Amino acid dipepetide frequency for Sinomonas humi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.393AlaAla: 20.393 ± 0.209	0.89AlaCys: 0.89 ± 0.032	6.958AlaAsp: 6.958 ± 0.084	8.991AlaGlu: 8.991 ± 0.122	4.041AlaPhe: 4.041 ± 0.057	12.128AlaGly: 12.128 ± 0.123	2.469AlaHis: 2.469 ± 0.048	5.272AlaIle: 5.272 ± 0.085	3.44AlaLys: 3.44 ± 0.062	13.707AlaLeu: 13.707 ± 0.138	2.661AlaMet: 2.661 ± 0.049	2.575AlaAsn: 2.575 ± 0.052	6.274AlaPro: 6.274 ± 0.099	4.362AlaGln: 4.362 ± 0.077	8.962AlaArg: 8.962 ± 0.103	7.713AlaSer: 7.713 ± 0.1	6.339AlaThr: 6.339 ± 0.098	11.98AlaVal: 11.98 ± 0.142	1.8AlaTrp: 1.8 ± 0.048	2.485AlaTyr: 2.485 ± 0.043	0.001AlaXaa: 0.001 ± 0.0
Cys	0.776CysAla: 0.776 ± 0.03	0.067CysCys: 0.067 ± 0.008	0.326CysAsp: 0.326 ± 0.017	0.357CysGlu: 0.357 ± 0.019	0.197CysPhe: 0.197 ± 0.014	0.77CysGly: 0.77 ± 0.03	0.151CysHis: 0.151 ± 0.012	0.249CysIle: 0.249 ± 0.014	0.095CysLys: 0.095 ± 0.009	0.591CysLeu: 0.591 ± 0.022	0.11CysMet: 0.11 ± 0.01	0.133CysAsn: 0.133 ± 0.01	0.352CysPro: 0.352 ± 0.019	0.177CysGln: 0.177 ± 0.015	0.429CysArg: 0.429 ± 0.02	0.413CysSer: 0.413 ± 0.022	0.454CysThr: 0.454 ± 0.022	0.453CysVal: 0.453 ± 0.022	0.087CysTrp: 0.087 ± 0.009	0.141CysTyr: 0.141 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.34AspAla: 7.34 ± 0.088	0.282AspCys: 0.282 ± 0.016	3.271AspAsp: 3.271 ± 0.063	3.86AspGlu: 3.86 ± 0.061	1.746AspPhe: 1.746 ± 0.042	5.494AspGly: 5.494 ± 0.075	1.172AspHis: 1.172 ± 0.034	2.058AspIle: 2.058 ± 0.045	1.126AspLys: 1.126 ± 0.037	5.703AspLeu: 5.703 ± 0.082	0.858AspMet: 0.858 ± 0.025	0.906AspAsn: 0.906 ± 0.033	3.84AspPro: 3.84 ± 0.063	1.506AspGln: 1.506 ± 0.041	3.856AspArg: 3.856 ± 0.071	2.62AspSer: 2.62 ± 0.05	2.396AspThr: 2.396 ± 0.049	4.888AspVal: 4.888 ± 0.069	0.821AspTrp: 0.821 ± 0.029	1.278AspTyr: 1.278 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	8.416GluAla: 8.416 ± 0.109	0.327GluCys: 0.327 ± 0.018	3.306GluAsp: 3.306 ± 0.062	3.884GluGlu: 3.884 ± 0.08	1.767GluPhe: 1.767 ± 0.04	4.988GluGly: 4.988 ± 0.073	1.623GluHis: 1.623 ± 0.039	2.639GluIle: 2.639 ± 0.053	1.624GluLys: 1.624 ± 0.044	7.09GluLeu: 7.09 ± 0.096	0.983GluMet: 0.983 ± 0.031	1.308GluAsn: 1.308 ± 0.038	3.091GluPro: 3.091 ± 0.07	2.309GluGln: 2.309 ± 0.049	5.398GluArg: 5.398 ± 0.088	3.056GluSer: 3.056 ± 0.052	2.988GluThr: 2.988 ± 0.057	4.599GluVal: 4.599 ± 0.072	0.922GluTrp: 0.922 ± 0.032	1.143GluTyr: 1.143 ± 0.033	0.001GluXaa: 0.001 ± 0.001
Phe	4.172PheAla: 4.172 ± 0.078	0.248PheCys: 0.248 ± 0.016	2.165PheAsp: 2.165 ± 0.049	1.908PheGlu: 1.908 ± 0.045	1.125PhePhe: 1.125 ± 0.037	3.427PheGly: 3.427 ± 0.063	0.639PheHis: 0.639 ± 0.026	1.155PheIle: 1.155 ± 0.036	0.658PheLys: 0.658 ± 0.026	2.849PheLeu: 2.849 ± 0.056	0.54PheMet: 0.54 ± 0.025	0.747PheAsn: 0.747 ± 0.027	1.533PhePro: 1.533 ± 0.036	0.784PheGln: 0.784 ± 0.032	1.908PheArg: 1.908 ± 0.046	1.854PheSer: 1.854 ± 0.041	1.99PheThr: 1.99 ± 0.052	2.693PheVal: 2.693 ± 0.055	0.455PheTrp: 0.455 ± 0.023	0.681PheTyr: 0.681 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	10.692GlyAla: 10.692 ± 0.135	0.703GlyCys: 0.703 ± 0.026	4.257GlyAsp: 4.257 ± 0.062	4.952GlyGlu: 4.952 ± 0.075	3.193GlyPhe: 3.193 ± 0.059	7.922GlyGly: 7.922 ± 0.117	2.073GlyHis: 2.073 ± 0.047	4.644GlyIle: 4.644 ± 0.081	2.611GlyLys: 2.611 ± 0.06	9.561GlyLeu: 9.561 ± 0.096	1.998GlyMet: 1.998 ± 0.044	2.002GlyAsn: 2.002 ± 0.045	4.32GlyPro: 4.32 ± 0.075	3.0GlyGln: 3.0 ± 0.051	6.68GlyArg: 6.68 ± 0.093	5.821GlySer: 5.821 ± 0.08	5.624GlyThr: 5.624 ± 0.072	7.51GlyVal: 7.51 ± 0.084	1.628GlyTrp: 1.628 ± 0.044	2.332GlyTyr: 2.332 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.53HisAla: 2.53 ± 0.05	0.153HisCys: 0.153 ± 0.013	1.171HisAsp: 1.171 ± 0.032	1.367HisGlu: 1.367 ± 0.039	0.615HisPhe: 0.615 ± 0.023	2.121HisGly: 2.121 ± 0.046	0.599HisHis: 0.599 ± 0.027	0.766HisIle: 0.766 ± 0.028	0.376HisLys: 0.376 ± 0.022	2.119HisLeu: 2.119 ± 0.05	0.373HisMet: 0.373 ± 0.018	0.397HisAsn: 0.397 ± 0.019	1.519HisPro: 1.519 ± 0.036	0.559HisGln: 0.559 ± 0.023	1.677HisArg: 1.677 ± 0.044	1.081HisSer: 1.081 ± 0.03	1.075HisThr: 1.075 ± 0.038	1.701HisVal: 1.701 ± 0.041	0.301HisTrp: 0.301 ± 0.017	0.495HisTyr: 0.495 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.995IleAla: 5.995 ± 0.074	0.274IleCys: 0.274 ± 0.017	2.669IleAsp: 2.669 ± 0.054	2.734IleGlu: 2.734 ± 0.049	1.162IlePhe: 1.162 ± 0.038	4.192IleGly: 4.192 ± 0.076	0.762IleHis: 0.762 ± 0.022	1.547IleIle: 1.547 ± 0.045	0.937IleLys: 0.937 ± 0.032	3.716IleLeu: 3.716 ± 0.075	0.682IleMet: 0.682 ± 0.028	1.008IleAsn: 1.008 ± 0.032	2.287IlePro: 2.287 ± 0.053	1.085IleGln: 1.085 ± 0.035	2.682IleArg: 2.682 ± 0.053	2.374IleSer: 2.374 ± 0.048	2.346IleThr: 2.346 ± 0.049	3.952IleVal: 3.952 ± 0.064	0.471IleTrp: 0.471 ± 0.022	0.681IleTyr: 0.681 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.417LysAla: 3.417 ± 0.062	0.1LysCys: 0.1 ± 0.01	1.472LysAsp: 1.472 ± 0.038	1.331LysGlu: 1.331 ± 0.039	0.642LysPhe: 0.642 ± 0.026	1.98LysGly: 1.98 ± 0.041	0.524LysHis: 0.524 ± 0.024	1.156LysIle: 1.156 ± 0.037	0.79LysLys: 0.79 ± 0.03	2.263LysLeu: 2.263 ± 0.045	0.466LysMet: 0.466 ± 0.022	0.598LysAsn: 0.598 ± 0.025	1.412LysPro: 1.412 ± 0.037	0.766LysGln: 0.766 ± 0.029	1.615LysArg: 1.615 ± 0.041	1.311LysSer: 1.311 ± 0.037	1.421LysThr: 1.421 ± 0.042	2.1LysVal: 2.1 ± 0.05	0.282LysTrp: 0.282 ± 0.016	0.577LysTyr: 0.577 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	15.242LeuAla: 15.242 ± 0.172	0.688LeuCys: 0.688 ± 0.026	6.192LeuAsp: 6.192 ± 0.081	6.107LeuGlu: 6.107 ± 0.09	2.913LeuPhe: 2.913 ± 0.051	9.92LeuGly: 9.92 ± 0.097	1.997LeuHis: 1.997 ± 0.044	3.939LeuIle: 3.939 ± 0.073	2.339LeuLys: 2.339 ± 0.05	10.0LeuLeu: 10.0 ± 0.127	1.731LeuMet: 1.731 ± 0.04	2.151LeuAsn: 2.151 ± 0.044	5.783LeuPro: 5.783 ± 0.08	2.493LeuGln: 2.493 ± 0.049	7.524LeuArg: 7.524 ± 0.101	5.811LeuSer: 5.811 ± 0.077	5.598LeuThr: 5.598 ± 0.078	9.051LeuVal: 9.051 ± 0.12	1.243LeuTrp: 1.243 ± 0.039	1.792LeuTyr: 1.792 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	2.482MetAla: 2.482 ± 0.05	0.125MetCys: 0.125 ± 0.01	0.956MetAsp: 0.956 ± 0.029	0.848MetGlu: 0.848 ± 0.033	0.582MetPhe: 0.582 ± 0.025	1.543MetGly: 1.543 ± 0.034	0.349MetHis: 0.349 ± 0.017	0.815MetIle: 0.815 ± 0.028	0.529MetLys: 0.529 ± 0.021	1.809MetLeu: 1.809 ± 0.035	0.367MetMet: 0.367 ± 0.02	0.5MetAsn: 0.5 ± 0.024	1.151MetPro: 1.151 ± 0.035	0.505MetGln: 0.505 ± 0.023	1.312MetArg: 1.312 ± 0.034	1.44MetSer: 1.44 ± 0.034	1.458MetThr: 1.458 ± 0.038	1.378MetVal: 1.378 ± 0.037	0.211MetTrp: 0.211 ± 0.013	0.306MetTyr: 0.306 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.714AsnAla: 2.714 ± 0.052	0.147AsnCys: 0.147 ± 0.012	1.11AsnAsp: 1.11 ± 0.036	1.087AsnGlu: 1.087 ± 0.034	0.73AsnPhe: 0.73 ± 0.029	2.191AsnGly: 2.191 ± 0.053	0.42AsnHis: 0.42 ± 0.019	0.888AsnIle: 0.888 ± 0.028	0.446AsnLys: 0.446 ± 0.024	2.135AsnLeu: 2.135 ± 0.051	0.41AsnMet: 0.41 ± 0.021	0.511AsnAsn: 0.511 ± 0.022	1.654AsnPro: 1.654 ± 0.043	0.702AsnGln: 0.702 ± 0.028	1.404AsnArg: 1.404 ± 0.04	1.228AsnSer: 1.228 ± 0.038	1.213AsnThr: 1.213 ± 0.036	1.852AsnVal: 1.852 ± 0.037	0.336AsnTrp: 0.336 ± 0.019	0.542AsnTyr: 0.542 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.136ProAla: 7.136 ± 0.116	0.228ProCys: 0.228 ± 0.015	3.53ProAsp: 3.53 ± 0.065	4.384ProGlu: 4.384 ± 0.072	1.694ProPhe: 1.694 ± 0.039	5.307ProGly: 5.307 ± 0.086	1.191ProHis: 1.191 ± 0.037	1.969ProIle: 1.969 ± 0.041	1.295ProLys: 1.295 ± 0.038	5.106ProLeu: 5.106 ± 0.082	0.948ProMet: 0.948 ± 0.028	1.207ProAsn: 1.207 ± 0.037	2.314ProPro: 2.314 ± 0.058	1.712ProGln: 1.712 ± 0.034	3.343ProArg: 3.343 ± 0.057	3.694ProSer: 3.694 ± 0.06	3.057ProThr: 3.057 ± 0.053	4.661ProVal: 4.661 ± 0.063	0.837ProTrp: 0.837 ± 0.033	1.093ProTyr: 1.093 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.927GlnAla: 3.927 ± 0.064	0.153GlnCys: 0.153 ± 0.012	1.378GlnAsp: 1.378 ± 0.039	1.563GlnGlu: 1.563 ± 0.039	0.916GlnPhe: 0.916 ± 0.024	2.396GlnGly: 2.396 ± 0.054	0.707GlnHis: 0.707 ± 0.028	1.444GlnIle: 1.444 ± 0.035	0.779GlnLys: 0.779 ± 0.026	3.535GlnLeu: 3.535 ± 0.061	0.561GlnMet: 0.561 ± 0.022	0.763GlnAsn: 0.763 ± 0.028	1.678GlnPro: 1.678 ± 0.044	1.335GlnGln: 1.335 ± 0.049	2.467GlnArg: 2.467 ± 0.057	1.603GlnSer: 1.603 ± 0.036	1.613GlnThr: 1.613 ± 0.046	2.271GlnVal: 2.271 ± 0.044	0.486GlnTrp: 0.486 ± 0.023	0.681GlnTyr: 0.681 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	8.436ArgAla: 8.436 ± 0.102	0.406ArgCys: 0.406 ± 0.019	3.681ArgAsp: 3.681 ± 0.061	4.858ArgGlu: 4.858 ± 0.082	2.3ArgPhe: 2.3 ± 0.055	5.462ArgGly: 5.462 ± 0.068	1.653ArgHis: 1.653 ± 0.043	3.395ArgIle: 3.395 ± 0.062	1.772ArgLys: 1.772 ± 0.048	7.962ArgLeu: 7.962 ± 0.11	1.516ArgMet: 1.516 ± 0.039	1.525ArgAsn: 1.525 ± 0.042	3.74ArgPro: 3.74 ± 0.064	2.224ArgGln: 2.224 ± 0.048	6.709ArgArg: 6.709 ± 0.115	4.054ArgSer: 4.054 ± 0.069	3.861ArgThr: 3.861 ± 0.069	5.45ArgVal: 5.45 ± 0.074	1.23ArgTrp: 1.23 ± 0.043	1.609ArgTyr: 1.609 ± 0.044	0.001ArgXaa: 0.001 ± 0.001
Ser	7.34SerAla: 7.34 ± 0.095	0.33SerCys: 0.33 ± 0.019	2.862SerAsp: 2.862 ± 0.057	3.234SerGlu: 3.234 ± 0.054	1.929SerPhe: 1.929 ± 0.048	6.11SerGly: 6.11 ± 0.082	1.132SerHis: 1.132 ± 0.036	2.441SerIle: 2.441 ± 0.045	1.355SerLys: 1.355 ± 0.039	5.896SerLeu: 5.896 ± 0.084	1.244SerMet: 1.244 ± 0.035	1.292SerAsn: 1.292 ± 0.032	3.409SerPro: 3.409 ± 0.063	1.759SerGln: 1.759 ± 0.042	3.955SerArg: 3.955 ± 0.062	4.064SerSer: 4.064 ± 0.09	3.29SerThr: 3.29 ± 0.062	4.651SerVal: 4.651 ± 0.07	0.893SerTrp: 0.893 ± 0.036	1.274SerTyr: 1.274 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	7.456ThrAla: 7.456 ± 0.09	0.298ThrCys: 0.298 ± 0.019	2.819ThrAsp: 2.819 ± 0.05	2.914ThrGlu: 2.914 ± 0.051	1.809ThrPhe: 1.809 ± 0.051	5.421ThrGly: 5.421 ± 0.086	1.041ThrHis: 1.041 ± 0.029	2.264ThrIle: 2.264 ± 0.044	1.328ThrLys: 1.328 ± 0.032	5.293ThrLeu: 5.293 ± 0.069	1.031ThrMet: 1.031 ± 0.032	1.222ThrAsn: 1.222 ± 0.034	3.551ThrPro: 3.551 ± 0.066	1.432ThrGln: 1.432 ± 0.039	3.096ThrArg: 3.096 ± 0.052	3.404ThrSer: 3.404 ± 0.064	3.381ThrThr: 3.381 ± 0.07	5.218ThrVal: 5.218 ± 0.081	0.76ThrTrp: 0.76 ± 0.027	1.163ThrTyr: 1.163 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	10.887ValAla: 10.887 ± 0.115	0.641ValCys: 0.641 ± 0.024	4.893ValAsp: 4.893 ± 0.063	5.091ValGlu: 5.091 ± 0.077	2.796ValPhe: 2.796 ± 0.05	6.974ValGly: 6.974 ± 0.1	1.8ValHis: 1.8 ± 0.044	3.561ValIle: 3.561 ± 0.063	1.901ValLys: 1.901 ± 0.047	9.271ValLeu: 9.271 ± 0.117	1.542ValMet: 1.542 ± 0.036	1.967ValAsn: 1.967 ± 0.045	4.93ValPro: 4.93 ± 0.068	2.371ValGln: 2.371 ± 0.045	6.055ValArg: 6.055 ± 0.082	4.848ValSer: 4.848 ± 0.076	4.831ValThr: 4.831 ± 0.067	8.586ValVal: 8.586 ± 0.107	1.099ValTrp: 1.099 ± 0.035	1.606ValTyr: 1.606 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.655TrpAla: 1.655 ± 0.044	0.113TrpCys: 0.113 ± 0.01	0.805TrpAsp: 0.805 ± 0.03	0.731TrpGlu: 0.731 ± 0.027	0.557TrpPhe: 0.557 ± 0.022	1.124TrpGly: 1.124 ± 0.034	0.324TrpHis: 0.324 ± 0.015	0.68TrpIle: 0.68 ± 0.029	0.388TrpLys: 0.388 ± 0.023	1.729TrpLeu: 1.729 ± 0.046	0.335TrpMet: 0.335 ± 0.017	0.454TrpAsn: 0.454 ± 0.023	0.698TrpPro: 0.698 ± 0.027	0.54TrpGln: 0.54 ± 0.026	1.097TrpArg: 1.097 ± 0.034	0.844TrpSer: 0.844 ± 0.028	0.8TrpThr: 0.8 ± 0.027	1.081TrpVal: 1.081 ± 0.029	0.299TrpTrp: 0.299 ± 0.017	0.269TrpTyr: 0.269 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.437TyrAla: 2.437 ± 0.045	0.152TyrCys: 0.152 ± 0.013	1.198TyrAsp: 1.198 ± 0.03	1.261TyrGlu: 1.261 ± 0.042	0.818TyrPhe: 0.818 ± 0.029	2.055TyrGly: 2.055 ± 0.044	0.369TyrHis: 0.369 ± 0.018	0.672TyrIle: 0.672 ± 0.028	0.434TyrLys: 0.434 ± 0.02	2.179TyrLeu: 2.179 ± 0.052	0.309TyrMet: 0.309 ± 0.017	0.454TyrAsn: 0.454 ± 0.022	1.167TyrPro: 1.167 ± 0.036	0.639TyrGln: 0.639 ± 0.028	1.671TyrArg: 1.671 ± 0.046	1.23TyrSer: 1.23 ± 0.038	1.168TyrThr: 1.168 ± 0.035	1.575TyrVal: 1.575 ± 0.039	0.359TyrTrp: 0.359 ± 0.02	0.521TyrTyr: 0.521 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3444 proteins (1076008 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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