Amino acid dipepetide frequency for Staphylococcus virus 108PVL

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.753AlaAla: 1.753 ± 0.677
0.457AlaCys: 0.457 ± 0.201
1.906AlaAsp: 1.906 ± 0.334
2.897AlaGlu: 2.897 ± 0.478
2.287AlaPhe: 2.287 ± 0.564
3.583AlaGly: 3.583 ± 0.669
0.686AlaHis: 0.686 ± 0.247
3.887AlaIle: 3.887 ± 0.566
4.497AlaLys: 4.497 ± 0.632
5.031AlaLeu: 5.031 ± 0.677
1.448AlaMet: 1.448 ± 0.305
3.506AlaAsn: 3.506 ± 0.48
1.296AlaPro: 1.296 ± 0.29
2.592AlaGln: 2.592 ± 0.456
3.201AlaArg: 3.201 ± 0.457
3.583AlaSer: 3.583 ± 0.579
4.192AlaThr: 4.192 ± 0.499
3.278AlaVal: 3.278 ± 0.398
0.305AlaTrp: 0.305 ± 0.132
1.829AlaTyr: 1.829 ± 0.355
0.0AlaXaa: 0.0 ± 0.0
Cys
0.305CysAla: 0.305 ± 0.153
0.0CysCys: 0.0 ± 0.0
0.229CysAsp: 0.229 ± 0.158
0.534CysGlu: 0.534 ± 0.217
0.305CysPhe: 0.305 ± 0.166
0.457CysGly: 0.457 ± 0.22
0.229CysHis: 0.229 ± 0.13
0.61CysIle: 0.61 ± 0.185
0.381CysLys: 0.381 ± 0.16
0.305CysLeu: 0.305 ± 0.124
0.152CysMet: 0.152 ± 0.102
0.305CysAsn: 0.305 ± 0.148
0.152CysPro: 0.152 ± 0.109
0.0CysGln: 0.0 ± 0.0
0.305CysArg: 0.305 ± 0.194
0.457CysSer: 0.457 ± 0.183
0.152CysThr: 0.152 ± 0.088
0.457CysVal: 0.457 ± 0.222
0.0CysTrp: 0.0 ± 0.0
0.457CysTyr: 0.457 ± 0.174
0.0CysXaa: 0.0 ± 0.0
Asp
2.744AspAla: 2.744 ± 0.395
0.381AspCys: 0.381 ± 0.178
4.116AspAsp: 4.116 ± 0.634
5.717AspGlu: 5.717 ± 0.699
3.201AspPhe: 3.201 ± 0.54
3.278AspGly: 3.278 ± 0.616
1.067AspHis: 1.067 ± 0.268
5.412AspIle: 5.412 ± 0.7
5.717AspLys: 5.717 ± 0.581
4.955AspLeu: 4.955 ± 0.622
1.753AspMet: 1.753 ± 0.325
3.278AspAsn: 3.278 ± 0.456
1.525AspPro: 1.525 ± 0.412
1.22AspGln: 1.22 ± 0.33
2.363AspArg: 2.363 ± 0.475
3.964AspSer: 3.964 ± 0.671
4.497AspThr: 4.497 ± 0.513
2.973AspVal: 2.973 ± 0.447
0.457AspTrp: 0.457 ± 0.194
3.201AspTyr: 3.201 ± 0.361
0.0AspXaa: 0.0 ± 0.0
Glu
3.354GluAla: 3.354 ± 0.7
0.457GluCys: 0.457 ± 0.155
3.811GluAsp: 3.811 ± 0.593
5.26GluGlu: 5.26 ± 0.698
3.201GluPhe: 3.201 ± 0.484
2.668GluGly: 2.668 ± 0.434
0.838GluHis: 0.838 ± 0.265
6.25GluIle: 6.25 ± 0.772
7.089GluLys: 7.089 ± 1.007
6.86GluLeu: 6.86 ± 1.0
2.515GluMet: 2.515 ± 0.416
5.717GluAsn: 5.717 ± 0.671
1.982GluPro: 1.982 ± 0.388
3.125GluGln: 3.125 ± 0.596
3.201GluArg: 3.201 ± 0.571
4.116GluSer: 4.116 ± 0.471
3.887GluThr: 3.887 ± 0.535
4.269GluVal: 4.269 ± 0.581
0.686GluTrp: 0.686 ± 0.233
3.583GluTyr: 3.583 ± 0.677
0.0GluXaa: 0.0 ± 0.0
Phe
1.829PheAla: 1.829 ± 0.366
0.381PheCys: 0.381 ± 0.19
2.668PheAsp: 2.668 ± 0.389
2.744PheGlu: 2.744 ± 0.519
0.762PhePhe: 0.762 ± 0.2
2.592PheGly: 2.592 ± 0.42
1.067PheHis: 1.067 ± 0.268
3.811PheIle: 3.811 ± 0.574
4.04PheLys: 4.04 ± 0.476
2.058PheLeu: 2.058 ± 0.37
1.22PheMet: 1.22 ± 0.302
3.506PheAsn: 3.506 ± 0.465
0.61PhePro: 0.61 ± 0.248
1.296PheGln: 1.296 ± 0.272
1.753PheArg: 1.753 ± 0.325
2.668PheSer: 2.668 ± 0.415
2.211PheThr: 2.211 ± 0.483
2.592PheVal: 2.592 ± 0.478
0.152PheTrp: 0.152 ± 0.09
1.448PheTyr: 1.448 ± 0.276
0.0PheXaa: 0.0 ± 0.0
Gly
3.354GlyAla: 3.354 ± 0.615
0.229GlyCys: 0.229 ± 0.129
3.125GlyAsp: 3.125 ± 0.455
3.201GlyGlu: 3.201 ± 0.563
3.43GlyPhe: 3.43 ± 0.483
3.43GlyGly: 3.43 ± 0.811
1.525GlyHis: 1.525 ± 0.338
4.192GlyIle: 4.192 ± 0.81
5.946GlyLys: 5.946 ± 0.819
4.726GlyLeu: 4.726 ± 0.84
1.296GlyMet: 1.296 ± 0.354
3.887GlyAsn: 3.887 ± 0.564
0.915GlyPro: 0.915 ± 0.273
2.211GlyGln: 2.211 ± 0.441
2.363GlyArg: 2.363 ± 0.428
3.354GlySer: 3.354 ± 0.435
2.897GlyThr: 2.897 ± 0.436
3.506GlyVal: 3.506 ± 0.628
1.067GlyTrp: 1.067 ± 0.345
3.354GlyTyr: 3.354 ± 0.481
0.0GlyXaa: 0.0 ± 0.0
His
0.991HisAla: 0.991 ± 0.327
0.152HisCys: 0.152 ± 0.106
0.838HisAsp: 0.838 ± 0.273
1.448HisGlu: 1.448 ± 0.313
0.838HisPhe: 0.838 ± 0.232
0.534HisGly: 0.534 ± 0.213
0.305HisHis: 0.305 ± 0.183
1.601HisIle: 1.601 ± 0.413
1.601HisLys: 1.601 ± 0.362
1.677HisLeu: 1.677 ± 0.314
0.457HisMet: 0.457 ± 0.155
1.448HisAsn: 1.448 ± 0.404
0.534HisPro: 0.534 ± 0.185
0.61HisGln: 0.61 ± 0.192
0.762HisArg: 0.762 ± 0.187
1.143HisSer: 1.143 ± 0.225
1.448HisThr: 1.448 ± 0.383
0.991HisVal: 0.991 ± 0.292
0.305HisTrp: 0.305 ± 0.143
0.838HisTyr: 0.838 ± 0.25
0.0HisXaa: 0.0 ± 0.0
Ile
4.421IleAla: 4.421 ± 0.555
0.534IleCys: 0.534 ± 0.218
5.336IleAsp: 5.336 ± 0.558
6.555IleGlu: 6.555 ± 0.777
2.363IlePhe: 2.363 ± 0.504
3.811IleGly: 3.811 ± 0.465
1.448IleHis: 1.448 ± 0.325
5.031IleIle: 5.031 ± 0.604
8.08IleLys: 8.08 ± 0.712
5.107IleLeu: 5.107 ± 0.682
1.829IleMet: 1.829 ± 0.298
5.717IleAsn: 5.717 ± 0.556
2.363IlePro: 2.363 ± 0.393
3.125IleGln: 3.125 ± 0.406
2.744IleArg: 2.744 ± 0.486
5.488IleSer: 5.488 ± 0.645
5.107IleThr: 5.107 ± 0.516
4.726IleVal: 4.726 ± 0.571
0.686IleTrp: 0.686 ± 0.402
2.515IleTyr: 2.515 ± 0.417
0.0IleXaa: 0.0 ± 0.0
Lys
6.022LysAla: 6.022 ± 0.572
0.229LysCys: 0.229 ± 0.16
6.022LysAsp: 6.022 ± 0.567
6.784LysGlu: 6.784 ± 0.872
4.04LysPhe: 4.04 ± 0.625
6.327LysGly: 6.327 ± 0.823
1.753LysHis: 1.753 ± 0.462
6.098LysIle: 6.098 ± 0.638
7.927LysLys: 7.927 ± 0.855
8.918LysLeu: 8.918 ± 0.817
2.287LysMet: 2.287 ± 0.464
4.955LysAsn: 4.955 ± 0.652
2.973LysPro: 2.973 ± 0.549
4.04LysGln: 4.04 ± 0.663
4.497LysArg: 4.497 ± 0.699
5.26LysSer: 5.26 ± 0.631
6.403LysThr: 6.403 ± 0.861
5.641LysVal: 5.641 ± 0.659
1.296LysTrp: 1.296 ± 0.341
4.65LysTyr: 4.65 ± 0.594
0.0LysXaa: 0.0 ± 0.0
Leu
3.506LeuAla: 3.506 ± 0.513
0.305LeuCys: 0.305 ± 0.133
5.107LeuAsp: 5.107 ± 0.723
6.327LeuGlu: 6.327 ± 0.827
3.049LeuPhe: 3.049 ± 0.547
4.497LeuGly: 4.497 ± 0.705
1.296LeuHis: 1.296 ± 0.242
5.793LeuIle: 5.793 ± 0.611
8.385LeuLys: 8.385 ± 1.04
6.022LeuLeu: 6.022 ± 0.847
1.22LeuMet: 1.22 ± 0.273
6.174LeuAsn: 6.174 ± 0.703
2.363LeuPro: 2.363 ± 0.492
2.744LeuGln: 2.744 ± 0.34
3.201LeuArg: 3.201 ± 0.507
5.946LeuSer: 5.946 ± 0.846
3.887LeuThr: 3.887 ± 0.435
4.421LeuVal: 4.421 ± 0.535
0.686LeuTrp: 0.686 ± 0.24
3.049LeuTyr: 3.049 ± 0.439
0.0LeuXaa: 0.0 ± 0.0
Met
1.601MetAla: 1.601 ± 0.319
0.152MetCys: 0.152 ± 0.113
1.448MetAsp: 1.448 ± 0.288
1.601MetGlu: 1.601 ± 0.39
1.601MetPhe: 1.601 ± 0.252
0.915MetGly: 0.915 ± 0.286
0.305MetHis: 0.305 ± 0.15
1.448MetIle: 1.448 ± 0.311
2.82MetLys: 2.82 ± 0.545
1.677MetLeu: 1.677 ± 0.307
0.686MetMet: 0.686 ± 0.246
2.134MetAsn: 2.134 ± 0.431
1.296MetPro: 1.296 ± 0.309
0.991MetGln: 0.991 ± 0.33
1.372MetArg: 1.372 ± 0.295
2.211MetSer: 2.211 ± 0.259
1.296MetThr: 1.296 ± 0.291
1.067MetVal: 1.067 ± 0.241
0.457MetTrp: 0.457 ± 0.156
1.067MetTyr: 1.067 ± 0.246
0.0MetXaa: 0.0 ± 0.0
Asn
3.049AsnAla: 3.049 ± 0.552
0.152AsnCys: 0.152 ± 0.099
4.574AsnAsp: 4.574 ± 0.591
4.802AsnGlu: 4.802 ± 0.565
1.601AsnPhe: 1.601 ± 0.45
5.869AsnGly: 5.869 ± 0.899
1.143AsnHis: 1.143 ± 0.304
5.488AsnIle: 5.488 ± 0.627
6.022AsnLys: 6.022 ± 0.713
5.107AsnLeu: 5.107 ± 0.59
2.211AsnMet: 2.211 ± 0.321
5.412AsnAsn: 5.412 ± 0.878
2.973AsnPro: 2.973 ± 0.399
3.811AsnGln: 3.811 ± 0.535
2.363AsnArg: 2.363 ± 0.351
4.345AsnSer: 4.345 ± 0.567
3.583AsnThr: 3.583 ± 0.455
3.506AsnVal: 3.506 ± 0.582
1.372AsnTrp: 1.372 ± 0.418
3.278AsnTyr: 3.278 ± 0.476
0.0AsnXaa: 0.0 ± 0.0
Pro
1.067ProAla: 1.067 ± 0.278
0.076ProCys: 0.076 ± 0.092
1.448ProAsp: 1.448 ± 0.328
1.982ProGlu: 1.982 ± 0.394
0.838ProPhe: 0.838 ± 0.265
1.448ProGly: 1.448 ± 0.299
0.534ProHis: 0.534 ± 0.215
2.363ProIle: 2.363 ± 0.349
2.897ProLys: 2.897 ± 0.575
2.287ProLeu: 2.287 ± 0.524
1.143ProMet: 1.143 ± 0.305
2.439ProAsn: 2.439 ± 0.354
1.067ProPro: 1.067 ± 0.225
0.915ProGln: 0.915 ± 0.284
0.686ProArg: 0.686 ± 0.238
1.753ProSer: 1.753 ± 0.444
1.677ProThr: 1.677 ± 0.453
1.296ProVal: 1.296 ± 0.271
0.305ProTrp: 0.305 ± 0.142
1.143ProTyr: 1.143 ± 0.279
0.0ProXaa: 0.0 ± 0.0
Gln
3.43GlnAla: 3.43 ± 0.477
0.534GlnCys: 0.534 ± 0.221
2.287GlnAsp: 2.287 ± 0.386
3.049GlnGlu: 3.049 ± 0.673
1.601GlnPhe: 1.601 ± 0.413
1.525GlnGly: 1.525 ± 0.351
0.61GlnHis: 0.61 ± 0.183
2.744GlnIle: 2.744 ± 0.437
3.125GlnLys: 3.125 ± 0.508
2.897GlnLeu: 2.897 ± 0.366
0.991GlnMet: 0.991 ± 0.277
3.659GlnAsn: 3.659 ± 0.744
0.838GlnPro: 0.838 ± 0.201
1.525GlnGln: 1.525 ± 0.332
2.211GlnArg: 2.211 ± 0.417
2.211GlnSer: 2.211 ± 0.489
2.134GlnThr: 2.134 ± 0.373
2.134GlnVal: 2.134 ± 0.417
0.305GlnTrp: 0.305 ± 0.131
1.525GlnTyr: 1.525 ± 0.383
0.0GlnXaa: 0.0 ± 0.0
Arg
2.287ArgAla: 2.287 ± 0.433
0.305ArgCys: 0.305 ± 0.185
3.125ArgAsp: 3.125 ± 0.424
3.659ArgGlu: 3.659 ± 0.561
1.525ArgPhe: 1.525 ± 0.288
1.982ArgGly: 1.982 ± 0.337
1.22ArgHis: 1.22 ± 0.286
3.506ArgIle: 3.506 ± 0.547
4.04ArgLys: 4.04 ± 0.568
3.278ArgLeu: 3.278 ± 0.461
1.067ArgMet: 1.067 ± 0.318
2.897ArgAsn: 2.897 ± 0.375
0.762ArgPro: 0.762 ± 0.244
1.601ArgGln: 1.601 ± 0.46
2.134ArgArg: 2.134 ± 0.385
1.525ArgSer: 1.525 ± 0.32
2.82ArgThr: 2.82 ± 0.377
2.363ArgVal: 2.363 ± 0.4
0.534ArgTrp: 0.534 ± 0.165
2.439ArgTyr: 2.439 ± 0.506
0.0ArgXaa: 0.0 ± 0.0
Ser
3.43SerAla: 3.43 ± 0.641
0.152SerCys: 0.152 ± 0.105
4.421SerAsp: 4.421 ± 0.715
5.107SerGlu: 5.107 ± 0.611
2.515SerPhe: 2.515 ± 0.438
4.192SerGly: 4.192 ± 0.635
1.296SerHis: 1.296 ± 0.26
6.25SerIle: 6.25 ± 0.638
6.098SerLys: 6.098 ± 0.739
4.116SerLeu: 4.116 ± 0.489
1.525SerMet: 1.525 ± 0.36
4.421SerAsn: 4.421 ± 0.586
0.915SerPro: 0.915 ± 0.3
2.973SerGln: 2.973 ± 0.584
2.897SerArg: 2.897 ± 0.382
3.887SerSer: 3.887 ± 0.521
2.973SerThr: 2.973 ± 0.458
2.897SerVal: 2.897 ± 0.526
0.534SerTrp: 0.534 ± 0.184
2.592SerTyr: 2.592 ± 0.599
0.0SerXaa: 0.0 ± 0.0
Thr
3.354ThrAla: 3.354 ± 0.483
0.305ThrCys: 0.305 ± 0.155
4.497ThrAsp: 4.497 ± 0.568
3.201ThrGlu: 3.201 ± 0.543
1.906ThrPhe: 1.906 ± 0.37
4.192ThrGly: 4.192 ± 0.66
1.601ThrHis: 1.601 ± 0.372
4.726ThrIle: 4.726 ± 0.463
5.107ThrLys: 5.107 ± 0.617
4.116ThrLeu: 4.116 ± 0.522
0.991ThrMet: 0.991 ± 0.27
2.973ThrAsn: 2.973 ± 0.569
2.287ThrPro: 2.287 ± 0.393
2.058ThrGln: 2.058 ± 0.424
2.82ThrArg: 2.82 ± 0.424
5.031ThrSer: 5.031 ± 0.711
3.583ThrThr: 3.583 ± 0.561
3.583ThrVal: 3.583 ± 0.557
0.838ThrTrp: 0.838 ± 0.265
2.439ThrTyr: 2.439 ± 0.421
0.0ThrXaa: 0.0 ± 0.0
Val
3.049ValAla: 3.049 ± 0.44
0.534ValCys: 0.534 ± 0.25
3.354ValAsp: 3.354 ± 0.508
4.04ValGlu: 4.04 ± 0.653
1.982ValPhe: 1.982 ± 0.38
3.583ValGly: 3.583 ± 0.818
0.61ValHis: 0.61 ± 0.219
3.887ValIle: 3.887 ± 0.534
6.784ValLys: 6.784 ± 0.635
4.574ValLeu: 4.574 ± 0.479
1.601ValMet: 1.601 ± 0.361
3.964ValAsn: 3.964 ± 0.504
1.525ValPro: 1.525 ± 0.316
1.982ValGln: 1.982 ± 0.341
1.829ValArg: 1.829 ± 0.371
3.201ValSer: 3.201 ± 0.465
4.345ValThr: 4.345 ± 0.756
4.345ValVal: 4.345 ± 0.656
0.381ValTrp: 0.381 ± 0.178
1.601ValTyr: 1.601 ± 0.292
0.0ValXaa: 0.0 ± 0.0
Trp
0.305TrpAla: 0.305 ± 0.162
0.0TrpCys: 0.0 ± 0.0
0.61TrpAsp: 0.61 ± 0.23
0.686TrpGlu: 0.686 ± 0.2
0.61TrpPhe: 0.61 ± 0.186
0.686TrpGly: 0.686 ± 0.219
0.0TrpHis: 0.0 ± 0.0
1.296TrpIle: 1.296 ± 0.351
0.915TrpLys: 0.915 ± 0.263
0.915TrpLeu: 0.915 ± 0.287
0.534TrpMet: 0.534 ± 0.186
1.067TrpAsn: 1.067 ± 0.395
0.229TrpPro: 0.229 ± 0.114
0.61TrpGln: 0.61 ± 0.181
0.457TrpArg: 0.457 ± 0.161
0.229TrpSer: 0.229 ± 0.12
0.61TrpThr: 0.61 ± 0.156
0.915TrpVal: 0.915 ± 0.291
0.152TrpTrp: 0.152 ± 0.097
0.305TrpTyr: 0.305 ± 0.136
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.363TyrAla: 2.363 ± 0.352
0.457TyrCys: 0.457 ± 0.171
2.897TyrAsp: 2.897 ± 0.526
3.278TyrGlu: 3.278 ± 0.409
1.753TyrPhe: 1.753 ± 0.394
2.439TyrGly: 2.439 ± 0.521
0.991TyrHis: 0.991 ± 0.253
2.668TyrIle: 2.668 ± 0.467
4.65TyrLys: 4.65 ± 0.515
3.354TyrLeu: 3.354 ± 0.532
1.143TyrMet: 1.143 ± 0.297
3.201TyrAsn: 3.201 ± 0.427
0.762TyrPro: 0.762 ± 0.16
1.906TyrGln: 1.906 ± 0.336
1.906TyrArg: 1.906 ± 0.405
2.82TyrSer: 2.82 ± 0.422
1.906TyrThr: 1.906 ± 0.401
2.211TyrVal: 2.211 ± 0.346
0.61TyrTrp: 0.61 ± 0.182
1.296TyrTyr: 1.296 ± 0.329
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 59 proteins (13120 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski