Amino acid dipepetide frequency for Candidatus Magnetomorum sp. HK-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.333AlaAla: 3.333 ± 0.044	0.749AlaCys: 0.749 ± 0.017	3.32AlaAsp: 3.32 ± 0.06	3.185AlaGlu: 3.185 ± 0.038	2.743AlaPhe: 2.743 ± 0.033	3.749AlaGly: 3.749 ± 0.087	1.062AlaHis: 1.062 ± 0.018	5.221AlaIle: 5.221 ± 0.045	3.48AlaLys: 3.48 ± 0.033	5.232AlaLeu: 5.232 ± 0.047	1.319AlaMet: 1.319 ± 0.02	3.173AlaAsn: 3.173 ± 0.045	1.748AlaPro: 1.748 ± 0.026	1.958AlaGln: 1.958 ± 0.024	2.046AlaArg: 2.046 ± 0.029	4.199AlaSer: 4.199 ± 0.074	3.056AlaThr: 3.056 ± 0.054	3.372AlaVal: 3.372 ± 0.032	0.64AlaTrp: 0.64 ± 0.016	2.275AlaTyr: 2.275 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.562CysAla: 0.562 ± 0.014	0.161CysCys: 0.161 ± 0.007	0.627CysAsp: 0.627 ± 0.015	0.591CysGlu: 0.591 ± 0.017	0.629CysPhe: 0.629 ± 0.016	0.763CysGly: 0.763 ± 0.017	0.304CysHis: 0.304 ± 0.011	0.944CysIle: 0.944 ± 0.02	0.71CysLys: 0.71 ± 0.017	1.055CysLeu: 1.055 ± 0.02	0.282CysMet: 0.282 ± 0.009	0.588CysAsn: 0.588 ± 0.015	0.493CysPro: 0.493 ± 0.013	0.479CysGln: 0.479 ± 0.013	0.462CysArg: 0.462 ± 0.013	0.848CysSer: 0.848 ± 0.021	0.487CysThr: 0.487 ± 0.014	0.604CysVal: 0.604 ± 0.015	0.119CysTrp: 0.119 ± 0.007	0.442CysTyr: 0.442 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.513AspAla: 3.513 ± 0.058	0.615AspCys: 0.615 ± 0.017	3.823AspAsp: 3.823 ± 0.068	3.752AspGlu: 3.752 ± 0.04	3.002AspPhe: 3.002 ± 0.035	4.119AspGly: 4.119 ± 0.085	1.335AspHis: 1.335 ± 0.021	6.508AspIle: 6.508 ± 0.086	3.641AspLys: 3.641 ± 0.043	5.427AspLeu: 5.427 ± 0.053	1.345AspMet: 1.345 ± 0.021	3.898AspAsn: 3.898 ± 0.059	2.395AspPro: 2.395 ± 0.033	2.607AspGln: 2.607 ± 0.031	2.171AspArg: 2.171 ± 0.029	4.231AspSer: 4.231 ± 0.059	3.344AspThr: 3.344 ± 0.056	3.191AspVal: 3.191 ± 0.046	0.72AspTrp: 0.72 ± 0.018	2.698AspTyr: 2.698 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	3.21GluAla: 3.21 ± 0.034	0.543GluCys: 0.543 ± 0.014	3.248GluAsp: 3.248 ± 0.04	3.153GluGlu: 3.153 ± 0.043	2.38GluPhe: 2.38 ± 0.028	2.811GluGly: 2.811 ± 0.04	1.027GluHis: 1.027 ± 0.021	5.937GluIle: 5.937 ± 0.052	5.871GluLys: 5.871 ± 0.078	5.314GluLeu: 5.314 ± 0.047	1.549GluMet: 1.549 ± 0.026	4.711GluAsn: 4.711 ± 0.035	1.665GluPro: 1.665 ± 0.024	2.264GluGln: 2.264 ± 0.033	2.255GluArg: 2.255 ± 0.037	4.192GluSer: 4.192 ± 0.036	3.795GluThr: 3.795 ± 0.033	2.696GluVal: 2.696 ± 0.03	0.684GluTrp: 0.684 ± 0.015	2.254GluTyr: 2.254 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	2.302PheAla: 2.302 ± 0.026	0.615PheCys: 0.615 ± 0.014	3.245PheAsp: 3.245 ± 0.033	2.941PheGlu: 2.941 ± 0.033	2.571PhePhe: 2.571 ± 0.034	2.571PheGly: 2.571 ± 0.039	1.027PheHis: 1.027 ± 0.017	3.973PheIle: 3.973 ± 0.039	2.943PheLys: 2.943 ± 0.045	3.943PheLeu: 3.943 ± 0.05	0.986PheMet: 0.986 ± 0.017	2.729PheAsn: 2.729 ± 0.031	1.556PhePro: 1.556 ± 0.026	1.97PheGln: 1.97 ± 0.028	1.585PheArg: 1.585 ± 0.025	4.298PheSer: 4.298 ± 0.039	2.822PheThr: 2.822 ± 0.041	2.529PheVal: 2.529 ± 0.025	0.546PheTrp: 0.546 ± 0.013	1.915PheTyr: 1.915 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	3.101GlyAla: 3.101 ± 0.069	0.709GlyCys: 0.709 ± 0.017	3.524GlyAsp: 3.524 ± 0.094	3.171GlyGlu: 3.171 ± 0.045	2.731GlyPhe: 2.731 ± 0.028	3.637GlyGly: 3.637 ± 0.076	1.207GlyHis: 1.207 ± 0.02	5.171GlyIle: 5.171 ± 0.043	4.453GlyLys: 4.453 ± 0.043	4.969GlyLeu: 4.969 ± 0.043	1.443GlyMet: 1.443 ± 0.021	3.922GlyAsn: 3.922 ± 0.075	1.341GlyPro: 1.341 ± 0.019	2.349GlyGln: 2.349 ± 0.034	2.04GlyArg: 2.04 ± 0.027	4.347GlySer: 4.347 ± 0.092	3.901GlyThr: 3.901 ± 0.082	3.239GlyVal: 3.239 ± 0.047	0.684GlyTrp: 0.684 ± 0.016	2.432GlyTyr: 2.432 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	1.131HisAla: 1.131 ± 0.02	0.253HisCys: 0.253 ± 0.009	1.015HisAsp: 1.015 ± 0.017	1.113HisGlu: 1.113 ± 0.022	1.102HisPhe: 1.102 ± 0.02	1.094HisGly: 1.094 ± 0.02	0.56HisHis: 0.56 ± 0.015	1.867HisIle: 1.867 ± 0.027	1.2HisLys: 1.2 ± 0.025	2.033HisLeu: 2.033 ± 0.028	0.444HisMet: 0.444 ± 0.014	0.944HisAsn: 0.944 ± 0.016	1.013HisPro: 1.013 ± 0.022	0.856HisGln: 0.856 ± 0.016	0.72HisArg: 0.72 ± 0.018	1.421HisSer: 1.421 ± 0.024	1.013HisThr: 1.013 ± 0.018	1.109HisVal: 1.109 ± 0.016	0.246HisTrp: 0.246 ± 0.008	0.912HisTyr: 0.912 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.222IleAla: 5.222 ± 0.04	1.039IleCys: 1.039 ± 0.022	6.335IleAsp: 6.335 ± 0.075	5.855IleGlu: 5.855 ± 0.047	4.025IlePhe: 4.025 ± 0.051	4.536IleGly: 4.536 ± 0.049	1.97IleHis: 1.97 ± 0.024	7.475IleIle: 7.475 ± 0.061	6.389IleLys: 6.389 ± 0.06	7.364IleLeu: 7.364 ± 0.052	1.576IleMet: 1.576 ± 0.021	5.92IleAsn: 5.92 ± 0.06	3.764IlePro: 3.764 ± 0.045	4.075IleGln: 4.075 ± 0.042	3.301IleArg: 3.301 ± 0.039	8.08IleSer: 8.08 ± 0.071	5.703IleThr: 5.703 ± 0.107	4.731IleVal: 4.731 ± 0.038	0.837IleTrp: 0.837 ± 0.018	3.222IleTyr: 3.222 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.082LysAla: 4.082 ± 0.046	0.651LysCys: 0.651 ± 0.016	4.224LysAsp: 4.224 ± 0.043	4.694LysGlu: 4.694 ± 0.063	2.395LysPhe: 2.395 ± 0.036	3.879LysGly: 3.879 ± 0.042	1.363LysHis: 1.363 ± 0.024	6.663LysIle: 6.663 ± 0.078	7.028LysLys: 7.028 ± 0.122	5.581LysLeu: 5.581 ± 0.063	1.673LysMet: 1.673 ± 0.033	5.263LysAsn: 5.263 ± 0.061	2.364LysPro: 2.364 ± 0.035	2.932LysGln: 2.932 ± 0.041	2.894LysArg: 2.894 ± 0.048	4.632LysSer: 4.632 ± 0.045	4.31LysThr: 4.31 ± 0.044	3.269LysVal: 3.269 ± 0.034	0.8LysTrp: 0.8 ± 0.018	2.812LysTyr: 2.812 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	4.801LeuAla: 4.801 ± 0.043	1.079LeuCys: 1.079 ± 0.024	4.896LeuAsp: 4.896 ± 0.048	5.165LeuGlu: 5.165 ± 0.044	4.335LeuPhe: 4.335 ± 0.049	4.168LeuGly: 4.168 ± 0.047	1.551LeuHis: 1.551 ± 0.025	7.54LeuIle: 7.54 ± 0.061	7.227LeuLys: 7.227 ± 0.082	7.584LeuLeu: 7.584 ± 0.083	1.968LeuMet: 1.968 ± 0.032	5.728LeuAsn: 5.728 ± 0.041	3.635LeuPro: 3.635 ± 0.041	2.764LeuGln: 2.764 ± 0.031	2.985LeuArg: 2.985 ± 0.046	8.163LeuSer: 8.163 ± 0.053	5.994LeuThr: 5.994 ± 0.082	4.13LeuVal: 4.13 ± 0.034	0.927LeuTrp: 0.927 ± 0.017	3.142LeuTyr: 3.142 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	1.473MetAla: 1.473 ± 0.021	0.209MetCys: 0.209 ± 0.009	1.518MetAsp: 1.518 ± 0.021	1.215MetGlu: 1.215 ± 0.019	0.807MetPhe: 0.807 ± 0.014	1.358MetGly: 1.358 ± 0.021	0.414MetHis: 0.414 ± 0.011	2.037MetIle: 2.037 ± 0.027	1.813MetLys: 1.813 ± 0.029	1.832MetLeu: 1.832 ± 0.029	0.529MetMet: 0.529 ± 0.014	1.516MetAsn: 1.516 ± 0.022	1.006MetPro: 1.006 ± 0.018	0.723MetGln: 0.723 ± 0.015	0.767MetArg: 0.767 ± 0.017	1.514MetSer: 1.514 ± 0.018	1.326MetThr: 1.326 ± 0.018	1.138MetVal: 1.138 ± 0.016	0.162MetTrp: 0.162 ± 0.006	0.599MetTyr: 0.599 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.772AsnAla: 3.772 ± 0.059	0.681AsnCys: 0.681 ± 0.014	4.304AsnAsp: 4.304 ± 0.065	3.934AsnGlu: 3.934 ± 0.037	2.652AsnPhe: 2.652 ± 0.031	3.93AsnGly: 3.93 ± 0.055	1.29AsnHis: 1.29 ± 0.021	6.213AsnIle: 6.213 ± 0.076	4.073AsnLys: 4.073 ± 0.049	5.287AsnLeu: 5.287 ± 0.04	1.335AsnMet: 1.335 ± 0.022	4.39AsnAsn: 4.39 ± 0.06	2.423AsnPro: 2.423 ± 0.025	2.888AsnGln: 2.888 ± 0.036	2.141AsnArg: 2.141 ± 0.026	4.161AsnSer: 4.161 ± 0.049	3.58AsnThr: 3.58 ± 0.062	3.281AsnVal: 3.281 ± 0.036	0.695AsnTrp: 0.695 ± 0.017	2.376AsnTyr: 2.376 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	1.747ProAla: 1.747 ± 0.026	0.353ProCys: 0.353 ± 0.011	3.016ProAsp: 3.016 ± 0.036	3.149ProGlu: 3.149 ± 0.037	1.885ProPhe: 1.885 ± 0.028	2.288ProGly: 2.288 ± 0.028	0.674ProHis: 0.674 ± 0.014	2.961ProIle: 2.961 ± 0.034	2.211ProLys: 2.211 ± 0.036	3.146ProLeu: 3.146 ± 0.037	0.729ProMet: 0.729 ± 0.016	1.797ProAsn: 1.797 ± 0.022	1.482ProPro: 1.482 ± 0.033	1.294ProGln: 1.294 ± 0.023	0.903ProArg: 0.903 ± 0.018	2.258ProSer: 2.258 ± 0.031	1.743ProThr: 1.743 ± 0.028	2.863ProVal: 2.863 ± 0.041	0.314ProTrp: 0.314 ± 0.01	1.372ProTyr: 1.372 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	2.454GlnAla: 2.454 ± 0.035	0.378GlnCys: 0.378 ± 0.011	1.843GlnAsp: 1.843 ± 0.025	2.134GlnGlu: 2.134 ± 0.03	1.684GlnPhe: 1.684 ± 0.024	1.926GlnGly: 1.926 ± 0.033	0.724GlnHis: 0.724 ± 0.016	3.517GlnIle: 3.517 ± 0.033	3.522GlnLys: 3.522 ± 0.058	3.836GlnLeu: 3.836 ± 0.042	1.016GlnMet: 1.016 ± 0.018	2.536GlnAsn: 2.536 ± 0.031	1.266GlnPro: 1.266 ± 0.022	1.488GlnGln: 1.488 ± 0.023	1.35GlnArg: 1.35 ± 0.025	3.096GlnSer: 3.096 ± 0.037	2.524GlnThr: 2.524 ± 0.031	2.08GlnVal: 2.08 ± 0.028	0.576GlnTrp: 0.576 ± 0.014	1.534GlnTyr: 1.534 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	1.781ArgAla: 1.781 ± 0.023	0.384ArgCys: 0.384 ± 0.012	1.708ArgAsp: 1.708 ± 0.025	1.959ArgGlu: 1.959 ± 0.036	2.0ArgPhe: 2.0 ± 0.035	1.671ArgGly: 1.671 ± 0.028	0.732ArgHis: 0.732 ± 0.019	3.437ArgIle: 3.437 ± 0.041	2.735ArgLys: 2.735 ± 0.048	3.734ArgLeu: 3.734 ± 0.05	0.901ArgMet: 0.901 ± 0.019	1.973ArgAsn: 1.973 ± 0.027	1.159ArgPro: 1.159 ± 0.022	1.404ArgGln: 1.404 ± 0.023	1.405ArgArg: 1.405 ± 0.029	2.259ArgSer: 2.259 ± 0.032	1.712ArgThr: 1.712 ± 0.024	1.957ArgVal: 1.957 ± 0.028	0.444ArgTrp: 0.444 ± 0.012	1.513ArgTyr: 1.513 ± 0.025	0.0ArgXaa: 0.0 ± 0.0
Ser	4.016SerAla: 4.016 ± 0.06	0.792SerCys: 0.792 ± 0.019	5.294SerAsp: 5.294 ± 0.084	4.557SerGlu: 4.557 ± 0.038	3.969SerPhe: 3.969 ± 0.04	5.898SerGly: 5.898 ± 0.103	1.423SerHis: 1.423 ± 0.021	7.073SerIle: 7.073 ± 0.074	4.681SerLys: 4.681 ± 0.048	6.75SerLeu: 6.75 ± 0.05	1.603SerMet: 1.603 ± 0.02	4.686SerAsn: 4.686 ± 0.062	2.74SerPro: 2.74 ± 0.032	2.803SerGln: 2.803 ± 0.03	2.192SerArg: 2.192 ± 0.031	5.809SerSer: 5.809 ± 0.095	3.932SerThr: 3.932 ± 0.062	4.286SerVal: 4.286 ± 0.051	0.886SerTrp: 0.886 ± 0.019	2.8SerTyr: 2.8 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	3.677ThrAla: 3.677 ± 0.073	0.608ThrCys: 0.608 ± 0.016	3.844ThrAsp: 3.844 ± 0.061	3.056ThrGlu: 3.056 ± 0.034	2.947ThrPhe: 2.947 ± 0.04	4.309ThrGly: 4.309 ± 0.082	1.108ThrHis: 1.108 ± 0.017	6.172ThrIle: 6.172 ± 0.106	2.941ThrLys: 2.941 ± 0.029	5.322ThrLeu: 5.322 ± 0.067	1.051ThrMet: 1.051 ± 0.017	3.26ThrAsn: 3.26 ± 0.052	2.463ThrPro: 2.463 ± 0.041	2.214ThrGln: 2.214 ± 0.031	1.676ThrArg: 1.676 ± 0.025	4.249ThrSer: 4.249 ± 0.078	3.22ThrThr: 3.22 ± 0.068	3.907ThrVal: 3.907 ± 0.066	0.599ThrTrp: 0.599 ± 0.014	2.194ThrTyr: 2.194 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	2.962ValAla: 2.962 ± 0.032	0.662ValCys: 0.662 ± 0.014	3.513ValAsp: 3.513 ± 0.042	3.081ValGlu: 3.081 ± 0.032	2.682ValPhe: 2.682 ± 0.03	2.787ValGly: 2.787 ± 0.043	1.032ValHis: 1.032 ± 0.017	4.472ValIle: 4.472 ± 0.038	3.556ValLys: 3.556 ± 0.034	4.78ValLeu: 4.78 ± 0.045	1.189ValMet: 1.189 ± 0.018	3.544ValAsn: 3.544 ± 0.044	1.861ValPro: 1.861 ± 0.026	2.05ValGln: 2.05 ± 0.024	1.999ValArg: 1.999 ± 0.03	4.723ValSer: 4.723 ± 0.052	3.324ValThr: 3.324 ± 0.05	2.943ValVal: 2.943 ± 0.028	0.641ValTrp: 0.641 ± 0.018	2.144ValTyr: 2.144 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	0.609TrpAla: 0.609 ± 0.015	0.133TrpCys: 0.133 ± 0.006	0.668TrpAsp: 0.668 ± 0.016	0.693TrpGlu: 0.693 ± 0.015	0.484TrpPhe: 0.484 ± 0.013	0.735TrpGly: 0.735 ± 0.021	0.294TrpHis: 0.294 ± 0.01	1.017TrpIle: 1.017 ± 0.019	0.767TrpLys: 0.767 ± 0.016	0.982TrpLeu: 0.982 ± 0.022	0.265TrpMet: 0.265 ± 0.008	0.719TrpAsn: 0.719 ± 0.018	0.307TrpPro: 0.307 ± 0.01	0.509TrpGln: 0.509 ± 0.012	0.41TrpArg: 0.41 ± 0.01	0.785TrpSer: 0.785 ± 0.017	0.608TrpThr: 0.608 ± 0.018	0.625TrpVal: 0.625 ± 0.016	0.124TrpTrp: 0.124 ± 0.006	0.404TrpTyr: 0.404 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.109TyrAla: 2.109 ± 0.036	0.537TyrCys: 0.537 ± 0.014	2.372TyrAsp: 2.372 ± 0.031	2.161TyrGlu: 2.161 ± 0.023	2.046TyrPhe: 2.046 ± 0.031	2.143TyrGly: 2.143 ± 0.026	0.952TyrHis: 0.952 ± 0.018	3.222TyrIle: 3.222 ± 0.038	2.268TyrLys: 2.268 ± 0.035	3.612TyrLeu: 3.612 ± 0.038	0.755TyrMet: 0.755 ± 0.014	2.11TyrAsn: 2.11 ± 0.028	1.503TyrPro: 1.503 ± 0.024	1.857TyrGln: 1.857 ± 0.026	1.564TyrArg: 1.564 ± 0.021	2.925TyrSer: 2.925 ± 0.033	2.424TyrThr: 2.424 ± 0.053	1.993TyrVal: 1.993 ± 0.025	0.49TyrTrp: 0.49 ± 0.014	1.874TyrTyr: 1.874 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10924 proteins (4167494 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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