Amino acid dipepetide frequency for Agromyces sp. OV415

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.856AlaAla: 22.856 ± 0.238
0.626AlaCys: 0.626 ± 0.024
9.668AlaAsp: 9.668 ± 0.108
8.631AlaGlu: 8.631 ± 0.089
4.281AlaPhe: 4.281 ± 0.065
13.711AlaGly: 13.711 ± 0.128
2.44AlaHis: 2.44 ± 0.048
6.135AlaIle: 6.135 ± 0.076
2.598AlaLys: 2.598 ± 0.062
13.898AlaLeu: 13.898 ± 0.15
2.527AlaMet: 2.527 ± 0.048
2.414AlaAsn: 2.414 ± 0.05
7.6AlaPro: 7.6 ± 0.116
3.38AlaGln: 3.38 ± 0.057
9.689AlaArg: 9.689 ± 0.111
7.86AlaSer: 7.86 ± 0.088
8.102AlaThr: 8.102 ± 0.092
12.254AlaVal: 12.254 ± 0.129
2.091AlaTrp: 2.091 ± 0.048
2.474AlaTyr: 2.474 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.562CysAla: 0.562 ± 0.023
0.048CysCys: 0.048 ± 0.007
0.307CysAsp: 0.307 ± 0.017
0.233CysGlu: 0.233 ± 0.015
0.164CysPhe: 0.164 ± 0.011
0.497CysGly: 0.497 ± 0.025
0.108CysHis: 0.108 ± 0.01
0.172CysIle: 0.172 ± 0.012
0.045CysLys: 0.045 ± 0.006
0.424CysLeu: 0.424 ± 0.02
0.066CysMet: 0.066 ± 0.007
0.088CysAsn: 0.088 ± 0.008
0.268CysPro: 0.268 ± 0.017
0.099CysGln: 0.099 ± 0.008
0.287CysArg: 0.287 ± 0.017
0.305CysSer: 0.305 ± 0.019
0.313CysThr: 0.313 ± 0.023
0.39CysVal: 0.39 ± 0.02
0.074CysTrp: 0.074 ± 0.008
0.09CysTyr: 0.09 ± 0.008
0.0CysXaa: 0.0 ± 0.0
Asp
10.274AspAla: 10.274 ± 0.104
0.246AspCys: 0.246 ± 0.014
4.701AspAsp: 4.701 ± 0.083
4.441AspGlu: 4.441 ± 0.068
1.717AspPhe: 1.717 ± 0.041
7.033AspGly: 7.033 ± 0.101
1.25AspHis: 1.25 ± 0.034
1.855AspIle: 1.855 ± 0.046
0.681AspLys: 0.681 ± 0.025
7.017AspLeu: 7.017 ± 0.081
0.596AspMet: 0.596 ± 0.021
0.731AspAsn: 0.731 ± 0.023
4.641AspPro: 4.641 ± 0.074
1.577AspGln: 1.577 ± 0.038
5.359AspArg: 5.359 ± 0.1
2.358AspSer: 2.358 ± 0.045
2.822AspThr: 2.822 ± 0.057
5.724AspVal: 5.724 ± 0.071
1.119AspTrp: 1.119 ± 0.033
1.251AspTyr: 1.251 ± 0.032
0.0AspXaa: 0.0 ± 0.0
Glu
7.659GluAla: 7.659 ± 0.094
0.25GluCys: 0.25 ± 0.015
2.35GluAsp: 2.35 ± 0.051
2.769GluGlu: 2.769 ± 0.053
1.892GluPhe: 1.892 ± 0.04
3.839GluGly: 3.839 ± 0.063
1.587GluHis: 1.587 ± 0.041
2.442GluIle: 2.442 ± 0.053
0.97GluLys: 0.97 ± 0.038
6.634GluLeu: 6.634 ± 0.085
0.783GluMet: 0.783 ± 0.026
0.988GluAsn: 0.988 ± 0.032
3.626GluPro: 3.626 ± 0.07
2.153GluGln: 2.153 ± 0.05
5.429GluArg: 5.429 ± 0.076
2.782GluSer: 2.782 ± 0.047
2.848GluThr: 2.848 ± 0.049
5.042GluVal: 5.042 ± 0.067
0.913GluTrp: 0.913 ± 0.027
1.178GluTyr: 1.178 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
4.574PheAla: 4.574 ± 0.071
0.147PheCys: 0.147 ± 0.013
2.549PheAsp: 2.549 ± 0.054
1.798PheGlu: 1.798 ± 0.036
0.981PhePhe: 0.981 ± 0.032
3.486PheGly: 3.486 ± 0.064
0.589PheHis: 0.589 ± 0.022
1.104PheIle: 1.104 ± 0.031
0.394PheLys: 0.394 ± 0.021
2.868PheLeu: 2.868 ± 0.057
0.368PheMet: 0.368 ± 0.017
0.615PheAsn: 0.615 ± 0.022
1.401PhePro: 1.401 ± 0.035
0.789PheGln: 0.789 ± 0.024
1.872PheArg: 1.872 ± 0.042
1.586PheSer: 1.586 ± 0.037
2.198PheThr: 2.198 ± 0.051
2.742PheVal: 2.742 ± 0.048
0.52PheTrp: 0.52 ± 0.023
0.59PheTyr: 0.59 ± 0.024
0.0PheXaa: 0.0 ± 0.0
Gly
12.155GlyAla: 12.155 ± 0.133
0.582GlyCys: 0.582 ± 0.025
5.812GlyAsp: 5.812 ± 0.092
5.116GlyGlu: 5.116 ± 0.07
3.389GlyPhe: 3.389 ± 0.053
8.523GlyGly: 8.523 ± 0.118
1.818GlyHis: 1.818 ± 0.044
4.548GlyIle: 4.548 ± 0.072
1.728GlyLys: 1.728 ± 0.044
9.042GlyLeu: 9.042 ± 0.111
1.75GlyMet: 1.75 ± 0.042
1.679GlyAsn: 1.679 ± 0.041
4.199GlyPro: 4.199 ± 0.06
2.346GlyGln: 2.346 ± 0.05
7.228GlyArg: 7.228 ± 0.094
5.29GlySer: 5.29 ± 0.076
5.887GlyThr: 5.887 ± 0.09
8.394GlyVal: 8.394 ± 0.099
1.793GlyTrp: 1.793 ± 0.044
2.266GlyTyr: 2.266 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
2.425HisAla: 2.425 ± 0.054
0.108HisCys: 0.108 ± 0.009
1.384HisAsp: 1.384 ± 0.037
1.118HisGlu: 1.118 ± 0.032
0.514HisPhe: 0.514 ± 0.019
2.074HisGly: 2.074 ± 0.043
0.527HisHis: 0.527 ± 0.024
0.575HisIle: 0.575 ± 0.023
0.228HisLys: 0.228 ± 0.012
2.012HisLeu: 2.012 ± 0.04
0.242HisMet: 0.242 ± 0.014
0.302HisAsn: 0.302 ± 0.014
1.605HisPro: 1.605 ± 0.039
0.431HisGln: 0.431 ± 0.02
1.634HisArg: 1.634 ± 0.041
0.828HisSer: 0.828 ± 0.028
0.846HisThr: 0.846 ± 0.028
1.721HisVal: 1.721 ± 0.039
0.302HisTrp: 0.302 ± 0.017
0.397HisTyr: 0.397 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
6.914IleAla: 6.914 ± 0.072
0.192IleCys: 0.192 ± 0.012
3.41IleAsp: 3.41 ± 0.052
2.86IleGlu: 2.86 ± 0.054
0.971IlePhe: 0.971 ± 0.03
4.563IleGly: 4.563 ± 0.079
0.611IleHis: 0.611 ± 0.023
1.577IleIle: 1.577 ± 0.04
0.59IleLys: 0.59 ± 0.028
3.204IleLeu: 3.204 ± 0.059
0.531IleMet: 0.531 ± 0.024
0.676IleAsn: 0.676 ± 0.024
2.149IlePro: 2.149 ± 0.047
0.854IleGln: 0.854 ± 0.025
2.748IleArg: 2.748 ± 0.059
1.938IleSer: 1.938 ± 0.043
2.675IleThr: 2.675 ± 0.047
4.366IleVal: 4.366 ± 0.067
0.488IleTrp: 0.488 ± 0.022
0.626IleTyr: 0.626 ± 0.024
0.0IleXaa: 0.0 ± 0.0
Lys
2.033LysAla: 2.033 ± 0.05
0.047LysCys: 0.047 ± 0.007
0.845LysAsp: 0.845 ± 0.03
0.764LysGlu: 0.764 ± 0.029
0.436LysPhe: 0.436 ± 0.021
1.344LysGly: 1.344 ± 0.037
0.379LysHis: 0.379 ± 0.02
0.658LysIle: 0.658 ± 0.029
0.48LysLys: 0.48 ± 0.026
1.699LysLeu: 1.699 ± 0.044
0.261LysMet: 0.261 ± 0.014
0.383LysAsn: 0.383 ± 0.018
1.041LysPro: 1.041 ± 0.03
0.596LysGln: 0.596 ± 0.025
1.351LysArg: 1.351 ± 0.038
0.948LysSer: 0.948 ± 0.031
1.068LysThr: 1.068 ± 0.033
1.556LysVal: 1.556 ± 0.044
0.233LysTrp: 0.233 ± 0.015
0.387LysTyr: 0.387 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
15.629LeuAla: 15.629 ± 0.159
0.427LeuCys: 0.427 ± 0.018
7.219LeuAsp: 7.219 ± 0.083
5.313LeuGlu: 5.313 ± 0.066
2.761LeuPhe: 2.761 ± 0.062
9.526LeuGly: 9.526 ± 0.101
1.823LeuHis: 1.823 ± 0.044
4.039LeuIle: 4.039 ± 0.081
1.478LeuLys: 1.478 ± 0.041
9.766LeuLeu: 9.766 ± 0.124
1.277LeuMet: 1.277 ± 0.037
1.672LeuAsn: 1.672 ± 0.038
5.499LeuPro: 5.499 ± 0.075
2.315LeuGln: 2.315 ± 0.045
7.33LeuArg: 7.33 ± 0.101
4.951LeuSer: 4.951 ± 0.07
5.69LeuThr: 5.69 ± 0.067
9.981LeuVal: 9.981 ± 0.111
1.227LeuTrp: 1.227 ± 0.034
1.503LeuTyr: 1.503 ± 0.035
0.0LeuXaa: 0.0 ± 0.0
Met
1.829MetAla: 1.829 ± 0.041
0.069MetCys: 0.069 ± 0.008
0.638MetAsp: 0.638 ± 0.027
0.533MetGlu: 0.533 ± 0.022
0.448MetPhe: 0.448 ± 0.021
1.129MetGly: 1.129 ± 0.032
0.337MetHis: 0.337 ± 0.015
0.632MetIle: 0.632 ± 0.023
0.295MetLys: 0.295 ± 0.014
1.612MetLeu: 1.612 ± 0.037
0.239MetMet: 0.239 ± 0.017
0.4MetAsn: 0.4 ± 0.02
1.112MetPro: 1.112 ± 0.03
0.468MetGln: 0.468 ± 0.019
1.211MetArg: 1.211 ± 0.029
1.19MetSer: 1.19 ± 0.034
1.592MetThr: 1.592 ± 0.034
1.126MetVal: 1.126 ± 0.031
0.178MetTrp: 0.178 ± 0.012
0.252MetTyr: 0.252 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
2.388AsnAla: 2.388 ± 0.048
0.1AsnCys: 0.1 ± 0.008
1.073AsnAsp: 1.073 ± 0.034
0.874AsnGlu: 0.874 ± 0.031
0.596AsnPhe: 0.596 ± 0.023
1.905AsnGly: 1.905 ± 0.042
0.35AsnHis: 0.35 ± 0.018
0.672AsnIle: 0.672 ± 0.024
0.284AsnLys: 0.284 ± 0.015
1.788AsnLeu: 1.788 ± 0.037
0.247AsnMet: 0.247 ± 0.016
0.335AsnAsn: 0.335 ± 0.018
1.454AsnPro: 1.454 ± 0.037
0.536AsnGln: 0.536 ± 0.022
1.238AsnArg: 1.238 ± 0.034
0.856AsnSer: 0.856 ± 0.027
1.048AsnThr: 1.048 ± 0.038
1.547AsnVal: 1.547 ± 0.041
0.292AsnTrp: 0.292 ± 0.016
0.418AsnTyr: 0.418 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
8.477ProAla: 8.477 ± 0.134
0.175ProCys: 0.175 ± 0.012
4.269ProAsp: 4.269 ± 0.061
3.862ProGlu: 3.862 ± 0.059
1.751ProPhe: 1.751 ± 0.037
5.74ProGly: 5.74 ± 0.074
1.042ProHis: 1.042 ± 0.031
2.259ProIle: 2.259 ± 0.044
0.991ProLys: 0.991 ± 0.033
4.762ProLeu: 4.762 ± 0.067
0.843ProMet: 0.843 ± 0.027
1.12ProAsn: 1.12 ± 0.029
2.713ProPro: 2.713 ± 0.064
1.345ProGln: 1.345 ± 0.034
3.43ProArg: 3.43 ± 0.056
3.056ProSer: 3.056 ± 0.053
3.791ProThr: 3.791 ± 0.063
5.342ProVal: 5.342 ± 0.061
0.977ProTrp: 0.977 ± 0.031
1.069ProTyr: 1.069 ± 0.027
0.0ProXaa: 0.0 ± 0.0
Gln
3.606GlnAla: 3.606 ± 0.064
0.106GlnCys: 0.106 ± 0.011
1.043GlnAsp: 1.043 ± 0.03
1.106GlnGlu: 1.106 ± 0.032
0.838GlnPhe: 0.838 ± 0.024
1.911GlnGly: 1.911 ± 0.039
0.527GlnHis: 0.527 ± 0.023
0.989GlnIle: 0.989 ± 0.03
0.532GlnLys: 0.532 ± 0.024
2.801GlnLeu: 2.801 ± 0.054
0.381GlnMet: 0.381 ± 0.02
0.537GlnAsn: 0.537 ± 0.021
1.542GlnPro: 1.542 ± 0.043
0.97GlnGln: 0.97 ± 0.031
2.207GlnArg: 2.207 ± 0.046
1.336GlnSer: 1.336 ± 0.035
1.418GlnThr: 1.418 ± 0.033
2.496GlnVal: 2.496 ± 0.042
0.426GlnTrp: 0.426 ± 0.02
0.599GlnTyr: 0.599 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
9.641ArgAla: 9.641 ± 0.115
0.295ArgCys: 0.295 ± 0.018
4.611ArgAsp: 4.611 ± 0.063
4.151ArgGlu: 4.151 ± 0.065
2.541ArgPhe: 2.541 ± 0.046
5.685ArgGly: 5.685 ± 0.086
1.619ArgHis: 1.619 ± 0.036
3.693ArgIle: 3.693 ± 0.058
1.157ArgLys: 1.157 ± 0.036
7.854ArgLeu: 7.854 ± 0.106
1.641ArgMet: 1.641 ± 0.038
1.299ArgAsn: 1.299 ± 0.032
4.111ArgPro: 4.111 ± 0.064
1.797ArgGln: 1.797 ± 0.042
7.127ArgArg: 7.127 ± 0.113
3.896ArgSer: 3.896 ± 0.054
4.369ArgThr: 4.369 ± 0.057
6.403ArgVal: 6.403 ± 0.094
1.232ArgTrp: 1.232 ± 0.026
1.617ArgTyr: 1.617 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.948SerAla: 6.948 ± 0.081
0.234SerCys: 0.234 ± 0.017
3.027SerAsp: 3.027 ± 0.061
2.479SerGlu: 2.479 ± 0.047
1.736SerPhe: 1.736 ± 0.04
5.687SerGly: 5.687 ± 0.082
0.899SerHis: 0.899 ± 0.03
2.422SerIle: 2.422 ± 0.046
0.977SerLys: 0.977 ± 0.03
4.855SerLeu: 4.855 ± 0.057
0.997SerMet: 0.997 ± 0.029
1.012SerAsn: 1.012 ± 0.03
3.046SerPro: 3.046 ± 0.054
1.214SerGln: 1.214 ± 0.031
3.385SerArg: 3.385 ± 0.058
2.94SerSer: 2.94 ± 0.068
3.488SerThr: 3.488 ± 0.059
4.518SerVal: 4.518 ± 0.061
0.863SerTrp: 0.863 ± 0.027
1.122SerTyr: 1.122 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
8.171ThrAla: 8.171 ± 0.091
0.277ThrCys: 0.277 ± 0.019
3.76ThrAsp: 3.76 ± 0.062
2.973ThrGlu: 2.973 ± 0.052
1.86ThrPhe: 1.86 ± 0.04
6.221ThrGly: 6.221 ± 0.081
1.022ThrHis: 1.022 ± 0.027
2.818ThrIle: 2.818 ± 0.051
1.04ThrLys: 1.04 ± 0.033
5.647ThrLeu: 5.647 ± 0.07
0.843ThrMet: 0.843 ± 0.025
1.141ThrAsn: 1.141 ± 0.039
3.93ThrPro: 3.93 ± 0.065
1.259ThrGln: 1.259 ± 0.034
3.736ThrArg: 3.736 ± 0.053
3.158ThrSer: 3.158 ± 0.055
3.895ThrThr: 3.895 ± 0.072
5.847ThrVal: 5.847 ± 0.088
0.992ThrTrp: 0.992 ± 0.027
1.135ThrTyr: 1.135 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
12.903ValAla: 12.903 ± 0.137
0.42ValCys: 0.42 ± 0.019
6.483ValAsp: 6.483 ± 0.089
5.338ValGlu: 5.338 ± 0.075
3.003ValPhe: 3.003 ± 0.052
7.64ValGly: 7.64 ± 0.088
1.712ValHis: 1.712 ± 0.039
4.096ValIle: 4.096 ± 0.065
1.465ValLys: 1.465 ± 0.04
9.624ValLeu: 9.624 ± 0.118
1.178ValMet: 1.178 ± 0.03
1.754ValAsn: 1.754 ± 0.034
5.314ValPro: 5.314 ± 0.076
2.141ValGln: 2.141 ± 0.043
6.513ValArg: 6.513 ± 0.08
4.598ValSer: 4.598 ± 0.062
5.489ValThr: 5.489 ± 0.09
9.655ValVal: 9.655 ± 0.114
1.14ValTrp: 1.14 ± 0.034
1.542ValTyr: 1.542 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
1.767TrpAla: 1.767 ± 0.041
0.08TrpCys: 0.08 ± 0.009
0.844TrpAsp: 0.844 ± 0.025
0.665TrpGlu: 0.665 ± 0.024
0.613TrpPhe: 0.613 ± 0.024
1.134TrpGly: 1.134 ± 0.032
0.326TrpHis: 0.326 ± 0.017
0.73TrpIle: 0.73 ± 0.028
0.299TrpLys: 0.299 ± 0.015
1.799TrpLeu: 1.799 ± 0.04
0.304TrpMet: 0.304 ± 0.014
0.456TrpAsn: 0.456 ± 0.02
0.8TrpPro: 0.8 ± 0.025
0.568TrpGln: 0.568 ± 0.027
1.271TrpArg: 1.271 ± 0.031
0.97TrpSer: 0.97 ± 0.029
1.014TrpThr: 1.014 ± 0.034
1.233TrpVal: 1.233 ± 0.033
0.414TrpTrp: 0.414 ± 0.02
0.314TrpTyr: 0.314 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.425TyrAla: 2.425 ± 0.042
0.112TyrCys: 0.112 ± 0.009
1.4TyrAsp: 1.4 ± 0.039
1.11TyrGlu: 1.11 ± 0.03
0.681TyrPhe: 0.681 ± 0.024
1.897TyrGly: 1.897 ± 0.042
0.306TyrHis: 0.306 ± 0.016
0.524TyrIle: 0.524 ± 0.024
0.276TyrLys: 0.276 ± 0.017
2.119TyrLeu: 2.119 ± 0.046
0.213TyrMet: 0.213 ± 0.015
0.399TyrAsn: 0.399 ± 0.018
0.963TyrPro: 0.963 ± 0.032
0.536TyrGln: 0.536 ± 0.02
1.692TyrArg: 1.692 ± 0.043
1.006TyrSer: 1.006 ± 0.03
1.172TyrThr: 1.172 ± 0.036
1.671TyrVal: 1.671 ± 0.04
0.328TyrTrp: 0.328 ± 0.017
0.415TyrTyr: 0.415 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3639 proteins (1232372 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski