Amino acid dipepetide frequency for Grifola frondosa (Maitake) (Polyporus frondosus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.964AlaAla: 8.964 ± 0.055	1.264AlaCys: 1.264 ± 0.017	4.422AlaAsp: 4.422 ± 0.028	5.0AlaGlu: 5.0 ± 0.039	3.371AlaPhe: 3.371 ± 0.028	5.417AlaGly: 5.417 ± 0.036	2.382AlaHis: 2.382 ± 0.024	4.183AlaIle: 4.183 ± 0.028	3.605AlaLys: 3.605 ± 0.034	8.554AlaLeu: 8.554 ± 0.042	2.004AlaMet: 2.004 ± 0.018	2.702AlaAsn: 2.702 ± 0.023	5.317AlaPro: 5.317 ± 0.042	3.414AlaGln: 3.414 ± 0.028	5.884AlaArg: 5.884 ± 0.039	7.772AlaSer: 7.772 ± 0.043	5.156AlaThr: 5.156 ± 0.029	5.662AlaVal: 5.662 ± 0.035	1.147AlaTrp: 1.147 ± 0.015	2.167AlaTyr: 2.167 ± 0.018	0.0AlaXaa: 0.0 ± 0.0
Cys	1.258CysAla: 1.258 ± 0.014	0.357CysCys: 0.357 ± 0.009	0.762CysAsp: 0.762 ± 0.012	0.661CysGlu: 0.661 ± 0.011	0.564CysPhe: 0.564 ± 0.011	1.075CysGly: 1.075 ± 0.017	0.403CysHis: 0.403 ± 0.01	0.803CysIle: 0.803 ± 0.013	0.535CysLys: 0.535 ± 0.01	1.445CysLeu: 1.445 ± 0.015	0.35CysMet: 0.35 ± 0.008	0.45CysAsn: 0.45 ± 0.009	0.893CysPro: 0.893 ± 0.014	0.449CysGln: 0.449 ± 0.01	0.983CysArg: 0.983 ± 0.015	1.23CysSer: 1.23 ± 0.014	0.875CysThr: 0.875 ± 0.014	0.959CysVal: 0.959 ± 0.014	0.246CysTrp: 0.246 ± 0.007	0.404CysTyr: 0.404 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	5.141AspAla: 5.141 ± 0.032	0.684AspCys: 0.684 ± 0.011	4.162AspAsp: 4.162 ± 0.042	4.225AspGlu: 4.225 ± 0.039	2.08AspPhe: 2.08 ± 0.021	3.854AspGly: 3.854 ± 0.032	1.325AspHis: 1.325 ± 0.018	3.142AspIle: 3.142 ± 0.024	1.951AspLys: 1.951 ± 0.021	4.855AspLeu: 4.855 ± 0.033	1.254AspMet: 1.254 ± 0.016	1.611AspAsn: 1.611 ± 0.017	3.356AspPro: 3.356 ± 0.025	1.582AspGln: 1.582 ± 0.017	2.945AspArg: 2.945 ± 0.023	4.036AspSer: 4.036 ± 0.032	2.916AspThr: 2.916 ± 0.025	4.228AspVal: 4.228 ± 0.028	0.826AspTrp: 0.826 ± 0.011	1.416AspTyr: 1.416 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	4.764GluAla: 4.764 ± 0.036	0.723GluCys: 0.723 ± 0.012	4.143GluAsp: 4.143 ± 0.034	5.02GluGlu: 5.02 ± 0.051	1.86GluPhe: 1.86 ± 0.018	3.471GluGly: 3.471 ± 0.025	1.563GluHis: 1.563 ± 0.019	2.714GluIle: 2.714 ± 0.023	2.882GluLys: 2.882 ± 0.029	5.214GluLeu: 5.214 ± 0.034	1.364GluMet: 1.364 ± 0.016	1.778GluAsn: 1.778 ± 0.019	2.638GluPro: 2.638 ± 0.025	2.168GluGln: 2.168 ± 0.023	4.082GluArg: 4.082 ± 0.035	3.844GluSer: 3.844 ± 0.028	2.905GluThr: 2.905 ± 0.028	3.617GluVal: 3.617 ± 0.03	0.89GluTrp: 0.89 ± 0.013	1.507GluTyr: 1.507 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.23PheAla: 3.23 ± 0.024	0.635PheCys: 0.635 ± 0.012	2.256PheAsp: 2.256 ± 0.02	1.967PheGlu: 1.967 ± 0.02	1.54PhePhe: 1.54 ± 0.017	2.6PheGly: 2.6 ± 0.03	1.002PheHis: 1.002 ± 0.013	1.787PheIle: 1.787 ± 0.021	1.43PheLys: 1.43 ± 0.018	3.54PheLeu: 3.54 ± 0.03	0.806PheMet: 0.806 ± 0.013	1.252PheAsn: 1.252 ± 0.016	2.134PhePro: 2.134 ± 0.023	1.213PheGln: 1.213 ± 0.015	2.088PheArg: 2.088 ± 0.022	3.196PheSer: 3.196 ± 0.026	2.186PheThr: 2.186 ± 0.024	2.577PheVal: 2.577 ± 0.024	0.576PheTrp: 0.576 ± 0.011	1.04PheTyr: 1.04 ± 0.012	0.0PheXaa: 0.0 ± 0.0
Gly	5.052GlyAla: 5.052 ± 0.038	0.956GlyCys: 0.956 ± 0.015	3.314GlyAsp: 3.314 ± 0.028	3.306GlyGlu: 3.306 ± 0.027	2.379GlyPhe: 2.379 ± 0.022	4.832GlyGly: 4.832 ± 0.05	1.699GlyHis: 1.699 ± 0.019	3.15GlyIle: 3.15 ± 0.027	2.949GlyLys: 2.949 ± 0.029	5.367GlyLeu: 5.367 ± 0.037	1.504GlyMet: 1.504 ± 0.018	1.976GlyAsn: 1.976 ± 0.022	3.265GlyPro: 3.265 ± 0.025	2.127GlyGln: 2.127 ± 0.024	4.228GlyArg: 4.228 ± 0.027	5.34GlySer: 5.34 ± 0.038	3.828GlyThr: 3.828 ± 0.027	4.105GlyVal: 4.105 ± 0.031	1.067GlyTrp: 1.067 ± 0.015	1.712GlyTyr: 1.712 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	2.461HisAla: 2.461 ± 0.021	0.432HisCys: 0.432 ± 0.009	1.469HisAsp: 1.469 ± 0.017	1.384HisGlu: 1.384 ± 0.015	1.033HisPhe: 1.033 ± 0.014	1.729HisGly: 1.729 ± 0.018	0.977HisHis: 0.977 ± 0.014	1.453HisIle: 1.453 ± 0.016	0.915HisLys: 0.915 ± 0.011	2.764HisLeu: 2.764 ± 0.024	0.574HisMet: 0.574 ± 0.01	0.856HisAsn: 0.856 ± 0.014	2.102HisPro: 2.102 ± 0.018	0.886HisGln: 0.886 ± 0.013	1.93HisArg: 1.93 ± 0.022	2.29HisSer: 2.29 ± 0.023	1.61HisThr: 1.61 ± 0.018	1.803HisVal: 1.803 ± 0.019	0.366HisTrp: 0.366 ± 0.009	0.727HisTyr: 0.727 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.282IleAla: 4.282 ± 0.033	0.832IleCys: 0.832 ± 0.013	2.715IleAsp: 2.715 ± 0.023	2.539IleGlu: 2.539 ± 0.021	1.933IlePhe: 1.933 ± 0.022	2.912IleGly: 2.912 ± 0.023	1.335IleHis: 1.335 ± 0.016	2.436IleIle: 2.436 ± 0.025	1.844IleLys: 1.844 ± 0.021	4.581IleLeu: 4.581 ± 0.031	1.027IleMet: 1.027 ± 0.015	1.569IleAsn: 1.569 ± 0.02	3.357IlePro: 3.357 ± 0.024	1.681IleGln: 1.681 ± 0.018	2.968IleArg: 2.968 ± 0.023	4.085IleSer: 4.085 ± 0.031	2.749IleThr: 2.749 ± 0.022	3.325IleVal: 3.325 ± 0.031	0.734IleTrp: 0.734 ± 0.012	1.328IleTyr: 1.328 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.778LysAla: 3.778 ± 0.033	0.525LysCys: 0.525 ± 0.01	2.337LysAsp: 2.337 ± 0.024	2.772LysGlu: 2.772 ± 0.028	1.308LysPhe: 1.308 ± 0.016	2.479LysGly: 2.479 ± 0.023	1.09LysHis: 1.09 ± 0.015	1.887LysIle: 1.887 ± 0.021	2.635LysLys: 2.635 ± 0.035	3.644LysLeu: 3.644 ± 0.026	0.916LysMet: 0.916 ± 0.013	1.356LysAsn: 1.356 ± 0.018	2.312LysPro: 2.312 ± 0.027	1.475LysGln: 1.475 ± 0.018	3.226LysArg: 3.226 ± 0.026	3.006LysSer: 3.006 ± 0.026	2.383LysThr: 2.383 ± 0.024	2.526LysVal: 2.526 ± 0.021	0.629LysTrp: 0.629 ± 0.011	1.141LysTyr: 1.141 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	8.146LeuAla: 8.146 ± 0.04	1.504LeuCys: 1.504 ± 0.019	5.085LeuAsp: 5.085 ± 0.033	5.189LeuGlu: 5.189 ± 0.039	3.427LeuPhe: 3.427 ± 0.029	5.373LeuGly: 5.373 ± 0.037	2.812LeuHis: 2.812 ± 0.026	3.94LeuIle: 3.94 ± 0.034	3.74LeuLys: 3.74 ± 0.025	8.937LeuLeu: 8.937 ± 0.054	1.795LeuMet: 1.795 ± 0.02	2.996LeuAsn: 2.996 ± 0.024	6.385LeuPro: 6.385 ± 0.039	3.72LeuGln: 3.72 ± 0.028	6.676LeuArg: 6.676 ± 0.045	8.211LeuSer: 8.211 ± 0.043	5.185LeuThr: 5.185 ± 0.036	5.7LeuVal: 5.7 ± 0.036	1.234LeuTrp: 1.234 ± 0.017	2.391LeuTyr: 2.391 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	1.864MetAla: 1.864 ± 0.018	0.302MetCys: 0.302 ± 0.008	1.253MetAsp: 1.253 ± 0.016	1.222MetGlu: 1.222 ± 0.015	0.784MetPhe: 0.784 ± 0.012	1.227MetGly: 1.227 ± 0.017	0.636MetHis: 0.636 ± 0.009	0.975MetIle: 0.975 ± 0.014	0.95MetLys: 0.95 ± 0.014	2.083MetLeu: 2.083 ± 0.021	0.541MetMet: 0.541 ± 0.012	0.754MetAsn: 0.754 ± 0.014	1.422MetPro: 1.422 ± 0.015	0.905MetGln: 0.905 ± 0.012	1.512MetArg: 1.512 ± 0.016	2.062MetSer: 2.062 ± 0.021	1.289MetThr: 1.289 ± 0.015	1.24MetVal: 1.24 ± 0.013	0.298MetTrp: 0.298 ± 0.008	0.553MetTyr: 0.553 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.074AsnAla: 3.074 ± 0.025	0.433AsnCys: 0.433 ± 0.01	1.673AsnAsp: 1.673 ± 0.017	1.625AsnGlu: 1.625 ± 0.018	1.225AsnPhe: 1.225 ± 0.015	2.356AsnGly: 2.356 ± 0.024	0.816AsnHis: 0.816 ± 0.012	1.883AsnIle: 1.883 ± 0.021	1.18AsnLys: 1.18 ± 0.015	2.971AsnLeu: 2.971 ± 0.025	0.752AsnMet: 0.752 ± 0.012	1.079AsnAsn: 1.079 ± 0.015	2.134AsnPro: 2.134 ± 0.022	0.959AsnGln: 0.959 ± 0.014	1.735AsnArg: 1.735 ± 0.02	2.432AsnSer: 2.432 ± 0.023	1.968AsnThr: 1.968 ± 0.02	2.389AsnVal: 2.389 ± 0.02	0.472AsnTrp: 0.472 ± 0.009	0.819AsnTyr: 0.819 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.809ProAla: 5.809 ± 0.047	0.734ProCys: 0.734 ± 0.012	3.231ProAsp: 3.231 ± 0.026	3.527ProGlu: 3.527 ± 0.031	2.263ProPhe: 2.263 ± 0.023	3.628ProGly: 3.628 ± 0.029	1.839ProHis: 1.839 ± 0.021	2.754ProIle: 2.754 ± 0.023	2.276ProLys: 2.276 ± 0.024	5.51ProLeu: 5.51 ± 0.035	1.148ProMet: 1.148 ± 0.016	2.039ProAsn: 2.039 ± 0.021	6.348ProPro: 6.348 ± 0.067	2.35ProGln: 2.35 ± 0.027	4.091ProArg: 4.091 ± 0.032	7.523ProSer: 7.523 ± 0.055	4.3ProThr: 4.3 ± 0.032	3.916ProVal: 3.916 ± 0.029	0.731ProTrp: 0.731 ± 0.012	1.586ProTyr: 1.586 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.17GlnAla: 3.17 ± 0.03	0.54GlnCys: 0.54 ± 0.011	1.88GlnAsp: 1.88 ± 0.02	2.057GlnGlu: 2.057 ± 0.021	1.276GlnPhe: 1.276 ± 0.016	1.963GlnGly: 1.963 ± 0.021	1.084GlnHis: 1.084 ± 0.016	1.665GlnIle: 1.665 ± 0.017	1.532GlnLys: 1.532 ± 0.018	3.406GlnLeu: 3.406 ± 0.028	0.834GlnMet: 0.834 ± 0.012	1.223GlnAsn: 1.223 ± 0.016	2.287GlnPro: 2.287 ± 0.025	1.745GlnGln: 1.745 ± 0.036	2.591GlnArg: 2.591 ± 0.021	2.963GlnSer: 2.963 ± 0.029	2.141GlnThr: 2.141 ± 0.02	2.089GlnVal: 2.089 ± 0.024	0.545GlnTrp: 0.545 ± 0.01	1.046GlnTyr: 1.046 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	5.79ArgAla: 5.79 ± 0.038	1.061ArgCys: 1.061 ± 0.017	3.329ArgAsp: 3.329 ± 0.025	3.85ArgGlu: 3.85 ± 0.033	2.268ArgPhe: 2.268 ± 0.021	3.831ArgGly: 3.831 ± 0.029	1.898ArgHis: 1.898 ± 0.021	3.193ArgIle: 3.193 ± 0.025	3.271ArgLys: 3.271 ± 0.03	6.037ArgLeu: 6.037 ± 0.034	1.559ArgMet: 1.559 ± 0.017	2.166ArgAsn: 2.166 ± 0.019	3.94ArgPro: 3.94 ± 0.037	2.394ArgGln: 2.394 ± 0.019	6.118ArgArg: 6.118 ± 0.044	5.625ArgSer: 5.625 ± 0.04	4.038ArgThr: 4.038 ± 0.027	3.916ArgVal: 3.916 ± 0.028	1.045ArgTrp: 1.045 ± 0.014	1.722ArgTyr: 1.722 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	7.576SerAla: 7.576 ± 0.049	1.212SerCys: 1.212 ± 0.017	4.406SerAsp: 4.406 ± 0.033	4.029SerGlu: 4.029 ± 0.035	3.177SerPhe: 3.177 ± 0.028	5.469SerGly: 5.469 ± 0.034	2.338SerHis: 2.338 ± 0.02	4.118SerIle: 4.118 ± 0.033	3.164SerLys: 3.164 ± 0.025	7.87SerLeu: 7.87 ± 0.046	1.864SerMet: 1.864 ± 0.018	2.703SerAsn: 2.703 ± 0.023	6.639SerPro: 6.639 ± 0.055	3.104SerGln: 3.104 ± 0.029	5.627SerArg: 5.627 ± 0.036	10.441SerSer: 10.441 ± 0.082	6.117SerThr: 6.117 ± 0.041	5.156SerVal: 5.156 ± 0.035	1.101SerTrp: 1.101 ± 0.013	2.024SerTyr: 2.024 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.258ThrAla: 5.258 ± 0.035	0.879ThrCys: 0.879 ± 0.015	2.787ThrAsp: 2.787 ± 0.026	2.719ThrGlu: 2.719 ± 0.027	2.42ThrPhe: 2.42 ± 0.024	3.628ThrGly: 3.628 ± 0.029	1.593ThrHis: 1.593 ± 0.017	3.011ThrIle: 3.011 ± 0.025	2.18ThrLys: 2.18 ± 0.02	5.672ThrLeu: 5.672 ± 0.034	1.258ThrMet: 1.258 ± 0.015	1.885ThrAsn: 1.885 ± 0.02	4.595ThrPro: 4.595 ± 0.031	1.983ThrGln: 1.983 ± 0.021	3.613ThrArg: 3.613 ± 0.026	5.908ThrSer: 5.908 ± 0.041	4.082ThrThr: 4.082 ± 0.037	3.891ThrVal: 3.891 ± 0.029	0.816ThrTrp: 0.816 ± 0.013	1.568ThrTyr: 1.568 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.494ValAla: 5.494 ± 0.035	0.96ValCys: 0.96 ± 0.015	3.928ValAsp: 3.928 ± 0.03	3.882ValGlu: 3.882 ± 0.029	2.491ValPhe: 2.491 ± 0.025	3.793ValGly: 3.793 ± 0.026	1.809ValHis: 1.809 ± 0.018	3.041ValIle: 3.041 ± 0.029	2.652ValLys: 2.652 ± 0.026	6.216ValLeu: 6.216 ± 0.035	1.376ValMet: 1.376 ± 0.014	2.061ValAsn: 2.061 ± 0.021	4.239ValPro: 4.239 ± 0.032	2.48ValGln: 2.48 ± 0.021	4.026ValArg: 4.026 ± 0.03	5.048ValSer: 5.048 ± 0.03	3.549ValThr: 3.549 ± 0.027	4.688ValVal: 4.688 ± 0.037	0.903ValTrp: 0.903 ± 0.015	1.688ValTyr: 1.688 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.063TrpAla: 1.063 ± 0.014	0.24TrpCys: 0.24 ± 0.007	0.868TrpAsp: 0.868 ± 0.014	0.797TrpGlu: 0.797 ± 0.013	0.558TrpPhe: 0.558 ± 0.009	0.789TrpGly: 0.789 ± 0.015	0.4TrpHis: 0.4 ± 0.009	0.743TrpIle: 0.743 ± 0.012	0.732TrpLys: 0.732 ± 0.012	1.287TrpLeu: 1.287 ± 0.015	0.387TrpMet: 0.387 ± 0.009	0.586TrpAsn: 0.586 ± 0.009	0.666TrpPro: 0.666 ± 0.012	0.517TrpGln: 0.517 ± 0.012	1.124TrpArg: 1.124 ± 0.015	1.091TrpSer: 1.091 ± 0.015	0.947TrpThr: 0.947 ± 0.013	0.829TrpVal: 0.829 ± 0.013	0.291TrpTrp: 0.291 ± 0.008	0.382TrpTyr: 0.382 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.213TyrAla: 2.213 ± 0.02	0.429TyrCys: 0.429 ± 0.009	1.568TyrAsp: 1.568 ± 0.019	1.378TyrGlu: 1.378 ± 0.015	1.096TyrPhe: 1.096 ± 0.016	1.731TyrGly: 1.731 ± 0.022	0.761TyrHis: 0.761 ± 0.011	1.357TyrIle: 1.357 ± 0.017	1.001TyrLys: 1.001 ± 0.013	2.494TyrLeu: 2.494 ± 0.022	0.56TyrMet: 0.56 ± 0.011	0.933TyrAsn: 0.933 ± 0.012	1.573TyrPro: 1.573 ± 0.017	0.885TyrGln: 0.885 ± 0.013	1.603TyrArg: 1.603 ± 0.018	2.033TyrSer: 2.033 ± 0.018	1.518TyrThr: 1.518 ± 0.019	1.708TyrVal: 1.708 ± 0.021	0.38TyrTrp: 0.38 ± 0.008	0.835TyrTyr: 0.835 ± 0.012	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 14985 proteins (5484969 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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