Amino acid dipepetide frequency for Brachybacterium nesterenkovii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.088AlaAla: 22.088 ± 0.252	0.939AlaCys: 0.939 ± 0.033	9.539AlaAsp: 9.539 ± 0.156	9.118AlaGlu: 9.118 ± 0.124	3.407AlaPhe: 3.407 ± 0.071	12.671AlaGly: 12.671 ± 0.149	2.759AlaHis: 2.759 ± 0.062	5.358AlaIle: 5.358 ± 0.088	2.263AlaLys: 2.263 ± 0.08	15.344AlaLeu: 15.344 ± 0.191	3.191AlaMet: 3.191 ± 0.066	1.648AlaAsn: 1.648 ± 0.054	8.532AlaPro: 8.532 ± 0.147	4.349AlaGln: 4.349 ± 0.076	11.049AlaArg: 11.049 ± 0.15	7.822AlaSer: 7.822 ± 0.109	7.015AlaThr: 7.015 ± 0.1	11.8AlaVal: 11.8 ± 0.12	1.959AlaTrp: 1.959 ± 0.05	2.193AlaTyr: 2.193 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.962CysAla: 0.962 ± 0.031	0.059CysCys: 0.059 ± 0.009	0.403CysAsp: 0.403 ± 0.022	0.373CysGlu: 0.373 ± 0.022	0.16CysPhe: 0.16 ± 0.015	0.762CysGly: 0.762 ± 0.032	0.157CysHis: 0.157 ± 0.013	0.231CysIle: 0.231 ± 0.019	0.056CysLys: 0.056 ± 0.008	0.546CysLeu: 0.546 ± 0.026	0.105CysMet: 0.105 ± 0.012	0.102CysAsn: 0.102 ± 0.01	0.426CysPro: 0.426 ± 0.023	0.131CysGln: 0.131 ± 0.011	0.506CysArg: 0.506 ± 0.031	0.391CysSer: 0.391 ± 0.023	0.425CysThr: 0.425 ± 0.024	0.508CysVal: 0.508 ± 0.026	0.095CysTrp: 0.095 ± 0.01	0.11CysTyr: 0.11 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	10.231AspAla: 10.231 ± 0.134	0.296AspCys: 0.296 ± 0.018	4.205AspAsp: 4.205 ± 0.086	4.376AspGlu: 4.376 ± 0.079	1.356AspPhe: 1.356 ± 0.039	6.66AspGly: 6.66 ± 0.129	1.3AspHis: 1.3 ± 0.037	2.157AspIle: 2.157 ± 0.056	0.862AspLys: 0.862 ± 0.036	6.933AspLeu: 6.933 ± 0.097	1.042AspMet: 1.042 ± 0.039	0.667AspAsn: 0.667 ± 0.032	5.049AspPro: 5.049 ± 0.087	1.53AspGln: 1.53 ± 0.049	4.883AspArg: 4.883 ± 0.085	2.457AspSer: 2.457 ± 0.049	2.752AspThr: 2.752 ± 0.057	5.474AspVal: 5.474 ± 0.079	0.781AspTrp: 0.781 ± 0.028	1.038AspTyr: 1.038 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.996GluAla: 7.996 ± 0.108	0.298GluCys: 0.298 ± 0.019	4.075GluAsp: 4.075 ± 0.078	3.579GluGlu: 3.579 ± 0.081	1.35GluPhe: 1.35 ± 0.046	4.86GluGly: 4.86 ± 0.071	1.97GluHis: 1.97 ± 0.049	2.852GluIle: 2.852 ± 0.068	1.319GluLys: 1.319 ± 0.05	6.44GluLeu: 6.44 ± 0.105	1.006GluMet: 1.006 ± 0.035	1.05GluAsn: 1.05 ± 0.036	3.104GluPro: 3.104 ± 0.063	2.386GluGln: 2.386 ± 0.06	5.914GluArg: 5.914 ± 0.089	2.706GluSer: 2.706 ± 0.061	3.227GluThr: 3.227 ± 0.06	4.689GluVal: 4.689 ± 0.062	0.549GluTrp: 0.549 ± 0.024	0.917GluTyr: 0.917 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.491PheAla: 3.491 ± 0.069	0.208PheCys: 0.208 ± 0.016	1.856PheAsp: 1.856 ± 0.05	1.524PheGlu: 1.524 ± 0.042	0.856PhePhe: 0.856 ± 0.035	2.688PheGly: 2.688 ± 0.064	0.561PheHis: 0.561 ± 0.026	0.893PheIle: 0.893 ± 0.04	0.359PheLys: 0.359 ± 0.022	2.501PheLeu: 2.501 ± 0.06	0.442PheMet: 0.442 ± 0.024	0.44PheAsn: 0.44 ± 0.021	1.319PhePro: 1.319 ± 0.042	0.592PheGln: 0.592 ± 0.025	1.595PheArg: 1.595 ± 0.048	1.461PheSer: 1.461 ± 0.043	1.779PheThr: 1.779 ± 0.044	2.147PheVal: 2.147 ± 0.055	0.413PheTrp: 0.413 ± 0.024	0.507PheTyr: 0.507 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	12.949GlyAla: 12.949 ± 0.176	0.675GlyCys: 0.675 ± 0.029	5.122GlyAsp: 5.122 ± 0.084	5.406GlyGlu: 5.406 ± 0.093	2.659GlyPhe: 2.659 ± 0.057	8.272GlyGly: 8.272 ± 0.132	1.963GlyHis: 1.963 ± 0.056	4.611GlyIle: 4.611 ± 0.079	1.873GlyLys: 1.873 ± 0.054	8.435GlyLeu: 8.435 ± 0.107	2.251GlyMet: 2.251 ± 0.055	1.247GlyAsn: 1.247 ± 0.042	4.729GlyPro: 4.729 ± 0.087	2.557GlyGln: 2.557 ± 0.065	7.463GlyArg: 7.463 ± 0.11	5.522GlySer: 5.522 ± 0.081	6.483GlyThr: 6.483 ± 0.095	6.94GlyVal: 6.94 ± 0.099	1.355GlyTrp: 1.355 ± 0.042	1.907GlyTyr: 1.907 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.602HisAla: 2.602 ± 0.059	0.145HisCys: 0.145 ± 0.013	1.487HisAsp: 1.487 ± 0.043	1.333HisGlu: 1.333 ± 0.045	0.428HisPhe: 0.428 ± 0.021	2.266HisGly: 2.266 ± 0.049	0.516HisHis: 0.516 ± 0.025	0.621HisIle: 0.621 ± 0.029	0.249HisLys: 0.249 ± 0.017	2.452HisLeu: 2.452 ± 0.063	0.319HisMet: 0.319 ± 0.019	0.31HisAsn: 0.31 ± 0.02	1.566HisPro: 1.566 ± 0.044	0.494HisGln: 0.494 ± 0.027	2.128HisArg: 2.128 ± 0.056	0.845HisSer: 0.845 ± 0.032	0.922HisThr: 0.922 ± 0.036	1.813HisVal: 1.813 ± 0.049	0.247HisTrp: 0.247 ± 0.017	0.386HisTyr: 0.386 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.717IleAla: 6.717 ± 0.097	0.293IleCys: 0.293 ± 0.018	3.373IleAsp: 3.373 ± 0.065	2.631IleGlu: 2.631 ± 0.058	0.871IlePhe: 0.871 ± 0.039	4.552IleGly: 4.552 ± 0.078	0.663IleHis: 0.663 ± 0.027	1.632IleIle: 1.632 ± 0.057	0.549IleLys: 0.549 ± 0.026	3.564IleLeu: 3.564 ± 0.073	0.694IleMet: 0.694 ± 0.027	0.631IleAsn: 0.631 ± 0.029	2.359IlePro: 2.359 ± 0.054	0.819IleGln: 0.819 ± 0.035	2.674IleArg: 2.674 ± 0.052	2.113IleSer: 2.113 ± 0.057	2.589IleThr: 2.589 ± 0.064	3.951IleVal: 3.951 ± 0.072	0.447IleTrp: 0.447 ± 0.026	0.556IleTyr: 0.556 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	2.126LysAla: 2.126 ± 0.069	0.069LysCys: 0.069 ± 0.01	1.117LysAsp: 1.117 ± 0.043	0.929LysGlu: 0.929 ± 0.045	0.338LysPhe: 0.338 ± 0.022	1.431LysGly: 1.431 ± 0.048	0.356LysHis: 0.356 ± 0.019	0.757LysIle: 0.757 ± 0.034	0.686LysLys: 0.686 ± 0.04	1.36LysLeu: 1.36 ± 0.047	0.283LysMet: 0.283 ± 0.018	0.441LysAsn: 0.441 ± 0.024	0.867LysPro: 0.867 ± 0.038	0.562LysGln: 0.562 ± 0.027	1.233LysArg: 1.233 ± 0.042	0.902LysSer: 0.902 ± 0.04	1.039LysThr: 1.039 ± 0.04	1.434LysVal: 1.434 ± 0.051	0.149LysTrp: 0.149 ± 0.014	0.324LysTyr: 0.324 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	15.883LeuAla: 15.883 ± 0.185	0.641LeuCys: 0.641 ± 0.028	6.74LeuAsp: 6.74 ± 0.088	5.787LeuGlu: 5.787 ± 0.086	2.38LeuPhe: 2.38 ± 0.062	9.603LeuGly: 9.603 ± 0.114	2.124LeuHis: 2.124 ± 0.051	3.773LeuIle: 3.773 ± 0.08	1.358LeuLys: 1.358 ± 0.054	10.961LeuLeu: 10.961 ± 0.157	1.785LeuMet: 1.785 ± 0.05	1.404LeuAsn: 1.404 ± 0.046	5.796LeuPro: 5.796 ± 0.09	2.297LeuGln: 2.297 ± 0.052	8.293LeuArg: 8.293 ± 0.11	5.108LeuSer: 5.108 ± 0.087	5.796LeuThr: 5.796 ± 0.096	9.34LeuVal: 9.34 ± 0.114	1.179LeuTrp: 1.179 ± 0.038	1.354LeuTyr: 1.354 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.398MetAla: 2.398 ± 0.057	0.126MetCys: 0.126 ± 0.012	1.064MetAsp: 1.064 ± 0.037	0.784MetGlu: 0.784 ± 0.031	0.502MetPhe: 0.502 ± 0.023	1.579MetGly: 1.579 ± 0.053	0.428MetHis: 0.428 ± 0.024	1.015MetIle: 1.015 ± 0.034	0.393MetLys: 0.393 ± 0.024	2.186MetLeu: 2.186 ± 0.054	0.4MetMet: 0.4 ± 0.019	0.483MetAsn: 0.483 ± 0.021	1.353MetPro: 1.353 ± 0.042	0.514MetGln: 0.514 ± 0.025	1.624MetArg: 1.624 ± 0.042	1.451MetSer: 1.451 ± 0.036	1.826MetThr: 1.826 ± 0.054	1.466MetVal: 1.466 ± 0.041	0.182MetTrp: 0.182 ± 0.015	0.272MetTyr: 0.272 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	1.944AsnAla: 1.944 ± 0.051	0.094AsnCys: 0.094 ± 0.013	0.779AsnAsp: 0.779 ± 0.034	0.66AsnGlu: 0.66 ± 0.028	0.365AsnPhe: 0.365 ± 0.021	1.377AsnGly: 1.377 ± 0.047	0.313AsnHis: 0.313 ± 0.019	0.657AsnIle: 0.657 ± 0.03	0.291AsnLys: 0.291 ± 0.02	1.495AsnLeu: 1.495 ± 0.043	0.296AsnMet: 0.296 ± 0.021	0.316AsnAsn: 0.316 ± 0.024	1.177AsnPro: 1.177 ± 0.04	0.388AsnGln: 0.388 ± 0.023	1.026AsnArg: 1.026 ± 0.037	0.732AsnSer: 0.732 ± 0.033	0.845AsnThr: 0.845 ± 0.032	1.175AsnVal: 1.175 ± 0.039	0.2AsnTrp: 0.2 ± 0.017	0.322AsnTyr: 0.322 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	8.88ProAla: 8.88 ± 0.135	0.28ProCys: 0.28 ± 0.018	4.035ProAsp: 4.035 ± 0.085	4.446ProGlu: 4.446 ± 0.076	1.623ProPhe: 1.623 ± 0.045	5.806ProGly: 5.806 ± 0.079	1.197ProHis: 1.197 ± 0.037	1.949ProIle: 1.949 ± 0.046	0.752ProLys: 0.752 ± 0.03	5.234ProLeu: 5.234 ± 0.08	1.04ProMet: 1.04 ± 0.034	0.685ProAsn: 0.685 ± 0.03	2.566ProPro: 2.566 ± 0.078	1.618ProGln: 1.618 ± 0.043	4.42ProArg: 4.42 ± 0.089	3.636ProSer: 3.636 ± 0.073	3.304ProThr: 3.304 ± 0.067	5.057ProVal: 5.057 ± 0.077	0.931ProTrp: 0.931 ± 0.034	0.96ProTyr: 0.96 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.535GlnAla: 3.535 ± 0.069	0.148GlnCys: 0.148 ± 0.014	1.502GlnAsp: 1.502 ± 0.048	1.553GlnGlu: 1.553 ± 0.047	0.667GlnPhe: 0.667 ± 0.029	2.471GlnGly: 2.471 ± 0.062	0.583GlnHis: 0.583 ± 0.026	1.384GlnIle: 1.384 ± 0.037	0.578GlnLys: 0.578 ± 0.03	2.613GlnLeu: 2.613 ± 0.062	0.573GlnMet: 0.573 ± 0.027	0.468GlnAsn: 0.468 ± 0.027	1.26GlnPro: 1.26 ± 0.045	1.087GlnGln: 1.087 ± 0.047	2.383GlnArg: 2.383 ± 0.061	1.272GlnSer: 1.272 ± 0.04	1.378GlnThr: 1.378 ± 0.04	2.315GlnVal: 2.315 ± 0.054	0.417GlnTrp: 0.417 ± 0.025	0.526GlnTyr: 0.526 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	10.783ArgAla: 10.783 ± 0.142	0.538ArgCys: 0.538 ± 0.026	4.672ArgAsp: 4.672 ± 0.085	5.425ArgGlu: 5.425 ± 0.092	2.27ArgPhe: 2.27 ± 0.046	6.317ArgGly: 6.317 ± 0.096	1.764ArgHis: 1.764 ± 0.047	3.956ArgIle: 3.956 ± 0.071	1.137ArgLys: 1.137 ± 0.042	7.965ArgLeu: 7.965 ± 0.116	1.957ArgMet: 1.957 ± 0.044	0.957ArgAsn: 0.957 ± 0.034	4.821ArgPro: 4.821 ± 0.103	1.85ArgGln: 1.85 ± 0.049	8.763ArgArg: 8.763 ± 0.15	4.612ArgSer: 4.612 ± 0.076	5.367ArgThr: 5.367 ± 0.078	5.467ArgVal: 5.467 ± 0.081	1.195ArgTrp: 1.195 ± 0.034	1.362ArgTyr: 1.362 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	7.738SerAla: 7.738 ± 0.096	0.376SerCys: 0.376 ± 0.023	3.052SerAsp: 3.052 ± 0.068	2.631SerGlu: 2.631 ± 0.061	1.638SerPhe: 1.638 ± 0.044	5.665SerGly: 5.665 ± 0.089	1.039SerHis: 1.039 ± 0.033	2.141SerIle: 2.141 ± 0.056	0.862SerLys: 0.862 ± 0.038	4.999SerLeu: 4.999 ± 0.08	1.231SerMet: 1.231 ± 0.04	0.79SerAsn: 0.79 ± 0.027	3.444SerPro: 3.444 ± 0.074	1.335SerGln: 1.335 ± 0.041	4.127SerArg: 4.127 ± 0.073	3.524SerSer: 3.524 ± 0.081	3.498SerThr: 3.498 ± 0.069	4.115SerVal: 4.115 ± 0.071	0.865SerTrp: 0.865 ± 0.03	0.947SerTyr: 0.947 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	8.507ThrAla: 8.507 ± 0.114	0.421ThrCys: 0.421 ± 0.026	3.611ThrAsp: 3.611 ± 0.063	3.109ThrGlu: 3.109 ± 0.065	1.573ThrPhe: 1.573 ± 0.051	6.325ThrGly: 6.325 ± 0.088	1.064ThrHis: 1.064 ± 0.029	2.539ThrIle: 2.539 ± 0.057	0.963ThrLys: 0.963 ± 0.041	5.47ThrLeu: 5.47 ± 0.091	1.143ThrMet: 1.143 ± 0.039	0.933ThrAsn: 0.933 ± 0.035	3.621ThrPro: 3.621 ± 0.064	1.326ThrGln: 1.326 ± 0.041	3.792ThrArg: 3.792 ± 0.072	3.363ThrSer: 3.363 ± 0.064	3.82ThrThr: 3.82 ± 0.09	5.424ThrVal: 5.424 ± 0.087	0.901ThrTrp: 0.901 ± 0.029	1.057ThrTyr: 1.057 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	10.536ValAla: 10.536 ± 0.118	0.626ValCys: 0.626 ± 0.029	5.486ValAsp: 5.486 ± 0.095	4.949ValGlu: 4.949 ± 0.084	2.224ValPhe: 2.224 ± 0.061	6.467ValGly: 6.467 ± 0.096	1.805ValHis: 1.805 ± 0.044	3.934ValIle: 3.934 ± 0.072	1.3ValLys: 1.3 ± 0.05	10.014ValLeu: 10.014 ± 0.135	1.67ValMet: 1.67 ± 0.046	1.234ValAsn: 1.234 ± 0.039	4.936ValPro: 4.936 ± 0.078	2.033ValGln: 2.033 ± 0.045	6.633ValArg: 6.633 ± 0.102	4.379ValSer: 4.379 ± 0.066	5.015ValThr: 5.015 ± 0.081	7.97ValVal: 7.97 ± 0.122	0.965ValTrp: 0.965 ± 0.038	1.255ValTyr: 1.255 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.527TrpAla: 1.527 ± 0.044	0.14TrpCys: 0.14 ± 0.013	0.742TrpAsp: 0.742 ± 0.028	0.688TrpGlu: 0.688 ± 0.027	0.446TrpPhe: 0.446 ± 0.026	1.011TrpGly: 1.011 ± 0.033	0.302TrpHis: 0.302 ± 0.017	0.655TrpIle: 0.655 ± 0.026	0.282TrpLys: 0.282 ± 0.019	1.35TrpLeu: 1.35 ± 0.042	0.34TrpMet: 0.34 ± 0.019	0.34TrpAsn: 0.34 ± 0.022	0.642TrpPro: 0.642 ± 0.029	0.383TrpGln: 0.383 ± 0.023	1.199TrpArg: 1.199 ± 0.042	0.847TrpSer: 0.847 ± 0.028	0.957TrpThr: 0.957 ± 0.034	0.964TrpVal: 0.964 ± 0.035	0.305TrpTrp: 0.305 ± 0.02	0.276TrpTyr: 0.276 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.149TyrAla: 2.149 ± 0.049	0.137TyrCys: 0.137 ± 0.013	1.188TyrAsp: 1.188 ± 0.039	0.988TyrGlu: 0.988 ± 0.035	0.518TyrPhe: 0.518 ± 0.031	1.636TyrGly: 1.636 ± 0.041	0.267TyrHis: 0.267 ± 0.018	0.567TyrIle: 0.567 ± 0.027	0.271TyrLys: 0.271 ± 0.019	1.739TyrLeu: 1.739 ± 0.045	0.275TyrMet: 0.275 ± 0.019	0.306TyrAsn: 0.306 ± 0.019	0.852TyrPro: 0.852 ± 0.03	0.461TyrGln: 0.461 ± 0.026	1.472TyrArg: 1.472 ± 0.046	0.873TyrSer: 0.873 ± 0.034	0.926TyrThr: 0.926 ± 0.035	1.383TyrVal: 1.383 ± 0.049	0.261TyrTrp: 0.261 ± 0.019	0.362TyrTyr: 0.362 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2675 proteins (870157 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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