Amino acid dipepetide frequency for Chryseobacterium sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.848AlaAla: 3.848 ± 0.091	0.483AlaCys: 0.483 ± 0.025	3.427AlaAsp: 3.427 ± 0.067	4.504AlaGlu: 4.504 ± 0.083	3.124AlaPhe: 3.124 ± 0.059	3.947AlaGly: 3.947 ± 0.073	1.018AlaHis: 1.018 ± 0.03	4.639AlaIle: 4.639 ± 0.08	5.15AlaLys: 5.15 ± 0.075	5.523AlaLeu: 5.523 ± 0.088	1.443AlaMet: 1.443 ± 0.042	3.257AlaAsn: 3.257 ± 0.065	1.658AlaPro: 1.658 ± 0.049	2.323AlaGln: 2.323 ± 0.053	1.855AlaArg: 1.855 ± 0.052	3.676AlaSer: 3.676 ± 0.072	3.138AlaThr: 3.138 ± 0.067	3.915AlaVal: 3.915 ± 0.078	0.581AlaTrp: 0.581 ± 0.028	2.137AlaTyr: 2.137 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.439CysAla: 0.439 ± 0.022	0.106CysCys: 0.106 ± 0.011	0.395CysAsp: 0.395 ± 0.021	0.48CysGlu: 0.48 ± 0.026	0.466CysPhe: 0.466 ± 0.024	0.619CysGly: 0.619 ± 0.029	0.184CysHis: 0.184 ± 0.016	0.567CysIle: 0.567 ± 0.027	0.557CysLys: 0.557 ± 0.027	0.612CysLeu: 0.612 ± 0.026	0.154CysMet: 0.154 ± 0.014	0.395CysAsn: 0.395 ± 0.022	0.312CysPro: 0.312 ± 0.025	0.213CysGln: 0.213 ± 0.017	0.208CysArg: 0.208 ± 0.016	0.524CysSer: 0.524 ± 0.027	0.381CysThr: 0.381 ± 0.021	0.445CysVal: 0.445 ± 0.023	0.061CysTrp: 0.061 ± 0.009	0.279CysTyr: 0.279 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.337AspAla: 3.337 ± 0.061	0.365AspCys: 0.365 ± 0.023	2.985AspAsp: 2.985 ± 0.063	4.455AspGlu: 4.455 ± 0.085	4.251AspPhe: 4.251 ± 0.065	3.285AspGly: 3.285 ± 0.075	1.013AspHis: 1.013 ± 0.039	4.176AspIle: 4.176 ± 0.072	4.597AspLys: 4.597 ± 0.076	5.565AspLeu: 5.565 ± 0.083	1.081AspMet: 1.081 ± 0.033	2.907AspAsn: 2.907 ± 0.058	1.684AspPro: 1.684 ± 0.046	1.947AspGln: 1.947 ± 0.051	1.788AspArg: 1.788 ± 0.044	3.255AspSer: 3.255 ± 0.07	2.318AspThr: 2.318 ± 0.061	3.487AspVal: 3.487 ± 0.064	0.787AspTrp: 0.787 ± 0.034	2.792AspTyr: 2.792 ± 0.063	0.0AspXaa: 0.0 ± 0.0
Glu	4.0GluAla: 4.0 ± 0.07	0.369GluCys: 0.369 ± 0.023	3.759GluAsp: 3.759 ± 0.075	5.357GluGlu: 5.357 ± 0.102	3.468GluPhe: 3.468 ± 0.067	3.571GluGly: 3.571 ± 0.064	1.144GluHis: 1.144 ± 0.038	6.567GluIle: 6.567 ± 0.107	7.831GluLys: 7.831 ± 0.114	6.259GluLeu: 6.259 ± 0.09	1.851GluMet: 1.851 ± 0.048	5.901GluAsn: 5.901 ± 0.082	1.51GluPro: 1.51 ± 0.047	2.283GluGln: 2.283 ± 0.054	2.548GluArg: 2.548 ± 0.071	3.791GluSer: 3.791 ± 0.067	3.712GluThr: 3.712 ± 0.075	4.137GluVal: 4.137 ± 0.073	0.713GluTrp: 0.713 ± 0.034	2.567GluTyr: 2.567 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	3.294PheAla: 3.294 ± 0.061	0.516PheCys: 0.516 ± 0.026	3.423PheAsp: 3.423 ± 0.066	3.75PheGlu: 3.75 ± 0.065	2.988PhePhe: 2.988 ± 0.067	3.628PheGly: 3.628 ± 0.071	0.972PheHis: 0.972 ± 0.032	4.057PheIle: 4.057 ± 0.077	4.085PheLys: 4.085 ± 0.072	5.165PheLeu: 5.165 ± 0.09	1.037PheMet: 1.037 ± 0.035	3.204PheAsn: 3.204 ± 0.069	1.975PhePro: 1.975 ± 0.044	1.72PheGln: 1.72 ± 0.045	1.79PheArg: 1.79 ± 0.052	4.336PheSer: 4.336 ± 0.07	3.083PheThr: 3.083 ± 0.061	3.165PheVal: 3.165 ± 0.067	0.612PheTrp: 0.612 ± 0.024	2.471PheTyr: 2.471 ± 0.054	0.0PheXaa: 0.0 ± 0.0
Gly	3.563GlyAla: 3.563 ± 0.081	0.524GlyCys: 0.524 ± 0.028	2.925GlyAsp: 2.925 ± 0.063	3.715GlyGlu: 3.715 ± 0.067	3.628GlyPhe: 3.628 ± 0.062	3.845GlyGly: 3.845 ± 0.098	1.022GlyHis: 1.022 ± 0.039	5.167GlyIle: 5.167 ± 0.075	5.777GlyLys: 5.777 ± 0.094	5.121GlyLeu: 5.121 ± 0.085	1.529GlyMet: 1.529 ± 0.038	3.734GlyAsn: 3.734 ± 0.081	0.99GlyPro: 0.99 ± 0.036	1.701GlyGln: 1.701 ± 0.046	1.939GlyArg: 1.939 ± 0.054	3.627GlySer: 3.627 ± 0.071	3.418GlyThr: 3.418 ± 0.079	3.686GlyVal: 3.686 ± 0.062	0.752GlyTrp: 0.752 ± 0.03	2.502GlyTyr: 2.502 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	0.903HisAla: 0.903 ± 0.032	0.182HisCys: 0.182 ± 0.015	0.898HisAsp: 0.898 ± 0.034	1.082HisGlu: 1.082 ± 0.034	1.205HisPhe: 1.205 ± 0.042	1.001HisGly: 1.001 ± 0.038	0.49HisHis: 0.49 ± 0.025	1.338HisIle: 1.338 ± 0.034	1.115HisLys: 1.115 ± 0.034	1.833HisLeu: 1.833 ± 0.051	0.298HisMet: 0.298 ± 0.018	0.918HisAsn: 0.918 ± 0.028	0.907HisPro: 0.907 ± 0.033	0.788HisGln: 0.788 ± 0.032	0.643HisArg: 0.643 ± 0.026	1.169HisSer: 1.169 ± 0.037	0.848HisThr: 0.848 ± 0.029	0.766HisVal: 0.766 ± 0.034	0.214HisTrp: 0.214 ± 0.017	0.847HisTyr: 0.847 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.126IleAla: 5.126 ± 0.071	0.7IleCys: 0.7 ± 0.03	4.859IleAsp: 4.859 ± 0.081	5.547IleGlu: 5.547 ± 0.087	4.112IlePhe: 4.112 ± 0.076	4.691IleGly: 4.691 ± 0.08	1.404IleHis: 1.404 ± 0.046	6.068IleIle: 6.068 ± 0.094	6.25IleLys: 6.25 ± 0.086	7.662IleLeu: 7.662 ± 0.104	1.474IleMet: 1.474 ± 0.041	4.785IleAsn: 4.785 ± 0.071	3.178IlePro: 3.178 ± 0.062	2.873IleGln: 2.873 ± 0.065	2.496IleArg: 2.496 ± 0.057	6.208IleSer: 6.208 ± 0.097	4.275IleThr: 4.275 ± 0.061	4.57IleVal: 4.57 ± 0.074	0.724IleTrp: 0.724 ± 0.033	2.918IleTyr: 2.918 ± 0.072	0.0IleXaa: 0.0 ± 0.0
Lys	5.007LysAla: 5.007 ± 0.068	0.374LysCys: 0.374 ± 0.022	5.385LysAsp: 5.385 ± 0.085	6.646LysGlu: 6.646 ± 0.107	3.774LysPhe: 3.774 ± 0.065	4.578LysGly: 4.578 ± 0.072	1.329LysHis: 1.329 ± 0.042	7.807LysIle: 7.807 ± 0.103	8.095LysLys: 8.095 ± 0.122	7.101LysLeu: 7.101 ± 0.09	2.406LysMet: 2.406 ± 0.058	6.634LysAsn: 6.634 ± 0.109	2.653LysPro: 2.653 ± 0.054	2.89LysGln: 2.89 ± 0.062	2.724LysArg: 2.724 ± 0.057	5.304LysSer: 5.304 ± 0.079	5.342LysThr: 5.342 ± 0.081	5.043LysVal: 5.043 ± 0.078	0.857LysTrp: 0.857 ± 0.03	3.318LysTyr: 3.318 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	5.509LeuAla: 5.509 ± 0.077	0.699LeuCys: 0.699 ± 0.029	4.988LeuAsp: 4.988 ± 0.073	6.375LeuGlu: 6.375 ± 0.098	4.705LeuPhe: 4.705 ± 0.079	5.502LeuGly: 5.502 ± 0.084	1.561LeuHis: 1.561 ± 0.039	6.813LeuIle: 6.813 ± 0.105	8.487LeuLys: 8.487 ± 0.113	8.224LeuLeu: 8.224 ± 0.129	2.176LeuMet: 2.176 ± 0.06	5.884LeuAsn: 5.884 ± 0.095	3.502LeuPro: 3.502 ± 0.069	3.459LeuGln: 3.459 ± 0.06	3.04LeuArg: 3.04 ± 0.064	6.651LeuSer: 6.651 ± 0.087	4.668LeuThr: 4.668 ± 0.074	4.919LeuVal: 4.919 ± 0.084	0.83LeuTrp: 0.83 ± 0.031	3.088LeuTyr: 3.088 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	1.369MetAla: 1.369 ± 0.038	0.119MetCys: 0.119 ± 0.012	1.144MetAsp: 1.144 ± 0.034	1.624MetGlu: 1.624 ± 0.038	0.914MetPhe: 0.914 ± 0.036	1.316MetGly: 1.316 ± 0.044	0.388MetHis: 0.388 ± 0.023	1.696MetIle: 1.696 ± 0.042	2.594MetLys: 2.594 ± 0.052	1.836MetLeu: 1.836 ± 0.043	0.789MetMet: 0.789 ± 0.033	1.513MetAsn: 1.513 ± 0.048	0.853MetPro: 0.853 ± 0.03	0.86MetGln: 0.86 ± 0.035	0.842MetArg: 0.842 ± 0.032	1.497MetSer: 1.497 ± 0.045	1.168MetThr: 1.168 ± 0.035	1.327MetVal: 1.327 ± 0.039	0.169MetTrp: 0.169 ± 0.012	0.685MetTyr: 0.685 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	3.842AsnAla: 3.842 ± 0.07	0.464AsnCys: 0.464 ± 0.027	3.292AsnAsp: 3.292 ± 0.058	4.15AsnGlu: 4.15 ± 0.077	3.61AsnPhe: 3.61 ± 0.072	3.904AsnGly: 3.904 ± 0.077	1.157AsnHis: 1.157 ± 0.038	5.202AsnIle: 5.202 ± 0.078	4.448AsnLys: 4.448 ± 0.085	6.021AsnLeu: 6.021 ± 0.087	1.229AsnMet: 1.229 ± 0.037	3.833AsnAsn: 3.833 ± 0.081	2.858AsnPro: 2.858 ± 0.061	2.6AsnGln: 2.6 ± 0.056	2.029AsnArg: 2.029 ± 0.05	4.267AsnSer: 4.267 ± 0.084	3.137AsnThr: 3.137 ± 0.07	3.55AsnVal: 3.55 ± 0.067	0.847AsnTrp: 0.847 ± 0.033	2.947AsnTyr: 2.947 ± 0.062	0.0AsnXaa: 0.0 ± 0.0
Pro	1.976ProAla: 1.976 ± 0.05	0.216ProCys: 0.216 ± 0.015	1.994ProAsp: 1.994 ± 0.046	3.095ProGlu: 3.095 ± 0.067	1.897ProPhe: 1.897 ± 0.053	1.688ProGly: 1.688 ± 0.048	0.624ProHis: 0.624 ± 0.026	2.4ProIle: 2.4 ± 0.054	2.828ProLys: 2.828 ± 0.063	2.73ProLeu: 2.73 ± 0.061	0.692ProMet: 0.692 ± 0.029	2.12ProAsn: 2.12 ± 0.049	0.712ProPro: 0.712 ± 0.033	1.235ProGln: 1.235 ± 0.033	0.901ProArg: 0.901 ± 0.033	2.03ProSer: 2.03 ± 0.045	1.858ProThr: 1.858 ± 0.04	2.363ProVal: 2.363 ± 0.052	0.316ProTrp: 0.316 ± 0.018	1.264ProTyr: 1.264 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	1.747GlnAla: 1.747 ± 0.054	0.181GlnCys: 0.181 ± 0.014	1.706GlnAsp: 1.706 ± 0.043	2.414GlnGlu: 2.414 ± 0.058	1.934GlnPhe: 1.934 ± 0.052	1.567GlnGly: 1.567 ± 0.045	0.601GlnHis: 0.601 ± 0.024	3.137GlnIle: 3.137 ± 0.068	3.789GlnLys: 3.789 ± 0.071	3.333GlnLeu: 3.333 ± 0.067	0.884GlnMet: 0.884 ± 0.033	2.878GlnAsn: 2.878 ± 0.063	1.18GlnPro: 1.18 ± 0.036	1.558GlnGln: 1.558 ± 0.047	1.255GlnArg: 1.255 ± 0.034	2.206GlnSer: 2.206 ± 0.047	1.998GlnThr: 1.998 ± 0.051	1.819GlnVal: 1.819 ± 0.042	0.312GlnTrp: 0.312 ± 0.019	1.476GlnTyr: 1.476 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	1.752ArgAla: 1.752 ± 0.044	0.22ArgCys: 0.22 ± 0.017	1.701ArgAsp: 1.701 ± 0.049	2.39ArgGlu: 2.39 ± 0.058	1.914ArgPhe: 1.914 ± 0.045	1.629ArgGly: 1.629 ± 0.046	0.582ArgHis: 0.582 ± 0.027	2.922ArgIle: 2.922 ± 0.058	3.169ArgLys: 3.169 ± 0.062	2.963ArgLeu: 2.963 ± 0.061	0.913ArgMet: 0.913 ± 0.031	2.217ArgAsn: 2.217 ± 0.053	0.966ArgPro: 0.966 ± 0.034	1.129ArgGln: 1.129 ± 0.033	1.255ArgArg: 1.255 ± 0.039	1.854ArgSer: 1.854 ± 0.048	1.669ArgThr: 1.669 ± 0.048	1.849ArgVal: 1.849 ± 0.045	0.343ArgTrp: 0.343 ± 0.02	1.242ArgTyr: 1.242 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.013SerAla: 4.013 ± 0.066	0.631SerCys: 0.631 ± 0.031	3.688SerAsp: 3.688 ± 0.069	4.827SerGlu: 4.827 ± 0.082	3.945SerPhe: 3.945 ± 0.063	4.466SerGly: 4.466 ± 0.086	1.159SerHis: 1.159 ± 0.038	4.987SerIle: 4.987 ± 0.076	5.565SerLys: 5.565 ± 0.083	6.0SerLeu: 6.0 ± 0.094	1.305SerMet: 1.305 ± 0.035	3.522SerAsn: 3.522 ± 0.07	2.202SerPro: 2.202 ± 0.051	2.492SerGln: 2.492 ± 0.064	2.065SerArg: 2.065 ± 0.051	4.268SerSer: 4.268 ± 0.092	3.377SerThr: 3.377 ± 0.065	4.081SerVal: 4.081 ± 0.074	0.691SerTrp: 0.691 ± 0.028	2.685SerTyr: 2.685 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	3.505ThrAla: 3.505 ± 0.068	0.308ThrCys: 0.308 ± 0.017	3.263ThrAsp: 3.263 ± 0.06	3.764ThrGlu: 3.764 ± 0.067	2.924ThrPhe: 2.924 ± 0.055	3.435ThrGly: 3.435 ± 0.071	0.855ThrHis: 0.855 ± 0.034	4.406ThrIle: 4.406 ± 0.07	4.095ThrLys: 4.095 ± 0.073	4.746ThrLeu: 4.746 ± 0.069	0.99ThrMet: 0.99 ± 0.035	2.943ThrAsn: 2.943 ± 0.06	2.11ThrPro: 2.11 ± 0.053	1.898ThrGln: 1.898 ± 0.049	1.461ThrArg: 1.461 ± 0.038	3.481ThrSer: 3.481 ± 0.07	2.93ThrThr: 2.93 ± 0.067	3.258ThrVal: 3.258 ± 0.063	0.495ThrTrp: 0.495 ± 0.026	2.118ThrTyr: 2.118 ± 0.057	0.0ThrXaa: 0.0 ± 0.0
Val	3.634ValAla: 3.634 ± 0.07	0.46ValCys: 0.46 ± 0.02	3.209ValAsp: 3.209 ± 0.054	3.969ValGlu: 3.969 ± 0.08	3.237ValPhe: 3.237 ± 0.064	3.493ValGly: 3.493 ± 0.077	0.87ValHis: 0.87 ± 0.031	4.518ValIle: 4.518 ± 0.078	4.904ValLys: 4.904 ± 0.072	5.543ValLeu: 5.543 ± 0.085	1.387ValMet: 1.387 ± 0.041	3.499ValAsn: 3.499 ± 0.075	1.973ValPro: 1.973 ± 0.043	1.831ValGln: 1.831 ± 0.043	1.893ValArg: 1.893 ± 0.046	4.439ValSer: 4.439 ± 0.072	3.089ValThr: 3.089 ± 0.055	3.594ValVal: 3.594 ± 0.076	0.602ValTrp: 0.602 ± 0.026	2.272ValTyr: 2.272 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.592TrpAla: 0.592 ± 0.025	0.106TrpCys: 0.106 ± 0.01	0.643TrpAsp: 0.643 ± 0.026	0.749TrpGlu: 0.749 ± 0.033	0.564TrpPhe: 0.564 ± 0.025	0.644TrpGly: 0.644 ± 0.027	0.198TrpHis: 0.198 ± 0.017	0.713TrpIle: 0.713 ± 0.028	0.98TrpLys: 0.98 ± 0.037	0.962TrpLeu: 0.962 ± 0.038	0.351TrpMet: 0.351 ± 0.023	0.798TrpAsn: 0.798 ± 0.032	0.223TrpPro: 0.223 ± 0.017	0.422TrpGln: 0.422 ± 0.022	0.365TrpArg: 0.365 ± 0.019	0.585TrpSer: 0.585 ± 0.025	0.527TrpThr: 0.527 ± 0.025	0.569TrpVal: 0.569 ± 0.026	0.145TrpTrp: 0.145 ± 0.014	0.388TrpTyr: 0.388 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.19TyrAla: 2.19 ± 0.056	0.374TyrCys: 0.374 ± 0.025	2.391TyrAsp: 2.391 ± 0.064	2.445TyrGlu: 2.445 ± 0.057	2.61TyrPhe: 2.61 ± 0.062	2.354TyrGly: 2.354 ± 0.061	0.874TyrHis: 0.874 ± 0.036	2.744TyrIle: 2.744 ± 0.053	2.95TyrLys: 2.95 ± 0.051	3.881TyrLeu: 3.881 ± 0.063	0.713TyrMet: 0.713 ± 0.027	2.443TyrAsn: 2.443 ± 0.051	1.495TyrPro: 1.495 ± 0.042	1.753TyrGln: 1.753 ± 0.046	1.583TyrArg: 1.583 ± 0.044	2.8TyrSer: 2.8 ± 0.06	2.05TyrThr: 2.05 ± 0.053	1.875TyrVal: 1.875 ± 0.047	0.472TyrTrp: 0.472 ± 0.024	1.813TyrTyr: 1.813 ± 0.055	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3175 proteins (888173 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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