Amino acid dipepetide frequency for Salinibacterium hongtaonis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.153AlaAla: 19.153 ± 0.261	0.583AlaCys: 0.583 ± 0.03	7.481AlaAsp: 7.481 ± 0.114	8.301AlaGlu: 8.301 ± 0.119	3.816AlaPhe: 3.816 ± 0.081	11.216AlaGly: 11.216 ± 0.206	2.219AlaHis: 2.219 ± 0.06	6.898AlaIle: 6.898 ± 0.113	2.987AlaLys: 2.987 ± 0.084	13.156AlaLeu: 13.156 ± 0.154	2.696AlaMet: 2.696 ± 0.059	2.596AlaAsn: 2.596 ± 0.063	5.967AlaPro: 5.967 ± 0.113	3.949AlaGln: 3.949 ± 0.074	8.013AlaArg: 8.013 ± 0.131	8.231AlaSer: 8.231 ± 0.142	7.686AlaThr: 7.686 ± 0.167	11.175AlaVal: 11.175 ± 0.152	1.649AlaTrp: 1.649 ± 0.051	2.258AlaTyr: 2.258 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.577CysAla: 0.577 ± 0.027	0.046CysCys: 0.046 ± 0.007	0.292CysAsp: 0.292 ± 0.018	0.242CysGlu: 0.242 ± 0.016	0.181CysPhe: 0.181 ± 0.017	0.58CysGly: 0.58 ± 0.024	0.105CysHis: 0.105 ± 0.011	0.228CysIle: 0.228 ± 0.016	0.055CysLys: 0.055 ± 0.008	0.46CysLeu: 0.46 ± 0.025	0.089CysMet: 0.089 ± 0.01	0.102CysAsn: 0.102 ± 0.011	0.248CysPro: 0.248 ± 0.016	0.093CysGln: 0.093 ± 0.012	0.326CysArg: 0.326 ± 0.022	0.358CysSer: 0.358 ± 0.024	0.293CysThr: 0.293 ± 0.019	0.401CysVal: 0.401 ± 0.022	0.058CysTrp: 0.058 ± 0.008	0.092CysTyr: 0.092 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	7.798AspAla: 7.798 ± 0.093	0.225AspCys: 0.225 ± 0.018	3.877AspAsp: 3.877 ± 0.087	4.088AspGlu: 4.088 ± 0.078	1.941AspPhe: 1.941 ± 0.048	5.352AspGly: 5.352 ± 0.088	1.144AspHis: 1.144 ± 0.037	2.762AspIle: 2.762 ± 0.058	1.121AspLys: 1.121 ± 0.043	5.772AspLeu: 5.772 ± 0.093	0.855AspMet: 0.855 ± 0.036	1.226AspAsn: 1.226 ± 0.041	3.5AspPro: 3.5 ± 0.075	1.468AspGln: 1.468 ± 0.045	4.004AspArg: 4.004 ± 0.077	3.411AspSer: 3.411 ± 0.066	2.829AspThr: 2.829 ± 0.075	5.007AspVal: 5.007 ± 0.081	0.828AspTrp: 0.828 ± 0.031	1.338AspTyr: 1.338 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.012GluAla: 7.012 ± 0.126	0.265GluCys: 0.265 ± 0.018	2.402GluAsp: 2.402 ± 0.06	2.862GluGlu: 2.862 ± 0.071	2.031GluPhe: 2.031 ± 0.048	4.159GluGly: 4.159 ± 0.072	1.463GluHis: 1.463 ± 0.041	3.078GluIle: 3.078 ± 0.07	1.607GluLys: 1.607 ± 0.051	6.657GluLeu: 6.657 ± 0.115	1.05GluMet: 1.05 ± 0.033	1.441GluAsn: 1.441 ± 0.048	2.967GluPro: 2.967 ± 0.069	2.261GluGln: 2.261 ± 0.054	4.653GluArg: 4.653 ± 0.104	3.673GluSer: 3.673 ± 0.068	3.107GluThr: 3.107 ± 0.054	4.557GluVal: 4.557 ± 0.094	0.857GluTrp: 0.857 ± 0.032	1.13GluTyr: 1.13 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	4.374PheAla: 4.374 ± 0.078	0.211PheCys: 0.211 ± 0.019	2.42PheAsp: 2.42 ± 0.057	1.906PheGlu: 1.906 ± 0.053	1.142PhePhe: 1.142 ± 0.044	3.594PheGly: 3.594 ± 0.073	0.525PheHis: 0.525 ± 0.023	1.512PheIle: 1.512 ± 0.045	0.509PheLys: 0.509 ± 0.026	2.729PheLeu: 2.729 ± 0.069	0.515PheMet: 0.515 ± 0.028	0.694PheAsn: 0.694 ± 0.028	1.249PhePro: 1.249 ± 0.037	0.685PheGln: 0.685 ± 0.027	1.691PheArg: 1.691 ± 0.051	2.2PheSer: 2.2 ± 0.058	2.166PheThr: 2.166 ± 0.05	3.095PheVal: 3.095 ± 0.066	0.473PheTrp: 0.473 ± 0.029	0.723PheTyr: 0.723 ± 0.033	0.0PheXaa: 0.0 ± 0.0
Gly	10.27GlyAla: 10.27 ± 0.188	0.496GlyCys: 0.496 ± 0.024	4.817GlyAsp: 4.817 ± 0.08	4.957GlyGlu: 4.957 ± 0.089	3.253GlyPhe: 3.253 ± 0.07	7.422GlyGly: 7.422 ± 0.179	1.804GlyHis: 1.804 ± 0.051	5.224GlyIle: 5.224 ± 0.087	2.325GlyLys: 2.325 ± 0.07	8.738GlyLeu: 8.738 ± 0.119	1.9GlyMet: 1.9 ± 0.051	1.949GlyAsn: 1.949 ± 0.064	3.452GlyPro: 3.452 ± 0.063	2.488GlyGln: 2.488 ± 0.059	5.529GlyArg: 5.529 ± 0.086	5.859GlySer: 5.859 ± 0.138	5.451GlyThr: 5.451 ± 0.127	7.96GlyVal: 7.96 ± 0.13	1.466GlyTrp: 1.466 ± 0.042	2.16GlyTyr: 2.16 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.021HisAla: 2.021 ± 0.053	0.121HisCys: 0.121 ± 0.012	1.255HisAsp: 1.255 ± 0.041	1.186HisGlu: 1.186 ± 0.041	0.557HisPhe: 0.557 ± 0.028	1.815HisGly: 1.815 ± 0.047	0.528HisHis: 0.528 ± 0.028	0.813HisIle: 0.813 ± 0.029	0.362HisLys: 0.362 ± 0.02	1.887HisLeu: 1.887 ± 0.047	0.305HisMet: 0.305 ± 0.019	0.444HisAsn: 0.444 ± 0.021	1.39HisPro: 1.39 ± 0.042	0.516HisGln: 0.516 ± 0.024	1.429HisArg: 1.429 ± 0.04	1.242HisSer: 1.242 ± 0.035	1.03HisThr: 1.03 ± 0.04	1.459HisVal: 1.459 ± 0.043	0.255HisTrp: 0.255 ± 0.015	0.459HisTyr: 0.459 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	7.771IleAla: 7.771 ± 0.117	0.257IleCys: 0.257 ± 0.018	3.783IleAsp: 3.783 ± 0.068	3.325IleGlu: 3.325 ± 0.063	1.418IlePhe: 1.418 ± 0.044	4.936IleGly: 4.936 ± 0.098	0.785IleHis: 0.785 ± 0.031	2.387IleIle: 2.387 ± 0.067	1.046IleLys: 1.046 ± 0.038	4.08IleLeu: 4.08 ± 0.083	0.837IleMet: 0.837 ± 0.032	1.237IleAsn: 1.237 ± 0.045	2.667IlePro: 2.667 ± 0.062	1.12IleGln: 1.12 ± 0.04	2.819IleArg: 2.819 ± 0.06	3.021IleSer: 3.021 ± 0.061	3.357IleThr: 3.357 ± 0.068	5.241IleVal: 5.241 ± 0.084	0.453IleTrp: 0.453 ± 0.024	0.906IleTyr: 0.906 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	2.806LysAla: 2.806 ± 0.075	0.077LysCys: 0.077 ± 0.008	1.141LysAsp: 1.141 ± 0.042	1.057LysGlu: 1.057 ± 0.04	0.584LysPhe: 0.584 ± 0.031	1.784LysGly: 1.784 ± 0.058	0.495LysHis: 0.495 ± 0.023	1.026LysIle: 1.026 ± 0.037	0.887LysLys: 0.887 ± 0.049	2.192LysLeu: 2.192 ± 0.049	0.473LysMet: 0.473 ± 0.025	0.64LysAsn: 0.64 ± 0.029	1.276LysPro: 1.276 ± 0.052	0.801LysGln: 0.801 ± 0.037	1.818LysArg: 1.818 ± 0.055	1.456LysSer: 1.456 ± 0.052	1.426LysThr: 1.426 ± 0.045	1.861LysVal: 1.861 ± 0.053	0.244LysTrp: 0.244 ± 0.019	0.529LysTyr: 0.529 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.96LeuAla: 13.96 ± 0.17	0.52LeuCys: 0.52 ± 0.026	6.345LeuAsp: 6.345 ± 0.097	5.342LeuGlu: 5.342 ± 0.097	3.0LeuPhe: 3.0 ± 0.072	9.211LeuGly: 9.211 ± 0.102	1.711LeuHis: 1.711 ± 0.05	5.024LeuIle: 5.024 ± 0.098	2.03LeuLys: 2.03 ± 0.059	9.934LeuLeu: 9.934 ± 0.143	1.802LeuMet: 1.802 ± 0.049	2.012LeuAsn: 2.012 ± 0.05	5.198LeuPro: 5.198 ± 0.086	2.439LeuGln: 2.439 ± 0.05	6.689LeuArg: 6.689 ± 0.112	6.593LeuSer: 6.593 ± 0.093	6.208LeuThr: 6.208 ± 0.109	9.107LeuVal: 9.107 ± 0.114	1.216LeuTrp: 1.216 ± 0.044	1.632LeuTyr: 1.632 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.38MetAla: 2.38 ± 0.055	0.099MetCys: 0.099 ± 0.011	0.775MetAsp: 0.775 ± 0.032	0.742MetGlu: 0.742 ± 0.03	0.585MetPhe: 0.585 ± 0.028	1.44MetGly: 1.44 ± 0.043	0.343MetHis: 0.343 ± 0.019	0.945MetIle: 0.945 ± 0.038	0.499MetLys: 0.499 ± 0.025	2.171MetLeu: 2.171 ± 0.054	0.371MetMet: 0.371 ± 0.024	0.523MetAsn: 0.523 ± 0.027	1.216MetPro: 1.216 ± 0.041	0.571MetGln: 0.571 ± 0.027	1.378MetArg: 1.378 ± 0.039	1.529MetSer: 1.529 ± 0.043	1.684MetThr: 1.684 ± 0.046	1.52MetVal: 1.52 ± 0.042	0.204MetTrp: 0.204 ± 0.016	0.291MetTyr: 0.291 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.626AsnAla: 2.626 ± 0.058	0.141AsnCys: 0.141 ± 0.013	1.387AsnAsp: 1.387 ± 0.04	1.199AsnGlu: 1.199 ± 0.041	0.757AsnPhe: 0.757 ± 0.03	2.204AsnGly: 2.204 ± 0.068	0.431AsnHis: 0.431 ± 0.021	1.054AsnIle: 1.054 ± 0.039	0.517AsnLys: 0.517 ± 0.024	2.179AsnLeu: 2.179 ± 0.05	0.404AsnMet: 0.404 ± 0.023	0.601AsnAsn: 0.601 ± 0.029	1.785AsnPro: 1.785 ± 0.046	0.611AsnGln: 0.611 ± 0.028	1.517AsnArg: 1.517 ± 0.04	1.365AsnSer: 1.365 ± 0.04	1.259AsnThr: 1.259 ± 0.04	1.87AsnVal: 1.87 ± 0.064	0.281AsnTrp: 0.281 ± 0.019	0.583AsnTyr: 0.583 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.455ProAla: 6.455 ± 0.12	0.177ProCys: 0.177 ± 0.015	3.258ProAsp: 3.258 ± 0.066	3.622ProGlu: 3.622 ± 0.08	1.708ProPhe: 1.708 ± 0.046	4.559ProGly: 4.559 ± 0.08	1.036ProHis: 1.036 ± 0.03	2.302ProIle: 2.302 ± 0.05	1.043ProLys: 1.043 ± 0.037	4.872ProLeu: 4.872 ± 0.097	0.912ProMet: 0.912 ± 0.035	1.183ProAsn: 1.183 ± 0.043	2.074ProPro: 2.074 ± 0.063	1.616ProGln: 1.616 ± 0.048	3.006ProArg: 3.006 ± 0.072	3.53ProSer: 3.53 ± 0.071	3.277ProThr: 3.277 ± 0.067	4.603ProVal: 4.603 ± 0.074	0.793ProTrp: 0.793 ± 0.031	1.01ProTyr: 1.01 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.48GlnAla: 3.48 ± 0.061	0.119GlnCys: 0.119 ± 0.011	1.107GlnAsp: 1.107 ± 0.039	1.334GlnGlu: 1.334 ± 0.043	0.975GlnPhe: 0.975 ± 0.034	2.114GlnGly: 2.114 ± 0.049	0.668GlnHis: 0.668 ± 0.028	1.48GlnIle: 1.48 ± 0.047	0.794GlnLys: 0.794 ± 0.034	3.375GlnLeu: 3.375 ± 0.064	0.589GlnMet: 0.589 ± 0.027	0.689GlnAsn: 0.689 ± 0.033	1.474GlnPro: 1.474 ± 0.04	1.209GlnGln: 1.209 ± 0.047	2.306GlnArg: 2.306 ± 0.048	1.837GlnSer: 1.837 ± 0.041	1.495GlnThr: 1.495 ± 0.039	2.408GlnVal: 2.408 ± 0.051	0.426GlnTrp: 0.426 ± 0.022	0.545GlnTyr: 0.545 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	7.646ArgAla: 7.646 ± 0.097	0.293ArgCys: 0.293 ± 0.021	3.914ArgAsp: 3.914 ± 0.072	4.064ArgGlu: 4.064 ± 0.097	2.299ArgPhe: 2.299 ± 0.061	4.928ArgGly: 4.928 ± 0.079	1.373ArgHis: 1.373 ± 0.045	3.546ArgIle: 3.546 ± 0.06	1.58ArgLys: 1.58 ± 0.055	6.662ArgLeu: 6.662 ± 0.124	1.753ArgMet: 1.753 ± 0.045	1.586ArgAsn: 1.586 ± 0.046	3.208ArgPro: 3.208 ± 0.079	2.081ArgGln: 2.081 ± 0.048	5.372ArgArg: 5.372 ± 0.107	4.269ArgSer: 4.269 ± 0.082	3.694ArgThr: 3.694 ± 0.067	5.416ArgVal: 5.416 ± 0.086	1.024ArgTrp: 1.024 ± 0.041	1.478ArgTyr: 1.478 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	8.422SerAla: 8.422 ± 0.161	0.269SerCys: 0.269 ± 0.019	3.621SerAsp: 3.621 ± 0.069	3.291SerGlu: 3.291 ± 0.068	2.128SerPhe: 2.128 ± 0.048	6.275SerGly: 6.275 ± 0.118	1.251SerHis: 1.251 ± 0.038	3.356SerIle: 3.356 ± 0.069	1.351SerLys: 1.351 ± 0.045	6.226SerLeu: 6.226 ± 0.086	1.364SerMet: 1.364 ± 0.041	1.422SerAsn: 1.422 ± 0.04	3.419SerPro: 3.419 ± 0.069	1.661SerGln: 1.661 ± 0.044	4.147SerArg: 4.147 ± 0.071	4.24SerSer: 4.24 ± 0.089	4.225SerThr: 4.225 ± 0.103	5.667SerVal: 5.667 ± 0.1	0.914SerTrp: 0.914 ± 0.038	1.278SerTyr: 1.278 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	7.7ThrAla: 7.7 ± 0.199	0.266ThrCys: 0.266 ± 0.017	3.258ThrAsp: 3.258 ± 0.062	3.216ThrGlu: 3.216 ± 0.065	1.86ThrPhe: 1.86 ± 0.054	5.658ThrGly: 5.658 ± 0.109	1.102ThrHis: 1.102 ± 0.032	3.442ThrIle: 3.442 ± 0.101	1.309ThrLys: 1.309 ± 0.048	6.115ThrLeu: 6.115 ± 0.092	1.059ThrMet: 1.059 ± 0.039	1.399ThrAsn: 1.399 ± 0.047	3.904ThrPro: 3.904 ± 0.074	1.564ThrGln: 1.564 ± 0.046	3.51ThrArg: 3.51 ± 0.063	3.79ThrSer: 3.79 ± 0.089	4.126ThrThr: 4.126 ± 0.137	6.228ThrVal: 6.228 ± 0.143	0.798ThrTrp: 0.798 ± 0.033	1.118ThrTyr: 1.118 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	11.787ValAla: 11.787 ± 0.16	0.444ValCys: 0.444 ± 0.023	5.481ValAsp: 5.481 ± 0.095	4.78ValGlu: 4.78 ± 0.082	2.911ValPhe: 2.911 ± 0.06	7.444ValGly: 7.444 ± 0.101	1.512ValHis: 1.512 ± 0.035	4.938ValIle: 4.938 ± 0.077	1.77ValLys: 1.77 ± 0.056	8.939ValLeu: 8.939 ± 0.122	1.623ValMet: 1.623 ± 0.049	2.083ValAsn: 2.083 ± 0.057	4.407ValPro: 4.407 ± 0.082	2.144ValGln: 2.144 ± 0.045	5.472ValArg: 5.472 ± 0.094	5.774ValSer: 5.774 ± 0.103	6.176ValThr: 6.176 ± 0.144	8.875ValVal: 8.875 ± 0.139	1.104ValTrp: 1.104 ± 0.039	1.562ValTyr: 1.562 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	1.509TrpAla: 1.509 ± 0.047	0.078TrpCys: 0.078 ± 0.011	0.684TrpAsp: 0.684 ± 0.03	0.536TrpGlu: 0.536 ± 0.026	0.517TrpPhe: 0.517 ± 0.026	1.024TrpGly: 1.024 ± 0.038	0.299TrpHis: 0.299 ± 0.019	0.681TrpIle: 0.681 ± 0.029	0.362TrpLys: 0.362 ± 0.025	1.673TrpLeu: 1.673 ± 0.047	0.339TrpMet: 0.339 ± 0.02	0.44TrpAsn: 0.44 ± 0.024	0.627TrpPro: 0.627 ± 0.027	0.572TrpGln: 0.572 ± 0.028	1.042TrpArg: 1.042 ± 0.038	0.829TrpSer: 0.829 ± 0.029	0.767TrpThr: 0.767 ± 0.03	1.123TrpVal: 1.123 ± 0.039	0.32TrpTrp: 0.32 ± 0.022	0.269TrpTyr: 0.269 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.282TyrAla: 2.282 ± 0.05	0.137TyrCys: 0.137 ± 0.012	1.247TyrAsp: 1.247 ± 0.043	1.184TyrGlu: 1.184 ± 0.04	0.751TyrPhe: 0.751 ± 0.03	1.806TyrGly: 1.806 ± 0.051	0.279TyrHis: 0.279 ± 0.018	0.75TyrIle: 0.75 ± 0.033	0.42TyrLys: 0.42 ± 0.021	2.154TyrLeu: 2.154 ± 0.052	0.329TyrMet: 0.329 ± 0.019	0.506TyrAsn: 0.506 ± 0.026	1.009TyrPro: 1.009 ± 0.035	0.572TyrGln: 0.572 ± 0.028	1.467TyrArg: 1.467 ± 0.043	1.317TyrSer: 1.317 ± 0.039	1.167TyrThr: 1.167 ± 0.037	1.656TyrVal: 1.656 ± 0.042	0.329TyrTrp: 0.329 ± 0.025	0.45TyrTyr: 0.45 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2605 proteins (856357 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---