Amino acid dipepetide frequency for Cellulomonas sp. SLBN-39

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
25.443AlaAla: 25.443 ± 0.238
0.892AlaCys: 0.892 ± 0.027
10.157AlaAsp: 10.157 ± 0.113
7.369AlaGlu: 7.369 ± 0.107
3.357AlaPhe: 3.357 ± 0.06
14.903AlaGly: 14.903 ± 0.131
3.123AlaHis: 3.123 ± 0.056
3.006AlaIle: 3.006 ± 0.055
1.468AlaLys: 1.468 ± 0.05
16.204AlaLeu: 16.204 ± 0.147
2.402AlaMet: 2.402 ± 0.052
1.603AlaAsn: 1.603 ± 0.045
9.264AlaPro: 9.264 ± 0.119
4.594AlaGln: 4.594 ± 0.071
12.268AlaArg: 12.268 ± 0.129
6.502AlaSer: 6.502 ± 0.088
9.366AlaThr: 9.366 ± 0.119
15.079AlaVal: 15.079 ± 0.14
2.564AlaTrp: 2.564 ± 0.051
2.407AlaTyr: 2.407 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.814CysAla: 0.814 ± 0.028
0.057CysCys: 0.057 ± 0.007
0.372CysAsp: 0.372 ± 0.019
0.251CysGlu: 0.251 ± 0.016
0.138CysPhe: 0.138 ± 0.011
0.613CysGly: 0.613 ± 0.022
0.121CysHis: 0.121 ± 0.011
0.099CysIle: 0.099 ± 0.009
0.049CysLys: 0.049 ± 0.006
0.47CysLeu: 0.47 ± 0.019
0.076CysMet: 0.076 ± 0.008
0.069CysAsn: 0.069 ± 0.008
0.352CysPro: 0.352 ± 0.021
0.118CysGln: 0.118 ± 0.009
0.369CysArg: 0.369 ± 0.016
0.306CysSer: 0.306 ± 0.015
0.449CysThr: 0.449 ± 0.02
0.506CysVal: 0.506 ± 0.023
0.081CysTrp: 0.081 ± 0.009
0.11CysTyr: 0.11 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
10.962AspAla: 10.962 ± 0.116
0.232AspCys: 0.232 ± 0.015
5.076AspAsp: 5.076 ± 0.076
4.21AspGlu: 4.21 ± 0.072
1.073AspPhe: 1.073 ± 0.03
7.759AspGly: 7.759 ± 0.106
1.303AspHis: 1.303 ± 0.037
1.022AspIle: 1.022 ± 0.035
0.625AspLys: 0.625 ± 0.025
7.521AspLeu: 7.521 ± 0.083
0.645AspMet: 0.645 ± 0.025
0.622AspAsn: 0.622 ± 0.027
5.22AspPro: 5.22 ± 0.078
1.458AspGln: 1.458 ± 0.037
4.818AspArg: 4.818 ± 0.069
1.616AspSer: 1.616 ± 0.039
2.596AspThr: 2.596 ± 0.048
8.264AspVal: 8.264 ± 0.085
0.813AspTrp: 0.813 ± 0.024
0.92AspTyr: 0.92 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
6.52GluAla: 6.52 ± 0.091
0.198GluCys: 0.198 ± 0.015
2.879GluAsp: 2.879 ± 0.052
2.473GluGlu: 2.473 ± 0.055
0.894GluPhe: 0.894 ± 0.032
3.658GluGly: 3.658 ± 0.061
1.789GluHis: 1.789 ± 0.041
1.794GluIle: 1.794 ± 0.042
0.715GluLys: 0.715 ± 0.027
5.425GluLeu: 5.425 ± 0.075
0.716GluMet: 0.716 ± 0.024
0.734GluAsn: 0.734 ± 0.026
3.361GluPro: 3.361 ± 0.067
2.269GluGln: 2.269 ± 0.054
4.801GluArg: 4.801 ± 0.075
1.693GluSer: 1.693 ± 0.04
2.313GluThr: 2.313 ± 0.047
5.239GluVal: 5.239 ± 0.07
0.544GluTrp: 0.544 ± 0.022
0.824GluTyr: 0.824 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
3.36PheAla: 3.36 ± 0.052
0.153PheCys: 0.153 ± 0.011
1.678PheAsp: 1.678 ± 0.041
1.14PheGlu: 1.14 ± 0.033
0.677PhePhe: 0.677 ± 0.025
2.511PheGly: 2.511 ± 0.043
0.447PheHis: 0.447 ± 0.019
0.454PheIle: 0.454 ± 0.022
0.269PheLys: 0.269 ± 0.015
2.117PheLeu: 2.117 ± 0.053
0.272PheMet: 0.272 ± 0.016
0.396PheAsn: 0.396 ± 0.018
0.992PhePro: 0.992 ± 0.026
0.528PheGln: 0.528 ± 0.023
1.405PheArg: 1.405 ± 0.033
1.154PheSer: 1.154 ± 0.033
1.699PheThr: 1.699 ± 0.047
2.531PheVal: 2.531 ± 0.058
0.38PheTrp: 0.38 ± 0.019
0.461PheTyr: 0.461 ± 0.021
0.0PheXaa: 0.0 ± 0.0
Gly
13.387GlyAla: 13.387 ± 0.137
0.579GlyCys: 0.579 ± 0.02
5.648GlyAsp: 5.648 ± 0.082
4.449GlyGlu: 4.449 ± 0.067
2.546GlyPhe: 2.546 ± 0.046
8.438GlyGly: 8.438 ± 0.116
2.041GlyHis: 2.041 ± 0.049
2.506GlyIle: 2.506 ± 0.05
1.346GlyLys: 1.346 ± 0.035
9.374GlyLeu: 9.374 ± 0.094
1.751GlyMet: 1.751 ± 0.043
1.213GlyAsn: 1.213 ± 0.036
5.68GlyPro: 5.68 ± 0.086
2.506GlyGln: 2.506 ± 0.045
7.772GlyArg: 7.772 ± 0.095
4.91GlySer: 4.91 ± 0.066
7.802GlyThr: 7.802 ± 0.093
9.345GlyVal: 9.345 ± 0.082
1.888GlyTrp: 1.888 ± 0.04
1.99GlyTyr: 1.99 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
3.167HisAla: 3.167 ± 0.052
0.105HisCys: 0.105 ± 0.009
1.626HisAsp: 1.626 ± 0.041
1.185HisGlu: 1.185 ± 0.03
0.376HisPhe: 0.376 ± 0.019
2.331HisGly: 2.331 ± 0.044
0.621HisHis: 0.621 ± 0.024
0.305HisIle: 0.305 ± 0.014
0.199HisLys: 0.199 ± 0.013
2.538HisLeu: 2.538 ± 0.052
0.228HisMet: 0.228 ± 0.013
0.256HisAsn: 0.256 ± 0.013
1.672HisPro: 1.672 ± 0.042
0.506HisGln: 0.506 ± 0.02
1.902HisArg: 1.902 ± 0.047
0.61HisSer: 0.61 ± 0.02
0.987HisThr: 0.987 ± 0.025
2.635HisVal: 2.635 ± 0.056
0.285HisTrp: 0.285 ± 0.015
0.338HisTyr: 0.338 ± 0.018
0.0HisXaa: 0.0 ± 0.0
Ile
3.475IleAla: 3.475 ± 0.063
0.144IleCys: 0.144 ± 0.011
1.795IleAsp: 1.795 ± 0.037
1.365IleGlu: 1.365 ± 0.036
0.525IlePhe: 0.525 ± 0.022
2.59IleGly: 2.59 ± 0.055
0.34IleHis: 0.34 ± 0.017
0.606IleIle: 0.606 ± 0.026
0.388IleLys: 0.388 ± 0.021
1.704IleLeu: 1.704 ± 0.046
0.324IleMet: 0.324 ± 0.016
0.45IleAsn: 0.45 ± 0.024
1.1IlePro: 1.1 ± 0.032
0.462IleGln: 0.462 ± 0.019
1.358IleArg: 1.358 ± 0.037
1.111IleSer: 1.111 ± 0.036
1.695IleThr: 1.695 ± 0.04
2.239IleVal: 2.239 ± 0.046
0.22IleTrp: 0.22 ± 0.012
0.351IleTyr: 0.351 ± 0.017
0.0IleXaa: 0.0 ± 0.0
Lys
1.454LysAla: 1.454 ± 0.043
0.049LysCys: 0.049 ± 0.007
0.731LysAsp: 0.731 ± 0.028
0.534LysGlu: 0.534 ± 0.023
0.24LysPhe: 0.24 ± 0.014
0.945LysGly: 0.945 ± 0.033
0.271LysHis: 0.271 ± 0.016
0.489LysIle: 0.489 ± 0.025
0.342LysLys: 0.342 ± 0.022
0.902LysLeu: 0.902 ± 0.032
0.189LysMet: 0.189 ± 0.015
0.269LysAsn: 0.269 ± 0.014
0.63LysPro: 0.63 ± 0.025
0.349LysGln: 0.349 ± 0.016
0.763LysArg: 0.763 ± 0.036
0.592LysSer: 0.592 ± 0.025
0.724LysThr: 0.724 ± 0.03
1.201LysVal: 1.201 ± 0.037
0.112LysTrp: 0.112 ± 0.009
0.232LysTyr: 0.232 ± 0.014
0.0LysXaa: 0.0 ± 0.0
Leu
17.085LeuAla: 17.085 ± 0.147
0.528LeuCys: 0.528 ± 0.021
7.776LeuAsp: 7.776 ± 0.082
4.605LeuGlu: 4.605 ± 0.072
1.944LeuPhe: 1.944 ± 0.044
9.604LeuGly: 9.604 ± 0.076
2.211LeuHis: 2.211 ± 0.049
1.646LeuIle: 1.646 ± 0.042
0.961LeuLys: 0.961 ± 0.03
11.149LeuLeu: 11.149 ± 0.141
1.256LeuMet: 1.256 ± 0.036
1.15LeuAsn: 1.15 ± 0.035
6.137LeuPro: 6.137 ± 0.079
2.248LeuGln: 2.248 ± 0.04
8.472LeuArg: 8.472 ± 0.107
4.086LeuSer: 4.086 ± 0.061
6.674LeuThr: 6.674 ± 0.078
12.694LeuVal: 12.694 ± 0.139
1.245LeuTrp: 1.245 ± 0.03
1.406LeuTyr: 1.406 ± 0.038
0.0LeuXaa: 0.0 ± 0.0
Met
1.883MetAla: 1.883 ± 0.045
0.088MetCys: 0.088 ± 0.009
0.747MetAsp: 0.747 ± 0.026
0.45MetGlu: 0.45 ± 0.02
0.36MetPhe: 0.36 ± 0.021
1.029MetGly: 1.029 ± 0.033
0.317MetHis: 0.317 ± 0.015
0.446MetIle: 0.446 ± 0.02
0.215MetLys: 0.215 ± 0.014
1.539MetLeu: 1.539 ± 0.041
0.188MetMet: 0.188 ± 0.013
0.235MetAsn: 0.235 ± 0.014
0.987MetPro: 0.987 ± 0.031
0.377MetGln: 0.377 ± 0.018
1.197MetArg: 1.197 ± 0.033
1.261MetSer: 1.261 ± 0.031
1.592MetThr: 1.592 ± 0.034
1.22MetVal: 1.22 ± 0.033
0.164MetTrp: 0.164 ± 0.012
0.213MetTyr: 0.213 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
1.737AsnAla: 1.737 ± 0.046
0.079AsnCys: 0.079 ± 0.008
0.797AsnAsp: 0.797 ± 0.032
0.558AsnGlu: 0.558 ± 0.023
0.365AsnPhe: 0.365 ± 0.017
1.359AsnGly: 1.359 ± 0.043
0.291AsnHis: 0.291 ± 0.016
0.423AsnIle: 0.423 ± 0.02
0.204AsnLys: 0.204 ± 0.014
1.315AsnLeu: 1.315 ± 0.032
0.192AsnMet: 0.192 ± 0.012
0.275AsnAsn: 0.275 ± 0.019
1.057AsnPro: 1.057 ± 0.035
0.381AsnGln: 0.381 ± 0.019
0.813AsnArg: 0.813 ± 0.027
0.509AsnSer: 0.509 ± 0.02
0.695AsnThr: 0.695 ± 0.029
1.343AsnVal: 1.343 ± 0.036
0.153AsnTrp: 0.153 ± 0.011
0.272AsnTyr: 0.272 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
10.774ProAla: 10.774 ± 0.123
0.239ProCys: 0.239 ± 0.011
5.037ProAsp: 5.037 ± 0.066
3.332ProGlu: 3.332 ± 0.062
1.429ProPhe: 1.429 ± 0.036
6.949ProGly: 6.949 ± 0.093
1.292ProHis: 1.292 ± 0.035
0.874ProIle: 0.874 ± 0.031
0.481ProLys: 0.481 ± 0.019
5.067ProLeu: 5.067 ± 0.066
0.867ProMet: 0.867 ± 0.024
0.634ProAsn: 0.634 ± 0.025
3.54ProPro: 3.54 ± 0.074
1.593ProGln: 1.593 ± 0.038
4.214ProArg: 4.214 ± 0.069
3.121ProSer: 3.121 ± 0.043
4.664ProThr: 4.664 ± 0.106
6.736ProVal: 6.736 ± 0.094
1.07ProTrp: 1.07 ± 0.032
0.981ProTyr: 0.981 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.87GlnAla: 3.87 ± 0.068
0.118GlnCys: 0.118 ± 0.01
1.596GlnAsp: 1.596 ± 0.035
1.282GlnGlu: 1.282 ± 0.038
0.563GlnPhe: 0.563 ± 0.026
2.126GlnGly: 2.126 ± 0.041
0.676GlnHis: 0.676 ± 0.023
0.955GlnIle: 0.955 ± 0.028
0.339GlnLys: 0.339 ± 0.018
2.639GlnLeu: 2.639 ± 0.044
0.495GlnMet: 0.495 ± 0.023
0.407GlnAsn: 0.407 ± 0.022
1.466GlnPro: 1.466 ± 0.044
1.062GlnGln: 1.062 ± 0.032
2.34GlnArg: 2.34 ± 0.041
0.955GlnSer: 0.955 ± 0.029
1.416GlnThr: 1.416 ± 0.034
3.582GlnVal: 3.582 ± 0.06
0.418GlnTrp: 0.418 ± 0.021
0.485GlnTyr: 0.485 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
11.724ArgAla: 11.724 ± 0.123
0.431ArgCys: 0.431 ± 0.024
4.546ArgAsp: 4.546 ± 0.073
3.84ArgGlu: 3.84 ± 0.063
1.918ArgPhe: 1.918 ± 0.039
6.136ArgGly: 6.136 ± 0.075
1.883ArgHis: 1.883 ± 0.046
2.126ArgIle: 2.126 ± 0.044
0.812ArgLys: 0.812 ± 0.034
8.367ArgLeu: 8.367 ± 0.107
1.483ArgMet: 1.483 ± 0.039
0.886ArgAsn: 0.886 ± 0.027
4.983ArgPro: 4.983 ± 0.076
1.911ArgGln: 1.911 ± 0.043
8.158ArgArg: 8.158 ± 0.106
3.861ArgSer: 3.861 ± 0.062
6.261ArgThr: 6.261 ± 0.08
7.554ArgVal: 7.554 ± 0.082
1.626ArgTrp: 1.626 ± 0.037
1.568ArgTyr: 1.568 ± 0.034
0.0ArgXaa: 0.0 ± 0.0
Ser
6.421SerAla: 6.421 ± 0.081
0.291SerCys: 0.291 ± 0.018
2.399SerAsp: 2.399 ± 0.046
1.72SerGlu: 1.72 ± 0.041
1.27SerPhe: 1.27 ± 0.033
5.004SerGly: 5.004 ± 0.074
0.789SerHis: 0.789 ± 0.023
1.175SerIle: 1.175 ± 0.033
0.499SerLys: 0.499 ± 0.021
4.021SerLeu: 4.021 ± 0.063
0.828SerMet: 0.828 ± 0.024
0.674SerAsn: 0.674 ± 0.025
2.884SerPro: 2.884 ± 0.056
1.078SerGln: 1.078 ± 0.032
3.262SerArg: 3.262 ± 0.049
2.679SerSer: 2.679 ± 0.062
3.77SerThr: 3.77 ± 0.069
4.195SerVal: 4.195 ± 0.062
0.873SerTrp: 0.873 ± 0.031
0.922SerTyr: 0.922 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
9.475ThrAla: 9.475 ± 0.121
0.444ThrCys: 0.444 ± 0.019
3.966ThrAsp: 3.966 ± 0.063
2.434ThrGlu: 2.434 ± 0.043
1.857ThrPhe: 1.857 ± 0.04
7.112ThrGly: 7.112 ± 0.096
1.249ThrHis: 1.249 ± 0.033
1.674ThrIle: 1.674 ± 0.043
0.671ThrLys: 0.671 ± 0.024
6.452ThrLeu: 6.452 ± 0.079
0.861ThrMet: 0.861 ± 0.03
0.953ThrAsn: 0.953 ± 0.031
5.048ThrPro: 5.048 ± 0.107
1.574ThrGln: 1.574 ± 0.042
4.335ThrArg: 4.335 ± 0.06
3.807ThrSer: 3.807 ± 0.072
5.38ThrThr: 5.38 ± 0.1
7.375ThrVal: 7.375 ± 0.112
1.276ThrTrp: 1.276 ± 0.037
1.327ThrTyr: 1.327 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
16.081ValAla: 16.081 ± 0.144
0.551ValCys: 0.551 ± 0.022
7.774ValAsp: 7.774 ± 0.101
6.043ValGlu: 6.043 ± 0.073
2.096ValPhe: 2.096 ± 0.047
9.281ValGly: 9.281 ± 0.109
2.46ValHis: 2.46 ± 0.051
2.028ValIle: 2.028 ± 0.046
1.045ValLys: 1.045 ± 0.032
12.518ValLeu: 12.518 ± 0.131
1.293ValMet: 1.293 ± 0.036
1.371ValAsn: 1.371 ± 0.033
6.897ValPro: 6.897 ± 0.087
2.663ValGln: 2.663 ± 0.048
8.938ValArg: 8.938 ± 0.101
4.11ValSer: 4.11 ± 0.059
7.052ValThr: 7.052 ± 0.109
14.327ValVal: 14.327 ± 0.135
1.319ValTrp: 1.319 ± 0.032
1.508ValTyr: 1.508 ± 0.043
0.0ValXaa: 0.0 ± 0.0
Trp
1.977TrpAla: 1.977 ± 0.038
0.134TrpCys: 0.134 ± 0.01
0.952TrpAsp: 0.952 ± 0.032
0.684TrpGlu: 0.684 ± 0.02
0.524TrpPhe: 0.524 ± 0.019
1.143TrpGly: 1.143 ± 0.035
0.347TrpHis: 0.347 ± 0.017
0.35TrpIle: 0.35 ± 0.018
0.17TrpLys: 0.17 ± 0.01
1.67TrpLeu: 1.67 ± 0.037
0.259TrpMet: 0.259 ± 0.013
0.327TrpAsn: 0.327 ± 0.016
0.755TrpPro: 0.755 ± 0.024
0.578TrpGln: 0.578 ± 0.022
1.372TrpArg: 1.372 ± 0.037
1.117TrpSer: 1.117 ± 0.035
1.107TrpThr: 1.107 ± 0.033
1.55TrpVal: 1.55 ± 0.037
0.462TrpTrp: 0.462 ± 0.022
0.295TrpTyr: 0.295 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.363TyrAla: 2.363 ± 0.046
0.111TyrCys: 0.111 ± 0.008
1.202TyrAsp: 1.202 ± 0.037
0.915TyrGlu: 0.915 ± 0.029
0.468TyrPhe: 0.468 ± 0.02
1.681TyrGly: 1.681 ± 0.04
0.302TyrHis: 0.302 ± 0.015
0.264TyrIle: 0.264 ± 0.017
0.221TyrLys: 0.221 ± 0.015
1.885TyrLeu: 1.885 ± 0.039
0.181TyrMet: 0.181 ± 0.012
0.295TyrAsn: 0.295 ± 0.018
0.869TyrPro: 0.869 ± 0.028
0.533TyrGln: 0.533 ± 0.025
1.518TyrArg: 1.518 ± 0.038
0.754TyrSer: 0.754 ± 0.03
1.027TyrThr: 1.027 ± 0.039
1.74TyrVal: 1.74 ± 0.047
0.279TyrTrp: 0.279 ± 0.015
0.361TyrTyr: 0.361 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3709 proteins (1256622 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski