Amino acid dipepetide frequency for Bacteroidales bacterium 6E

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.136AlaAla: 5.136 ± 0.09	0.636AlaCys: 0.636 ± 0.025	3.81AlaAsp: 3.81 ± 0.069	4.184AlaGlu: 4.184 ± 0.058	3.235AlaPhe: 3.235 ± 0.05	5.934AlaGly: 5.934 ± 0.083	1.216AlaHis: 1.216 ± 0.033	5.109AlaIle: 5.109 ± 0.079	3.156AlaLys: 3.156 ± 0.051	6.188AlaLeu: 6.188 ± 0.081	1.872AlaMet: 1.872 ± 0.041	3.142AlaAsn: 3.142 ± 0.053	2.277AlaPro: 2.277 ± 0.048	2.247AlaGln: 2.247 ± 0.043	3.455AlaArg: 3.455 ± 0.062	4.464AlaSer: 4.464 ± 0.075	3.727AlaThr: 3.727 ± 0.088	4.432AlaVal: 4.432 ± 0.066	0.965AlaTrp: 0.965 ± 0.026	2.365AlaTyr: 2.365 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.467CysAla: 0.467 ± 0.019	0.112CysCys: 0.112 ± 0.01	0.53CysAsp: 0.53 ± 0.037	0.498CysGlu: 0.498 ± 0.024	0.376CysPhe: 0.376 ± 0.019	0.686CysGly: 0.686 ± 0.03	0.28CysHis: 0.28 ± 0.022	0.513CysIle: 0.513 ± 0.021	0.371CysLys: 0.371 ± 0.019	0.632CysLeu: 0.632 ± 0.022	0.202CysMet: 0.202 ± 0.014	0.397CysAsn: 0.397 ± 0.021	0.41CysPro: 0.41 ± 0.024	0.294CysGln: 0.294 ± 0.019	0.39CysArg: 0.39 ± 0.017	0.54CysSer: 0.54 ± 0.024	0.476CysThr: 0.476 ± 0.025	0.427CysVal: 0.427 ± 0.017	0.093CysTrp: 0.093 ± 0.008	0.279CysTyr: 0.279 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.508AspAla: 3.508 ± 0.069	0.431AspCys: 0.431 ± 0.027	2.837AspAsp: 2.837 ± 0.055	3.713AspGlu: 3.713 ± 0.06	3.183AspPhe: 3.183 ± 0.053	3.953AspGly: 3.953 ± 0.087	1.216AspHis: 1.216 ± 0.03	4.126AspIle: 4.126 ± 0.063	3.195AspLys: 3.195 ± 0.055	5.266AspLeu: 5.266 ± 0.073	1.396AspMet: 1.396 ± 0.036	2.788AspAsn: 2.788 ± 0.066	2.67AspPro: 2.67 ± 0.05	2.067AspGln: 2.067 ± 0.042	2.631AspArg: 2.631 ± 0.048	2.894AspSer: 2.894 ± 0.048	2.492AspThr: 2.492 ± 0.045	3.382AspVal: 3.382 ± 0.062	0.899AspTrp: 0.899 ± 0.028	2.44AspTyr: 2.44 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	4.368GluAla: 4.368 ± 0.071	0.428GluCys: 0.428 ± 0.02	2.899GluAsp: 2.899 ± 0.054	4.442GluGlu: 4.442 ± 0.075	2.918GluPhe: 2.918 ± 0.044	4.098GluGly: 4.098 ± 0.063	1.064GluHis: 1.064 ± 0.027	5.304GluIle: 5.304 ± 0.063	4.984GluLys: 4.984 ± 0.071	6.048GluLeu: 6.048 ± 0.087	2.069GluMet: 2.069 ± 0.043	3.815GluAsn: 3.815 ± 0.065	2.127GluPro: 2.127 ± 0.039	2.114GluGln: 2.114 ± 0.053	2.893GluArg: 2.893 ± 0.055	3.665GluSer: 3.665 ± 0.056	3.445GluThr: 3.445 ± 0.05	4.373GluVal: 4.373 ± 0.061	0.923GluTrp: 0.923 ± 0.027	2.371GluTyr: 2.371 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.061PheAla: 3.061 ± 0.051	0.388PheCys: 0.388 ± 0.018	2.993PheAsp: 2.993 ± 0.041	2.969PheGlu: 2.969 ± 0.057	2.468PhePhe: 2.468 ± 0.053	3.633PheGly: 3.633 ± 0.059	1.053PheHis: 1.053 ± 0.029	3.379PheIle: 3.379 ± 0.058	2.257PheLys: 2.257 ± 0.043	4.449PheLeu: 4.449 ± 0.067	1.37PheMet: 1.37 ± 0.036	2.613PheAsn: 2.613 ± 0.049	2.002PhePro: 2.002 ± 0.038	1.496PheGln: 1.496 ± 0.039	2.702PheArg: 2.702 ± 0.048	3.814PheSer: 3.814 ± 0.063	3.057PheThr: 3.057 ± 0.055	3.037PheVal: 3.037 ± 0.055	0.693PheTrp: 0.693 ± 0.027	1.902PheTyr: 1.902 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	4.382GlyAla: 4.382 ± 0.072	0.732GlyCys: 0.732 ± 0.034	3.687GlyAsp: 3.687 ± 0.064	4.198GlyGlu: 4.198 ± 0.056	3.726GlyPhe: 3.726 ± 0.053	5.035GlyGly: 5.035 ± 0.08	1.362GlyHis: 1.362 ± 0.039	5.921GlyIle: 5.921 ± 0.071	5.039GlyLys: 5.039 ± 0.074	6.382GlyLeu: 6.382 ± 0.083	2.187GlyMet: 2.187 ± 0.041	4.017GlyAsn: 4.017 ± 0.072	1.941GlyPro: 1.941 ± 0.043	2.415GlyGln: 2.415 ± 0.044	3.14GlyArg: 3.14 ± 0.054	4.66GlySer: 4.66 ± 0.074	4.526GlyThr: 4.526 ± 0.11	4.5GlyVal: 4.5 ± 0.062	1.128GlyTrp: 1.128 ± 0.034	3.185GlyTyr: 3.185 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	1.21HisAla: 1.21 ± 0.034	0.204HisCys: 0.204 ± 0.013	1.098HisAsp: 1.098 ± 0.028	1.251HisGlu: 1.251 ± 0.038	1.214HisPhe: 1.214 ± 0.031	1.417HisGly: 1.417 ± 0.037	0.61HisHis: 0.61 ± 0.022	1.368HisIle: 1.368 ± 0.034	0.97HisLys: 0.97 ± 0.028	1.995HisLeu: 1.995 ± 0.038	0.46HisMet: 0.46 ± 0.019	0.902HisAsn: 0.902 ± 0.026	1.223HisPro: 1.223 ± 0.029	0.765HisGln: 0.765 ± 0.025	0.957HisArg: 0.957 ± 0.03	1.249HisSer: 1.249 ± 0.032	1.005HisThr: 1.005 ± 0.03	1.099HisVal: 1.099 ± 0.035	0.293HisTrp: 0.293 ± 0.016	0.846HisTyr: 0.846 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.095IleAla: 5.095 ± 0.067	0.595IleCys: 0.595 ± 0.021	4.352IleAsp: 4.352 ± 0.06	4.615IleGlu: 4.615 ± 0.067	3.31IlePhe: 3.31 ± 0.062	4.8IleGly: 4.8 ± 0.075	1.592IleHis: 1.592 ± 0.038	5.054IleIle: 5.054 ± 0.085	3.616IleLys: 3.616 ± 0.065	6.939IleLeu: 6.939 ± 0.088	1.584IleMet: 1.584 ± 0.035	3.408IleAsn: 3.408 ± 0.058	3.526IlePro: 3.526 ± 0.058	2.388IleGln: 2.388 ± 0.041	4.169IleArg: 4.169 ± 0.063	5.294IleSer: 5.294 ± 0.069	4.508IleThr: 4.508 ± 0.082	4.314IleVal: 4.314 ± 0.066	0.871IleTrp: 0.871 ± 0.028	2.602IleTyr: 2.602 ± 0.055	0.0IleXaa: 0.0 ± 0.0
Lys	4.188LysAla: 4.188 ± 0.068	0.34LysCys: 0.34 ± 0.015	3.1LysAsp: 3.1 ± 0.052	4.171LysGlu: 4.171 ± 0.08	2.194LysPhe: 2.194 ± 0.044	4.032LysGly: 4.032 ± 0.069	1.032LysHis: 1.032 ± 0.031	4.38LysIle: 4.38 ± 0.07	3.881LysLys: 3.881 ± 0.065	5.047LysLeu: 5.047 ± 0.071	1.797LysMet: 1.797 ± 0.041	3.22LysAsn: 3.22 ± 0.054	2.432LysPro: 2.432 ± 0.045	1.889LysGln: 1.889 ± 0.04	2.688LysArg: 2.688 ± 0.045	3.635LysSer: 3.635 ± 0.049	3.237LysThr: 3.237 ± 0.054	4.112LysVal: 4.112 ± 0.062	0.776LysTrp: 0.776 ± 0.028	2.509LysTyr: 2.509 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	6.581LeuAla: 6.581 ± 0.089	0.689LeuCys: 0.689 ± 0.024	4.907LeuAsp: 4.907 ± 0.069	5.694LeuGlu: 5.694 ± 0.078	4.621LeuPhe: 4.621 ± 0.076	5.889LeuGly: 5.889 ± 0.082	1.732LeuHis: 1.732 ± 0.037	6.313LeuIle: 6.313 ± 0.091	6.341LeuLys: 6.341 ± 0.076	8.626LeuLeu: 8.626 ± 0.11	2.435LeuMet: 2.435 ± 0.047	4.647LeuAsn: 4.647 ± 0.064	4.233LeuPro: 4.233 ± 0.064	3.161LeuGln: 3.161 ± 0.057	4.122LeuArg: 4.122 ± 0.059	6.411LeuSer: 6.411 ± 0.073	5.364LeuThr: 5.364 ± 0.075	6.183LeuVal: 6.183 ± 0.078	1.03LeuTrp: 1.03 ± 0.028	3.183LeuTyr: 3.183 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.287MetAla: 2.287 ± 0.05	0.146MetCys: 0.146 ± 0.011	1.426MetAsp: 1.426 ± 0.034	1.828MetGlu: 1.828 ± 0.037	1.053MetPhe: 1.053 ± 0.031	1.91MetGly: 1.91 ± 0.045	0.478MetHis: 0.478 ± 0.021	1.813MetIle: 1.813 ± 0.039	2.229MetLys: 2.229 ± 0.046	2.346MetLeu: 2.346 ± 0.05	0.779MetMet: 0.779 ± 0.026	1.484MetAsn: 1.484 ± 0.034	1.185MetPro: 1.185 ± 0.028	0.931MetGln: 0.931 ± 0.026	1.112MetArg: 1.112 ± 0.031	1.478MetSer: 1.478 ± 0.034	1.448MetThr: 1.448 ± 0.033	2.048MetVal: 2.048 ± 0.042	0.237MetTrp: 0.237 ± 0.014	0.742MetTyr: 0.742 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.21AsnAla: 3.21 ± 0.048	0.441AsnCys: 0.441 ± 0.03	2.722AsnAsp: 2.722 ± 0.059	3.043AsnGlu: 3.043 ± 0.047	2.419AsnPhe: 2.419 ± 0.05	3.854AsnGly: 3.854 ± 0.071	1.196AsnHis: 1.196 ± 0.029	3.678AsnIle: 3.678 ± 0.06	2.576AsnLys: 2.576 ± 0.051	4.977AsnLeu: 4.977 ± 0.064	1.25AsnMet: 1.25 ± 0.033	2.561AsnAsn: 2.561 ± 0.058	2.933AsnPro: 2.933 ± 0.049	2.089AsnGln: 2.089 ± 0.046	2.704AsnArg: 2.704 ± 0.046	2.98AsnSer: 2.98 ± 0.057	2.646AsnThr: 2.646 ± 0.055	2.956AsnVal: 2.956 ± 0.056	0.744AsnTrp: 0.744 ± 0.026	2.149AsnTyr: 2.149 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	3.163ProAla: 3.163 ± 0.056	0.258ProCys: 0.258 ± 0.015	3.137ProAsp: 3.137 ± 0.049	3.809ProGlu: 3.809 ± 0.054	2.048ProPhe: 2.048 ± 0.042	3.658ProGly: 3.658 ± 0.056	0.802ProHis: 0.802 ± 0.029	2.289ProIle: 2.289 ± 0.042	1.798ProLys: 1.798 ± 0.038	3.349ProLeu: 3.349 ± 0.052	1.001ProMet: 1.001 ± 0.029	1.806ProAsn: 1.806 ± 0.042	1.246ProPro: 1.246 ± 0.038	1.267ProGln: 1.267 ± 0.038	1.496ProArg: 1.496 ± 0.034	2.541ProSer: 2.541 ± 0.047	1.926ProThr: 1.926 ± 0.049	3.884ProVal: 3.884 ± 0.06	0.613ProTrp: 0.613 ± 0.027	1.584ProTyr: 1.584 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.246GlnAla: 2.246 ± 0.045	0.202GlnCys: 0.202 ± 0.013	1.519GlnAsp: 1.519 ± 0.039	2.158GlnGlu: 2.158 ± 0.042	1.58GlnPhe: 1.58 ± 0.038	2.202GlnGly: 2.202 ± 0.038	0.638GlnHis: 0.638 ± 0.022	2.451GlnIle: 2.451 ± 0.039	2.362GlnLys: 2.362 ± 0.048	3.317GlnLeu: 3.317 ± 0.054	1.0GlnMet: 1.0 ± 0.027	1.83GlnAsn: 1.83 ± 0.035	1.515GlnPro: 1.515 ± 0.032	1.333GlnGln: 1.333 ± 0.04	1.546GlnArg: 1.546 ± 0.033	2.064GlnSer: 2.064 ± 0.044	1.866GlnThr: 1.866 ± 0.044	2.437GlnVal: 2.437 ± 0.05	0.49GlnTrp: 0.49 ± 0.02	1.366GlnTyr: 1.366 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.481ArgAla: 2.481 ± 0.053	0.282ArgCys: 0.282 ± 0.015	2.509ArgAsp: 2.509 ± 0.042	3.573ArgGlu: 3.573 ± 0.061	2.592ArgPhe: 2.592 ± 0.043	2.57ArgGly: 2.57 ± 0.047	0.981ArgHis: 0.981 ± 0.032	4.021ArgIle: 4.021 ± 0.062	3.517ArgLys: 3.517 ± 0.062	4.578ArgLeu: 4.578 ± 0.074	1.491ArgMet: 1.491 ± 0.037	2.838ArgAsn: 2.838 ± 0.054	1.666ArgPro: 1.666 ± 0.036	1.899ArgGln: 1.899 ± 0.038	2.092ArgArg: 2.092 ± 0.043	2.567ArgSer: 2.567 ± 0.049	2.344ArgThr: 2.344 ± 0.046	2.745ArgVal: 2.745 ± 0.048	0.687ArgTrp: 0.687 ± 0.021	2.054ArgTyr: 2.054 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	4.283SerAla: 4.283 ± 0.067	0.626SerCys: 0.626 ± 0.024	3.633SerAsp: 3.633 ± 0.059	3.932SerGlu: 3.932 ± 0.056	3.511SerPhe: 3.511 ± 0.053	5.768SerGly: 5.768 ± 0.086	1.334SerHis: 1.334 ± 0.029	4.332SerIle: 4.332 ± 0.06	3.129SerLys: 3.129 ± 0.049	6.102SerLeu: 6.102 ± 0.068	1.615SerMet: 1.615 ± 0.035	2.875SerAsn: 2.875 ± 0.045	2.622SerPro: 2.622 ± 0.043	2.203SerGln: 2.203 ± 0.043	3.012SerArg: 3.012 ± 0.053	4.025SerSer: 4.025 ± 0.066	3.208SerThr: 3.208 ± 0.065	4.509SerVal: 4.509 ± 0.076	0.875SerTrp: 0.875 ± 0.028	2.541SerTyr: 2.541 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	3.906ThrAla: 3.906 ± 0.081	0.407ThrCys: 0.407 ± 0.028	3.38ThrAsp: 3.38 ± 0.069	3.221ThrGlu: 3.221 ± 0.056	2.719ThrPhe: 2.719 ± 0.058	5.162ThrGly: 5.162 ± 0.083	1.043ThrHis: 1.043 ± 0.029	4.171ThrIle: 4.171 ± 0.088	2.322ThrLys: 2.322 ± 0.047	5.131ThrLeu: 5.131 ± 0.07	1.313ThrMet: 1.313 ± 0.033	2.453ThrAsn: 2.453 ± 0.054	2.664ThrPro: 2.664 ± 0.055	1.643ThrGln: 1.643 ± 0.039	2.528ThrArg: 2.528 ± 0.042	3.583ThrSer: 3.583 ± 0.065	3.166ThrThr: 3.166 ± 0.085	3.897ThrVal: 3.897 ± 0.107	0.754ThrTrp: 0.754 ± 0.034	2.17ThrTyr: 2.17 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	4.647ValAla: 4.647 ± 0.062	0.581ValCys: 0.581 ± 0.024	3.558ValAsp: 3.558 ± 0.065	4.051ValGlu: 4.051 ± 0.056	3.302ValPhe: 3.302 ± 0.065	3.877ValGly: 3.877 ± 0.063	1.229ValHis: 1.229 ± 0.035	5.011ValIle: 5.011 ± 0.058	3.944ValLys: 3.944 ± 0.054	5.676ValLeu: 5.676 ± 0.079	1.816ValMet: 1.816 ± 0.044	3.413ValAsn: 3.413 ± 0.058	2.796ValPro: 2.796 ± 0.046	1.837ValGln: 1.837 ± 0.041	3.125ValArg: 3.125 ± 0.048	4.747ValSer: 4.747 ± 0.068	4.238ValThr: 4.238 ± 0.111	4.796ValVal: 4.796 ± 0.089	0.873ValTrp: 0.873 ± 0.025	2.518ValTyr: 2.518 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.842TrpAla: 0.842 ± 0.024	0.12TrpCys: 0.12 ± 0.009	0.774TrpAsp: 0.774 ± 0.029	0.868TrpGlu: 0.868 ± 0.028	0.698TrpPhe: 0.698 ± 0.026	0.916TrpGly: 0.916 ± 0.028	0.333TrpHis: 0.333 ± 0.017	1.036TrpIle: 1.036 ± 0.034	0.92TrpLys: 0.92 ± 0.026	1.31TrpLeu: 1.31 ± 0.031	0.42TrpMet: 0.42 ± 0.02	0.806TrpAsn: 0.806 ± 0.026	0.425TrpPro: 0.425 ± 0.02	0.567TrpGln: 0.567 ± 0.023	0.57TrpArg: 0.57 ± 0.021	0.8TrpSer: 0.8 ± 0.028	0.725TrpThr: 0.725 ± 0.029	0.793TrpVal: 0.793 ± 0.03	0.233TrpTrp: 0.233 ± 0.013	0.544TrpTyr: 0.544 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.491TyrAla: 2.491 ± 0.044	0.356TyrCys: 0.356 ± 0.016	2.218TyrAsp: 2.218 ± 0.054	2.129TyrGlu: 2.129 ± 0.042	2.168TyrPhe: 2.168 ± 0.039	2.77TyrGly: 2.77 ± 0.048	0.947TyrHis: 0.947 ± 0.025	2.362TyrIle: 2.362 ± 0.045	2.051TyrLys: 2.051 ± 0.038	3.803TyrLeu: 3.803 ± 0.06	0.9TyrMet: 0.9 ± 0.027	2.111TyrAsn: 2.111 ± 0.047	1.787TyrPro: 1.787 ± 0.043	1.518TyrGln: 1.518 ± 0.032	2.158TyrArg: 2.158 ± 0.05	2.721TyrSer: 2.721 ± 0.052	2.23TyrThr: 2.23 ± 0.06	2.108TyrVal: 2.108 ± 0.04	0.522TyrTrp: 0.522 ± 0.021	1.725TyrTyr: 1.725 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3618 proteins (1318582 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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