrGln: 1.756 ± 0.044	3.529ThrArg: 3.529 ± 0.059	2.925ThrSer: 2.925 ± 0.055	2.904ThrThr: 2.904 ± 0.064	4.25ThrVal: 4.25 ± 0.092	0.705ThrTrp: 0.705 ± 0.027	1.343ThrTyr: 1.343 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	8.583ValAla: 8.583 ± 0.105	0.674ValCys: 0.674 ± 0.022	4.191ValAsp: 4.191 ± 0.076	4.62ValGlu: 4.62 ± 0.067	2.94ValPhe: 2.94 ± 0.061	5.477ValGly: 5.477 ± 0.067	1.28ValHis: 1.28 ± 0.033	4.212ValIle: 4.212 ± 0.063	2.189ValLys: 2.189 ± 0.049	7.279ValLeu: 7.279 ± 0.092	2.111ValMet: 2.111 ± 0.045	1.901ValAsn: 1.901 ± 0.047	3.445ValPro: 3.445 ± 0.055	2.085ValGln: 2.085 ± 0.04	3.956ValArg: 3.956 ± 0.06	4.403ValSer: 4.403 ± 0.07	4.727ValThr: 4.727 ± 0.111	5.625ValVal: 5.625 ± 0.082	0.951ValTrp: 0.951 ± 0.03	1.519ValTyr: 1.519 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.368TrpAla: 1.368 ± 0.037	0.136TrpCys: 0.136 ± 0.011	0.841TrpAsp: 0.841 ± 0.028	0.657TrpGlu: 0.657 ± 0.025	0.595TrpPhe: 0.595 ± 0.021	1.043TrpGly: 1.043 ± 0.031	0.296TrpHis: 0.296 ± 0.015	0.694TrpIle: 0.694 ± 0.024	0.442TrpLys: 0.442 ± 0.019	1.554TrpLeu: 1.554 ± 0.041	0.424TrpMet: 0.424 ± 0.019	0.401TrpAsn: 0.401 ± 0.017	0.674TrpPro: 0.674 ± 0.027	0.558TrpGln: 0.558 ± 0.02	1.06TrpArg: 1.06 ± 0.034	0.781TrpSer: 0.781 ± 0.027	0.81TrpThr: 0.81 ± 0.027	0.913TrpVal: 0.913 ± 0.029	0.237TrpTrp: 0.237 ± 0.016	0.26TrpTyr: 0.26 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.576TyrAla: 2.576 ± 0.051	0.237TyrCys: 0.237 ± 0.012	1.636TyrAsp: 1.636 ± 0.035	1.304TyrGlu: 1.304 ± 0.037	0.919TyrPhe: 0.919 ± 0.029	2.148TyrGly: 2.148 ± 0.041	0.515TyrHis: 0.515 ± 0.021	0.966TyrIle: 0.966 ± 0.029	0.695TyrLys: 0.695 ± 0.026	2.31TyrLeu: 2.31 ± 0.045	0.508TyrMet: 0.508 ± 0.02	0.61TyrAsn: 0.61 ± 0.025	1.046TyrPro: 1.046 ± 0.029	0.678TyrGln: 0.678 ± 0.027	1.429TyrArg: 1.429 ± 0.032	1.128TyrSer: 1.128 ± 0.034	1.258TyrThr: 1.258 ± 0.041	1.54TyrVal: 1.54 ± 0.039	0.367TyrTrp: 0.367 ± 0.019	0.56TyrTyr: 0.56 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3849 proteins (1189232 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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