Amino acid dipepetide frequency for Hydrogenivirga sp. 128-5-R1-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.78AlaAla: 2.78 ± 0.081
0.613AlaCys: 0.613 ± 0.029
2.686AlaAsp: 2.686 ± 0.058
4.509AlaGlu: 4.509 ± 0.079
3.023AlaPhe: 3.023 ± 0.057
4.473AlaGly: 4.473 ± 0.075
1.049AlaHis: 1.049 ± 0.038
4.136AlaIle: 4.136 ± 0.069
4.996AlaLys: 4.996 ± 0.074
7.35AlaLeu: 7.35 ± 0.113
1.387AlaMet: 1.387 ± 0.04
1.971AlaAsn: 1.971 ± 0.047
1.828AlaPro: 1.828 ± 0.048
1.776AlaGln: 1.776 ± 0.047
2.859AlaArg: 2.859 ± 0.056
3.102AlaSer: 3.102 ± 0.058
2.502AlaThr: 2.502 ± 0.059
5.757AlaVal: 5.757 ± 0.079
0.489AlaTrp: 0.489 ± 0.023
2.553AlaTyr: 2.553 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.491CysAla: 0.491 ± 0.022
0.102CysCys: 0.102 ± 0.013
0.402CysAsp: 0.402 ± 0.022
0.595CysGlu: 0.595 ± 0.027
0.29CysPhe: 0.29 ± 0.02
0.831CysGly: 0.831 ± 0.033
0.226CysHis: 0.226 ± 0.017
0.474CysIle: 0.474 ± 0.02
0.519CysLys: 0.519 ± 0.026
0.592CysLeu: 0.592 ± 0.027
0.172CysMet: 0.172 ± 0.013
0.279CysAsn: 0.279 ± 0.018
0.57CysPro: 0.57 ± 0.024
0.191CysGln: 0.191 ± 0.016
0.412CysArg: 0.412 ± 0.021
0.518CysSer: 0.518 ± 0.021
0.346CysThr: 0.346 ± 0.019
0.546CysVal: 0.546 ± 0.026
0.067CysTrp: 0.067 ± 0.008
0.311CysTyr: 0.311 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
2.628AspAla: 2.628 ± 0.053
0.385AspCys: 0.385 ± 0.022
1.826AspAsp: 1.826 ± 0.051
3.99AspGlu: 3.99 ± 0.067
2.936AspPhe: 2.936 ± 0.057
2.829AspGly: 2.829 ± 0.054
0.522AspHis: 0.522 ± 0.022
5.087AspIle: 5.087 ± 0.081
4.067AspLys: 4.067 ± 0.067
4.966AspLeu: 4.966 ± 0.078
1.244AspMet: 1.244 ± 0.034
1.711AspAsn: 1.711 ± 0.051
2.215AspPro: 2.215 ± 0.054
0.686AspGln: 0.686 ± 0.028
3.225AspArg: 3.225 ± 0.059
2.173AspSer: 2.173 ± 0.051
2.389AspThr: 2.389 ± 0.054
3.975AspVal: 3.975 ± 0.062
0.547AspTrp: 0.547 ± 0.025
2.345AspTyr: 2.345 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
5.084GluAla: 5.084 ± 0.091
0.525GluCys: 0.525 ± 0.024
4.838GluAsp: 4.838 ± 0.074
10.566GluGlu: 10.566 ± 0.168
3.865GluPhe: 3.865 ± 0.07
6.398GluGly: 6.398 ± 0.094
1.292GluHis: 1.292 ± 0.038
6.642GluIle: 6.642 ± 0.097
8.626GluLys: 8.626 ± 0.135
9.373GluLeu: 9.373 ± 0.121
1.493GluMet: 1.493 ± 0.041
4.076GluAsn: 4.076 ± 0.074
2.203GluPro: 2.203 ± 0.053
1.533GluGln: 1.533 ± 0.042
5.168GluArg: 5.168 ± 0.084
3.46GluSer: 3.46 ± 0.07
3.21GluThr: 3.21 ± 0.065
7.076GluVal: 7.076 ± 0.101
0.701GluTrp: 0.701 ± 0.027
2.509GluTyr: 2.509 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
2.729PheAla: 2.729 ± 0.058
0.424PheCys: 0.424 ± 0.019
2.198PheAsp: 2.198 ± 0.051
3.419PheGlu: 3.419 ± 0.064
2.649PhePhe: 2.649 ± 0.069
3.531PheGly: 3.531 ± 0.064
0.724PheHis: 0.724 ± 0.026
3.83PheIle: 3.83 ± 0.072
3.544PheLys: 3.544 ± 0.066
5.863PheLeu: 5.863 ± 0.102
1.116PheMet: 1.116 ± 0.04
1.874PheAsn: 1.874 ± 0.051
1.865PhePro: 1.865 ± 0.048
0.985PheGln: 0.985 ± 0.029
2.347PheArg: 2.347 ± 0.058
3.328PheSer: 3.328 ± 0.066
2.308PheThr: 2.308 ± 0.053
3.562PheVal: 3.562 ± 0.066
0.511PheTrp: 0.511 ± 0.026
2.21PheTyr: 2.21 ± 0.052
0.0PheXaa: 0.0 ± 0.0
Gly
4.211GlyAla: 4.211 ± 0.084
0.702GlyCys: 0.702 ± 0.032
3.454GlyAsp: 3.454 ± 0.064
5.326GlyGlu: 5.326 ± 0.082
3.756GlyPhe: 3.756 ± 0.067
4.963GlyGly: 4.963 ± 0.089
1.14GlyHis: 1.14 ± 0.036
5.552GlyIle: 5.552 ± 0.071
6.109GlyLys: 6.109 ± 0.078
6.143GlyLeu: 6.143 ± 0.102
1.676GlyMet: 1.676 ± 0.04
2.672GlyAsn: 2.672 ± 0.073
1.088GlyPro: 1.088 ± 0.04
1.446GlyGln: 1.446 ± 0.041
3.887GlyArg: 3.887 ± 0.065
3.754GlySer: 3.754 ± 0.071
3.171GlyThr: 3.171 ± 0.067
5.824GlyVal: 5.824 ± 0.088
0.735GlyTrp: 0.735 ± 0.031
3.022GlyTyr: 3.022 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
0.847HisAla: 0.847 ± 0.032
0.163HisCys: 0.163 ± 0.014
0.625HisAsp: 0.625 ± 0.023
0.99HisGlu: 0.99 ± 0.033
0.801HisPhe: 0.801 ± 0.025
1.109HisGly: 1.109 ± 0.042
0.393HisHis: 0.393 ± 0.023
1.324HisIle: 1.324 ± 0.039
0.903HisLys: 0.903 ± 0.033
1.66HisLeu: 1.66 ± 0.041
0.377HisMet: 0.377 ± 0.02
0.543HisAsn: 0.543 ± 0.026
0.936HisPro: 0.936 ± 0.03
0.387HisGln: 0.387 ± 0.019
1.008HisArg: 1.008 ± 0.033
0.871HisSer: 0.871 ± 0.03
0.825HisThr: 0.825 ± 0.027
0.971HisVal: 0.971 ± 0.032
0.15HisTrp: 0.15 ± 0.012
0.658HisTyr: 0.658 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
4.998IleAla: 4.998 ± 0.092
0.479IleCys: 0.479 ± 0.024
4.561IleAsp: 4.561 ± 0.069
6.684IleGlu: 6.684 ± 0.091
3.305IlePhe: 3.305 ± 0.071
4.64IleGly: 4.64 ± 0.065
1.09IleHis: 1.09 ± 0.031
5.005IleIle: 5.005 ± 0.088
6.619IleLys: 6.619 ± 0.107
7.377IleLeu: 7.377 ± 0.103
1.202IleMet: 1.202 ± 0.037
3.453IleAsn: 3.453 ± 0.092
3.558IlePro: 3.558 ± 0.061
1.601IleGln: 1.601 ± 0.046
3.521IleArg: 3.521 ± 0.066
4.218IleSer: 4.218 ± 0.072
3.973IleThr: 3.973 ± 0.063
5.028IleVal: 5.028 ± 0.079
0.494IleTrp: 0.494 ± 0.023
2.973IleTyr: 2.973 ± 0.066
0.0IleXaa: 0.0 ± 0.0
Lys
5.142LysAla: 5.142 ± 0.076
0.443LysCys: 0.443 ± 0.024
4.742LysAsp: 4.742 ± 0.08
9.576LysGlu: 9.576 ± 0.13
3.188LysPhe: 3.188 ± 0.056
5.786LysGly: 5.786 ± 0.084
1.261LysHis: 1.261 ± 0.038
5.943LysIle: 5.943 ± 0.119
7.524LysLys: 7.524 ± 0.123
8.217LysLeu: 8.217 ± 0.119
1.41LysMet: 1.41 ± 0.038
4.026LysAsn: 4.026 ± 0.087
3.175LysPro: 3.175 ± 0.059
1.754LysGln: 1.754 ± 0.051
4.35LysArg: 4.35 ± 0.068
3.611LysSer: 3.611 ± 0.069
3.694LysThr: 3.694 ± 0.061
6.74LysVal: 6.74 ± 0.083
0.653LysTrp: 0.653 ± 0.027
2.846LysTyr: 2.846 ± 0.072
0.0LysXaa: 0.0 ± 0.0
Leu
6.159LeuAla: 6.159 ± 0.093
0.683LeuCys: 0.683 ± 0.026
4.555LeuAsp: 4.555 ± 0.067
8.686LeuGlu: 8.686 ± 0.118
4.936LeuPhe: 4.936 ± 0.11
6.959LeuGly: 6.959 ± 0.087
1.517LeuHis: 1.517 ± 0.04
7.614LeuIle: 7.614 ± 0.095
10.144LeuLys: 10.144 ± 0.105
10.447LeuLeu: 10.447 ± 0.157
2.238LeuMet: 2.238 ± 0.041
4.043LeuAsn: 4.043 ± 0.07
4.055LeuPro: 4.055 ± 0.078
2.33LeuGln: 2.33 ± 0.053
5.772LeuArg: 5.772 ± 0.092
7.575LeuSer: 7.575 ± 0.117
4.761LeuThr: 4.761 ± 0.075
6.51LeuVal: 6.51 ± 0.095
1.021LeuTrp: 1.021 ± 0.035
3.898LeuTyr: 3.898 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
1.356MetAla: 1.356 ± 0.044
0.137MetCys: 0.137 ± 0.013
1.079MetAsp: 1.079 ± 0.035
1.901MetGlu: 1.901 ± 0.052
0.88MetPhe: 0.88 ± 0.03
1.636MetGly: 1.636 ± 0.047
0.306MetHis: 0.306 ± 0.016
1.209MetIle: 1.209 ± 0.035
1.952MetLys: 1.952 ± 0.045
1.893MetLeu: 1.893 ± 0.048
0.384MetMet: 0.384 ± 0.028
0.821MetAsn: 0.821 ± 0.029
0.915MetPro: 0.915 ± 0.035
0.456MetGln: 0.456 ± 0.022
1.206MetArg: 1.206 ± 0.033
1.266MetSer: 1.266 ± 0.038
0.872MetThr: 0.872 ± 0.031
1.49MetVal: 1.49 ± 0.036
0.178MetTrp: 0.178 ± 0.014
0.58MetTyr: 0.58 ± 0.024
0.0MetXaa: 0.0 ± 0.0
Asn
2.341AsnAla: 2.341 ± 0.054
0.361AsnCys: 0.361 ± 0.019
1.449AsnAsp: 1.449 ± 0.052
2.456AsnGlu: 2.456 ± 0.054
2.095AsnPhe: 2.095 ± 0.053
2.152AsnGly: 2.152 ± 0.065
0.523AsnHis: 0.523 ± 0.023
3.609AsnIle: 3.609 ± 0.095
2.943AsnLys: 2.943 ± 0.075
4.771AsnLeu: 4.771 ± 0.077
0.801AsnMet: 0.801 ± 0.029
1.58AsnAsn: 1.58 ± 0.071
2.467AsnPro: 2.467 ± 0.053
0.944AsnGln: 0.944 ± 0.039
2.02AsnArg: 2.02 ± 0.046
1.949AsnSer: 1.949 ± 0.049
1.891AsnThr: 1.891 ± 0.052
2.874AsnVal: 2.874 ± 0.059
0.431AsnTrp: 0.431 ± 0.024
1.67AsnTyr: 1.67 ± 0.046
0.0AsnXaa: 0.0 ± 0.0
Pro
2.142ProAla: 2.142 ± 0.048
0.309ProCys: 0.309 ± 0.019
2.391ProAsp: 2.391 ± 0.048
4.235ProGlu: 4.235 ± 0.077
2.09ProPhe: 2.09 ± 0.05
1.986ProGly: 1.986 ± 0.049
0.756ProHis: 0.756 ± 0.023
2.399ProIle: 2.399 ± 0.048
2.679ProLys: 2.679 ± 0.059
3.599ProLeu: 3.599 ± 0.062
0.741ProMet: 0.741 ± 0.027
1.286ProAsn: 1.286 ± 0.034
1.754ProPro: 1.754 ± 0.053
1.088ProGln: 1.088 ± 0.032
1.523ProArg: 1.523 ± 0.04
2.256ProSer: 2.256 ± 0.048
1.778ProThr: 1.778 ± 0.053
3.435ProVal: 3.435 ± 0.065
0.338ProTrp: 0.338 ± 0.02
1.693ProTyr: 1.693 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
1.438GlnAla: 1.438 ± 0.042
0.153GlnCys: 0.153 ± 0.012
1.007GlnAsp: 1.007 ± 0.029
2.162GlnGlu: 2.162 ± 0.059
0.912GlnPhe: 0.912 ± 0.029
1.343GlnGly: 1.343 ± 0.038
0.354GlnHis: 0.354 ± 0.017
1.866GlnIle: 1.866 ± 0.047
2.013GlnLys: 2.013 ± 0.051
2.197GlnLeu: 2.197 ± 0.047
0.516GlnMet: 0.516 ± 0.024
0.979GlnAsn: 0.979 ± 0.035
0.831GlnPro: 0.831 ± 0.03
0.667GlnGln: 0.667 ± 0.034
1.307GlnArg: 1.307 ± 0.04
1.038GlnSer: 1.038 ± 0.031
1.058GlnThr: 1.058 ± 0.032
1.637GlnVal: 1.637 ± 0.049
0.193GlnTrp: 0.193 ± 0.014
0.659GlnTyr: 0.659 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
3.307ArgAla: 3.307 ± 0.061
0.428ArgCys: 0.428 ± 0.02
2.813ArgAsp: 2.813 ± 0.065
5.902ArgGlu: 5.902 ± 0.117
2.606ArgPhe: 2.606 ± 0.058
3.541ArgGly: 3.541 ± 0.065
0.778ArgHis: 0.778 ± 0.034
3.816ArgIle: 3.816 ± 0.061
4.439ArgLys: 4.439 ± 0.068
5.317ArgLeu: 5.317 ± 0.087
1.068ArgMet: 1.068 ± 0.035
1.963ArgAsn: 1.963 ± 0.049
1.522ArgPro: 1.522 ± 0.042
1.189ArgGln: 1.189 ± 0.035
3.245ArgArg: 3.245 ± 0.076
2.263ArgSer: 2.263 ± 0.047
1.936ArgThr: 1.936 ± 0.051
4.295ArgVal: 4.295 ± 0.075
0.638ArgTrp: 0.638 ± 0.029
2.1ArgTyr: 2.1 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
3.376SerAla: 3.376 ± 0.065
0.568SerCys: 0.568 ± 0.027
2.49SerAsp: 2.49 ± 0.05
3.899SerGlu: 3.899 ± 0.072
3.164SerPhe: 3.164 ± 0.065
3.917SerGly: 3.917 ± 0.071
0.825SerHis: 0.825 ± 0.034
3.975SerIle: 3.975 ± 0.073
3.901SerLys: 3.901 ± 0.075
6.518SerLeu: 6.518 ± 0.106
1.259SerMet: 1.259 ± 0.033
1.777SerAsn: 1.777 ± 0.048
2.372SerPro: 2.372 ± 0.049
1.406SerGln: 1.406 ± 0.04
2.574SerArg: 2.574 ± 0.054
3.354SerSer: 3.354 ± 0.079
2.318SerThr: 2.318 ± 0.054
4.1SerVal: 4.1 ± 0.066
0.528SerTrp: 0.528 ± 0.022
2.403SerTyr: 2.403 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
3.158ThrAla: 3.158 ± 0.065
0.38ThrCys: 0.38 ± 0.019
2.241ThrAsp: 2.241 ± 0.049
2.949ThrGlu: 2.949 ± 0.062
2.255ThrPhe: 2.255 ± 0.049
3.792ThrGly: 3.792 ± 0.073
0.755ThrHis: 0.755 ± 0.029
2.904ThrIle: 2.904 ± 0.058
2.929ThrLys: 2.929 ± 0.059
4.906ThrLeu: 4.906 ± 0.075
0.809ThrMet: 0.809 ± 0.028
1.495ThrAsn: 1.495 ± 0.047
2.249ThrPro: 2.249 ± 0.05
1.083ThrGln: 1.083 ± 0.03
1.656ThrArg: 1.656 ± 0.046
2.276ThrSer: 2.276 ± 0.054
2.223ThrThr: 2.223 ± 0.057
3.324ThrVal: 3.324 ± 0.068
0.307ThrTrp: 0.307 ± 0.02
1.837ThrTyr: 1.837 ± 0.052
0.0ThrXaa: 0.0 ± 0.0
Val
4.905ValAla: 4.905 ± 0.078
0.676ValCys: 0.676 ± 0.034
3.84ValAsp: 3.84 ± 0.065
6.546ValGlu: 6.546 ± 0.101
3.884ValPhe: 3.884 ± 0.074
5.431ValGly: 5.431 ± 0.077
1.187ValHis: 1.187 ± 0.035
5.614ValIle: 5.614 ± 0.09
6.521ValLys: 6.521 ± 0.082
7.777ValLeu: 7.777 ± 0.102
1.568ValMet: 1.568 ± 0.042
2.911ValAsn: 2.911 ± 0.058
3.041ValPro: 3.041 ± 0.065
1.618ValGln: 1.618 ± 0.042
4.193ValArg: 4.193 ± 0.071
5.075ValSer: 5.075 ± 0.076
2.072ValThr: 2.072 ± 0.05
6.993ValVal: 6.993 ± 0.122
0.741ValTrp: 0.741 ± 0.027
2.916ValTyr: 2.916 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.543TrpAla: 0.543 ± 0.024
0.092TrpCys: 0.092 ± 0.011
0.559TrpAsp: 0.559 ± 0.027
0.912TrpGlu: 0.912 ± 0.037
0.464TrpPhe: 0.464 ± 0.024
0.639TrpGly: 0.639 ± 0.026
0.189TrpHis: 0.189 ± 0.014
0.726TrpIle: 0.726 ± 0.029
0.845TrpLys: 0.845 ± 0.033
0.899TrpLeu: 0.899 ± 0.036
0.217TrpMet: 0.217 ± 0.015
0.372TrpAsn: 0.372 ± 0.018
0.142TrpPro: 0.142 ± 0.013
0.282TrpGln: 0.282 ± 0.016
0.454TrpArg: 0.454 ± 0.024
0.42TrpSer: 0.42 ± 0.018
0.372TrpThr: 0.372 ± 0.019
0.692TrpVal: 0.692 ± 0.032
0.118TrpTrp: 0.118 ± 0.011
0.294TrpTyr: 0.294 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.203TyrAla: 2.203 ± 0.052
0.311TyrCys: 0.311 ± 0.017
1.992TyrAsp: 1.992 ± 0.051
3.336TyrGlu: 3.336 ± 0.065
1.917TyrPhe: 1.917 ± 0.055
2.676TyrGly: 2.676 ± 0.054
0.655TyrHis: 0.655 ± 0.025
3.053TyrIle: 3.053 ± 0.064
2.809TyrLys: 2.809 ± 0.069
4.039TyrLeu: 4.039 ± 0.067
0.836TyrMet: 0.836 ± 0.033
1.493TyrAsn: 1.493 ± 0.039
1.694TyrPro: 1.694 ± 0.042
0.907TyrGln: 0.907 ± 0.038
2.436TyrArg: 2.436 ± 0.057
2.218TyrSer: 2.218 ± 0.053
1.83TyrThr: 1.83 ± 0.048
2.68TyrVal: 2.68 ± 0.052
0.389TyrTrp: 0.389 ± 0.022
1.607TyrTyr: 1.607 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3805 proteins (957714 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski