Amino acid dipepetide frequency for Marinifilaceae bacterium T3-2 S1-C

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.258AlaAla: 4.258 ± 0.072	0.755AlaCys: 0.755 ± 0.031	3.544AlaAsp: 3.544 ± 0.054	3.805AlaGlu: 3.805 ± 0.065	3.329AlaPhe: 3.329 ± 0.061	4.137AlaGly: 4.137 ± 0.082	1.072AlaHis: 1.072 ± 0.03	5.449AlaIle: 5.449 ± 0.073	4.741AlaLys: 4.741 ± 0.069	6.042AlaLeu: 6.042 ± 0.094	1.642AlaMet: 1.642 ± 0.041	3.416AlaAsn: 3.416 ± 0.058	1.717AlaPro: 1.717 ± 0.04	2.268AlaGln: 2.268 ± 0.043	2.225AlaArg: 2.225 ± 0.049	3.977AlaSer: 3.977 ± 0.072	2.971AlaThr: 2.971 ± 0.066	3.767AlaVal: 3.767 ± 0.065	0.636AlaTrp: 0.636 ± 0.023	2.581AlaTyr: 2.581 ± 0.05	0.007AlaXaa: 0.007 ± 0.003
Cys	0.518CysAla: 0.518 ± 0.025	0.142CysCys: 0.142 ± 0.011	0.555CysAsp: 0.555 ± 0.023	0.617CysGlu: 0.617 ± 0.025	0.514CysPhe: 0.514 ± 0.024	0.786CysGly: 0.786 ± 0.032	0.245CysHis: 0.245 ± 0.023	0.713CysIle: 0.713 ± 0.024	0.682CysLys: 0.682 ± 0.029	0.867CysLeu: 0.867 ± 0.031	0.236CysMet: 0.236 ± 0.014	0.557CysAsn: 0.557 ± 0.02	0.448CysPro: 0.448 ± 0.023	0.284CysGln: 0.284 ± 0.014	0.377CysArg: 0.377 ± 0.017	0.728CysSer: 0.728 ± 0.028	0.499CysThr: 0.499 ± 0.024	0.551CysVal: 0.551 ± 0.025	0.095CysTrp: 0.095 ± 0.01	0.378CysTyr: 0.378 ± 0.018	0.003CysXaa: 0.003 ± 0.002
Asp	3.419AspAla: 3.419 ± 0.063	0.532AspCys: 0.532 ± 0.024	2.585AspAsp: 2.585 ± 0.055	3.45AspGlu: 3.45 ± 0.063	3.458AspPhe: 3.458 ± 0.066	3.395AspGly: 3.395 ± 0.072	1.001AspHis: 1.001 ± 0.032	4.479AspIle: 4.479 ± 0.065	4.104AspLys: 4.104 ± 0.063	5.806AspLeu: 5.806 ± 0.079	1.273AspMet: 1.273 ± 0.035	2.762AspAsn: 2.762 ± 0.053	1.737AspPro: 1.737 ± 0.044	1.998AspGln: 1.998 ± 0.052	2.134AspArg: 2.134 ± 0.041	3.27AspSer: 3.27 ± 0.059	2.405AspThr: 2.405 ± 0.051	3.304AspVal: 3.304 ± 0.068	0.708AspTrp: 0.708 ± 0.027	2.669AspTyr: 2.669 ± 0.053	0.013AspXaa: 0.013 ± 0.005
Glu	3.98GluAla: 3.98 ± 0.063	0.517GluCys: 0.517 ± 0.021	3.36GluAsp: 3.36 ± 0.063	4.965GluGlu: 4.965 ± 0.084	3.077GluPhe: 3.077 ± 0.058	3.467GluGly: 3.467 ± 0.061	1.09GluHis: 1.09 ± 0.03	5.927GluIle: 5.927 ± 0.077	6.121GluLys: 6.121 ± 0.093	6.603GluLeu: 6.603 ± 0.086	1.93GluMet: 1.93 ± 0.043	4.423GluAsn: 4.423 ± 0.067	1.384GluPro: 1.384 ± 0.038	2.275GluGln: 2.275 ± 0.05	2.477GluArg: 2.477 ± 0.049	3.764GluSer: 3.764 ± 0.058	2.851GluThr: 2.851 ± 0.05	3.98GluVal: 3.98 ± 0.069	0.669GluTrp: 0.669 ± 0.025	2.537GluTyr: 2.537 ± 0.046	0.018GluXaa: 0.018 ± 0.004
Phe	3.214PheAla: 3.214 ± 0.051	0.556PheCys: 0.556 ± 0.021	3.052PheAsp: 3.052 ± 0.06	3.233PheGlu: 3.233 ± 0.052	2.546PhePhe: 2.546 ± 0.053	3.444PheGly: 3.444 ± 0.053	0.973PheHis: 0.973 ± 0.03	3.901PheIle: 3.901 ± 0.066	3.352PheLys: 3.352 ± 0.059	4.918PheLeu: 4.918 ± 0.088	1.189PheMet: 1.189 ± 0.033	2.815PheAsn: 2.815 ± 0.055	1.731PhePro: 1.731 ± 0.038	1.73PheGln: 1.73 ± 0.036	1.92PheArg: 1.92 ± 0.042	3.886PheSer: 3.886 ± 0.067	2.92PheThr: 2.92 ± 0.064	3.083PheVal: 3.083 ± 0.055	0.606PheTrp: 0.606 ± 0.024	2.093PheTyr: 2.093 ± 0.046	0.019PheXaa: 0.019 ± 0.007
Gly	4.034GlyAla: 4.034 ± 0.08	0.688GlyCys: 0.688 ± 0.03	3.23GlyAsp: 3.23 ± 0.066	3.77GlyGlu: 3.77 ± 0.057	3.508GlyPhe: 3.508 ± 0.061	4.286GlyGly: 4.286 ± 0.086	1.076GlyHis: 1.076 ± 0.032	5.916GlyIle: 5.916 ± 0.082	5.437GlyLys: 5.437 ± 0.078	5.796GlyLeu: 5.796 ± 0.08	1.817GlyMet: 1.817 ± 0.045	3.71GlyAsn: 3.71 ± 0.068	1.185GlyPro: 1.185 ± 0.032	1.67GlyGln: 1.67 ± 0.041	2.256GlyArg: 2.256 ± 0.045	3.857GlySer: 3.857 ± 0.069	3.459GlyThr: 3.459 ± 0.078	4.296GlyVal: 4.296 ± 0.064	0.745GlyTrp: 0.745 ± 0.033	2.695GlyTyr: 2.695 ± 0.054	0.015GlyXaa: 0.015 ± 0.005
His	1.012HisAla: 1.012 ± 0.031	0.229HisCys: 0.229 ± 0.015	0.908HisAsp: 0.908 ± 0.028	1.043HisGlu: 1.043 ± 0.028	1.176HisPhe: 1.176 ± 0.033	1.092HisGly: 1.092 ± 0.037	0.493HisHis: 0.493 ± 0.022	1.45HisIle: 1.45 ± 0.039	1.233HisLys: 1.233 ± 0.035	2.018HisLeu: 2.018 ± 0.038	0.391HisMet: 0.391 ± 0.018	0.869HisAsn: 0.869 ± 0.027	0.985HisPro: 0.985 ± 0.032	0.77HisGln: 0.77 ± 0.024	0.76HisArg: 0.76 ± 0.026	1.149HisSer: 1.149 ± 0.033	0.873HisThr: 0.873 ± 0.027	0.949HisVal: 0.949 ± 0.026	0.216HisTrp: 0.216 ± 0.014	0.817HisTyr: 0.817 ± 0.027	0.008HisXaa: 0.008 ± 0.002
Ile	5.799IleAla: 5.799 ± 0.078	0.872IleCys: 0.872 ± 0.029	4.752IleAsp: 4.752 ± 0.068	5.333IleGlu: 5.333 ± 0.085	3.762IlePhe: 3.762 ± 0.064	5.414IleGly: 5.414 ± 0.081	1.722IleHis: 1.722 ± 0.042	6.174IleIle: 6.174 ± 0.092	5.737IleLys: 5.737 ± 0.081	7.816IleLeu: 7.816 ± 0.103	1.558IleMet: 1.558 ± 0.034	4.593IleAsn: 4.593 ± 0.072	3.582IlePro: 3.582 ± 0.054	3.059IleGln: 3.059 ± 0.058	3.355IleArg: 3.355 ± 0.059	6.382IleSer: 6.382 ± 0.078	4.191IleThr: 4.191 ± 0.064	4.81IleVal: 4.81 ± 0.077	0.816IleTrp: 0.816 ± 0.028	2.991IleTyr: 2.991 ± 0.05	0.019IleXaa: 0.019 ± 0.005
Lys	4.943LysAla: 4.943 ± 0.077	0.56LysCys: 0.56 ± 0.024	4.503LysAsp: 4.503 ± 0.065	6.509LysGlu: 6.509 ± 0.099	3.099LysPhe: 3.099 ± 0.051	4.721LysGly: 4.721 ± 0.064	1.409LysHis: 1.409 ± 0.037	6.665LysIle: 6.665 ± 0.092	6.752LysLys: 6.752 ± 0.109	7.053LysLeu: 7.053 ± 0.083	2.161LysMet: 2.161 ± 0.043	4.95LysAsn: 4.95 ± 0.081	2.203LysPro: 2.203 ± 0.041	2.949LysGln: 2.949 ± 0.058	3.096LysArg: 3.096 ± 0.054	4.85LysSer: 4.85 ± 0.074	4.084LysThr: 4.084 ± 0.064	4.639LysVal: 4.639 ± 0.074	0.794LysTrp: 0.794 ± 0.025	3.372LysTyr: 3.372 ± 0.058	0.019LysXaa: 0.019 ± 0.007
Leu	6.021LeuAla: 6.021 ± 0.087	0.9LeuCys: 0.9 ± 0.029	5.011LeuAsp: 5.011 ± 0.063	6.096LeuGlu: 6.096 ± 0.08	5.201LeuPhe: 5.201 ± 0.096	5.886LeuGly: 5.886 ± 0.084	1.745LeuHis: 1.745 ± 0.04	7.581LeuIle: 7.581 ± 0.102	7.972LeuLys: 7.972 ± 0.093	9.563LeuLeu: 9.563 ± 0.13	2.261LeuMet: 2.261 ± 0.051	5.729LeuAsn: 5.729 ± 0.073	3.546LeuPro: 3.546 ± 0.055	3.477LeuGln: 3.477 ± 0.065	3.653LeuArg: 3.653 ± 0.059	7.314LeuSer: 7.314 ± 0.084	4.441LeuThr: 4.441 ± 0.071	5.419LeuVal: 5.419 ± 0.079	0.81LeuTrp: 0.81 ± 0.029	3.269LeuTyr: 3.269 ± 0.059	0.024LeuXaa: 0.024 ± 0.006
Met	1.705MetAla: 1.705 ± 0.041	0.159MetCys: 0.159 ± 0.012	1.483MetAsp: 1.483 ± 0.037	1.699MetGlu: 1.699 ± 0.037	0.849MetPhe: 0.849 ± 0.028	1.779MetGly: 1.779 ± 0.042	0.44MetHis: 0.44 ± 0.021	1.89MetIle: 1.89 ± 0.043	2.266MetLys: 2.266 ± 0.049	2.038MetLeu: 2.038 ± 0.047	0.601MetMet: 0.601 ± 0.024	1.605MetAsn: 1.605 ± 0.038	0.951MetPro: 0.951 ± 0.027	0.875MetGln: 0.875 ± 0.028	0.925MetArg: 0.925 ± 0.024	1.416MetSer: 1.416 ± 0.031	1.035MetThr: 1.035 ± 0.025	1.576MetVal: 1.576 ± 0.042	0.18MetTrp: 0.18 ± 0.013	0.666MetTyr: 0.666 ± 0.022	0.008MetXaa: 0.008 ± 0.003
Asn	3.389AsnAla: 3.389 ± 0.059	0.565AsnCys: 0.565 ± 0.026	2.66AsnAsp: 2.66 ± 0.048	3.38AsnGlu: 3.38 ± 0.058	2.919AsnPhe: 2.919 ± 0.047	3.847AsnGly: 3.847 ± 0.069	1.087AsnHis: 1.087 ± 0.032	4.788AsnIle: 4.788 ± 0.07	4.448AsnLys: 4.448 ± 0.078	5.784AsnLeu: 5.784 ± 0.078	1.351AsnMet: 1.351 ± 0.03	3.228AsnAsn: 3.228 ± 0.069	2.702AsnPro: 2.702 ± 0.048	2.436AsnGln: 2.436 ± 0.049	2.501AsnArg: 2.501 ± 0.055	3.822AsnSer: 3.822 ± 0.061	3.081AsnThr: 3.081 ± 0.057	3.09AsnVal: 3.09 ± 0.06	0.831AsnTrp: 0.831 ± 0.03	2.78AsnTyr: 2.78 ± 0.052	0.025AsnXaa: 0.025 ± 0.006
Pro	1.981ProAla: 1.981 ± 0.046	0.294ProCys: 0.294 ± 0.015	2.12ProAsp: 2.12 ± 0.044	2.794ProGlu: 2.794 ± 0.049	1.725ProPhe: 1.725 ± 0.042	2.023ProGly: 2.023 ± 0.045	0.604ProHis: 0.604 ± 0.025	2.826ProIle: 2.826 ± 0.047	2.477ProLys: 2.477 ± 0.048	2.818ProLeu: 2.818 ± 0.049	0.764ProMet: 0.764 ± 0.026	2.035ProAsn: 2.035 ± 0.047	0.791ProPro: 0.791 ± 0.032	1.144ProGln: 1.144 ± 0.03	1.016ProArg: 1.016 ± 0.033	2.005ProSer: 2.005 ± 0.046	1.596ProThr: 1.596 ± 0.041	2.464ProVal: 2.464 ± 0.046	0.321ProTrp: 0.321 ± 0.017	1.337ProTyr: 1.337 ± 0.033	0.009ProXaa: 0.009 ± 0.003
Gln	2.217GlnAla: 2.217 ± 0.044	0.23GlnCys: 0.23 ± 0.014	1.715GlnAsp: 1.715 ± 0.04	2.501GlnGlu: 2.501 ± 0.052	1.772GlnPhe: 1.772 ± 0.047	1.732GlnGly: 1.732 ± 0.046	0.636GlnHis: 0.636 ± 0.023	3.219GlnIle: 3.219 ± 0.059	3.378GlnLys: 3.378 ± 0.065	3.663GlnLeu: 3.663 ± 0.057	1.005GlnMet: 1.005 ± 0.034	2.349GlnAsn: 2.349 ± 0.05	0.953GlnPro: 0.953 ± 0.034	1.388GlnGln: 1.388 ± 0.038	1.308GlnArg: 1.308 ± 0.039	2.061GlnSer: 2.061 ± 0.046	1.783GlnThr: 1.783 ± 0.046	2.017GlnVal: 2.017 ± 0.043	0.359GlnTrp: 0.359 ± 0.021	1.372GlnTyr: 1.372 ± 0.036	0.017GlnXaa: 0.017 ± 0.004
Arg	2.074ArgAla: 2.074 ± 0.035	0.324ArgCys: 0.324 ± 0.018	1.941ArgAsp: 1.941 ± 0.039	2.639ArgGlu: 2.639 ± 0.047	2.048ArgPhe: 2.048 ± 0.046	2.03ArgGly: 2.03 ± 0.047	0.658ArgHis: 0.658 ± 0.023	3.536ArgIle: 3.536 ± 0.06	3.684ArgLys: 3.684 ± 0.057	3.51ArgLeu: 3.51 ± 0.058	1.082ArgMet: 1.082 ± 0.025	2.414ArgAsn: 2.414 ± 0.047	1.118ArgPro: 1.118 ± 0.033	1.258ArgGln: 1.258 ± 0.032	1.587ArgArg: 1.587 ± 0.044	2.262ArgSer: 2.262 ± 0.05	1.868ArgThr: 1.868 ± 0.044	2.224ArgVal: 2.224 ± 0.04	0.426ArgTrp: 0.426 ± 0.021	1.664ArgTyr: 1.664 ± 0.044	0.018ArgXaa: 0.018 ± 0.005
Ser	3.823SerAla: 3.823 ± 0.063	0.712SerCys: 0.712 ± 0.024	3.72SerAsp: 3.72 ± 0.056	4.108SerGlu: 4.108 ± 0.063	3.75SerPhe: 3.75 ± 0.06	4.701SerGly: 4.701 ± 0.089	1.144SerHis: 1.144 ± 0.035	5.754SerIle: 5.754 ± 0.078	5.099SerLys: 5.099 ± 0.076	6.383SerLeu: 6.383 ± 0.082	1.486SerMet: 1.486 ± 0.041	3.777SerAsn: 3.777 ± 0.066	2.087SerPro: 2.087 ± 0.048	2.172SerGln: 2.172 ± 0.047	2.501SerArg: 2.501 ± 0.041	4.397SerSer: 4.397 ± 0.074	3.177SerThr: 3.177 ± 0.064	4.024SerVal: 4.024 ± 0.067	0.715SerTrp: 0.715 ± 0.03	2.83SerTyr: 2.83 ± 0.055	0.024SerXaa: 0.024 ± 0.007
Thr	3.189ThrAla: 3.189 ± 0.068	0.496ThrCys: 0.496 ± 0.024	2.932ThrAsp: 2.932 ± 0.052	2.795ThrGlu: 2.795 ± 0.05	2.313ThrPhe: 2.313 ± 0.05	3.773ThrGly: 3.773 ± 0.069	0.904ThrHis: 0.904 ± 0.029	4.251ThrIle: 4.251 ± 0.068	3.479ThrLys: 3.479 ± 0.061	4.332ThrLeu: 4.332 ± 0.066	0.859ThrMet: 0.859 ± 0.03	2.883ThrAsn: 2.883 ± 0.057	2.146ThrPro: 2.146 ± 0.047	1.642ThrGln: 1.642 ± 0.04	1.713ThrArg: 1.713 ± 0.044	3.359ThrSer: 3.359 ± 0.063	2.717ThrThr: 2.717 ± 0.061	2.962ThrVal: 2.962 ± 0.072	0.445ThrTrp: 0.445 ± 0.021	2.03ThrTyr: 2.03 ± 0.054	0.012ThrXaa: 0.012 ± 0.004
Val	3.803ValAla: 3.803 ± 0.061	0.686ValCys: 0.686 ± 0.027	3.726ValAsp: 3.726 ± 0.067	3.776ValGlu: 3.776 ± 0.06	3.165ValPhe: 3.165 ± 0.052	3.673ValGly: 3.673 ± 0.061	1.027ValHis: 1.027 ± 0.03	4.715ValIle: 4.715 ± 0.073	4.482ValLys: 4.482 ± 0.064	5.779ValLeu: 5.779 ± 0.086	1.395ValMet: 1.395 ± 0.037	3.554ValAsn: 3.554 ± 0.062	2.08ValPro: 2.08 ± 0.048	1.825ValGln: 1.825 ± 0.039	2.276ValArg: 2.276 ± 0.047	4.225ValSer: 4.225 ± 0.074	2.649ValThr: 2.649 ± 0.062	4.109ValVal: 4.109 ± 0.075	0.589ValTrp: 0.589 ± 0.026	2.228ValTyr: 2.228 ± 0.052	0.016ValXaa: 0.016 ± 0.004
Trp	0.584TrpAla: 0.584 ± 0.022	0.123TrpCys: 0.123 ± 0.011	0.625TrpAsp: 0.625 ± 0.025	0.742TrpGlu: 0.742 ± 0.026	0.553TrpPhe: 0.553 ± 0.022	0.717TrpGly: 0.717 ± 0.026	0.18TrpHis: 0.18 ± 0.013	0.887TrpIle: 0.887 ± 0.027	0.862TrpLys: 0.862 ± 0.032	0.954TrpLeu: 0.954 ± 0.03	0.337TrpMet: 0.337 ± 0.016	0.674TrpAsn: 0.674 ± 0.026	0.181TrpPro: 0.181 ± 0.012	0.409TrpGln: 0.409 ± 0.02	0.417TrpArg: 0.417 ± 0.023	0.67TrpSer: 0.67 ± 0.03	0.507TrpThr: 0.507 ± 0.027	0.614TrpVal: 0.614 ± 0.025	0.138TrpTrp: 0.138 ± 0.012	0.415TrpTyr: 0.415 ± 0.019	0.005TrpXaa: 0.005 ± 0.002
Tyr	2.364TyrAla: 2.364 ± 0.051	0.451TyrCys: 0.451 ± 0.023	2.072TyrAsp: 2.072 ± 0.047	2.146TyrGlu: 2.146 ± 0.047	2.403TyrPhe: 2.403 ± 0.056	2.52TyrGly: 2.52 ± 0.049	0.934TyrHis: 0.934 ± 0.032	2.594TyrIle: 2.594 ± 0.052	3.002TyrLys: 3.002 ± 0.057	4.141TyrLeu: 4.141 ± 0.068	0.8TyrMet: 0.8 ± 0.029	2.356TyrAsn: 2.356 ± 0.054	1.605TyrPro: 1.605 ± 0.04	2.037TyrGln: 2.037 ± 0.045	1.85TyrArg: 1.85 ± 0.042	2.968TyrSer: 2.968 ± 0.057	2.116TyrThr: 2.116 ± 0.052	1.88TyrVal: 1.88 ± 0.044	0.489TyrTrp: 0.489 ± 0.021	1.81TyrTyr: 1.81 ± 0.048	0.007TyrXaa: 0.007 ± 0.002
Xaa	0.012XaaAla: 0.012 ± 0.003	0.006XaaCys: 0.006 ± 0.003	0.01XaaAsp: 0.01 ± 0.005	0.015XaaGlu: 0.015 ± 0.004	0.013XaaPhe: 0.013 ± 0.004	0.025XaaGly: 0.025 ± 0.005	0.002XaaHis: 0.002 ± 0.001	0.02XaaIle: 0.02 ± 0.006	0.023XaaLys: 0.023 ± 0.006	0.032XaaLeu: 0.032 ± 0.009	0.008XaaMet: 0.008 ± 0.004	0.017XaaAsn: 0.017 ± 0.005	0.009XaaPro: 0.009 ± 0.003	0.01XaaGln: 0.01 ± 0.003	0.019XaaArg: 0.019 ± 0.006	0.023XaaSer: 0.023 ± 0.006	0.011XaaThr: 0.011 ± 0.003	0.018XaaVal: 0.018 ± 0.004	0.006XaaTrp: 0.006 ± 0.002	0.011XaaTyr: 0.011 ± 0.004	0.036XaaXaa: 0.036 ± 0.011

Statistics based on 3389 proteins (1141565 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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