Amino acid dipepetide frequency for Lysobacter arseniciresistens ZS79

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.261AlaAla: 19.261 ± 0.239	1.166AlaCys: 1.166 ± 0.041	8.211AlaAsp: 8.211 ± 0.116	7.52AlaGlu: 7.52 ± 0.13	4.117AlaPhe: 4.117 ± 0.086	12.402AlaGly: 12.402 ± 0.156	2.631AlaHis: 2.631 ± 0.068	5.475AlaIle: 5.475 ± 0.095	3.065AlaLys: 3.065 ± 0.097	15.304AlaLeu: 15.304 ± 0.201	3.505AlaMet: 3.505 ± 0.076	2.769AlaAsn: 2.769 ± 0.065	6.432AlaPro: 6.432 ± 0.115	4.667AlaGln: 4.667 ± 0.076	10.589AlaArg: 10.589 ± 0.144	6.1AlaSer: 6.1 ± 0.111	6.771AlaThr: 6.771 ± 0.112	9.341AlaVal: 9.341 ± 0.109	1.944AlaTrp: 1.944 ± 0.061	2.283AlaTyr: 2.283 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.994CysAla: 0.994 ± 0.039	0.09CysCys: 0.09 ± 0.011	0.497CysAsp: 0.497 ± 0.026	0.476CysGlu: 0.476 ± 0.027	0.249CysPhe: 0.249 ± 0.018	0.858CysGly: 0.858 ± 0.039	0.242CysHis: 0.242 ± 0.02	0.32CysIle: 0.32 ± 0.022	0.155CysLys: 0.155 ± 0.015	0.681CysLeu: 0.681 ± 0.03	0.131CysMet: 0.131 ± 0.013	0.171CysAsn: 0.171 ± 0.014	0.369CysPro: 0.369 ± 0.024	0.196CysGln: 0.196 ± 0.016	0.569CysArg: 0.569 ± 0.027	0.406CysSer: 0.406 ± 0.028	0.405CysThr: 0.405 ± 0.024	0.639CysVal: 0.639 ± 0.03	0.11CysTrp: 0.11 ± 0.013	0.176CysTyr: 0.176 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	9.389AspAla: 9.389 ± 0.124	0.418AspCys: 0.418 ± 0.02	4.128AspAsp: 4.128 ± 0.083	3.859AspGlu: 3.859 ± 0.07	2.125AspPhe: 2.125 ± 0.054	6.71AspGly: 6.71 ± 0.105	1.388AspHis: 1.388 ± 0.045	2.455AspIle: 2.455 ± 0.061	1.421AspLys: 1.421 ± 0.051	5.825AspLeu: 5.825 ± 0.092	1.185AspMet: 1.185 ± 0.049	1.394AspAsn: 1.394 ± 0.047	3.813AspPro: 3.813 ± 0.075	1.634AspGln: 1.634 ± 0.051	4.677AspArg: 4.677 ± 0.082	2.535AspSer: 2.535 ± 0.058	3.041AspThr: 3.041 ± 0.064	4.493AspVal: 4.493 ± 0.081	1.169AspTrp: 1.169 ± 0.043	1.708AspTyr: 1.708 ± 0.052	0.0AspXaa: 0.0 ± 0.0
Glu	7.732GluAla: 7.732 ± 0.136	0.381GluCys: 0.381 ± 0.025	2.709GluAsp: 2.709 ± 0.069	2.377GluGlu: 2.377 ± 0.067	1.912GluPhe: 1.912 ± 0.055	4.177GluGly: 4.177 ± 0.074	1.555GluHis: 1.555 ± 0.05	2.453GluIle: 2.453 ± 0.057	1.494GluLys: 1.494 ± 0.058	6.707GluLeu: 6.707 ± 0.097	1.216GluMet: 1.216 ± 0.045	1.162GluAsn: 1.162 ± 0.043	3.02GluPro: 3.02 ± 0.064	2.651GluGln: 2.651 ± 0.056	5.55GluArg: 5.55 ± 0.086	2.59GluSer: 2.59 ± 0.064	2.676GluThr: 2.676 ± 0.058	4.655GluVal: 4.655 ± 0.093	0.715GluTrp: 0.715 ± 0.034	1.182GluTyr: 1.182 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	4.21PheAla: 4.21 ± 0.076	0.317PheCys: 0.317 ± 0.023	2.942PheAsp: 2.942 ± 0.082	2.114PheGlu: 2.114 ± 0.057	1.165PhePhe: 1.165 ± 0.047	3.566PheGly: 3.566 ± 0.073	0.762PheHis: 0.762 ± 0.029	1.242PheIle: 1.242 ± 0.046	0.776PheLys: 0.776 ± 0.035	2.779PheLeu: 2.779 ± 0.06	0.636PheMet: 0.636 ± 0.029	1.022PheAsn: 1.022 ± 0.038	1.313PhePro: 1.313 ± 0.045	0.903PheGln: 0.903 ± 0.034	2.188PheArg: 2.188 ± 0.046	1.699PheSer: 1.699 ± 0.046	1.675PheThr: 1.675 ± 0.05	2.59PheVal: 2.59 ± 0.065	0.469PheTrp: 0.469 ± 0.032	0.703PheTyr: 0.703 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.721GlyAla: 9.721 ± 0.144	0.772GlyCys: 0.772 ± 0.03	5.792GlyAsp: 5.792 ± 0.1	5.536GlyGlu: 5.536 ± 0.092	3.518GlyPhe: 3.518 ± 0.082	7.945GlyGly: 7.945 ± 0.142	2.217GlyHis: 2.217 ± 0.055	3.959GlyIle: 3.959 ± 0.076	2.855GlyLys: 2.855 ± 0.068	8.923GlyLeu: 8.923 ± 0.118	2.39GlyMet: 2.39 ± 0.057	2.429GlyAsn: 2.429 ± 0.061	3.188GlyPro: 3.188 ± 0.067	2.935GlyGln: 2.935 ± 0.061	6.846GlyArg: 6.846 ± 0.093	4.546GlySer: 4.546 ± 0.09	4.44GlyThr: 4.44 ± 0.087	6.829GlyVal: 6.829 ± 0.109	1.647GlyTrp: 1.647 ± 0.048	2.38GlyTyr: 2.38 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	3.139HisAla: 3.139 ± 0.071	0.263HisCys: 0.263 ± 0.02	1.494HisAsp: 1.494 ± 0.051	1.212HisGlu: 1.212 ± 0.042	0.809HisPhe: 0.809 ± 0.035	2.437HisGly: 2.437 ± 0.054	0.628HisHis: 0.628 ± 0.029	0.73HisIle: 0.73 ± 0.032	0.452HisLys: 0.452 ± 0.023	2.188HisLeu: 2.188 ± 0.059	0.432HisMet: 0.432 ± 0.025	0.501HisAsn: 0.501 ± 0.027	1.499HisPro: 1.499 ± 0.05	0.607HisGln: 0.607 ± 0.028	1.806HisArg: 1.806 ± 0.045	0.916HisSer: 0.916 ± 0.036	0.976HisThr: 0.976 ± 0.038	1.687HisVal: 1.687 ± 0.047	0.411HisTrp: 0.411 ± 0.024	0.615HisTyr: 0.615 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.009IleAla: 6.009 ± 0.088	0.305IleCys: 0.305 ± 0.023	3.439IleAsp: 3.439 ± 0.066	3.255IleGlu: 3.255 ± 0.077	0.992IlePhe: 0.992 ± 0.04	4.24IleGly: 4.24 ± 0.081	0.846IleHis: 0.846 ± 0.034	1.279IleIle: 1.279 ± 0.049	1.097IleLys: 1.097 ± 0.043	2.744IleLeu: 2.744 ± 0.066	0.524IleMet: 0.524 ± 0.031	1.223IleAsn: 1.223 ± 0.05	1.915IlePro: 1.915 ± 0.063	0.96IleGln: 0.96 ± 0.039	2.814IleArg: 2.814 ± 0.069	1.847IleSer: 1.847 ± 0.056	2.078IleThr: 2.078 ± 0.056	3.089IleVal: 3.089 ± 0.065	0.365IleTrp: 0.365 ± 0.023	0.779IleTyr: 0.779 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.218LysAla: 3.218 ± 0.099	0.122LysCys: 0.122 ± 0.013	1.341LysAsp: 1.341 ± 0.05	1.157LysGlu: 1.157 ± 0.046	0.706LysPhe: 0.706 ± 0.028	1.834LysGly: 1.834 ± 0.049	0.574LysHis: 0.574 ± 0.03	1.043LysIle: 1.043 ± 0.04	0.967LysLys: 0.967 ± 0.068	2.829LysLeu: 2.829 ± 0.073	0.55LysMet: 0.55 ± 0.029	0.569LysAsn: 0.569 ± 0.033	1.671LysPro: 1.671 ± 0.052	1.023LysGln: 1.023 ± 0.037	2.007LysArg: 2.007 ± 0.068	1.286LysSer: 1.286 ± 0.051	1.374LysThr: 1.374 ± 0.052	2.088LysVal: 2.088 ± 0.067	0.301LysTrp: 0.301 ± 0.023	0.586LysTyr: 0.586 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	15.721LeuAla: 15.721 ± 0.196	0.804LeuCys: 0.804 ± 0.032	7.239LeuAsp: 7.239 ± 0.107	5.692LeuGlu: 5.692 ± 0.086	3.159LeuPhe: 3.159 ± 0.07	8.927LeuGly: 8.927 ± 0.113	2.4LeuHis: 2.4 ± 0.067	3.401LeuIle: 3.401 ± 0.077	2.685LeuLys: 2.685 ± 0.061	11.451LeuLeu: 11.451 ± 0.195	2.19LeuMet: 2.19 ± 0.054	2.096LeuAsn: 2.096 ± 0.051	6.276LeuPro: 6.276 ± 0.113	3.821LeuGln: 3.821 ± 0.067	8.812LeuArg: 8.812 ± 0.12	5.274LeuSer: 5.274 ± 0.088	4.478LeuThr: 4.478 ± 0.085	8.73LeuVal: 8.73 ± 0.127	1.323LeuTrp: 1.323 ± 0.048	2.057LeuTyr: 2.057 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.831MetAla: 2.831 ± 0.063	0.148MetCys: 0.148 ± 0.015	1.177MetAsp: 1.177 ± 0.041	1.011MetGlu: 1.011 ± 0.037	0.657MetPhe: 0.657 ± 0.03	1.62MetGly: 1.62 ± 0.045	0.469MetHis: 0.469 ± 0.027	0.807MetIle: 0.807 ± 0.036	0.844MetLys: 0.844 ± 0.033	2.491MetLeu: 2.491 ± 0.066	0.491MetMet: 0.491 ± 0.03	0.633MetAsn: 0.633 ± 0.032	1.474MetPro: 1.474 ± 0.047	0.912MetGln: 0.912 ± 0.041	1.739MetArg: 1.739 ± 0.052	1.361MetSer: 1.361 ± 0.049	1.444MetThr: 1.444 ± 0.044	1.563MetVal: 1.563 ± 0.052	0.182MetTrp: 0.182 ± 0.016	0.385MetTyr: 0.385 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.049AsnAla: 3.049 ± 0.074	0.189AsnCys: 0.189 ± 0.017	1.338AsnAsp: 1.338 ± 0.045	1.105AsnGlu: 1.105 ± 0.043	0.777AsnPhe: 0.777 ± 0.036	2.11AsnGly: 2.11 ± 0.064	0.483AsnHis: 0.483 ± 0.023	1.047AsnIle: 1.047 ± 0.04	0.575AsnLys: 0.575 ± 0.031	2.447AsnLeu: 2.447 ± 0.071	0.398AsnMet: 0.398 ± 0.021	0.588AsnAsn: 0.588 ± 0.031	1.736AsnPro: 1.736 ± 0.05	0.658AsnGln: 0.658 ± 0.034	1.814AsnArg: 1.814 ± 0.046	0.956AsnSer: 0.956 ± 0.042	1.191AsnThr: 1.191 ± 0.042	1.732AsnVal: 1.732 ± 0.049	0.352AsnTrp: 0.352 ± 0.021	0.57AsnTyr: 0.57 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	8.028ProAla: 8.028 ± 0.123	0.309ProCys: 0.309 ± 0.021	3.707ProAsp: 3.707 ± 0.083	3.427ProGlu: 3.427 ± 0.066	1.546ProPhe: 1.546 ± 0.047	5.055ProGly: 5.055 ± 0.07	1.105ProHis: 1.105 ± 0.04	1.604ProIle: 1.604 ± 0.047	1.227ProLys: 1.227 ± 0.043	5.245ProLeu: 5.245 ± 0.093	1.24ProMet: 1.24 ± 0.036	1.055ProAsn: 1.055 ± 0.037	2.958ProPro: 2.958 ± 0.094	1.803ProGln: 1.803 ± 0.048	3.664ProArg: 3.664 ± 0.081	2.445ProSer: 2.445 ± 0.059	2.335ProThr: 2.335 ± 0.058	4.703ProVal: 4.703 ± 0.085	0.773ProTrp: 0.773 ± 0.032	1.174ProTyr: 1.174 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	4.784GlnAla: 4.784 ± 0.095	0.206GlnCys: 0.206 ± 0.017	1.412GlnAsp: 1.412 ± 0.048	1.255GlnGlu: 1.255 ± 0.045	1.046GlnPhe: 1.046 ± 0.038	2.379GlnGly: 2.379 ± 0.056	0.797GlnHis: 0.797 ± 0.03	1.323GlnIle: 1.323 ± 0.048	0.807GlnLys: 0.807 ± 0.041	4.072GlnLeu: 4.072 ± 0.078	0.776GlnMet: 0.776 ± 0.029	0.603GlnAsn: 0.603 ± 0.033	2.147GlnPro: 2.147 ± 0.058	1.588GlnGln: 1.588 ± 0.057	3.235GlnArg: 3.235 ± 0.07	1.501GlnSer: 1.501 ± 0.049	1.382GlnThr: 1.382 ± 0.041	3.044GlnVal: 3.044 ± 0.067	0.55GlnTrp: 0.55 ± 0.022	0.746GlnTyr: 0.746 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	9.098ArgAla: 9.098 ± 0.131	0.546ArgCys: 0.546 ± 0.028	5.036ArgAsp: 5.036 ± 0.088	5.289ArgGlu: 5.289 ± 0.085	3.089ArgPhe: 3.089 ± 0.068	5.84ArgGly: 5.84 ± 0.101	2.129ArgHis: 2.129 ± 0.057	3.908ArgIle: 3.908 ± 0.067	2.056ArgLys: 2.056 ± 0.059	8.922ArgLeu: 8.922 ± 0.136	2.036ArgMet: 2.036 ± 0.05	1.918ArgAsn: 1.918 ± 0.054	3.861ArgPro: 3.861 ± 0.079	2.757ArgGln: 2.757 ± 0.062	6.446ArgArg: 6.446 ± 0.113	3.468ArgSer: 3.468 ± 0.066	3.545ArgThr: 3.545 ± 0.068	5.726ArgVal: 5.726 ± 0.088	1.376ArgTrp: 1.376 ± 0.042	2.174ArgTyr: 2.174 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	5.566SerAla: 5.566 ± 0.105	0.36SerCys: 0.36 ± 0.022	2.673SerAsp: 2.673 ± 0.062	2.446SerGlu: 2.446 ± 0.057	1.699SerPhe: 1.699 ± 0.044	4.903SerGly: 4.903 ± 0.083	1.047SerHis: 1.047 ± 0.037	2.031SerIle: 2.031 ± 0.052	1.199SerLys: 1.199 ± 0.044	4.912SerLeu: 4.912 ± 0.067	1.052SerMet: 1.052 ± 0.035	1.242SerAsn: 1.242 ± 0.042	2.622SerPro: 2.622 ± 0.058	1.501SerGln: 1.501 ± 0.046	3.654SerArg: 3.654 ± 0.081	2.42SerSer: 2.42 ± 0.069	2.528SerThr: 2.528 ± 0.063	3.545SerVal: 3.545 ± 0.074	0.67SerTrp: 0.67 ± 0.03	1.149SerTyr: 1.149 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.338ThrAla: 6.338 ± 0.106	0.36ThrCys: 0.36 ± 0.023	2.861ThrAsp: 2.861 ± 0.066	2.154ThrGlu: 2.154 ± 0.054	1.482ThrPhe: 1.482 ± 0.045	4.991ThrGly: 4.991 ± 0.098	1.041ThrHis: 1.041 ± 0.039	1.946ThrIle: 1.946 ± 0.045	0.882ThrLys: 0.882 ± 0.037	5.751ThrLeu: 5.751 ± 0.084	0.947ThrMet: 0.947 ± 0.039	0.924ThrAsn: 0.924 ± 0.037	3.205ThrPro: 3.205 ± 0.063	1.257ThrGln: 1.257 ± 0.04	3.69ThrArg: 3.69 ± 0.071	2.196ThrSer: 2.196 ± 0.059	2.602ThrThr: 2.602 ± 0.063	4.372ThrVal: 4.372 ± 0.074	0.602ThrTrp: 0.602 ± 0.026	0.988ThrTyr: 0.988 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	10.49ValAla: 10.49 ± 0.124	0.64ValCys: 0.64 ± 0.029	5.291ValAsp: 5.291 ± 0.088	5.279ValGlu: 5.279 ± 0.088	2.636ValPhe: 2.636 ± 0.069	5.98ValGly: 5.98 ± 0.112	1.636ValHis: 1.636 ± 0.048	3.364ValIle: 3.364 ± 0.067	1.778ValLys: 1.778 ± 0.061	8.71ValLeu: 8.71 ± 0.122	1.723ValMet: 1.723 ± 0.061	1.833ValAsn: 1.833 ± 0.052	4.124ValPro: 4.124 ± 0.076	2.286ValGln: 2.286 ± 0.05	5.677ValArg: 5.677 ± 0.093	3.722ValSer: 3.722 ± 0.081	3.891ValThr: 3.891 ± 0.072	6.766ValVal: 6.766 ± 0.117	0.867ValTrp: 0.867 ± 0.035	1.498ValTyr: 1.498 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.253TrpAla: 1.253 ± 0.044	0.143TrpCys: 0.143 ± 0.012	0.729TrpAsp: 0.729 ± 0.031	0.565TrpGlu: 0.565 ± 0.028	0.563TrpPhe: 0.563 ± 0.029	0.914TrpGly: 0.914 ± 0.034	0.368TrpHis: 0.368 ± 0.021	0.673TrpIle: 0.673 ± 0.03	0.431TrpLys: 0.431 ± 0.024	2.22TrpLeu: 2.22 ± 0.061	0.39TrpMet: 0.39 ± 0.021	0.435TrpAsn: 0.435 ± 0.024	0.715TrpPro: 0.715 ± 0.034	0.709TrpGln: 0.709 ± 0.034	1.331TrpArg: 1.331 ± 0.047	0.822TrpSer: 0.822 ± 0.037	0.672TrpThr: 0.672 ± 0.03	0.997TrpVal: 0.997 ± 0.04	0.294TrpTrp: 0.294 ± 0.023	0.284TrpTyr: 0.284 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.724TyrAla: 2.724 ± 0.057	0.192TyrCys: 0.192 ± 0.017	1.35TyrAsp: 1.35 ± 0.048	1.185TyrGlu: 1.185 ± 0.041	0.825TyrPhe: 0.825 ± 0.036	1.983TyrGly: 1.983 ± 0.053	0.487TyrHis: 0.487 ± 0.024	0.74TyrIle: 0.74 ± 0.029	0.48TyrLys: 0.48 ± 0.024	2.332TyrLeu: 2.332 ± 0.062	0.424TyrMet: 0.424 ± 0.025	0.551TyrAsn: 0.551 ± 0.032	1.066TyrPro: 1.066 ± 0.041	0.783TyrGln: 0.783 ± 0.03	2.11TyrArg: 2.11 ± 0.051	1.129TyrSer: 1.129 ± 0.043	1.087TyrThr: 1.087 ± 0.045	1.604TyrVal: 1.604 ± 0.053	0.385TyrTrp: 0.385 ± 0.023	0.537TyrTyr: 0.537 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2363 proteins (756334 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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