Amino acid dipepetide frequency for Lactobacillus coleohominis 101-4-CHN

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.768AlaAla: 6.768 ± 0.159
0.436AlaCys: 0.436 ± 0.031
5.001AlaAsp: 5.001 ± 0.111
4.123AlaGlu: 4.123 ± 0.093
3.091AlaPhe: 3.091 ± 0.086
5.787AlaGly: 5.787 ± 0.12
1.719AlaHis: 1.719 ± 0.052
5.602AlaIle: 5.602 ± 0.134
5.56AlaLys: 5.56 ± 0.117
6.955AlaLeu: 6.955 ± 0.132
2.253AlaMet: 2.253 ± 0.073
3.946AlaAsn: 3.946 ± 0.09
2.42AlaPro: 2.42 ± 0.068
3.501AlaGln: 3.501 ± 0.104
2.957AlaArg: 2.957 ± 0.079
4.004AlaSer: 4.004 ± 0.088
4.872AlaThr: 4.872 ± 0.102
5.614AlaVal: 5.614 ± 0.116
0.665AlaTrp: 0.665 ± 0.04
2.366AlaTyr: 2.366 ± 0.061
0.0AlaXaa: 0.0 ± 0.0
Cys
0.454CysAla: 0.454 ± 0.034
0.058CysCys: 0.058 ± 0.012
0.283CysAsp: 0.283 ± 0.026
0.279CysGlu: 0.279 ± 0.023
0.287CysPhe: 0.287 ± 0.02
0.645CysGly: 0.645 ± 0.037
0.217CysHis: 0.217 ± 0.022
0.352CysIle: 0.352 ± 0.026
0.205CysLys: 0.205 ± 0.021
0.673CysLeu: 0.673 ± 0.039
0.115CysMet: 0.115 ± 0.014
0.231CysAsn: 0.231 ± 0.02
0.304CysPro: 0.304 ± 0.03
0.32CysGln: 0.32 ± 0.026
0.247CysArg: 0.247 ± 0.022
0.336CysSer: 0.336 ± 0.029
0.281CysThr: 0.281 ± 0.019
0.39CysVal: 0.39 ± 0.029
0.103CysTrp: 0.103 ± 0.016
0.237CysTyr: 0.237 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
4.127AspAla: 4.127 ± 0.095
0.275AspCys: 0.275 ± 0.023
4.281AspAsp: 4.281 ± 0.128
4.034AspGlu: 4.034 ± 0.105
2.615AspPhe: 2.615 ± 0.083
4.016AspGly: 4.016 ± 0.115
1.974AspHis: 1.974 ± 0.065
3.463AspIle: 3.463 ± 0.09
3.013AspLys: 3.013 ± 0.098
5.556AspLeu: 5.556 ± 0.11
1.377AspMet: 1.377 ± 0.061
2.703AspAsn: 2.703 ± 0.08
2.515AspPro: 2.515 ± 0.084
4.046AspGln: 4.046 ± 0.113
2.625AspArg: 2.625 ± 0.082
2.732AspSer: 2.732 ± 0.084
2.595AspThr: 2.595 ± 0.082
4.046AspVal: 4.046 ± 0.09
0.728AspTrp: 0.728 ± 0.041
2.671AspTyr: 2.671 ± 0.083
0.0AspXaa: 0.0 ± 0.0
Glu
3.743GluAla: 3.743 ± 0.109
0.255GluCys: 0.255 ± 0.022
2.671GluAsp: 2.671 ± 0.083
3.047GluGlu: 3.047 ± 0.093
2.046GluPhe: 2.046 ± 0.065
2.615GluGly: 2.615 ± 0.083
1.317GluHis: 1.317 ± 0.057
3.747GluIle: 3.747 ± 0.092
3.624GluLys: 3.624 ± 0.094
5.54GluLeu: 5.54 ± 0.114
1.853GluMet: 1.853 ± 0.059
2.822GluAsn: 2.822 ± 0.07
1.65GluPro: 1.65 ± 0.06
2.991GluGln: 2.991 ± 0.094
2.806GluArg: 2.806 ± 0.097
2.338GluSer: 2.338 ± 0.08
2.734GluThr: 2.734 ± 0.074
3.606GluVal: 3.606 ± 0.091
0.541GluTrp: 0.541 ± 0.036
1.924GluTyr: 1.924 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
3.25PheAla: 3.25 ± 0.088
0.358PheCys: 0.358 ± 0.028
2.701PheAsp: 2.701 ± 0.069
1.745PheGlu: 1.745 ± 0.065
1.833PhePhe: 1.833 ± 0.074
3.168PheGly: 3.168 ± 0.091
1.007PheHis: 1.007 ± 0.043
2.995PheIle: 2.995 ± 0.1
2.386PheLys: 2.386 ± 0.07
3.423PheLeu: 3.423 ± 0.108
1.138PheMet: 1.138 ± 0.041
2.281PheAsn: 2.281 ± 0.08
1.429PhePro: 1.429 ± 0.055
1.455PheGln: 1.455 ± 0.06
1.467PheArg: 1.467 ± 0.058
2.597PheSer: 2.597 ± 0.088
2.454PheThr: 2.454 ± 0.075
2.925PheVal: 2.925 ± 0.074
0.503PheTrp: 0.503 ± 0.036
1.532PheTyr: 1.532 ± 0.061
0.0PheXaa: 0.0 ± 0.0
Gly
4.768GlyAla: 4.768 ± 0.115
0.468GlyCys: 0.468 ± 0.035
3.64GlyAsp: 3.64 ± 0.101
3.272GlyGlu: 3.272 ± 0.082
2.828GlyPhe: 2.828 ± 0.086
4.348GlyGly: 4.348 ± 0.112
1.803GlyHis: 1.803 ± 0.054
5.194GlyIle: 5.194 ± 0.121
4.452GlyLys: 4.452 ± 0.104
6.271GlyLeu: 6.271 ± 0.12
2.1GlyMet: 2.1 ± 0.068
3.174GlyAsn: 3.174 ± 0.087
1.616GlyPro: 1.616 ± 0.061
3.405GlyGln: 3.405 ± 0.1
2.812GlyArg: 2.812 ± 0.085
3.924GlySer: 3.924 ± 0.098
4.187GlyThr: 4.187 ± 0.1
4.802GlyVal: 4.802 ± 0.112
0.844GlyTrp: 0.844 ± 0.04
2.866GlyTyr: 2.866 ± 0.079
0.0GlyXaa: 0.0 ± 0.0
His
1.59HisAla: 1.59 ± 0.057
0.169HisCys: 0.169 ± 0.017
1.556HisAsp: 1.556 ± 0.051
1.483HisGlu: 1.483 ± 0.049
1.226HisPhe: 1.226 ± 0.05
1.914HisGly: 1.914 ± 0.074
1.065HisHis: 1.065 ± 0.053
1.357HisIle: 1.357 ± 0.053
1.079HisLys: 1.079 ± 0.05
2.589HisLeu: 2.589 ± 0.075
0.569HisMet: 0.569 ± 0.034
1.11HisAsn: 1.11 ± 0.048
1.347HisPro: 1.347 ± 0.054
1.859HisGln: 1.859 ± 0.064
1.282HisArg: 1.282 ± 0.058
1.365HisSer: 1.365 ± 0.054
1.085HisThr: 1.085 ± 0.048
1.578HisVal: 1.578 ± 0.049
0.318HisTrp: 0.318 ± 0.025
1.232HisTyr: 1.232 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
5.721IleAla: 5.721 ± 0.123
0.607IleCys: 0.607 ± 0.036
4.404IleAsp: 4.404 ± 0.11
3.339IleGlu: 3.339 ± 0.092
2.87IlePhe: 2.87 ± 0.106
4.923IleGly: 4.923 ± 0.105
1.558IleHis: 1.558 ± 0.064
5.224IleIle: 5.224 ± 0.136
4.43IleLys: 4.43 ± 0.099
5.797IleLeu: 5.797 ± 0.143
1.769IleMet: 1.769 ± 0.06
3.873IleAsn: 3.873 ± 0.095
2.788IlePro: 2.788 ± 0.08
2.756IleGln: 2.756 ± 0.085
2.585IleArg: 2.585 ± 0.084
4.1IleSer: 4.1 ± 0.096
4.334IleThr: 4.334 ± 0.098
5.009IleVal: 5.009 ± 0.126
0.679IleTrp: 0.679 ± 0.042
2.241IleTyr: 2.241 ± 0.069
0.0IleXaa: 0.0 ± 0.0
Lys
4.388LysAla: 4.388 ± 0.111
0.269LysCys: 0.269 ± 0.026
3.51LysAsp: 3.51 ± 0.09
3.57LysGlu: 3.57 ± 0.1
2.115LysPhe: 2.115 ± 0.061
3.196LysGly: 3.196 ± 0.09
1.495LysHis: 1.495 ± 0.053
4.211LysIle: 4.211 ± 0.098
4.716LysLys: 4.716 ± 0.119
5.887LysLeu: 5.887 ± 0.115
2.289LysMet: 2.289 ± 0.068
3.431LysAsn: 3.431 ± 0.083
2.219LysPro: 2.219 ± 0.077
3.435LysGln: 3.435 ± 0.091
3.136LysArg: 3.136 ± 0.08
2.993LysSer: 2.993 ± 0.094
3.636LysThr: 3.636 ± 0.096
4.37LysVal: 4.37 ± 0.105
0.679LysTrp: 0.679 ± 0.042
2.557LysTyr: 2.557 ± 0.081
0.0LysXaa: 0.0 ± 0.0
Leu
8.4LeuAla: 8.4 ± 0.142
0.589LeuCys: 0.589 ± 0.04
5.202LeuAsp: 5.202 ± 0.105
4.032LeuGlu: 4.032 ± 0.096
3.578LeuPhe: 3.578 ± 0.106
6.289LeuGly: 6.289 ± 0.118
2.197LeuHis: 2.197 ± 0.072
6.703LeuIle: 6.703 ± 0.153
5.899LeuLys: 5.899 ± 0.102
8.569LeuLeu: 8.569 ± 0.185
2.716LeuMet: 2.716 ± 0.071
4.876LeuAsn: 4.876 ± 0.096
4.235LeuPro: 4.235 ± 0.097
4.125LeuGln: 4.125 ± 0.108
4.032LeuArg: 4.032 ± 0.103
5.791LeuSer: 5.791 ± 0.122
6.414LeuThr: 6.414 ± 0.113
6.685LeuVal: 6.685 ± 0.143
0.792LeuTrp: 0.792 ± 0.043
2.712LeuTyr: 2.712 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.511MetAla: 2.511 ± 0.073
0.141MetCys: 0.141 ± 0.017
1.562MetAsp: 1.562 ± 0.058
1.341MetGlu: 1.341 ± 0.05
0.979MetPhe: 0.979 ± 0.048
1.914MetGly: 1.914 ± 0.066
0.575MetHis: 0.575 ± 0.031
2.149MetIle: 2.149 ± 0.072
2.084MetLys: 2.084 ± 0.065
2.342MetLeu: 2.342 ± 0.066
1.003MetMet: 1.003 ± 0.044
1.56MetAsn: 1.56 ± 0.038
1.075MetPro: 1.075 ± 0.047
1.132MetGln: 1.132 ± 0.044
1.19MetArg: 1.19 ± 0.045
1.672MetSer: 1.672 ± 0.055
1.976MetThr: 1.976 ± 0.071
2.092MetVal: 2.092 ± 0.072
0.169MetTrp: 0.169 ± 0.019
0.76MetTyr: 0.76 ± 0.041
0.0MetXaa: 0.0 ± 0.0
Asn
3.608AsnAla: 3.608 ± 0.107
0.336AsnCys: 0.336 ± 0.024
3.282AsnAsp: 3.282 ± 0.076
2.838AsnGlu: 2.838 ± 0.076
1.912AsnPhe: 1.912 ± 0.068
4.006AsnGly: 4.006 ± 0.104
1.58AsnHis: 1.58 ± 0.056
2.943AsnIle: 2.943 ± 0.082
2.673AsnLys: 2.673 ± 0.085
4.155AsnLeu: 4.155 ± 0.105
1.305AsnMet: 1.305 ± 0.054
3.029AsnAsn: 3.029 ± 0.079
2.273AsnPro: 2.273 ± 0.073
3.027AsnGln: 3.027 ± 0.093
2.215AsnArg: 2.215 ± 0.069
2.768AsnSer: 2.768 ± 0.085
2.615AsnThr: 2.615 ± 0.078
3.522AsnVal: 3.522 ± 0.09
0.738AsnTrp: 0.738 ± 0.039
2.193AsnTyr: 2.193 ± 0.078
0.0AsnXaa: 0.0 ± 0.0
Pro
3.033ProAla: 3.033 ± 0.083
0.145ProCys: 0.145 ± 0.016
2.557ProAsp: 2.557 ± 0.09
2.766ProGlu: 2.766 ± 0.079
1.771ProPhe: 1.771 ± 0.062
2.255ProGly: 2.255 ± 0.072
0.913ProHis: 0.913 ± 0.04
2.386ProIle: 2.386 ± 0.068
2.183ProLys: 2.183 ± 0.066
3.427ProLeu: 3.427 ± 0.086
0.846ProMet: 0.846 ± 0.04
1.998ProAsn: 1.998 ± 0.058
0.563ProPro: 0.563 ± 0.033
1.978ProGln: 1.978 ± 0.062
1.357ProArg: 1.357 ± 0.055
2.117ProSer: 2.117 ± 0.066
2.525ProThr: 2.525 ± 0.081
3.218ProVal: 3.218 ± 0.085
0.394ProTrp: 0.394 ± 0.029
1.24ProTyr: 1.24 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
3.982GlnAla: 3.982 ± 0.108
0.195GlnCys: 0.195 ± 0.018
2.364GlnAsp: 2.364 ± 0.085
2.659GlnGlu: 2.659 ± 0.084
1.94GlnPhe: 1.94 ± 0.064
2.543GlnGly: 2.543 ± 0.077
1.262GlnHis: 1.262 ± 0.062
3.491GlnIle: 3.491 ± 0.103
3.475GlnLys: 3.475 ± 0.093
5.811GlnLeu: 5.811 ± 0.135
1.449GlnMet: 1.449 ± 0.044
2.324GlnAsn: 2.324 ± 0.074
2.135GlnPro: 2.135 ± 0.073
3.493GlnGln: 3.493 ± 0.129
2.88GlnArg: 2.88 ± 0.101
2.748GlnSer: 2.748 ± 0.086
3.005GlnThr: 3.005 ± 0.098
3.477GlnVal: 3.477 ± 0.088
0.615GlnTrp: 0.615 ± 0.031
1.91GlnTyr: 1.91 ± 0.065
0.0GlnXaa: 0.0 ± 0.0
Arg
2.824ArgAla: 2.824 ± 0.092
0.223ArgCys: 0.223 ± 0.023
2.342ArgAsp: 2.342 ± 0.063
2.466ArgGlu: 2.466 ± 0.073
1.938ArgPhe: 1.938 ± 0.069
2.456ArgGly: 2.456 ± 0.084
1.357ArgHis: 1.357 ± 0.052
2.864ArgIle: 2.864 ± 0.079
2.631ArgLys: 2.631 ± 0.085
4.49ArgLeu: 4.49 ± 0.128
1.21ArgMet: 1.21 ± 0.052
2.018ArgAsn: 2.018 ± 0.074
1.684ArgPro: 1.684 ± 0.063
3.071ArgGln: 3.071 ± 0.093
2.458ArgArg: 2.458 ± 0.088
2.201ArgSer: 2.201 ± 0.068
2.275ArgThr: 2.275 ± 0.064
2.975ArgVal: 2.975 ± 0.096
0.557ArgTrp: 0.557 ± 0.029
1.809ArgTyr: 1.809 ± 0.067
0.0ArgXaa: 0.0 ± 0.0
Ser
4.396SerAla: 4.396 ± 0.105
0.275SerCys: 0.275 ± 0.022
3.059SerAsp: 3.059 ± 0.09
2.563SerGlu: 2.563 ± 0.081
2.502SerPhe: 2.502 ± 0.079
4.245SerGly: 4.245 ± 0.096
1.393SerHis: 1.393 ± 0.053
3.606SerIle: 3.606 ± 0.08
3.176SerLys: 3.176 ± 0.097
5.686SerLeu: 5.686 ± 0.127
1.554SerMet: 1.554 ± 0.053
2.752SerAsn: 2.752 ± 0.082
1.897SerPro: 1.897 ± 0.059
2.726SerGln: 2.726 ± 0.068
2.408SerArg: 2.408 ± 0.076
3.775SerSer: 3.775 ± 0.132
3.256SerThr: 3.256 ± 0.086
3.636SerVal: 3.636 ± 0.082
0.665SerTrp: 0.665 ± 0.038
2.056SerTyr: 2.056 ± 0.063
0.0SerXaa: 0.0 ± 0.0
Thr
4.81ThrAla: 4.81 ± 0.111
0.273ThrCys: 0.273 ± 0.023
3.542ThrAsp: 3.542 ± 0.102
2.788ThrGlu: 2.788 ± 0.077
2.356ThrPhe: 2.356 ± 0.081
4.438ThrGly: 4.438 ± 0.109
1.242ThrHis: 1.242 ± 0.046
4.703ThrIle: 4.703 ± 0.105
4.034ThrLys: 4.034 ± 0.102
4.989ThrLeu: 4.989 ± 0.103
1.582ThrMet: 1.582 ± 0.057
3.144ThrAsn: 3.144 ± 0.084
2.842ThrPro: 2.842 ± 0.093
2.135ThrGln: 2.135 ± 0.069
1.992ThrArg: 1.992 ± 0.059
3.284ThrSer: 3.284 ± 0.096
4.115ThrThr: 4.115 ± 0.132
4.965ThrVal: 4.965 ± 0.125
0.617ThrTrp: 0.617 ± 0.036
1.954ThrTyr: 1.954 ± 0.068
0.0ThrXaa: 0.0 ± 0.0
Val
6.141ValAla: 6.141 ± 0.119
0.513ValCys: 0.513 ± 0.036
4.573ValAsp: 4.573 ± 0.1
3.405ValGlu: 3.405 ± 0.089
2.474ValPhe: 2.474 ± 0.076
4.744ValGly: 4.744 ± 0.113
1.586ValHis: 1.586 ± 0.057
5.449ValIle: 5.449 ± 0.119
4.537ValLys: 4.537 ± 0.108
6.225ValLeu: 6.225 ± 0.119
2.052ValMet: 2.052 ± 0.068
3.58ValAsn: 3.58 ± 0.094
2.864ValPro: 2.864 ± 0.075
3.035ValGln: 3.035 ± 0.088
2.87ValArg: 2.87 ± 0.079
4.171ValSer: 4.171 ± 0.09
4.896ValThr: 4.896 ± 0.14
5.632ValVal: 5.632 ± 0.135
0.665ValTrp: 0.665 ± 0.04
2.235ValTyr: 2.235 ± 0.072
0.0ValXaa: 0.0 ± 0.0
Trp
0.706TrpAla: 0.706 ± 0.031
0.08TrpCys: 0.08 ± 0.013
0.563TrpAsp: 0.563 ± 0.039
0.402TrpGlu: 0.402 ± 0.028
0.553TrpPhe: 0.553 ± 0.035
0.74TrpGly: 0.74 ± 0.044
0.334TrpHis: 0.334 ± 0.028
0.653TrpIle: 0.653 ± 0.033
0.503TrpLys: 0.503 ± 0.034
1.417TrpLeu: 1.417 ± 0.065
0.326TrpMet: 0.326 ± 0.027
0.553TrpAsn: 0.553 ± 0.034
0.324TrpPro: 0.324 ± 0.028
0.691TrpGln: 0.691 ± 0.038
0.583TrpArg: 0.583 ± 0.039
0.667TrpSer: 0.667 ± 0.041
0.577TrpThr: 0.577 ± 0.034
0.653TrpVal: 0.653 ± 0.036
0.201TrpTrp: 0.201 ± 0.021
0.4TrpTyr: 0.4 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.422TyrAla: 2.422 ± 0.072
0.352TyrCys: 0.352 ± 0.029
2.299TyrAsp: 2.299 ± 0.074
1.717TyrGlu: 1.717 ± 0.062
1.733TyrPhe: 1.733 ± 0.064
2.535TyrGly: 2.535 ± 0.069
1.18TyrHis: 1.18 ± 0.05
1.914TyrIle: 1.914 ± 0.062
1.443TyrLys: 1.443 ± 0.053
4.034TyrLeu: 4.034 ± 0.101
0.718TyrMet: 0.718 ± 0.036
1.612TyrAsn: 1.612 ± 0.063
1.489TyrPro: 1.489 ± 0.05
2.577TyrGln: 2.577 ± 0.093
1.948TyrArg: 1.948 ± 0.066
2.046TyrSer: 2.046 ± 0.069
1.972TyrThr: 1.972 ± 0.067
2.452TyrVal: 2.452 ± 0.077
0.452TyrTrp: 0.452 ± 0.03
1.526TyrTyr: 1.526 ± 0.067
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1652 proteins (497507 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski