Amino acid dipepetide frequency for Cellvibrio sp. 79

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.485AlaAla: 9.485 ± 0.099
0.96AlaCys: 0.96 ± 0.029
5.198AlaAsp: 5.198 ± 0.057
5.668AlaGlu: 5.668 ± 0.076
3.252AlaPhe: 3.252 ± 0.053
6.898AlaGly: 6.898 ± 0.079
1.78AlaHis: 1.78 ± 0.037
6.057AlaIle: 6.057 ± 0.066
4.267AlaLys: 4.267 ± 0.061
9.603AlaLeu: 9.603 ± 0.112
2.114AlaMet: 2.114 ± 0.035
4.265AlaAsn: 4.265 ± 0.071
3.596AlaPro: 3.596 ± 0.064
4.402AlaGln: 4.402 ± 0.057
4.662AlaArg: 4.662 ± 0.057
5.88AlaSer: 5.88 ± 0.075
5.202AlaThr: 5.202 ± 0.075
6.018AlaVal: 6.018 ± 0.063
1.071AlaTrp: 1.071 ± 0.025
2.661AlaTyr: 2.661 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.848CysAla: 0.848 ± 0.027
0.139CysCys: 0.139 ± 0.01
0.517CysAsp: 0.517 ± 0.023
0.504CysGlu: 0.504 ± 0.019
0.399CysPhe: 0.399 ± 0.018
0.802CysGly: 0.802 ± 0.025
0.266CysHis: 0.266 ± 0.013
0.539CysIle: 0.539 ± 0.019
0.428CysLys: 0.428 ± 0.018
0.872CysLeu: 0.872 ± 0.021
0.179CysMet: 0.179 ± 0.012
0.389CysAsn: 0.389 ± 0.017
0.414CysPro: 0.414 ± 0.017
0.318CysGln: 0.318 ± 0.015
0.439CysArg: 0.439 ± 0.019
0.698CysSer: 0.698 ± 0.023
0.507CysThr: 0.507 ± 0.021
0.624CysVal: 0.624 ± 0.02
0.154CysTrp: 0.154 ± 0.01
0.285CysTyr: 0.285 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
5.064AspAla: 5.064 ± 0.053
0.462AspCys: 0.462 ± 0.02
2.93AspAsp: 2.93 ± 0.053
3.495AspGlu: 3.495 ± 0.063
2.426AspPhe: 2.426 ± 0.043
4.145AspGly: 4.145 ± 0.078
1.099AspHis: 1.099 ± 0.03
3.613AspIle: 3.613 ± 0.049
2.838AspLys: 2.838 ± 0.05
5.336AspLeu: 5.336 ± 0.061
1.121AspMet: 1.121 ± 0.028
2.496AspAsn: 2.496 ± 0.051
2.304AspPro: 2.304 ± 0.041
2.09AspGln: 2.09 ± 0.042
2.406AspArg: 2.406 ± 0.043
3.284AspSer: 3.284 ± 0.052
2.64AspThr: 2.64 ± 0.048
3.69AspVal: 3.69 ± 0.059
0.922AspTrp: 0.922 ± 0.025
2.177AspTyr: 2.177 ± 0.04
0.0AspXaa: 0.0 ± 0.0
Glu
4.786GluAla: 4.786 ± 0.073
0.406GluCys: 0.406 ± 0.018
2.543GluAsp: 2.543 ± 0.038
3.159GluGlu: 3.159 ± 0.063
2.577GluPhe: 2.577 ± 0.044
3.261GluGly: 3.261 ± 0.051
1.312GluHis: 1.312 ± 0.036
3.866GluIle: 3.866 ± 0.046
3.65GluLys: 3.65 ± 0.061
6.604GluLeu: 6.604 ± 0.072
1.263GluMet: 1.263 ± 0.029
2.718GluAsn: 2.718 ± 0.043
2.025GluPro: 2.025 ± 0.042
3.26GluGln: 3.26 ± 0.068
3.264GluArg: 3.264 ± 0.052
3.36GluSer: 3.36 ± 0.046
3.09GluThr: 3.09 ± 0.039
3.467GluVal: 3.467 ± 0.055
0.863GluTrp: 0.863 ± 0.024
1.765GluTyr: 1.765 ± 0.035
0.0GluXaa: 0.0 ± 0.0
Phe
3.743PheAla: 3.743 ± 0.053
0.511PheCys: 0.511 ± 0.018
2.658PheAsp: 2.658 ± 0.04
2.193PheGlu: 2.193 ± 0.033
1.971PhePhe: 1.971 ± 0.043
3.012PheGly: 3.012 ± 0.049
0.836PheHis: 0.836 ± 0.023
2.716PheIle: 2.716 ± 0.045
1.787PheLys: 1.787 ± 0.04
3.588PheLeu: 3.588 ± 0.058
0.91PheMet: 0.91 ± 0.024
2.197PheAsn: 2.197 ± 0.035
1.54PhePro: 1.54 ± 0.031
1.309PheGln: 1.309 ± 0.029
1.683PheArg: 1.683 ± 0.031
3.34PheSer: 3.34 ± 0.047
2.471PheThr: 2.471 ± 0.046
2.676PheVal: 2.676 ± 0.048
0.587PheTrp: 0.587 ± 0.019
1.53PheTyr: 1.53 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
5.952GlyAla: 5.952 ± 0.08
0.814GlyCys: 0.814 ± 0.025
3.997GlyAsp: 3.997 ± 0.062
4.004GlyGlu: 4.004 ± 0.052
3.41GlyPhe: 3.41 ± 0.043
5.353GlyGly: 5.353 ± 0.103
1.446GlyHis: 1.446 ± 0.033
4.635GlyIle: 4.635 ± 0.057
3.905GlyLys: 3.905 ± 0.05
6.963GlyLeu: 6.963 ± 0.08
1.661GlyMet: 1.661 ± 0.035
3.499GlyAsn: 3.499 ± 0.09
1.833GlyPro: 1.833 ± 0.036
2.668GlyGln: 2.668 ± 0.049
3.241GlyArg: 3.241 ± 0.053
4.538GlySer: 4.538 ± 0.085
3.926GlyThr: 3.926 ± 0.084
5.25GlyVal: 5.25 ± 0.07
1.167GlyTrp: 1.167 ± 0.029
2.534GlyTyr: 2.534 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
1.687HisAla: 1.687 ± 0.036
0.281HisCys: 0.281 ± 0.016
0.983HisAsp: 0.983 ± 0.029
1.128HisGlu: 1.128 ± 0.03
1.051HisPhe: 1.051 ± 0.024
1.414HisGly: 1.414 ± 0.036
0.679HisHis: 0.679 ± 0.025
1.345HisIle: 1.345 ± 0.028
0.97HisLys: 0.97 ± 0.025
2.222HisLeu: 2.222 ± 0.04
0.48HisMet: 0.48 ± 0.02
0.918HisAsn: 0.918 ± 0.026
1.161HisPro: 1.161 ± 0.031
1.05HisGln: 1.05 ± 0.03
1.043HisArg: 1.043 ± 0.027
1.379HisSer: 1.379 ± 0.032
1.045HisThr: 1.045 ± 0.028
1.154HisVal: 1.154 ± 0.029
0.411HisTrp: 0.411 ± 0.017
0.895HisTyr: 0.895 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
6.757IleAla: 6.757 ± 0.073
0.6IleCys: 0.6 ± 0.02
4.008IleAsp: 4.008 ± 0.052
4.113IleGlu: 4.113 ± 0.045
2.411IlePhe: 2.411 ± 0.045
4.539IleGly: 4.539 ± 0.055
1.322IleHis: 1.322 ± 0.03
3.521IleIle: 3.521 ± 0.062
3.21IleLys: 3.21 ± 0.043
4.888IleLeu: 4.888 ± 0.067
1.014IleMet: 1.014 ± 0.029
3.543IleAsn: 3.543 ± 0.048
2.902IlePro: 2.902 ± 0.046
2.261IleGln: 2.261 ± 0.038
2.916IleArg: 2.916 ± 0.043
4.479IleSer: 4.479 ± 0.055
3.954IleThr: 3.954 ± 0.06
3.811IleVal: 3.811 ± 0.049
0.687IleTrp: 0.687 ± 0.02
1.95IleTyr: 1.95 ± 0.037
0.0IleXaa: 0.0 ± 0.0
Lys
4.244LysAla: 4.244 ± 0.071
0.281LysCys: 0.281 ± 0.016
2.417LysAsp: 2.417 ± 0.042
2.562LysGlu: 2.562 ± 0.042
1.666LysPhe: 1.666 ± 0.029
2.828LysGly: 2.828 ± 0.046
1.032LysHis: 1.032 ± 0.026
3.368LysIle: 3.368 ± 0.053
2.91LysLys: 2.91 ± 0.064
4.886LysLeu: 4.886 ± 0.059
1.113LysMet: 1.113 ± 0.025
2.743LysAsn: 2.743 ± 0.043
2.47LysPro: 2.47 ± 0.051
2.171LysGln: 2.171 ± 0.042
2.346LysArg: 2.346 ± 0.045
3.093LysSer: 3.093 ± 0.041
3.171LysThr: 3.171 ± 0.044
3.166LysVal: 3.166 ± 0.048
0.492LysTrp: 0.492 ± 0.015
1.358LysTyr: 1.358 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
10.098LeuAla: 10.098 ± 0.105
0.958LeuCys: 0.958 ± 0.025
5.51LeuAsp: 5.51 ± 0.068
5.481LeuGlu: 5.481 ± 0.075
3.985LeuPhe: 3.985 ± 0.061
6.997LeuGly: 6.997 ± 0.07
2.174LeuHis: 2.174 ± 0.045
6.254LeuIle: 6.254 ± 0.076
4.71LeuLys: 4.71 ± 0.063
10.957LeuLeu: 10.957 ± 0.139
2.185LeuMet: 2.185 ± 0.041
4.524LeuAsn: 4.524 ± 0.054
4.962LeuPro: 4.962 ± 0.07
4.52LeuGln: 4.52 ± 0.067
5.388LeuArg: 5.388 ± 0.071
6.723LeuSer: 6.723 ± 0.069
5.716LeuThr: 5.716 ± 0.065
6.995LeuVal: 6.995 ± 0.068
1.324LeuTrp: 1.324 ± 0.032
2.491LeuTyr: 2.491 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
1.999MetAla: 1.999 ± 0.041
0.145MetCys: 0.145 ± 0.009
1.059MetAsp: 1.059 ± 0.026
1.121MetGlu: 1.121 ± 0.029
0.731MetPhe: 0.731 ± 0.025
1.485MetGly: 1.485 ± 0.033
0.455MetHis: 0.455 ± 0.018
1.192MetIle: 1.192 ± 0.031
1.151MetLys: 1.151 ± 0.026
2.188MetLeu: 2.188 ± 0.042
0.497MetMet: 0.497 ± 0.019
1.023MetAsn: 1.023 ± 0.026
1.044MetPro: 1.044 ± 0.028
0.988MetGln: 0.988 ± 0.026
1.133MetArg: 1.133 ± 0.03
1.51MetSer: 1.51 ± 0.034
1.222MetThr: 1.222 ± 0.027
1.342MetVal: 1.342 ± 0.03
0.174MetTrp: 0.174 ± 0.011
0.423MetTyr: 0.423 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
4.178AsnAla: 4.178 ± 0.065
0.49AsnCys: 0.49 ± 0.019
2.424AsnAsp: 2.424 ± 0.055
2.405AsnGlu: 2.405 ± 0.042
1.913AsnPhe: 1.913 ± 0.042
3.652AsnGly: 3.652 ± 0.083
0.994AsnHis: 0.994 ± 0.027
2.945AsnIle: 2.945 ± 0.054
2.239AsnLys: 2.239 ± 0.038
4.573AsnLeu: 4.573 ± 0.057
0.845AsnMet: 0.845 ± 0.023
2.643AsnAsn: 2.643 ± 0.063
2.626AsnPro: 2.626 ± 0.051
2.084AsnGln: 2.084 ± 0.043
2.203AsnArg: 2.203 ± 0.038
3.201AsnSer: 3.201 ± 0.054
2.767AsnThr: 2.767 ± 0.054
2.728AsnVal: 2.728 ± 0.047
0.82AsnTrp: 0.82 ± 0.023
1.721AsnTyr: 1.721 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
4.549ProAla: 4.549 ± 0.067
0.312ProCys: 0.312 ± 0.016
2.764ProAsp: 2.764 ± 0.041
3.176ProGlu: 3.176 ± 0.056
1.68ProPhe: 1.68 ± 0.032
3.043ProGly: 3.043 ± 0.042
0.882ProHis: 0.882 ± 0.022
2.397ProIle: 2.397 ± 0.034
1.736ProLys: 1.736 ± 0.032
4.395ProLeu: 4.395 ± 0.058
0.814ProMet: 0.814 ± 0.023
1.714ProAsn: 1.714 ± 0.038
1.531ProPro: 1.531 ± 0.038
1.839ProGln: 1.839 ± 0.034
1.665ProArg: 1.665 ± 0.037
2.413ProSer: 2.413 ± 0.045
2.226ProThr: 2.226 ± 0.04
3.429ProVal: 3.429 ± 0.056
0.599ProTrp: 0.599 ± 0.019
1.226ProTyr: 1.226 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.917GlnAla: 3.917 ± 0.055
0.331GlnCys: 0.331 ± 0.015
1.833GlnAsp: 1.833 ± 0.033
2.295GlnGlu: 2.295 ± 0.043
1.711GlnPhe: 1.711 ± 0.027
2.763GlnGly: 2.763 ± 0.047
1.118GlnHis: 1.118 ± 0.031
2.558GlnIle: 2.558 ± 0.038
2.084GlnLys: 2.084 ± 0.044
5.458GlnLeu: 5.458 ± 0.085
0.95GlnMet: 0.95 ± 0.025
1.57GlnAsn: 1.57 ± 0.033
1.827GlnPro: 1.827 ± 0.041
3.114GlnGln: 3.114 ± 0.069
2.5GlnArg: 2.5 ± 0.048
2.54GlnSer: 2.54 ± 0.042
2.347GlnThr: 2.347 ± 0.038
2.93GlnVal: 2.93 ± 0.048
0.727GlnTrp: 0.727 ± 0.022
1.225GlnTyr: 1.225 ± 0.026
0.0GlnXaa: 0.0 ± 0.0
Arg
4.119ArgAla: 4.119 ± 0.055
0.425ArgCys: 0.425 ± 0.016
2.908ArgAsp: 2.908 ± 0.041
3.235ArgGlu: 3.235 ± 0.056
2.258ArgPhe: 2.258 ± 0.039
2.931ArgGly: 2.931 ± 0.049
1.111ArgHis: 1.111 ± 0.029
3.384ArgIle: 3.384 ± 0.042
2.366ArgLys: 2.366 ± 0.037
5.236ArgLeu: 5.236 ± 0.064
1.175ArgMet: 1.175 ± 0.032
2.276ArgAsn: 2.276 ± 0.038
1.702ArgPro: 1.702 ± 0.031
2.118ArgGln: 2.118 ± 0.047
2.47ArgArg: 2.47 ± 0.049
2.825ArgSer: 2.825 ± 0.039
2.461ArgThr: 2.461 ± 0.037
3.396ArgVal: 3.396 ± 0.05
0.867ArgTrp: 0.867 ± 0.027
1.861ArgTyr: 1.861 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
6.245SerAla: 6.245 ± 0.066
0.61SerCys: 0.61 ± 0.025
3.271SerAsp: 3.271 ± 0.051
3.392SerGlu: 3.392 ± 0.046
2.842SerPhe: 2.842 ± 0.039
5.409SerGly: 5.409 ± 0.079
1.336SerHis: 1.336 ± 0.031
4.156SerIle: 4.156 ± 0.059
2.651SerLys: 2.651 ± 0.04
6.96SerLeu: 6.96 ± 0.077
1.285SerMet: 1.285 ± 0.028
2.88SerAsn: 2.88 ± 0.056
2.829SerPro: 2.829 ± 0.042
2.408SerGln: 2.408 ± 0.042
2.988SerArg: 2.988 ± 0.046
6.245SerSer: 6.245 ± 0.205
3.704SerThr: 3.704 ± 0.059
4.685SerVal: 4.685 ± 0.08
0.991SerTrp: 0.991 ± 0.025
2.075SerTyr: 2.075 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
5.408ThrAla: 5.408 ± 0.083
0.466ThrCys: 0.466 ± 0.018
3.013ThrAsp: 3.013 ± 0.041
2.992ThrGlu: 2.992 ± 0.05
2.182ThrPhe: 2.182 ± 0.049
4.733ThrGly: 4.733 ± 0.081
1.238ThrHis: 1.238 ± 0.028
3.343ThrIle: 3.343 ± 0.051
2.206ThrLys: 2.206 ± 0.041
5.891ThrLeu: 5.891 ± 0.06
0.895ThrMet: 0.895 ± 0.025
2.691ThrAsn: 2.691 ± 0.061
2.971ThrPro: 2.971 ± 0.039
2.374ThrGln: 2.374 ± 0.042
2.73ThrArg: 2.73 ± 0.042
3.687ThrSer: 3.687 ± 0.058
3.378ThrThr: 3.378 ± 0.068
3.611ThrVal: 3.611 ± 0.062
0.716ThrTrp: 0.716 ± 0.021
1.829ThrTyr: 1.829 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
6.375ValAla: 6.375 ± 0.088
0.614ValCys: 0.614 ± 0.023
4.086ValAsp: 4.086 ± 0.056
3.862ValGlu: 3.862 ± 0.059
2.74ValPhe: 2.74 ± 0.049
4.349ValGly: 4.349 ± 0.069
1.208ValHis: 1.208 ± 0.027
4.576ValIle: 4.576 ± 0.049
3.205ValLys: 3.205 ± 0.05
6.248ValLeu: 6.248 ± 0.066
1.499ValMet: 1.499 ± 0.036
3.3ValAsn: 3.3 ± 0.056
2.733ValPro: 2.733 ± 0.045
2.354ValGln: 2.354 ± 0.038
3.277ValArg: 3.277 ± 0.055
4.654ValSer: 4.654 ± 0.069
4.038ValThr: 4.038 ± 0.075
4.967ValVal: 4.967 ± 0.077
0.826ValTrp: 0.826 ± 0.024
1.876ValTyr: 1.876 ± 0.032
0.001ValXaa: 0.001 ± 0.001
Trp
1.003TrpAla: 1.003 ± 0.026
0.156TrpCys: 0.156 ± 0.009
0.682TrpAsp: 0.682 ± 0.024
0.69TrpGlu: 0.69 ± 0.023
0.596TrpPhe: 0.596 ± 0.025
0.964TrpGly: 0.964 ± 0.03
0.343TrpHis: 0.343 ± 0.014
0.839TrpIle: 0.839 ± 0.023
0.601TrpLys: 0.601 ± 0.021
1.788TrpLeu: 1.788 ± 0.035
0.326TrpMet: 0.326 ± 0.015
0.745TrpAsn: 0.745 ± 0.026
0.554TrpPro: 0.554 ± 0.018
0.887TrpGln: 0.887 ± 0.025
0.835TrpArg: 0.835 ± 0.023
0.902TrpSer: 0.902 ± 0.026
0.678TrpThr: 0.678 ± 0.023
0.935TrpVal: 0.935 ± 0.025
0.27TrpTrp: 0.27 ± 0.014
0.436TrpTyr: 0.436 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.58TyrAla: 2.58 ± 0.04
0.36TyrCys: 0.36 ± 0.016
1.74TyrAsp: 1.74 ± 0.055
1.764TyrGlu: 1.764 ± 0.035
1.458TyrPhe: 1.458 ± 0.029
2.216TyrGly: 2.216 ± 0.039
0.667TyrHis: 0.667 ± 0.02
1.58TyrIle: 1.58 ± 0.034
1.403TyrLys: 1.403 ± 0.029
3.297TyrLeu: 3.297 ± 0.053
0.557TyrMet: 0.557 ± 0.02
1.316TyrAsn: 1.316 ± 0.033
1.364TyrPro: 1.364 ± 0.031
1.585TyrGln: 1.585 ± 0.034
1.934TyrArg: 1.934 ± 0.033
2.21TyrSer: 2.21 ± 0.045
1.81TyrThr: 1.81 ± 0.041
1.913TyrVal: 1.913 ± 0.035
0.563TyrTrp: 0.563 ± 0.019
1.067TyrTyr: 1.067 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.001XaaSer: 0.001 ± 0.001
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.001XaaXaa: 0.001 ± 0.001
Statistics based on 4688 proteins (1645598 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski