Amino acid dipepetide frequency for Ornithinibacillus halophilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.383AlaAla: 4.383 ± 0.084
0.51AlaCys: 0.51 ± 0.028
3.019AlaAsp: 3.019 ± 0.064
4.004AlaGlu: 4.004 ± 0.071
3.086AlaPhe: 3.086 ± 0.07
4.446AlaGly: 4.446 ± 0.09
1.077AlaHis: 1.077 ± 0.037
5.941AlaIle: 5.941 ± 0.093
4.351AlaLys: 4.351 ± 0.069
6.423AlaLeu: 6.423 ± 0.083
1.886AlaMet: 1.886 ± 0.049
2.871AlaAsn: 2.871 ± 0.065
1.92AlaPro: 1.92 ± 0.061
1.858AlaGln: 1.858 ± 0.044
2.305AlaArg: 2.305 ± 0.052
3.866AlaSer: 3.866 ± 0.071
3.442AlaThr: 3.442 ± 0.062
4.714AlaVal: 4.714 ± 0.093
0.579AlaTrp: 0.579 ± 0.029
2.241AlaTyr: 2.241 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.304CysAla: 0.304 ± 0.018
0.077CysCys: 0.077 ± 0.009
0.34CysAsp: 0.34 ± 0.019
0.385CysGlu: 0.385 ± 0.019
0.242CysPhe: 0.242 ± 0.018
0.582CysGly: 0.582 ± 0.028
0.163CysHis: 0.163 ± 0.015
0.453CysIle: 0.453 ± 0.022
0.326CysLys: 0.326 ± 0.02
0.501CysLeu: 0.501 ± 0.026
0.15CysMet: 0.15 ± 0.013
0.253CysAsn: 0.253 ± 0.016
0.293CysPro: 0.293 ± 0.018
0.193CysGln: 0.193 ± 0.014
0.192CysArg: 0.192 ± 0.014
0.431CysSer: 0.431 ± 0.021
0.347CysThr: 0.347 ± 0.022
0.342CysVal: 0.342 ± 0.02
0.053CysTrp: 0.053 ± 0.007
0.238CysTyr: 0.238 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.258AspAla: 3.258 ± 0.074
0.347AspCys: 0.347 ± 0.018
3.054AspAsp: 3.054 ± 0.071
5.222AspGlu: 5.222 ± 0.097
2.538AspPhe: 2.538 ± 0.059
3.582AspGly: 3.582 ± 0.077
1.18AspHis: 1.18 ± 0.042
4.584AspIle: 4.584 ± 0.076
3.436AspLys: 3.436 ± 0.059
5.078AspLeu: 5.078 ± 0.079
1.456AspMet: 1.456 ± 0.037
2.374AspAsn: 2.374 ± 0.052
2.004AspPro: 2.004 ± 0.046
1.951AspGln: 1.951 ± 0.045
2.138AspArg: 2.138 ± 0.054
3.005AspSer: 3.005 ± 0.055
2.73AspThr: 2.73 ± 0.059
4.174AspVal: 4.174 ± 0.07
0.634AspTrp: 0.634 ± 0.028
2.538AspTyr: 2.538 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
5.004GluAla: 5.004 ± 0.069
0.277GluCys: 0.277 ± 0.019
4.532GluAsp: 4.532 ± 0.084
8.108GluGlu: 8.108 ± 0.138
2.863GluPhe: 2.863 ± 0.059
4.26GluGly: 4.26 ± 0.071
1.496GluHis: 1.496 ± 0.034
6.084GluIle: 6.084 ± 0.076
6.884GluLys: 6.884 ± 0.114
7.506GluLeu: 7.506 ± 0.097
2.324GluMet: 2.324 ± 0.048
4.405GluAsn: 4.405 ± 0.081
2.018GluPro: 2.018 ± 0.053
3.42GluGln: 3.42 ± 0.067
3.482GluArg: 3.482 ± 0.077
3.888GluSer: 3.888 ± 0.067
3.903GluThr: 3.903 ± 0.068
5.588GluVal: 5.588 ± 0.084
0.83GluTrp: 0.83 ± 0.032
2.513GluTyr: 2.513 ± 0.055
0.0GluXaa: 0.0 ± 0.0
Phe
2.902PheAla: 2.902 ± 0.064
0.297PheCys: 0.297 ± 0.015
2.487PheAsp: 2.487 ± 0.054
2.878PheGlu: 2.878 ± 0.057
2.37PhePhe: 2.37 ± 0.062
3.209PheGly: 3.209 ± 0.065
1.003PheHis: 1.003 ± 0.034
4.24PheIle: 4.24 ± 0.087
2.358PheLys: 2.358 ± 0.049
4.549PheLeu: 4.549 ± 0.089
1.155PheMet: 1.155 ± 0.033
2.036PheAsn: 2.036 ± 0.046
1.686PhePro: 1.686 ± 0.044
1.622PheGln: 1.622 ± 0.044
1.425PheArg: 1.425 ± 0.043
3.204PheSer: 3.204 ± 0.059
2.66PheThr: 2.66 ± 0.052
3.083PheVal: 3.083 ± 0.065
0.47PheTrp: 0.47 ± 0.028
1.805PheTyr: 1.805 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
4.395GlyAla: 4.395 ± 0.085
0.465GlyCys: 0.465 ± 0.027
3.396GlyAsp: 3.396 ± 0.067
4.778GlyGlu: 4.778 ± 0.087
3.294GlyPhe: 3.294 ± 0.072
4.526GlyGly: 4.526 ± 0.091
1.333GlyHis: 1.333 ± 0.039
5.923GlyIle: 5.923 ± 0.089
4.688GlyLys: 4.688 ± 0.078
6.229GlyLeu: 6.229 ± 0.1
2.076GlyMet: 2.076 ± 0.051
2.949GlyAsn: 2.949 ± 0.062
1.667GlyPro: 1.667 ± 0.045
2.041GlyGln: 2.041 ± 0.052
2.382GlyArg: 2.382 ± 0.054
3.753GlySer: 3.753 ± 0.067
3.931GlyThr: 3.931 ± 0.087
5.029GlyVal: 5.029 ± 0.096
0.739GlyTrp: 0.739 ± 0.033
2.812GlyTyr: 2.812 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
1.249HisAla: 1.249 ± 0.036
0.182HisCys: 0.182 ± 0.014
1.098HisAsp: 1.098 ± 0.035
1.442HisGlu: 1.442 ± 0.043
1.023HisPhe: 1.023 ± 0.033
1.439HisGly: 1.439 ± 0.041
0.68HisHis: 0.68 ± 0.033
1.54HisIle: 1.54 ± 0.038
1.028HisLys: 1.028 ± 0.032
1.951HisLeu: 1.951 ± 0.047
0.517HisMet: 0.517 ± 0.024
0.865HisAsn: 0.865 ± 0.031
1.071HisPro: 1.071 ± 0.033
0.877HisGln: 0.877 ± 0.031
0.857HisArg: 0.857 ± 0.027
1.115HisSer: 1.115 ± 0.033
1.0HisThr: 1.0 ± 0.029
1.369HisVal: 1.369 ± 0.041
0.214HisTrp: 0.214 ± 0.016
0.881HisTyr: 0.881 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.897IleAla: 5.897 ± 0.102
0.55IleCys: 0.55 ± 0.021
4.797IleAsp: 4.797 ± 0.079
6.095IleGlu: 6.095 ± 0.081
3.592IlePhe: 3.592 ± 0.079
6.029IleGly: 6.029 ± 0.11
1.794IleHis: 1.794 ± 0.043
6.884IleIle: 6.884 ± 0.113
4.869IleLys: 4.869 ± 0.083
7.573IleLeu: 7.573 ± 0.129
1.86IleMet: 1.86 ± 0.044
3.847IleAsn: 3.847 ± 0.068
3.582IlePro: 3.582 ± 0.063
3.135IleGln: 3.135 ± 0.066
3.079IleArg: 3.079 ± 0.061
5.252IleSer: 5.252 ± 0.077
4.747IleThr: 4.747 ± 0.077
5.87IleVal: 5.87 ± 0.089
0.677IleTrp: 0.677 ± 0.025
2.703IleTyr: 2.703 ± 0.057
0.0IleXaa: 0.0 ± 0.0
Lys
4.1LysAla: 4.1 ± 0.068
0.284LysCys: 0.284 ± 0.018
4.063LysAsp: 4.063 ± 0.07
7.106LysGlu: 7.106 ± 0.108
2.003LysPhe: 2.003 ± 0.046
4.045LysGly: 4.045 ± 0.076
1.355LysHis: 1.355 ± 0.038
4.608LysIle: 4.608 ± 0.066
5.742LysLys: 5.742 ± 0.089
5.857LysLeu: 5.857 ± 0.085
2.04LysMet: 2.04 ± 0.049
3.623LysAsn: 3.623 ± 0.07
2.16LysPro: 2.16 ± 0.053
3.266LysGln: 3.266 ± 0.061
3.239LysArg: 3.239 ± 0.057
3.355LysSer: 3.355 ± 0.065
3.449LysThr: 3.449 ± 0.064
4.671LysVal: 4.671 ± 0.065
0.798LysTrp: 0.798 ± 0.028
2.163LysTyr: 2.163 ± 0.053
0.0LysXaa: 0.0 ± 0.0
Leu
6.52LeuAla: 6.52 ± 0.108
0.527LeuCys: 0.527 ± 0.025
4.982LeuAsp: 4.982 ± 0.083
7.025LeuGlu: 7.025 ± 0.103
4.898LeuPhe: 4.898 ± 0.096
6.295LeuGly: 6.295 ± 0.095
1.859LeuHis: 1.859 ± 0.044
7.604LeuIle: 7.604 ± 0.114
6.099LeuLys: 6.099 ± 0.087
9.872LeuLeu: 9.872 ± 0.142
2.425LeuMet: 2.425 ± 0.057
4.384LeuAsn: 4.384 ± 0.073
3.825LeuPro: 3.825 ± 0.061
3.42LeuGln: 3.42 ± 0.066
3.349LeuArg: 3.349 ± 0.065
6.314LeuSer: 6.314 ± 0.092
5.499LeuThr: 5.499 ± 0.08
6.346LeuVal: 6.346 ± 0.104
0.72LeuTrp: 0.72 ± 0.032
3.203LeuTyr: 3.203 ± 0.066
0.0LeuXaa: 0.0 ± 0.0
Met
1.821MetAla: 1.821 ± 0.044
0.112MetCys: 0.112 ± 0.01
1.718MetAsp: 1.718 ± 0.044
2.187MetGlu: 2.187 ± 0.047
1.048MetPhe: 1.048 ± 0.034
1.717MetGly: 1.717 ± 0.046
0.466MetHis: 0.466 ± 0.023
2.137MetIle: 2.137 ± 0.05
2.36MetLys: 2.36 ± 0.05
2.412MetLeu: 2.412 ± 0.056
0.817MetMet: 0.817 ± 0.029
1.616MetAsn: 1.616 ± 0.046
0.922MetPro: 0.922 ± 0.033
0.963MetGln: 0.963 ± 0.03
1.049MetArg: 1.049 ± 0.034
1.619MetSer: 1.619 ± 0.039
1.571MetThr: 1.571 ± 0.041
1.81MetVal: 1.81 ± 0.041
0.212MetTrp: 0.212 ± 0.014
0.805MetTyr: 0.805 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
2.697AsnAla: 2.697 ± 0.06
0.284AsnCys: 0.284 ± 0.017
2.756AsnAsp: 2.756 ± 0.048
4.129AsnGlu: 4.129 ± 0.063
1.959AsnPhe: 1.959 ± 0.05
3.422AsnGly: 3.422 ± 0.07
1.181AsnHis: 1.181 ± 0.036
3.668AsnIle: 3.668 ± 0.064
3.384AsnLys: 3.384 ± 0.063
4.097AsnLeu: 4.097 ± 0.061
1.347AsnMet: 1.347 ± 0.039
2.847AsnAsn: 2.847 ± 0.078
2.22AsnPro: 2.22 ± 0.043
2.236AsnGln: 2.236 ± 0.061
2.194AsnArg: 2.194 ± 0.052
2.637AsnSer: 2.637 ± 0.055
2.384AsnThr: 2.384 ± 0.053
3.226AsnVal: 3.226 ± 0.057
0.585AsnTrp: 0.585 ± 0.026
1.89AsnTyr: 1.89 ± 0.049
0.0AsnXaa: 0.0 ± 0.0
Pro
1.897ProAla: 1.897 ± 0.049
0.172ProCys: 0.172 ± 0.015
2.093ProAsp: 2.093 ± 0.052
3.024ProGlu: 3.024 ± 0.067
1.821ProPhe: 1.821 ± 0.046
2.377ProGly: 2.377 ± 0.065
0.735ProHis: 0.735 ± 0.029
3.125ProIle: 3.125 ± 0.062
2.18ProLys: 2.18 ± 0.051
3.163ProLeu: 3.163 ± 0.063
0.837ProMet: 0.837 ± 0.031
1.865ProAsn: 1.865 ± 0.041
0.949ProPro: 0.949 ± 0.032
1.012ProGln: 1.012 ± 0.036
1.064ProArg: 1.064 ± 0.04
2.232ProSer: 2.232 ± 0.049
2.136ProThr: 2.136 ± 0.05
2.669ProVal: 2.669 ± 0.054
0.352ProTrp: 0.352 ± 0.017
1.376ProTyr: 1.376 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
2.46GlnAla: 2.46 ± 0.057
0.149GlnCys: 0.149 ± 0.013
1.881GlnAsp: 1.881 ± 0.043
3.076GlnGlu: 3.076 ± 0.063
1.606GlnPhe: 1.606 ± 0.043
2.163GlnGly: 2.163 ± 0.05
0.774GlnHis: 0.774 ± 0.028
2.602GlnIle: 2.602 ± 0.054
2.659GlnLys: 2.659 ± 0.054
4.102GlnLeu: 4.102 ± 0.072
1.082GlnMet: 1.082 ± 0.037
1.702GlnAsn: 1.702 ± 0.043
1.151GlnPro: 1.151 ± 0.033
1.862GlnGln: 1.862 ± 0.052
1.443GlnArg: 1.443 ± 0.046
2.281GlnSer: 2.281 ± 0.054
1.93GlnThr: 1.93 ± 0.044
2.479GlnVal: 2.479 ± 0.051
0.394GlnTrp: 0.394 ± 0.02
1.242GlnTyr: 1.242 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
2.204ArgAla: 2.204 ± 0.056
0.238ArgCys: 0.238 ± 0.018
2.078ArgAsp: 2.078 ± 0.051
3.05ArgGlu: 3.05 ± 0.064
1.702ArgPhe: 1.702 ± 0.042
2.28ArgGly: 2.28 ± 0.057
0.7ArgHis: 0.7 ± 0.026
3.068ArgIle: 3.068 ± 0.059
3.111ArgLys: 3.111 ± 0.066
3.723ArgLeu: 3.723 ± 0.067
1.215ArgMet: 1.215 ± 0.034
2.05ArgAsn: 2.05 ± 0.054
1.132ArgPro: 1.132 ± 0.037
1.35ArgGln: 1.35 ± 0.048
1.708ArgArg: 1.708 ± 0.054
2.066ArgSer: 2.066 ± 0.046
1.958ArgThr: 1.958 ± 0.043
2.655ArgVal: 2.655 ± 0.064
0.398ArgTrp: 0.398 ± 0.02
1.534ArgTyr: 1.534 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
3.167SerAla: 3.167 ± 0.061
0.309SerCys: 0.309 ± 0.019
3.105SerAsp: 3.105 ± 0.058
4.173SerGlu: 4.173 ± 0.088
3.118SerPhe: 3.118 ± 0.058
4.181SerGly: 4.181 ± 0.076
1.147SerHis: 1.147 ± 0.03
5.612SerIle: 5.612 ± 0.077
3.794SerLys: 3.794 ± 0.066
5.749SerLeu: 5.749 ± 0.081
1.691SerMet: 1.691 ± 0.041
3.045SerAsn: 3.045 ± 0.066
2.019SerPro: 2.019 ± 0.046
1.916SerGln: 1.916 ± 0.043
2.082SerArg: 2.082 ± 0.049
3.881SerSer: 3.881 ± 0.077
3.226SerThr: 3.226 ± 0.058
4.09SerVal: 4.09 ± 0.068
0.633SerTrp: 0.633 ± 0.028
2.427SerTyr: 2.427 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
3.412ThrAla: 3.412 ± 0.061
0.295ThrCys: 0.295 ± 0.019
2.907ThrAsp: 2.907 ± 0.059
3.703ThrGlu: 3.703 ± 0.064
2.607ThrPhe: 2.607 ± 0.054
3.855ThrGly: 3.855 ± 0.068
0.985ThrHis: 0.985 ± 0.031
5.162ThrIle: 5.162 ± 0.08
3.433ThrLys: 3.433 ± 0.055
5.098ThrLeu: 5.098 ± 0.079
1.368ThrMet: 1.368 ± 0.042
2.753ThrAsn: 2.753 ± 0.052
2.185ThrPro: 2.185 ± 0.051
1.449ThrGln: 1.449 ± 0.042
1.789ThrArg: 1.789 ± 0.045
3.337ThrSer: 3.337 ± 0.069
3.214ThrThr: 3.214 ± 0.067
4.286ThrVal: 4.286 ± 0.091
0.551ThrTrp: 0.551 ± 0.025
2.119ThrTyr: 2.119 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
4.66ValAla: 4.66 ± 0.075
0.467ValCys: 0.467 ± 0.022
4.189ValAsp: 4.189 ± 0.076
5.393ValGlu: 5.393 ± 0.088
3.188ValPhe: 3.188 ± 0.066
4.793ValGly: 4.793 ± 0.079
1.333ValHis: 1.333 ± 0.037
6.02ValIle: 6.02 ± 0.096
4.382ValLys: 4.382 ± 0.069
6.784ValLeu: 6.784 ± 0.096
1.928ValMet: 1.928 ± 0.044
3.391ValAsn: 3.391 ± 0.07
2.603ValPro: 2.603 ± 0.051
2.372ValGln: 2.372 ± 0.051
2.494ValArg: 2.494 ± 0.054
4.454ValSer: 4.454 ± 0.078
4.105ValThr: 4.105 ± 0.075
5.368ValVal: 5.368 ± 0.089
0.601ValTrp: 0.601 ± 0.026
2.282ValTyr: 2.282 ± 0.056
0.0ValXaa: 0.0 ± 0.0
Trp
0.556TrpAla: 0.556 ± 0.027
0.059TrpCys: 0.059 ± 0.007
0.571TrpAsp: 0.571 ± 0.028
0.733TrpGlu: 0.733 ± 0.031
0.512TrpPhe: 0.512 ± 0.029
0.672TrpGly: 0.672 ± 0.031
0.186TrpHis: 0.186 ± 0.013
0.845TrpIle: 0.845 ± 0.031
0.765TrpLys: 0.765 ± 0.032
1.076TrpLeu: 1.076 ± 0.041
0.314TrpMet: 0.314 ± 0.017
0.572TrpAsn: 0.572 ± 0.026
0.242TrpPro: 0.242 ± 0.017
0.333TrpGln: 0.333 ± 0.019
0.345TrpArg: 0.345 ± 0.019
0.584TrpSer: 0.584 ± 0.027
0.466TrpThr: 0.466 ± 0.022
0.652TrpVal: 0.652 ± 0.026
0.138TrpTrp: 0.138 ± 0.013
0.392TrpTyr: 0.392 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.037TyrAla: 2.037 ± 0.049
0.263TyrCys: 0.263 ± 0.019
2.219TyrAsp: 2.219 ± 0.054
2.874TyrGlu: 2.874 ± 0.066
1.97TyrPhe: 1.97 ± 0.05
2.531TyrGly: 2.531 ± 0.051
0.951TyrHis: 0.951 ± 0.031
2.733TyrIle: 2.733 ± 0.053
2.078TyrLys: 2.078 ± 0.052
3.423TyrLeu: 3.423 ± 0.066
0.873TyrMet: 0.873 ± 0.032
1.698TyrAsn: 1.698 ± 0.046
1.432TyrPro: 1.432 ± 0.04
1.759TyrGln: 1.759 ± 0.048
1.604TyrArg: 1.604 ± 0.038
2.091TyrSer: 2.091 ± 0.051
1.81TyrThr: 1.81 ± 0.046
2.385TyrVal: 2.385 ± 0.055
0.433TyrTrp: 0.433 ± 0.021
1.67TyrTyr: 1.67 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3462 proteins (975949 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski