Amino acid dipepetide frequency for Klebsiella phage 1611E-K2-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.842AlaAla: 8.842 ± 1.282
1.382AlaCys: 1.382 ± 0.575
5.803AlaAsp: 5.803 ± 1.03
4.697AlaGlu: 4.697 ± 0.845
2.763AlaPhe: 2.763 ± 0.56
7.184AlaGly: 7.184 ± 1.773
0.829AlaHis: 0.829 ± 0.401
4.697AlaIle: 4.697 ± 0.65
5.526AlaLys: 5.526 ± 1.029
5.25AlaLeu: 5.25 ± 0.844
2.211AlaMet: 2.211 ± 0.48
4.007AlaAsn: 4.007 ± 0.697
2.349AlaPro: 2.349 ± 0.511
4.283AlaGln: 4.283 ± 0.988
4.421AlaArg: 4.421 ± 0.895
6.079AlaSer: 6.079 ± 1.312
5.388AlaThr: 5.388 ± 0.856
6.355AlaVal: 6.355 ± 1.113
0.829AlaTrp: 0.829 ± 0.323
2.625AlaTyr: 2.625 ± 0.476
0.0AlaXaa: 0.0 ± 0.0
Cys
1.243CysAla: 1.243 ± 0.367
0.138CysCys: 0.138 ± 0.155
0.414CysAsp: 0.414 ± 0.224
1.382CysGlu: 1.382 ± 0.318
0.553CysPhe: 0.553 ± 0.312
0.829CysGly: 0.829 ± 0.276
0.276CysHis: 0.276 ± 0.158
1.105CysIle: 1.105 ± 0.443
1.105CysLys: 1.105 ± 0.44
1.105CysLeu: 1.105 ± 0.285
0.138CysMet: 0.138 ± 0.125
0.967CysAsn: 0.967 ± 0.352
2.072CysPro: 2.072 ± 0.879
0.553CysGln: 0.553 ± 0.202
1.243CysArg: 1.243 ± 0.343
1.105CysSer: 1.105 ± 0.349
1.105CysThr: 1.105 ± 0.404
0.829CysVal: 0.829 ± 0.453
0.0CysTrp: 0.0 ± 0.0
0.138CysTyr: 0.138 ± 0.114
0.0CysXaa: 0.0 ± 0.0
Asp
5.526AspAla: 5.526 ± 0.888
0.691AspCys: 0.691 ± 0.296
3.592AspAsp: 3.592 ± 0.597
3.73AspGlu: 3.73 ± 0.965
3.04AspPhe: 3.04 ± 0.712
7.184AspGly: 7.184 ± 1.103
0.553AspHis: 0.553 ± 0.227
4.697AspIle: 4.697 ± 0.752
2.901AspLys: 2.901 ± 0.688
3.178AspLeu: 3.178 ± 0.498
2.349AspMet: 2.349 ± 0.691
3.178AspAsn: 3.178 ± 0.714
2.072AspPro: 2.072 ± 0.527
1.382AspGln: 1.382 ± 0.336
4.007AspArg: 4.007 ± 0.714
3.592AspSer: 3.592 ± 0.585
3.454AspThr: 3.454 ± 0.653
5.25AspVal: 5.25 ± 0.836
1.796AspTrp: 1.796 ± 0.496
1.658AspTyr: 1.658 ± 0.474
0.0AspXaa: 0.0 ± 0.0
Glu
3.868GluAla: 3.868 ± 0.973
0.691GluCys: 0.691 ± 0.304
2.901GluAsp: 2.901 ± 0.736
2.072GluGlu: 2.072 ± 0.463
1.796GluPhe: 1.796 ± 0.445
3.178GluGly: 3.178 ± 0.503
0.967GluHis: 0.967 ± 0.311
2.763GluIle: 2.763 ± 0.556
3.178GluLys: 3.178 ± 0.58
4.974GluLeu: 4.974 ± 1.073
0.553GluMet: 0.553 ± 0.3
2.072GluAsn: 2.072 ± 0.817
1.243GluPro: 1.243 ± 0.363
3.454GluGln: 3.454 ± 0.622
2.625GluArg: 2.625 ± 0.678
3.316GluSer: 3.316 ± 0.581
2.211GluThr: 2.211 ± 0.602
3.04GluVal: 3.04 ± 0.531
0.967GluTrp: 0.967 ± 0.225
2.487GluTyr: 2.487 ± 0.645
0.0GluXaa: 0.0 ± 0.0
Phe
3.454PheAla: 3.454 ± 0.657
0.553PheCys: 0.553 ± 0.219
3.04PheAsp: 3.04 ± 0.693
2.072PheGlu: 2.072 ± 0.445
1.243PhePhe: 1.243 ± 0.4
2.763PheGly: 2.763 ± 0.48
0.414PheHis: 0.414 ± 0.2
2.763PheIle: 2.763 ± 0.707
1.934PheLys: 1.934 ± 0.322
1.382PheLeu: 1.382 ± 0.366
1.243PheMet: 1.243 ± 0.485
3.178PheAsn: 3.178 ± 0.535
2.072PhePro: 2.072 ± 0.418
1.243PheGln: 1.243 ± 0.449
2.901PheArg: 2.901 ± 0.69
2.072PheSer: 2.072 ± 0.521
2.763PheThr: 2.763 ± 0.615
2.211PheVal: 2.211 ± 0.581
0.553PheTrp: 0.553 ± 0.229
1.105PheTyr: 1.105 ± 0.315
0.0PheXaa: 0.0 ± 0.0
Gly
6.632GlyAla: 6.632 ± 1.279
1.382GlyCys: 1.382 ± 0.438
6.355GlyAsp: 6.355 ± 0.661
2.901GlyGlu: 2.901 ± 0.52
2.349GlyPhe: 2.349 ± 0.631
8.013GlyGly: 8.013 ± 1.764
0.553GlyHis: 0.553 ± 0.275
4.974GlyIle: 4.974 ± 1.023
5.665GlyLys: 5.665 ± 0.811
4.697GlyLeu: 4.697 ± 0.71
2.072GlyMet: 2.072 ± 0.311
3.178GlyAsn: 3.178 ± 0.646
1.796GlyPro: 1.796 ± 0.553
3.04GlyGln: 3.04 ± 0.543
3.73GlyArg: 3.73 ± 0.575
5.665GlySer: 5.665 ± 0.943
4.559GlyThr: 4.559 ± 1.477
6.632GlyVal: 6.632 ± 0.767
1.382GlyTrp: 1.382 ± 0.326
3.316GlyTyr: 3.316 ± 0.457
0.0GlyXaa: 0.0 ± 0.0
His
1.105HisAla: 1.105 ± 0.466
0.691HisCys: 0.691 ± 0.277
1.382HisAsp: 1.382 ± 0.439
0.138HisGlu: 0.138 ± 0.114
1.243HisPhe: 1.243 ± 0.332
2.487HisGly: 2.487 ± 0.959
0.553HisHis: 0.553 ± 0.234
1.105HisIle: 1.105 ± 0.544
1.243HisLys: 1.243 ± 0.425
1.52HisLeu: 1.52 ± 0.346
0.414HisMet: 0.414 ± 0.202
1.243HisAsn: 1.243 ± 0.416
0.553HisPro: 0.553 ± 0.234
0.414HisGln: 0.414 ± 0.279
1.243HisArg: 1.243 ± 0.401
0.691HisSer: 0.691 ± 0.314
0.829HisThr: 0.829 ± 0.234
1.934HisVal: 1.934 ± 0.574
0.553HisTrp: 0.553 ± 0.257
0.829HisTyr: 0.829 ± 0.36
0.0HisXaa: 0.0 ± 0.0
Ile
4.145IleAla: 4.145 ± 0.893
0.967IleCys: 0.967 ± 0.434
4.007IleAsp: 4.007 ± 0.667
3.454IleGlu: 3.454 ± 0.749
1.934IlePhe: 1.934 ± 0.469
3.04IleGly: 3.04 ± 0.527
1.658IleHis: 1.658 ± 0.62
3.04IleIle: 3.04 ± 0.701
3.178IleLys: 3.178 ± 0.821
2.763IleLeu: 2.763 ± 0.556
2.072IleMet: 2.072 ± 0.569
3.454IleAsn: 3.454 ± 0.962
2.625IlePro: 2.625 ± 0.59
2.211IleGln: 2.211 ± 0.498
3.178IleArg: 3.178 ± 0.569
3.316IleSer: 3.316 ± 0.762
4.145IleThr: 4.145 ± 0.557
3.454IleVal: 3.454 ± 0.531
0.553IleTrp: 0.553 ± 0.261
1.796IleTyr: 1.796 ± 0.424
0.0IleXaa: 0.0 ± 0.0
Lys
4.283LysAla: 4.283 ± 0.625
1.243LysCys: 1.243 ± 0.443
4.007LysAsp: 4.007 ± 1.048
1.934LysGlu: 1.934 ± 0.546
2.072LysPhe: 2.072 ± 0.423
3.454LysGly: 3.454 ± 0.636
1.243LysHis: 1.243 ± 0.51
3.04LysIle: 3.04 ± 0.505
3.316LysLys: 3.316 ± 0.843
3.592LysLeu: 3.592 ± 0.784
1.382LysMet: 1.382 ± 0.32
2.901LysAsn: 2.901 ± 0.564
1.796LysPro: 1.796 ± 0.503
1.658LysGln: 1.658 ± 0.615
3.592LysArg: 3.592 ± 0.744
4.007LysSer: 4.007 ± 0.649
4.145LysThr: 4.145 ± 0.564
2.901LysVal: 2.901 ± 0.723
1.52LysTrp: 1.52 ± 0.372
1.105LysTyr: 1.105 ± 0.533
0.0LysXaa: 0.0 ± 0.0
Leu
6.355LeuAla: 6.355 ± 0.929
1.382LeuCys: 1.382 ± 0.379
6.217LeuAsp: 6.217 ± 0.674
3.73LeuGlu: 3.73 ± 0.684
2.072LeuPhe: 2.072 ± 0.422
4.974LeuGly: 4.974 ± 0.709
1.658LeuHis: 1.658 ± 0.478
2.349LeuIle: 2.349 ± 0.448
2.901LeuLys: 2.901 ± 0.724
4.421LeuLeu: 4.421 ± 0.746
2.349LeuMet: 2.349 ± 0.576
4.559LeuAsn: 4.559 ± 0.884
2.072LeuPro: 2.072 ± 0.541
2.211LeuGln: 2.211 ± 0.505
3.316LeuArg: 3.316 ± 0.553
5.388LeuSer: 5.388 ± 0.658
4.974LeuThr: 4.974 ± 0.799
4.697LeuVal: 4.697 ± 0.856
0.967LeuTrp: 0.967 ± 0.318
2.072LeuTyr: 2.072 ± 0.577
0.0LeuXaa: 0.0 ± 0.0
Met
2.211MetAla: 2.211 ± 0.599
0.414MetCys: 0.414 ± 0.226
1.52MetAsp: 1.52 ± 0.406
1.796MetGlu: 1.796 ± 0.248
2.072MetPhe: 2.072 ± 0.504
1.105MetGly: 1.105 ± 0.34
0.691MetHis: 0.691 ± 0.209
0.967MetIle: 0.967 ± 0.336
0.691MetLys: 0.691 ± 0.273
1.658MetLeu: 1.658 ± 0.499
1.105MetMet: 1.105 ± 0.412
1.105MetAsn: 1.105 ± 0.475
0.967MetPro: 0.967 ± 0.319
0.967MetGln: 0.967 ± 0.236
3.178MetArg: 3.178 ± 0.695
2.487MetSer: 2.487 ± 0.458
2.487MetThr: 2.487 ± 0.393
1.382MetVal: 1.382 ± 0.431
0.138MetTrp: 0.138 ± 0.136
0.967MetTyr: 0.967 ± 0.286
0.0MetXaa: 0.0 ± 0.0
Asn
4.836AsnAla: 4.836 ± 0.731
1.105AsnCys: 1.105 ± 0.398
2.763AsnAsp: 2.763 ± 0.654
1.934AsnGlu: 1.934 ± 0.527
1.796AsnPhe: 1.796 ± 0.545
5.25AsnGly: 5.25 ± 1.061
1.796AsnHis: 1.796 ± 0.44
3.178AsnIle: 3.178 ± 0.569
1.658AsnLys: 1.658 ± 0.552
2.763AsnLeu: 2.763 ± 0.374
1.52AsnMet: 1.52 ± 0.541
4.283AsnAsn: 4.283 ± 1.05
3.73AsnPro: 3.73 ± 0.895
1.658AsnGln: 1.658 ± 0.489
2.901AsnArg: 2.901 ± 0.764
4.283AsnSer: 4.283 ± 0.925
2.625AsnThr: 2.625 ± 0.601
3.04AsnVal: 3.04 ± 0.642
1.382AsnTrp: 1.382 ± 0.377
1.658AsnTyr: 1.658 ± 0.509
0.0AsnXaa: 0.0 ± 0.0
Pro
4.145ProAla: 4.145 ± 0.638
0.414ProCys: 0.414 ± 0.202
2.349ProAsp: 2.349 ± 0.544
2.072ProGlu: 2.072 ± 0.522
1.243ProPhe: 1.243 ± 0.401
4.283ProGly: 4.283 ± 1.095
0.276ProHis: 0.276 ± 0.272
2.072ProIle: 2.072 ± 0.498
1.52ProLys: 1.52 ± 0.347
3.316ProLeu: 3.316 ± 0.552
0.553ProMet: 0.553 ± 0.243
1.934ProAsn: 1.934 ± 0.358
1.52ProPro: 1.52 ± 0.425
1.243ProGln: 1.243 ± 0.358
2.211ProArg: 2.211 ± 0.423
2.487ProSer: 2.487 ± 0.47
2.625ProThr: 2.625 ± 0.636
4.283ProVal: 4.283 ± 0.772
0.414ProTrp: 0.414 ± 0.216
1.105ProTyr: 1.105 ± 0.359
0.0ProXaa: 0.0 ± 0.0
Gln
2.072GlnAla: 2.072 ± 0.793
0.553GlnCys: 0.553 ± 0.219
1.52GlnAsp: 1.52 ± 0.36
2.211GlnGlu: 2.211 ± 0.454
1.658GlnPhe: 1.658 ± 0.568
2.487GlnGly: 2.487 ± 0.701
0.967GlnHis: 0.967 ± 0.237
2.349GlnIle: 2.349 ± 0.528
1.382GlnLys: 1.382 ± 0.399
4.836GlnLeu: 4.836 ± 1.166
2.072GlnMet: 2.072 ± 0.829
1.796GlnAsn: 1.796 ± 0.477
1.243GlnPro: 1.243 ± 0.497
2.625GlnGln: 2.625 ± 0.749
2.625GlnArg: 2.625 ± 0.665
2.625GlnSer: 2.625 ± 0.632
3.868GlnThr: 3.868 ± 0.576
2.487GlnVal: 2.487 ± 0.589
0.276GlnTrp: 0.276 ± 0.168
1.382GlnTyr: 1.382 ± 0.433
0.0GlnXaa: 0.0 ± 0.0
Arg
4.145ArgAla: 4.145 ± 0.78
1.105ArgCys: 1.105 ± 0.353
3.178ArgAsp: 3.178 ± 0.616
3.592ArgGlu: 3.592 ± 0.834
2.625ArgPhe: 2.625 ± 0.551
2.487ArgGly: 2.487 ± 0.678
1.243ArgHis: 1.243 ± 0.39
3.04ArgIle: 3.04 ± 0.572
2.349ArgLys: 2.349 ± 0.627
4.283ArgLeu: 4.283 ± 0.625
1.796ArgMet: 1.796 ± 0.391
2.763ArgAsn: 2.763 ± 0.392
2.763ArgPro: 2.763 ± 0.461
3.178ArgGln: 3.178 ± 0.865
2.625ArgArg: 2.625 ± 0.571
3.04ArgSer: 3.04 ± 0.459
3.316ArgThr: 3.316 ± 0.364
4.283ArgVal: 4.283 ± 0.785
0.553ArgTrp: 0.553 ± 0.403
2.487ArgTyr: 2.487 ± 0.629
0.0ArgXaa: 0.0 ± 0.0
Ser
7.322SerAla: 7.322 ± 1.214
0.691SerCys: 0.691 ± 0.245
3.454SerAsp: 3.454 ± 0.548
1.796SerGlu: 1.796 ± 0.386
3.454SerPhe: 3.454 ± 0.65
4.421SerGly: 4.421 ± 0.698
2.072SerHis: 2.072 ± 0.578
2.901SerIle: 2.901 ± 0.619
4.283SerLys: 4.283 ± 0.803
5.941SerLeu: 5.941 ± 0.996
1.796SerMet: 1.796 ± 0.542
4.145SerAsn: 4.145 ± 0.695
1.934SerPro: 1.934 ± 0.629
4.145SerGln: 4.145 ± 0.666
3.316SerArg: 3.316 ± 0.715
5.25SerSer: 5.25 ± 1.002
4.283SerThr: 4.283 ± 0.773
3.04SerVal: 3.04 ± 0.605
0.414SerTrp: 0.414 ± 0.271
2.625SerTyr: 2.625 ± 0.56
0.0SerXaa: 0.0 ± 0.0
Thr
6.079ThrAla: 6.079 ± 1.455
1.382ThrCys: 1.382 ± 0.366
3.316ThrAsp: 3.316 ± 0.636
2.487ThrGlu: 2.487 ± 0.477
3.04ThrPhe: 3.04 ± 0.566
6.632ThrGly: 6.632 ± 1.12
2.349ThrHis: 2.349 ± 0.726
4.974ThrIle: 4.974 ± 0.557
2.763ThrLys: 2.763 ± 0.673
4.421ThrLeu: 4.421 ± 0.752
1.382ThrMet: 1.382 ± 0.26
3.04ThrAsn: 3.04 ± 0.449
3.868ThrPro: 3.868 ± 0.413
2.211ThrGln: 2.211 ± 0.728
2.487ThrArg: 2.487 ± 0.639
4.283ThrSer: 4.283 ± 0.835
5.112ThrThr: 5.112 ± 1.171
4.836ThrVal: 4.836 ± 0.831
1.52ThrTrp: 1.52 ± 0.572
2.072ThrTyr: 2.072 ± 0.631
0.0ThrXaa: 0.0 ± 0.0
Val
6.217ValAla: 6.217 ± 1.151
1.105ValCys: 1.105 ± 0.301
4.145ValAsp: 4.145 ± 0.808
4.283ValGlu: 4.283 ± 1.1
2.625ValPhe: 2.625 ± 0.723
5.25ValGly: 5.25 ± 0.804
0.967ValHis: 0.967 ± 0.605
2.901ValIle: 2.901 ± 0.42
3.868ValLys: 3.868 ± 0.566
4.145ValLeu: 4.145 ± 0.709
1.934ValMet: 1.934 ± 0.582
3.178ValAsn: 3.178 ± 0.553
3.316ValPro: 3.316 ± 0.636
2.487ValGln: 2.487 ± 0.758
3.454ValArg: 3.454 ± 0.644
3.73ValSer: 3.73 ± 0.511
7.184ValThr: 7.184 ± 0.93
3.178ValVal: 3.178 ± 0.549
0.691ValTrp: 0.691 ± 0.265
3.316ValTyr: 3.316 ± 0.635
0.0ValXaa: 0.0 ± 0.0
Trp
0.967TrpAla: 0.967 ± 0.329
0.138TrpCys: 0.138 ± 0.114
0.967TrpAsp: 0.967 ± 0.316
0.276TrpGlu: 0.276 ± 0.168
0.138TrpPhe: 0.138 ± 0.128
0.967TrpGly: 0.967 ± 0.423
0.691TrpHis: 0.691 ± 0.222
0.829TrpIle: 0.829 ± 0.386
1.658TrpLys: 1.658 ± 0.386
1.52TrpLeu: 1.52 ± 0.448
0.0TrpMet: 0.0 ± 0.0
1.243TrpAsn: 1.243 ± 0.508
0.553TrpPro: 0.553 ± 0.291
0.553TrpGln: 0.553 ± 0.21
0.553TrpArg: 0.553 ± 0.199
1.382TrpSer: 1.382 ± 0.321
0.691TrpThr: 0.691 ± 0.279
1.382TrpVal: 1.382 ± 0.345
0.276TrpTrp: 0.276 ± 0.163
0.553TrpTyr: 0.553 ± 0.286
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.072TyrAla: 2.072 ± 0.499
0.276TyrCys: 0.276 ± 0.251
2.901TyrAsp: 2.901 ± 0.649
1.796TyrGlu: 1.796 ± 0.528
1.243TyrPhe: 1.243 ± 0.322
2.901TyrGly: 2.901 ± 0.668
0.414TyrHis: 0.414 ± 0.276
1.243TyrIle: 1.243 ± 0.401
2.072TyrLys: 2.072 ± 0.381
3.04TyrLeu: 3.04 ± 0.542
0.829TyrMet: 0.829 ± 0.355
1.934TyrAsn: 1.934 ± 0.444
1.52TyrPro: 1.52 ± 0.635
1.52TyrGln: 1.52 ± 0.382
1.243TyrArg: 1.243 ± 0.344
2.487TyrSer: 2.487 ± 0.69
2.487TyrThr: 2.487 ± 0.406
2.763TyrVal: 2.763 ± 0.628
0.553TyrTrp: 0.553 ± 0.298
0.967TyrTyr: 0.967 ± 0.414
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 17 proteins (7239 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski