Amino acid dipepetide frequency for Influenza A virus (A/little yellow-shouldered bat/Guatemala/060/2010(H17N10))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.844AlaAla: 3.844 ± 1.275
1.357AlaCys: 1.357 ± 0.512
1.357AlaAsp: 1.357 ± 0.65
2.488AlaGlu: 2.488 ± 0.617
2.261AlaPhe: 2.261 ± 0.935
3.392AlaGly: 3.392 ± 0.836
1.357AlaHis: 1.357 ± 0.368
4.071AlaIle: 4.071 ± 0.795
2.035AlaLys: 2.035 ± 0.827
5.201AlaLeu: 5.201 ± 1.353
2.488AlaMet: 2.488 ± 0.976
3.618AlaAsn: 3.618 ± 0.304
2.261AlaPro: 2.261 ± 0.288
3.618AlaGln: 3.618 ± 0.725
2.94AlaArg: 2.94 ± 0.785
4.071AlaSer: 4.071 ± 1.177
3.392AlaThr: 3.392 ± 0.667
4.523AlaVal: 4.523 ± 1.046
0.452AlaTrp: 0.452 ± 0.288
1.583AlaTyr: 1.583 ± 0.468
0.0AlaXaa: 0.0 ± 0.0
Cys
0.452CysAla: 0.452 ± 0.361
0.678CysCys: 0.678 ± 0.379
0.452CysAsp: 0.452 ± 0.321
0.905CysGlu: 0.905 ± 0.613
1.809CysPhe: 1.809 ± 0.97
0.452CysGly: 0.452 ± 0.291
0.678CysHis: 0.678 ± 0.25
0.905CysIle: 0.905 ± 0.461
1.583CysLys: 1.583 ± 0.35
0.905CysLeu: 0.905 ± 0.415
0.452CysMet: 0.452 ± 0.33
1.131CysAsn: 1.131 ± 0.476
0.452CysPro: 0.452 ± 0.447
1.131CysGln: 1.131 ± 0.559
1.131CysArg: 1.131 ± 0.661
0.678CysSer: 0.678 ± 0.467
0.905CysThr: 0.905 ± 0.4
0.905CysVal: 0.905 ± 0.307
0.226CysTrp: 0.226 ± 0.186
0.452CysTyr: 0.452 ± 0.296
0.0CysXaa: 0.0 ± 0.0
Asp
3.392AspAla: 3.392 ± 0.931
0.905AspCys: 0.905 ± 0.331
2.261AspAsp: 2.261 ± 0.476
3.844AspGlu: 3.844 ± 0.867
1.809AspPhe: 1.809 ± 0.488
3.166AspGly: 3.166 ± 0.534
0.226AspHis: 0.226 ± 0.186
2.714AspIle: 2.714 ± 0.682
1.809AspLys: 1.809 ± 0.558
5.427AspLeu: 5.427 ± 0.753
0.905AspMet: 0.905 ± 0.4
2.035AspAsn: 2.035 ± 0.595
2.94AspPro: 2.94 ± 0.885
1.131AspGln: 1.131 ± 0.368
2.035AspArg: 2.035 ± 0.704
2.488AspSer: 2.488 ± 0.621
2.488AspThr: 2.488 ± 0.631
1.809AspVal: 1.809 ± 0.503
0.452AspTrp: 0.452 ± 0.231
2.488AspTyr: 2.488 ± 0.834
0.0AspXaa: 0.0 ± 0.0
Glu
2.488GluAla: 2.488 ± 0.596
0.678GluCys: 0.678 ± 0.483
3.392GluAsp: 3.392 ± 0.646
6.332GluGlu: 6.332 ± 1.231
2.714GluPhe: 2.714 ± 0.715
6.784GluGly: 6.784 ± 1.561
0.905GluHis: 0.905 ± 0.463
5.427GluIle: 5.427 ± 0.726
7.915GluLys: 7.915 ± 1.456
5.88GluLeu: 5.88 ± 0.936
2.714GluMet: 2.714 ± 0.799
4.749GluAsn: 4.749 ± 0.77
2.035GluPro: 2.035 ± 0.66
2.488GluGln: 2.488 ± 0.506
4.071GluArg: 4.071 ± 0.909
5.88GluSer: 5.88 ± 0.841
2.94GluThr: 2.94 ± 0.828
4.975GluVal: 4.975 ± 1.336
1.357GluTrp: 1.357 ± 0.497
1.809GluTyr: 1.809 ± 0.607
0.0GluXaa: 0.0 ± 0.0
Phe
0.452PheAla: 0.452 ± 0.231
0.452PheCys: 0.452 ± 0.288
2.261PheAsp: 2.261 ± 0.952
4.749PheGlu: 4.749 ± 0.976
1.583PhePhe: 1.583 ± 0.561
1.809PheGly: 1.809 ± 0.512
0.678PheHis: 0.678 ± 0.296
2.488PheIle: 2.488 ± 0.864
2.035PheLys: 2.035 ± 0.693
3.392PheLeu: 3.392 ± 0.523
0.452PheMet: 0.452 ± 0.303
2.94PheAsn: 2.94 ± 0.756
1.357PhePro: 1.357 ± 0.496
2.714PheGln: 2.714 ± 0.56
1.583PheArg: 1.583 ± 0.549
3.844PheSer: 3.844 ± 0.812
2.035PheThr: 2.035 ± 0.473
3.166PheVal: 3.166 ± 0.639
0.678PheTrp: 0.678 ± 0.342
1.809PheTyr: 1.809 ± 0.439
0.0PheXaa: 0.0 ± 0.0
Gly
3.618GlyAla: 3.618 ± 0.965
0.452GlyCys: 0.452 ± 0.447
2.714GlyAsp: 2.714 ± 0.379
5.201GlyGlu: 5.201 ± 1.39
3.392GlyPhe: 3.392 ± 0.661
2.94GlyGly: 2.94 ± 0.743
0.678GlyHis: 0.678 ± 0.33
4.071GlyIle: 4.071 ± 0.782
4.071GlyLys: 4.071 ± 1.136
5.654GlyLeu: 5.654 ± 1.404
2.261GlyMet: 2.261 ± 0.642
4.975GlyAsn: 4.975 ± 1.198
3.166GlyPro: 3.166 ± 0.761
2.261GlyGln: 2.261 ± 0.46
4.975GlyArg: 4.975 ± 0.829
3.166GlySer: 3.166 ± 1.14
5.201GlyThr: 5.201 ± 0.818
3.392GlyVal: 3.392 ± 0.743
1.131GlyTrp: 1.131 ± 0.653
2.488GlyTyr: 2.488 ± 0.836
0.0GlyXaa: 0.0 ± 0.0
His
0.226HisAla: 0.226 ± 0.221
0.0HisCys: 0.0 ± 0.0
0.452HisAsp: 0.452 ± 0.268
0.905HisGlu: 0.905 ± 0.366
1.131HisPhe: 1.131 ± 0.521
0.905HisGly: 0.905 ± 0.444
0.452HisHis: 0.452 ± 0.268
1.357HisIle: 1.357 ± 0.366
1.131HisLys: 1.131 ± 0.446
2.035HisLeu: 2.035 ± 0.418
0.905HisMet: 0.905 ± 0.315
0.452HisAsn: 0.452 ± 0.447
0.905HisPro: 0.905 ± 0.356
0.678HisGln: 0.678 ± 0.397
1.131HisArg: 1.131 ± 0.524
0.678HisSer: 0.678 ± 0.369
0.678HisThr: 0.678 ± 0.387
0.0HisVal: 0.0 ± 0.0
0.452HisTrp: 0.452 ± 0.296
0.452HisTyr: 0.452 ± 0.269
0.0HisXaa: 0.0 ± 0.0
Ile
4.071IleAla: 4.071 ± 0.827
1.357IleCys: 1.357 ± 0.386
3.844IleAsp: 3.844 ± 1.304
5.201IleGlu: 5.201 ± 1.185
1.357IlePhe: 1.357 ± 0.273
4.071IleGly: 4.071 ± 0.442
0.678IleHis: 0.678 ± 0.329
4.975IleIle: 4.975 ± 1.077
5.88IleLys: 5.88 ± 0.752
7.01IleLeu: 7.01 ± 1.018
3.392IleMet: 3.392 ± 0.792
4.297IleAsn: 4.297 ± 1.068
2.035IlePro: 2.035 ± 0.512
4.523IleGln: 4.523 ± 0.733
4.975IleArg: 4.975 ± 1.255
4.297IleSer: 4.297 ± 0.48
4.297IleThr: 4.297 ± 0.906
2.261IleVal: 2.261 ± 0.636
1.131IleTrp: 1.131 ± 0.405
1.809IleTyr: 1.809 ± 0.632
0.0IleXaa: 0.0 ± 0.0
Lys
7.237LysAla: 7.237 ± 1.062
1.357LysCys: 1.357 ± 0.506
3.618LysAsp: 3.618 ± 0.415
4.975LysGlu: 4.975 ± 1.145
2.94LysPhe: 2.94 ± 0.967
5.201LysGly: 5.201 ± 1.284
0.452LysHis: 0.452 ± 0.366
2.488LysIle: 2.488 ± 0.665
4.749LysLys: 4.749 ± 1.624
5.654LysLeu: 5.654 ± 0.839
2.714LysMet: 2.714 ± 0.333
2.488LysAsn: 2.488 ± 0.953
0.905LysPro: 0.905 ± 0.4
0.905LysGln: 0.905 ± 0.387
4.523LysArg: 4.523 ± 1.068
3.392LysSer: 3.392 ± 0.865
3.618LysThr: 3.618 ± 0.818
2.488LysVal: 2.488 ± 0.53
1.809LysTrp: 1.809 ± 0.527
2.261LysTyr: 2.261 ± 0.711
0.0LysXaa: 0.0 ± 0.0
Leu
4.975LeuAla: 4.975 ± 1.387
0.905LeuCys: 0.905 ± 0.449
4.071LeuAsp: 4.071 ± 0.72
7.463LeuGlu: 7.463 ± 0.811
2.488LeuPhe: 2.488 ± 0.488
4.749LeuGly: 4.749 ± 0.776
1.131LeuHis: 1.131 ± 0.428
7.237LeuIle: 7.237 ± 0.921
7.01LeuLys: 7.01 ± 1.112
10.403LeuLeu: 10.403 ± 2.275
3.618LeuMet: 3.618 ± 0.661
6.106LeuAsn: 6.106 ± 0.938
4.523LeuPro: 4.523 ± 0.679
2.94LeuGln: 2.94 ± 0.473
4.749LeuArg: 4.749 ± 0.726
6.106LeuSer: 6.106 ± 1.312
6.106LeuThr: 6.106 ± 1.664
3.392LeuVal: 3.392 ± 0.781
2.035LeuTrp: 2.035 ± 0.556
2.261LeuTyr: 2.261 ± 0.794
0.0LeuXaa: 0.0 ± 0.0
Met
3.392MetAla: 3.392 ± 1.046
0.905MetCys: 0.905 ± 0.454
2.261MetAsp: 2.261 ± 0.531
5.88MetGlu: 5.88 ± 0.88
0.678MetPhe: 0.678 ± 0.561
1.809MetGly: 1.809 ± 0.843
0.226MetHis: 0.226 ± 0.187
4.071MetIle: 4.071 ± 0.773
2.488MetLys: 2.488 ± 1.048
1.809MetLeu: 1.809 ± 0.662
1.357MetMet: 1.357 ± 0.563
0.678MetAsn: 0.678 ± 0.327
0.905MetPro: 0.905 ± 0.306
0.678MetGln: 0.678 ± 0.372
1.583MetArg: 1.583 ± 0.6
1.809MetSer: 1.809 ± 0.574
2.261MetThr: 2.261 ± 0.577
1.583MetVal: 1.583 ± 0.604
0.226MetTrp: 0.226 ± 0.186
0.678MetTyr: 0.678 ± 0.387
0.0MetXaa: 0.0 ± 0.0
Asn
2.261AsnAla: 2.261 ± 0.517
0.678AsnCys: 0.678 ± 0.458
3.166AsnAsp: 3.166 ± 0.829
4.071AsnGlu: 4.071 ± 0.879
3.166AsnPhe: 3.166 ± 0.626
4.071AsnGly: 4.071 ± 1.444
0.905AsnHis: 0.905 ± 0.361
3.618AsnIle: 3.618 ± 0.822
2.261AsnLys: 2.261 ± 0.4
5.88AsnLeu: 5.88 ± 1.064
1.131AsnMet: 1.131 ± 0.602
3.166AsnAsn: 3.166 ± 1.223
6.106AsnPro: 6.106 ± 1.072
2.714AsnGln: 2.714 ± 0.715
2.714AsnArg: 2.714 ± 0.865
6.106AsnSer: 6.106 ± 1.18
4.071AsnThr: 4.071 ± 0.821
2.261AsnVal: 2.261 ± 0.839
1.583AsnTrp: 1.583 ± 0.466
1.131AsnTyr: 1.131 ± 0.347
0.0AsnXaa: 0.0 ± 0.0
Pro
2.035ProAla: 2.035 ± 0.548
0.452ProCys: 0.452 ± 0.354
1.809ProAsp: 1.809 ± 0.439
2.94ProGlu: 2.94 ± 0.673
2.261ProPhe: 2.261 ± 0.561
2.261ProGly: 2.261 ± 0.424
0.0ProHis: 0.0 ± 0.0
3.844ProIle: 3.844 ± 0.627
1.583ProLys: 1.583 ± 0.493
3.166ProLeu: 3.166 ± 0.914
0.905ProMet: 0.905 ± 0.365
2.261ProAsn: 2.261 ± 0.682
2.035ProPro: 2.035 ± 0.526
1.583ProGln: 1.583 ± 0.584
2.261ProArg: 2.261 ± 0.759
2.035ProSer: 2.035 ± 0.478
3.166ProThr: 3.166 ± 0.76
1.809ProVal: 1.809 ± 0.461
0.452ProTrp: 0.452 ± 0.288
1.131ProTyr: 1.131 ± 0.531
0.0ProXaa: 0.0 ± 0.0
Gln
2.261GlnAla: 2.261 ± 1.014
0.452GlnCys: 0.452 ± 0.213
1.131GlnAsp: 1.131 ± 0.59
2.94GlnGlu: 2.94 ± 0.745
0.678GlnPhe: 0.678 ± 0.239
2.94GlnGly: 2.94 ± 0.655
0.452GlnHis: 0.452 ± 0.321
2.714GlnIle: 2.714 ± 0.67
2.714GlnLys: 2.714 ± 0.888
2.94GlnLeu: 2.94 ± 0.681
2.714GlnMet: 2.714 ± 1.113
3.166GlnAsn: 3.166 ± 0.958
1.131GlnPro: 1.131 ± 0.398
2.488GlnGln: 2.488 ± 0.525
3.844GlnArg: 3.844 ± 0.183
2.94GlnSer: 2.94 ± 0.67
3.618GlnThr: 3.618 ± 0.934
1.809GlnVal: 1.809 ± 0.408
0.226GlnTrp: 0.226 ± 0.186
0.678GlnTyr: 0.678 ± 0.32
0.0GlnXaa: 0.0 ± 0.0
Arg
3.618ArgAla: 3.618 ± 0.704
0.452ArgCys: 0.452 ± 0.231
2.261ArgAsp: 2.261 ± 0.262
3.166ArgGlu: 3.166 ± 0.876
1.131ArgPhe: 1.131 ± 0.444
5.427ArgGly: 5.427 ± 1.185
0.678ArgHis: 0.678 ± 0.335
4.975ArgIle: 4.975 ± 1.179
2.488ArgLys: 2.488 ± 0.551
5.201ArgLeu: 5.201 ± 1.328
2.488ArgMet: 2.488 ± 1.255
4.749ArgAsn: 4.749 ± 0.529
0.905ArgPro: 0.905 ± 0.404
1.583ArgGln: 1.583 ± 0.633
4.297ArgArg: 4.297 ± 1.025
3.844ArgSer: 3.844 ± 0.631
6.332ArgThr: 6.332 ± 1.18
2.488ArgVal: 2.488 ± 0.947
0.452ArgTrp: 0.452 ± 0.318
0.905ArgTyr: 0.905 ± 0.571
0.0ArgXaa: 0.0 ± 0.0
Ser
4.071SerAla: 4.071 ± 0.971
1.809SerCys: 1.809 ± 1.2
2.261SerAsp: 2.261 ± 0.321
4.071SerGlu: 4.071 ± 1.087
4.071SerPhe: 4.071 ± 0.911
4.297SerGly: 4.297 ± 0.815
1.809SerHis: 1.809 ± 0.555
5.201SerIle: 5.201 ± 0.828
3.392SerLys: 3.392 ± 0.637
5.427SerLeu: 5.427 ± 0.713
3.166SerMet: 3.166 ± 1.075
2.261SerAsn: 2.261 ± 0.426
2.035SerPro: 2.035 ± 0.677
3.844SerGln: 3.844 ± 0.716
2.714SerArg: 2.714 ± 0.665
6.332SerSer: 6.332 ± 1.695
5.654SerThr: 5.654 ± 1.082
2.035SerVal: 2.035 ± 0.288
0.678SerTrp: 0.678 ± 0.373
2.488SerTyr: 2.488 ± 0.665
0.0SerXaa: 0.0 ± 0.0
Thr
4.071ThrAla: 4.071 ± 1.314
1.809ThrCys: 1.809 ± 0.557
2.94ThrAsp: 2.94 ± 0.51
4.071ThrGlu: 4.071 ± 0.978
3.392ThrPhe: 3.392 ± 0.58
4.523ThrGly: 4.523 ± 1.182
1.583ThrHis: 1.583 ± 0.537
5.88ThrIle: 5.88 ± 1.011
3.392ThrLys: 3.392 ± 0.763
6.558ThrLeu: 6.558 ± 1.779
1.131ThrMet: 1.131 ± 0.324
6.106ThrAsn: 6.106 ± 1.185
1.583ThrPro: 1.583 ± 0.525
2.94ThrGln: 2.94 ± 0.801
2.94ThrArg: 2.94 ± 0.922
4.071ThrSer: 4.071 ± 1.086
4.523ThrThr: 4.523 ± 0.835
3.392ThrVal: 3.392 ± 0.77
0.226ThrTrp: 0.226 ± 0.186
2.035ThrTyr: 2.035 ± 0.675
0.0ThrXaa: 0.0 ± 0.0
Val
2.94ValAla: 2.94 ± 1.071
1.357ValCys: 1.357 ± 0.452
2.714ValAsp: 2.714 ± 0.932
3.166ValGlu: 3.166 ± 0.745
2.261ValPhe: 2.261 ± 0.722
2.714ValGly: 2.714 ± 0.967
0.905ValHis: 0.905 ± 0.3
2.488ValIle: 2.488 ± 0.733
3.844ValLys: 3.844 ± 0.881
7.237ValLeu: 7.237 ± 1.364
0.905ValMet: 0.905 ± 0.306
2.94ValAsn: 2.94 ± 0.681
1.583ValPro: 1.583 ± 0.435
1.583ValGln: 1.583 ± 0.53
2.035ValArg: 2.035 ± 1.107
2.488ValSer: 2.488 ± 0.947
1.809ValThr: 1.809 ± 0.57
1.357ValVal: 1.357 ± 0.399
0.226ValTrp: 0.226 ± 0.221
1.357ValTyr: 1.357 ± 0.532
0.0ValXaa: 0.0 ± 0.0
Trp
0.226TrpAla: 0.226 ± 0.221
0.0TrpCys: 0.0 ± 0.0
0.678TrpAsp: 0.678 ± 0.295
1.809TrpGlu: 1.809 ± 0.594
0.452TrpPhe: 0.452 ± 0.231
1.809TrpGly: 1.809 ± 0.64
0.452TrpHis: 0.452 ± 0.313
1.131TrpIle: 1.131 ± 0.4
1.357TrpLys: 1.357 ± 0.552
0.905TrpLeu: 0.905 ± 0.48
0.678TrpMet: 0.678 ± 0.406
0.905TrpAsn: 0.905 ± 0.306
0.226TrpPro: 0.226 ± 0.183
0.226TrpGln: 0.226 ± 0.223
0.226TrpArg: 0.226 ± 0.231
0.678TrpSer: 0.678 ± 0.457
1.809TrpThr: 1.809 ± 0.713
0.905TrpVal: 0.905 ± 0.398
0.452TrpTrp: 0.452 ± 0.226
0.226TrpTyr: 0.226 ± 0.223
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.678TyrAla: 0.678 ± 0.23
0.226TyrCys: 0.226 ± 0.183
0.678TyrAsp: 0.678 ± 0.379
1.583TyrGlu: 1.583 ± 0.533
0.905TyrPhe: 0.905 ± 0.351
2.488TyrGly: 2.488 ± 0.586
0.678TyrHis: 0.678 ± 0.239
1.809TyrIle: 1.809 ± 0.648
2.035TyrLys: 2.035 ± 0.358
1.583TyrLeu: 1.583 ± 0.513
0.678TyrMet: 0.678 ± 0.276
2.035TyrAsn: 2.035 ± 0.822
0.905TyrPro: 0.905 ± 0.422
1.809TyrGln: 1.809 ± 0.335
2.714TyrArg: 2.714 ± 1.171
2.714TyrSer: 2.714 ± 0.7
2.261TyrThr: 2.261 ± 0.85
1.357TyrVal: 1.357 ± 0.378
0.905TyrTrp: 0.905 ± 0.32
1.357TyrTyr: 1.357 ± 0.645
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 10 proteins (4423 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski