Amino acid dipepetide frequency for Croceibacterium mercuriale

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.433AlaAla: 20.433 ± 0.242	1.072AlaCys: 1.072 ± 0.038	8.521AlaAsp: 8.521 ± 0.111	8.283AlaGlu: 8.283 ± 0.122	4.101AlaPhe: 4.101 ± 0.063	13.426AlaGly: 13.426 ± 0.16	2.345AlaHis: 2.345 ± 0.062	6.564AlaIle: 6.564 ± 0.094	2.675AlaLys: 2.675 ± 0.065	14.525AlaLeu: 14.525 ± 0.19	3.77AlaMet: 3.77 ± 0.068	2.892AlaAsn: 2.892 ± 0.066	6.654AlaPro: 6.654 ± 0.106	5.107AlaGln: 5.107 ± 0.085	10.212AlaArg: 10.212 ± 0.135	6.011AlaSer: 6.011 ± 0.084	7.248AlaThr: 7.248 ± 0.104	8.944AlaVal: 8.944 ± 0.104	1.732AlaTrp: 1.732 ± 0.052	2.46AlaTyr: 2.46 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.996CysAla: 0.996 ± 0.035	0.09CysCys: 0.09 ± 0.011	0.496CysAsp: 0.496 ± 0.025	0.369CysGlu: 0.369 ± 0.021	0.26CysPhe: 0.26 ± 0.017	0.795CysGly: 0.795 ± 0.032	0.184CysHis: 0.184 ± 0.015	0.313CysIle: 0.313 ± 0.02	0.123CysLys: 0.123 ± 0.014	0.672CysLeu: 0.672 ± 0.029	0.144CysMet: 0.144 ± 0.013	0.218CysAsn: 0.218 ± 0.018	0.398CysPro: 0.398 ± 0.025	0.202CysGln: 0.202 ± 0.013	0.576CysArg: 0.576 ± 0.024	0.388CysSer: 0.388 ± 0.023	0.449CysThr: 0.449 ± 0.022	0.533CysVal: 0.533 ± 0.024	0.107CysTrp: 0.107 ± 0.01	0.155CysTyr: 0.155 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	8.114AspAla: 8.114 ± 0.103	0.473AspCys: 0.473 ± 0.023	3.325AspAsp: 3.325 ± 0.069	3.167AspGlu: 3.167 ± 0.065	2.021AspPhe: 2.021 ± 0.057	6.354AspGly: 6.354 ± 0.104	1.368AspHis: 1.368 ± 0.045	2.645AspIle: 2.645 ± 0.057	1.271AspLys: 1.271 ± 0.043	6.052AspLeu: 6.052 ± 0.087	1.42AspMet: 1.42 ± 0.037	1.361AspAsn: 1.361 ± 0.038	4.174AspPro: 4.174 ± 0.073	1.87AspGln: 1.87 ± 0.04	5.212AspArg: 5.212 ± 0.08	2.317AspSer: 2.317 ± 0.064	2.886AspThr: 2.886 ± 0.058	4.056AspVal: 4.056 ± 0.067	1.155AspTrp: 1.155 ± 0.037	1.535AspTyr: 1.535 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	7.386GluAla: 7.386 ± 0.108	0.3GluCys: 0.3 ± 0.02	2.804GluAsp: 2.804 ± 0.058	3.057GluGlu: 3.057 ± 0.067	1.531GluPhe: 1.531 ± 0.042	4.446GluGly: 4.446 ± 0.085	1.12GluHis: 1.12 ± 0.031	2.539GluIle: 2.539 ± 0.056	1.24GluLys: 1.24 ± 0.039	5.508GluLeu: 5.508 ± 0.074	1.231GluMet: 1.231 ± 0.036	1.157GluAsn: 1.157 ± 0.037	2.663GluPro: 2.663 ± 0.061	2.555GluGln: 2.555 ± 0.062	4.903GluArg: 4.903 ± 0.094	1.966GluSer: 1.966 ± 0.044	2.752GluThr: 2.752 ± 0.05	3.898GluVal: 3.898 ± 0.066	0.87GluTrp: 0.87 ± 0.027	1.039GluTyr: 1.039 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	5.013PheAla: 5.013 ± 0.076	0.318PheCys: 0.318 ± 0.021	2.671PheAsp: 2.671 ± 0.052	1.753PheGlu: 1.753 ± 0.046	1.213PhePhe: 1.213 ± 0.038	3.539PheGly: 3.539 ± 0.07	0.723PheHis: 0.723 ± 0.03	1.293PheIle: 1.293 ± 0.037	0.543PheLys: 0.543 ± 0.026	2.935PheLeu: 2.935 ± 0.069	0.72PheMet: 0.72 ± 0.029	0.999PheAsn: 0.999 ± 0.038	1.475PhePro: 1.475 ± 0.041	0.879PheGln: 0.879 ± 0.036	2.238PheArg: 2.238 ± 0.054	1.836PheSer: 1.836 ± 0.059	2.239PheThr: 2.239 ± 0.047	2.567PheVal: 2.567 ± 0.058	0.538PheTrp: 0.538 ± 0.025	0.912PheTyr: 0.912 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	10.846GlyAla: 10.846 ± 0.144	0.849GlyCys: 0.849 ± 0.028	5.12GlyAsp: 5.12 ± 0.079	5.058GlyGlu: 5.058 ± 0.067	3.576GlyPhe: 3.576 ± 0.062	8.754GlyGly: 8.754 ± 0.198	1.9GlyHis: 1.9 ± 0.054	4.245GlyIle: 4.245 ± 0.087	2.46GlyLys: 2.46 ± 0.064	8.992GlyLeu: 8.992 ± 0.093	2.433GlyMet: 2.433 ± 0.062	2.435GlyAsn: 2.435 ± 0.081	3.952GlyPro: 3.952 ± 0.072	3.575GlyGln: 3.575 ± 0.056	7.015GlyArg: 7.015 ± 0.083	4.932GlySer: 4.932 ± 0.108	5.765GlyThr: 5.765 ± 0.112	6.34GlyVal: 6.34 ± 0.091	1.862GlyTrp: 1.862 ± 0.058	2.212GlyTyr: 2.212 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.652HisAla: 2.652 ± 0.063	0.179HisCys: 0.179 ± 0.014	1.313HisAsp: 1.313 ± 0.036	0.952HisGlu: 0.952 ± 0.032	0.756HisPhe: 0.756 ± 0.032	2.148HisGly: 2.148 ± 0.053	0.579HisHis: 0.579 ± 0.031	0.742HisIle: 0.742 ± 0.03	0.35HisLys: 0.35 ± 0.02	1.991HisLeu: 1.991 ± 0.048	0.414HisMet: 0.414 ± 0.022	0.462HisAsn: 0.462 ± 0.025	1.333HisPro: 1.333 ± 0.044	0.607HisGln: 0.607 ± 0.03	1.573HisArg: 1.573 ± 0.046	0.83HisSer: 0.83 ± 0.028	0.822HisThr: 0.822 ± 0.029	1.42HisVal: 1.42 ± 0.039	0.372HisTrp: 0.372 ± 0.021	0.497HisTyr: 0.497 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	7.073IleAla: 7.073 ± 0.091	0.375IleCys: 0.375 ± 0.02	3.456IleAsp: 3.456 ± 0.069	2.833IleGlu: 2.833 ± 0.054	1.325IlePhe: 1.325 ± 0.044	4.839IleGly: 4.839 ± 0.078	0.783IleHis: 0.783 ± 0.029	1.858IleIle: 1.858 ± 0.052	0.817IleLys: 0.817 ± 0.032	3.35IleLeu: 3.35 ± 0.07	0.838IleMet: 0.838 ± 0.028	1.282IleAsn: 1.282 ± 0.042	2.077IlePro: 2.077 ± 0.05	1.022IleGln: 1.022 ± 0.033	3.113IleArg: 3.113 ± 0.053	2.18IleSer: 2.18 ± 0.057	2.666IleThr: 2.666 ± 0.055	3.74IleVal: 3.74 ± 0.075	0.53IleTrp: 0.53 ± 0.026	0.915IleTyr: 0.915 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	2.705LysAla: 2.705 ± 0.062	0.098LysCys: 0.098 ± 0.01	1.094LysAsp: 1.094 ± 0.042	0.945LysGlu: 0.945 ± 0.043	0.556LysPhe: 0.556 ± 0.027	1.875LysGly: 1.875 ± 0.057	0.402LysHis: 0.402 ± 0.023	0.922LysIle: 0.922 ± 0.041	0.661LysLys: 0.661 ± 0.04	2.282LysLeu: 2.282 ± 0.062	0.479LysMet: 0.479 ± 0.025	0.507LysAsn: 0.507 ± 0.024	1.326LysPro: 1.326 ± 0.039	0.742LysGln: 0.742 ± 0.028	1.665LysArg: 1.665 ± 0.043	0.987LysSer: 0.987 ± 0.038	1.111LysThr: 1.111 ± 0.039	1.602LysVal: 1.602 ± 0.046	0.258LysTrp: 0.258 ± 0.018	0.428LysTyr: 0.428 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	16.011LeuAla: 16.011 ± 0.205	0.715LeuCys: 0.715 ± 0.028	6.317LeuAsp: 6.317 ± 0.076	4.903LeuGlu: 4.903 ± 0.082	3.671LeuPhe: 3.671 ± 0.06	8.479LeuGly: 8.479 ± 0.098	1.977LeuHis: 1.977 ± 0.05	4.106LeuIle: 4.106 ± 0.067	2.139LeuLys: 2.139 ± 0.055	10.763LeuLeu: 10.763 ± 0.167	2.062LeuMet: 2.062 ± 0.045	2.282LeuAsn: 2.282 ± 0.056	6.216LeuPro: 6.216 ± 0.101	3.298LeuGln: 3.298 ± 0.064	7.386LeuArg: 7.386 ± 0.107	5.48LeuSer: 5.48 ± 0.091	5.851LeuThr: 5.851 ± 0.083	7.915LeuVal: 7.915 ± 0.094	1.323LeuTrp: 1.323 ± 0.043	1.959LeuTyr: 1.959 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.324MetAla: 3.324 ± 0.066	0.139MetCys: 0.139 ± 0.012	1.151MetAsp: 1.151 ± 0.038	1.088MetGlu: 1.088 ± 0.032	0.61MetPhe: 0.61 ± 0.029	1.749MetGly: 1.749 ± 0.05	0.446MetHis: 0.446 ± 0.022	1.187MetIle: 1.187 ± 0.037	0.658MetLys: 0.658 ± 0.025	2.514MetLeu: 2.514 ± 0.06	0.551MetMet: 0.551 ± 0.025	0.623MetAsn: 0.623 ± 0.027	1.512MetPro: 1.512 ± 0.05	0.915MetGln: 0.915 ± 0.032	1.775MetArg: 1.775 ± 0.049	1.249MetSer: 1.249 ± 0.033	1.498MetThr: 1.498 ± 0.048	1.683MetVal: 1.683 ± 0.04	0.249MetTrp: 0.249 ± 0.016	0.312MetTyr: 0.312 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.016AsnAla: 3.016 ± 0.061	0.225AsnCys: 0.225 ± 0.017	1.308AsnAsp: 1.308 ± 0.046	1.007AsnGlu: 1.007 ± 0.035	0.85AsnPhe: 0.85 ± 0.035	2.428AsnGly: 2.428 ± 0.077	0.48AsnHis: 0.48 ± 0.025	1.157AsnIle: 1.157 ± 0.041	0.472AsnLys: 0.472 ± 0.023	2.502AsnLeu: 2.502 ± 0.067	0.549AsnMet: 0.549 ± 0.026	0.743AsnAsn: 0.743 ± 0.038	1.766AsnPro: 1.766 ± 0.048	0.719AsnGln: 0.719 ± 0.033	1.881AsnArg: 1.881 ± 0.05	1.183AsnSer: 1.183 ± 0.044	1.175AsnThr: 1.175 ± 0.043	1.926AsnVal: 1.926 ± 0.055	0.416AsnTrp: 0.416 ± 0.022	0.68AsnTyr: 0.68 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	8.431ProAla: 8.431 ± 0.132	0.348ProCys: 0.348 ± 0.019	4.193ProAsp: 4.193 ± 0.071	3.368ProGlu: 3.368 ± 0.057	1.976ProPhe: 1.976 ± 0.047	5.269ProGly: 5.269 ± 0.079	1.097ProHis: 1.097 ± 0.038	2.062ProIle: 2.062 ± 0.049	0.912ProLys: 0.912 ± 0.036	5.371ProLeu: 5.371 ± 0.084	1.094ProMet: 1.094 ± 0.037	1.138ProAsn: 1.138 ± 0.031	2.868ProPro: 2.868 ± 0.083	1.983ProGln: 1.983 ± 0.056	3.26ProArg: 3.26 ± 0.056	2.453ProSer: 2.453 ± 0.055	2.614ProThr: 2.614 ± 0.056	4.838ProVal: 4.838 ± 0.076	0.746ProTrp: 0.746 ± 0.027	1.074ProTyr: 1.074 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	5.056GlnAla: 5.056 ± 0.079	0.221GlnCys: 0.221 ± 0.017	1.784GlnAsp: 1.784 ± 0.037	1.547GlnGlu: 1.547 ± 0.039	1.182GlnPhe: 1.182 ± 0.036	2.859GlnGly: 2.859 ± 0.066	0.7GlnHis: 0.7 ± 0.029	1.552GlnIle: 1.552 ± 0.039	0.651GlnLys: 0.651 ± 0.033	3.886GlnLeu: 3.886 ± 0.066	0.883GlnMet: 0.883 ± 0.033	0.739GlnAsn: 0.739 ± 0.036	2.238GlnPro: 2.238 ± 0.05	1.608GlnGln: 1.608 ± 0.053	2.867GlnArg: 2.867 ± 0.062	1.585GlnSer: 1.585 ± 0.044	1.744GlnThr: 1.744 ± 0.047	3.035GlnVal: 3.035 ± 0.053	0.507GlnTrp: 0.507 ± 0.024	0.677GlnTyr: 0.677 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	9.13ArgAla: 9.13 ± 0.132	0.489ArgCys: 0.489 ± 0.027	4.475ArgAsp: 4.475 ± 0.073	3.985ArgGlu: 3.985 ± 0.068	3.168ArgPhe: 3.168 ± 0.065	5.317ArgGly: 5.317 ± 0.077	1.789ArgHis: 1.789 ± 0.053	4.017ArgIle: 4.017 ± 0.068	1.603ArgLys: 1.603 ± 0.049	8.7ArgLeu: 8.7 ± 0.121	2.022ArgMet: 2.022 ± 0.047	1.945ArgAsn: 1.945 ± 0.046	4.066ArgPro: 4.066 ± 0.068	3.062ArgGln: 3.062 ± 0.072	6.24ArgArg: 6.24 ± 0.113	3.579ArgSer: 3.579 ± 0.063	4.052ArgThr: 4.052 ± 0.064	5.168ArgVal: 5.168 ± 0.077	1.425ArgTrp: 1.425 ± 0.046	1.757ArgTyr: 1.757 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	6.097SerAla: 6.097 ± 0.079	0.341SerCys: 0.341 ± 0.021	2.78SerAsp: 2.78 ± 0.057	2.157SerGlu: 2.157 ± 0.054	2.126SerPhe: 2.126 ± 0.059	5.195SerGly: 5.195 ± 0.098	0.879SerHis: 0.879 ± 0.027	2.178SerIle: 2.178 ± 0.058	0.947SerLys: 0.947 ± 0.035	4.858SerLeu: 4.858 ± 0.078	1.073SerMet: 1.073 ± 0.035	1.207SerAsn: 1.207 ± 0.041	2.655SerPro: 2.655 ± 0.051	1.478SerGln: 1.478 ± 0.042	3.402SerArg: 3.402 ± 0.062	2.409SerSer: 2.409 ± 0.061	2.578SerThr: 2.578 ± 0.055	3.406SerVal: 3.406 ± 0.067	0.849SerTrp: 0.849 ± 0.034	1.271SerTyr: 1.271 ± 0.042	0.0SerXaa: 0.0 ± 0.0
Thr	6.695ThrAla: 6.695 ± 0.099	0.432ThrCys: 0.432 ± 0.024	3.168ThrAsp: 3.168 ± 0.064	2.414ThrGlu: 2.414 ± 0.048	1.982ThrPhe: 1.982 ± 0.048	6.097ThrGly: 6.097 ± 0.094	0.98ThrHis: 0.98 ± 0.029	2.973ThrIle: 2.973 ± 0.063	0.95ThrLys: 0.95 ± 0.035	6.176ThrLeu: 6.176 ± 0.089	1.242ThrMet: 1.242 ± 0.039	1.363ThrAsn: 1.363 ± 0.044	3.619ThrPro: 3.619 ± 0.067	1.683ThrGln: 1.683 ± 0.046	3.757ThrArg: 3.757 ± 0.066	2.617ThrSer: 2.617 ± 0.058	2.919ThrThr: 2.919 ± 0.058	4.24ThrVal: 4.24 ± 0.089	0.645ThrTrp: 0.645 ± 0.026	1.268ThrTyr: 1.268 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	9.954ValAla: 9.954 ± 0.113	0.449ValCys: 0.449 ± 0.023	4.351ValAsp: 4.351 ± 0.067	4.507ValGlu: 4.507 ± 0.074	2.145ValPhe: 2.145 ± 0.043	5.62ValGly: 5.62 ± 0.104	1.358ValHis: 1.358 ± 0.039	3.394ValIle: 3.394 ± 0.06	1.434ValLys: 1.434 ± 0.047	7.749ValLeu: 7.749 ± 0.102	1.589ValMet: 1.589 ± 0.044	2.008ValAsn: 2.008 ± 0.052	4.328ValPro: 4.328 ± 0.073	2.433ValGln: 2.433 ± 0.052	5.379ValArg: 5.379 ± 0.08	3.835ValSer: 3.835 ± 0.069	4.927ValThr: 4.927 ± 0.085	5.358ValVal: 5.358 ± 0.091	0.889ValTrp: 0.889 ± 0.036	1.209ValTyr: 1.209 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.465TrpAla: 1.465 ± 0.043	0.14TrpCys: 0.14 ± 0.013	0.857TrpAsp: 0.857 ± 0.033	0.588TrpGlu: 0.588 ± 0.029	0.58TrpPhe: 0.58 ± 0.027	1.055TrpGly: 1.055 ± 0.037	0.411TrpHis: 0.411 ± 0.024	0.594TrpIle: 0.594 ± 0.029	0.322TrpLys: 0.322 ± 0.02	1.961TrpLeu: 1.961 ± 0.059	0.343TrpMet: 0.343 ± 0.02	0.485TrpAsn: 0.485 ± 0.027	0.76TrpPro: 0.76 ± 0.029	0.815TrpGln: 0.815 ± 0.036	1.513TrpArg: 1.513 ± 0.042	0.905TrpSer: 0.905 ± 0.032	0.826TrpThr: 0.826 ± 0.033	0.876TrpVal: 0.876 ± 0.032	0.328TrpTrp: 0.328 ± 0.021	0.328TrpTyr: 0.328 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.576TyrAla: 2.576 ± 0.054	0.217TyrCys: 0.217 ± 0.016	1.59TyrAsp: 1.59 ± 0.045	0.987TyrGlu: 0.987 ± 0.032	0.773TyrPhe: 0.773 ± 0.032	2.075TyrGly: 2.075 ± 0.061	0.471TyrHis: 0.471 ± 0.026	0.731TyrIle: 0.731 ± 0.032	0.419TyrLys: 0.419 ± 0.023	2.067TyrLeu: 2.067 ± 0.049	0.376TyrMet: 0.376 ± 0.02	0.64TyrAsn: 0.64 ± 0.033	1.015TyrPro: 1.015 ± 0.035	0.766TyrGln: 0.766 ± 0.031	2.023TyrArg: 2.023 ± 0.051	1.142TyrSer: 1.142 ± 0.042	1.099TyrThr: 1.099 ± 0.04	1.372TyrVal: 1.372 ± 0.04	0.348TyrTrp: 0.348 ± 0.022	0.547TyrTyr: 0.547 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2758 proteins (921998 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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